Superfan and photographer Tyren Redd outdid himself.

"I will hold the vote hostage if I have to."

The King was honored for his extensive philanthropic work

The Pantene Style Stage is full of fashionable stars.

Got me boo'd up, boo'd up!

Sponsored by Credit Karma.

Grab a Coke with your bestie!

Grab a Coke with your bestie!

The only way to go from the Main Stage, is up.

#ICYMI

Is your organization aiming to increase the participation of minority-and women-owned businesses in state and local transportation projects? TRB will conduct a webinar on Wednesday, May 27, 2020, from 2:00 PM to 3:30 PM Eastern to discuss how to meet the goals set by the U.S. Department of Transportation Disadvantaged Business Enterprise (USDOT DBE). State and local transportation projects that receive federal funding are mandated to go through the triennial DBE goal-setting process. Make your next goals...

Critical Issues in Trucking Workforce Development , released by the Mineta Transportation Institute at San Jose State University

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources.

IBM and Health Benefits Limited announce agreement to introduce National Infrastructure Platform to District Health Boards, based on IBM Cloud.

宝塚花組新トップ柚香光が「みなさんに会える日を楽しみに…」お披露目公演初日が延期中/芸能/デイリースポーツ online https://t.co/9MU84zVJzC #DailySports— デイリースポーツ (@Daily_Online) March 31, 2020 この投稿をInstagramで見る ...

予約開始しました!! 宝塚おとめ2020年度版 宝塚ムック 発売日： 2020/4/24 【インタビュー】 VOCE（ヴォーチェ）｜美容雑誌『VOCE』公式サイト 宝塚花組トップスターを直撃！【柚香光】さんの輝きの秘密は？ with online - 講談社公式 - | 恋も仕事もわた...

1010ll:

https://www.instagram.com/p/BbC7ZP5FEdJ/?

1. Happy birthday Sai Pallavi: 4 times the actress redefined female superstar tag  Onmanorama
2. Birthday Special! Sai Pallavi is the epitome of elegance and grace in sarees. PHOTOS  Times of India
3. Happy Birthday Sai Pallavi: 5 Instagram Pictures Of The Actress You Can’t Miss  News18
4. Happy birthday Sai Pallavi: A powerhouse performer  Deccan Herald
5. Sai Pallavi birthday: Rana Daggubati, Naga Chaitanya and others send wishes  The Indian Express
6. View Full coverage on Google News

Valerie De Booser deelt uitdagende foto op Instagram vanuit haar kot  Het NieuwsbladHele verhaal bekijken via Google Nieuws

Food, art, even public space now seems to revolve around aesthetic value as judged by the social network.

Whether it’s a small new restaurant or a major art gallery exhibition, it seems Toronto’s cultural institutions must cater to the “like” seeking set. The price of success today is a sacrifice made at the altar of Instagram. Of course, to some, it’s not viewed as a sacrifice at all, especially when it boosts business […]

The post Has Toronto Become a City of Instagram Photo Ops? appeared first on Torontoist.

Instagram уверенно удерживает репутацию ведущей онлайн-маркетинговой платформы. Взаимодействие инстаграмеров с различными брендами в 10 раз активнее по сравнению с пользователями Facebook. Тем не менее, не все маркетологи знают, как грамотно управлять своим аккаунтом для того, чтобы привлечь к своему бизнесу как можно больше потенциальных клиентов. Сегодня мы расскажем о новом приложении Combin, которое очень облегчает специалистам решение этих задач.