44-year-old Antoine Anderson appeared in Magistrates Court charged with escaping lawful custody from the Prison Farm in St. George’s. It is related to an alleged incident earlier this week, and as it is an indictable offense he was not required to enter a plea. Anderson is due to reappear in the Supreme Court at the […]

Three men appeared in Magistrate’s Court today [Aug 26] charged in connection with the death of Marcus Wilson, who was fatally stabbed earlier this month in Warwick. Jaja DeSilva, Isiah Smith and Omari Williams were charged in connection with the matter. The defendants, who are aged from 18 to their mid 20s, were not required to […]

MP Zane DeSilva was charged today [Oct 26] in Magistrate’s Court with allegedly violating the Proceeds of Crime act. The charge alleged that between April 2018 and August 2018, he “entered into or became concerned in an arrangement, which you knew or suspected facilitated the use or control of criminal property by or on behalf […]

What is the fake "Seedify Regstration" website?

While browsing suspicious websites, our researchers discovered the "Seedify Regstration" scam. It imitates the Seedify website (seedify.fund). The scheme operates as a cryptocurrency drainer and steals funds from exposed digital wallets. It must be emphasized that this scam is not associated with Seedify.

Registration is now open for National O.T.O. Conference XIV, to be held in Denver, Colorado, August 3-6 2023. NOTOCON is normally held every two years, but it was canceled in 2021 due to the pandemic, so this will be our first NOTOCON since 2019.

NOTOCON XIV is fast approaching! The cutoff date to receive our group rate at the hotel is Friday, July 21st. Please reserve now. The speaker schedule has been published on the NOTOCON website. Event registration is still open! We can’t wait to see all of you in August, and wish you all safe travels!

It's the eve of the Texas Book Festival so make sure you check out the festivities on the Capitol grounds! And here's a tentative list of projects from Austin authors and illustrators releasing next year! For previous years, go here.

Picture Books, Easy Readers, and Board Books

WHAT DO YOU DO WITH A VOICE LIKE THAT? by Chris Barton, ill. by Ekua Holmes (Simon & Schuster/Beach Lane 2018).

MIGHTY TRUCK: ON THE FARM, by Chris Barton, ill. by Troy Cummings (HarperCollins, May 2018).

PENGUIN AND TINY SHRIMP DON'T DO BEDTIME, by Cate Berry, ill. by Charles Santoso (Balzer + Bray/HarperCollins 2018).

ABRAHAM LINCOLN'S DUELING WORDS, by Donna Janell Bowman, ill. by S.D. Schindler (Peachtree, 2018)

THE BOOK THAT JAKE BORROWED, by Susan Kralovansky (Pelican 2018).

COUNTING COLORS IN TEXAS, by Susan Kralovansky (Pelican 2018).

KATE, WHO TAMED THE WIND, by Liz Garton Scanlon, ill. by Lee White (Schwartz & Wade, Spring 2018).

FRANCES IN THE COUNTRY, by Liz Garton Scanlon, ill. by Sean Qualls (Neal Porter Books/Roaring Brook Press, Summer 2018).

DEAR SUBSTITUTE, by Liz Garton Scanlon, ill. by Chris Raschka (Disney-Hyperion, Summer 2018).

STALEBREAD CHARLIE AND THE RAZZY, DAZZY SPASM BAND,  by Michael Mahin, ill. by Don Tate (Houghton Mifflin Harcourt, 2018).

PAR-TAY: DANCE OF THE VEGGIES (AND THEIR FRIENDS), by Eloise Greenfield, ill. by Don Tate (Alazar Press 2018).

POTATO KING: THE STORY OF JUNIUS G. GROVES, by Don Tate (Knopf 2018).
 

Middle Grade

THE BOY, THE BOAT, AND THE BEAST, by Samantha Clark (Paula Wiseman Books/Simon & Schuster, Summer 2018).

KNOCKOUT, by K.A. Holt (Chronicle, Spring 2018).

DEAR ME (tent. title), by K.A. Holt (Scholastic, Summer 2018).

THE PARKER INHERITANCE, by Varian Johnson (Scholastic, Spring 2018).

THE CAMELOT CODE: THE ONCE AND FUTURE GEEK, by Mari Mancusi (Disney-Hyperion, Oct. 2018).

GIRLS WHO CODE: LIGHTS, MUSIC, CODE, by Jo Whittemore (Penguin Workshop, Spring 2018).

REVENGE OF THE TEACHER'S PETS, by Jennifer Ziegler (Scholastic, June 2018).

Young Adult

HEARTS UNBROKEN, by Cynthia Leitich Smith (Candlewick Press, 2018).

AVENGED, by Amy Tintera (HarperTeen, May 2018).

This illustrator, John Holcroft, is genius! check out his website for more.

 

One year after Creative Commons (CC) hosted an exploratory Open Culture Roundtable, in Lisbon, Portugal, which initiated the Towards a Recommendation on Open Culture (TAROC) global initiative, nearly 50 stakeholders from all continents gathered again for a strategic workshop, in Lisbon in May 2024. In this blog post, we share a snapshot of key highlights.

The post A Quick Look at the CC Strategic Workshop on Open Heritage appeared first on Creative Commons.

Image by Mario Jr. Nicorelli is licensed via CC BY-NC 2.0 Over the past weeks, the CC board and team have been working behind the scenes on our strategy refresh. We are excited to share our progress as we enter the community engagement phase of the refresh and explain how you can contribute to the process.…

The post CC Is Refreshing Its Strategy. Here’s Why Your Voice Matters. appeared first on Creative Commons.

In May 2024, CC organized a strategic workshop in Lisbon to develop a roadmap for future action to advance our work towards a UNESCO instrument on open cultural heritage. In this blog post, we share the full report and some of its key highlights.

The post CC strategic workshop reveals big opportunities for open access to cultural heritage appeared first on Creative Commons.

Examining MicroStrategy’s record-shattering $21bn ATM Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter. History, they say, doesn’t repeat, but it often rhymes. Bitcoin-hodling MicroStrategy is an excellent example. In early 2000, MicroStrategy embodied the…

With the internet changing everyday staying on top of new trends and changes surrounding SEO should be a top priority of any professional SEO Company. Within the last year or more the SEO industry has changed immensely. Some of these changes include the Panda and Penguin filters and the recent changes of the exact match […]

Steph Caskenette made these awesome illustrations.

read more

Prissydent-elect Donald Trump has picked South Dakota Governor Kristi Noem, who penned the book 'No Going Back' that detailed her murdering a puppy, horses, and at least one goat, as his next secretary of the Department of Homeland Security.

Hey, at least he didn't pick Ted Nugent, Kid Rock, Marjorie Taylor Greene, Lauren Boebert, Catturd, or Steve Bannon for the role, all of whom allegedly have not shot a dog in the face -- yet.

CNN reports:

Noem will be tapped to take over the agency as two key immigration hardliners — Stephen Miller and Tom Homan — are slated to serve in senior roles, signaling Trump is serious about his promise to crack down on his immigration pledges. With his selection of Noem, Trump is ensuring a loyalist will head an agency he prioritizes and that is key to his domestic agenda.

The department saw an immense amount of turmoil the last time Trump was in office. Then, DHS had five different leaders, only two of whom were Senate-confirmed. The agency has a $60 billion budget and hundreds of thousands of employees.

Noem, who previously was a South Dakota representative, will now be tasked with overseeing a sprawling agency that oversees everything from US Customs and Border Protection and Immigration and Customs Enforcement to the Federal Emergency Management Agency and the US Secret Service.

read more

Full Article

Looking for a hugely entertaining alphabet book that also has an uplifting message of empowerment for young readers? I highly recommend T. REXES CAN'T TIE THEIR SHOES by Anna Lazowski and Steph Laberis, launching June 29th, 2021 from Doubleday Books For Young Readers. The back matter also has an alphabetized factoid list of "all the amazing things animals CAN do!"

This is an alphabet book that can be appreciated by grown-ups as well as young readers, with lots of potential discussion points. The illustrations of animals in ridiculous situations are so SOOOOO FUN --- omigosh, even as I'm writing this post, I went back to look through the digital ARC and can't decide which is my favourite, though I'm leaning toward the "Cheetahs can't chew bubble gum" page.

I asked debut picture book author Anna Lazowski if she had any advice for young writers, and here's what she said:

"Write what you want to write, because as you move through the publishing process, it will become incredibly important for you to truly believe in your work. The rejections in this industry are endless, and they come at every stage. Critique partners might reject elements of your manuscript, agents will reject your work, and once you're on submission to editors, they will reject your work. Then once you're finally published, some reviewers will reject your work. If you don't fully believe in your stories, this will be extremely hard to take. It's hard as it is, so make sure you're all in on the work you're doing. It will make the rest a little bit easier to navigate."

Wise advice. Thank you, Anna! And congrats to you and Steph on your upcoming launch!

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Also see other Advice For Young Writers and Illustrators From Children's Book Creators and my other Interviews With Children's Book Creators.

Image at the top of this post was created for my new #BookADay book journal. For more info about Donalyn Miller's #BookADay challenge, see Donalyn's post in the Nerdy Book Club blog.

Hazel Mitchell has helped create more than twenty children's books, including her award-winning picture book Toby (Candlewick Press). Her illustrations appear in books by Cynthia Lord, JaNay Brown-Wood (Imani's Moon was mentioned on the Stephen Colbert show!), Lynn Parrish Sutton, Liza Gardner Walsh and others. You can find out more about Hazel and her work at HazelMitchell.com, Facebook, Instagram and Twitter.

Synopsis of SWEET PEA SUMMER (Candlewick):

During her mother’s absence, a young girl discovers the joys of gardening—and the rewards of persistence and a sharp eye—in a sweet intergenerational story. With warm, child-friendly illustrations and a simple narration, Hazel Mitchell tells a timeless story about holding on to hope in hard times and finding the strength and determination to see it through. A brief author’s note at the end offers a bit of history and a few details about sweet peas for aspiring gardeners.

Q. What inspired you to write Sweet Pea Summer?

My inspiration for the book were memories I have from staying with my grandparents when I was little (4-6 years old). They lived in a row of mill cottages in a Yorkshire town called Huddersfield. The town was born out of the wool trade and had many factories and tall towers, but was surrounded by beautiful countryside. I started to sketch my memories of staying with them - the cottage, the garden, the countryside with the moors and mill chimneys, the cats that were always scampering around, the long road that stretched away up a sloping hill to the town itself.

My granddad was an excellent gardener. I suspect this came from the war years in Britain when everyone grew their own food as much as possible. In my memory the garden was so, so long with a little greenhouse and was stuffed with veggies and flowers. Of course, my memory exaggerated everything. I was seeing through a small child's eyes. I even googled the road on Google Streetview and the cottage and the garden are still there, just much smaller than I recalled.

I decided there was a story in these sketches and my rememberings. I find that I'm often inspired by childhood memories, places and real life things, like my own dog who is the main character in the book 'Toby', also from Candlewick Press. I've even been known to use my house in books, or feature the landscape of Maine, where I live, and sometimes I draw objects from my home. it gives authenticity I think.

Q. What was the writing and illustration process like?

After some note making, more doodles and musing I decided on the main character of a girl. She's not exactly me. My sister also went to stay with my grandparents when my mother was ill and that was really the nugget that set me rolling. The girl is sad and missing her mother, so Grandpa invites her to help in the garden and, in particular, to look after the sweet peas. (My own grandfather grew chrysanthemums, but I decided children would relate more to sweet peas. Plus it is easier to say!).

The grandparents do not look like my grandparents and even though the child is not really me, I guess she shares some of my personality characteristics and DO I love gardening! (Although I always fail with sweet peas, which is ironic). I found I had all the inspiration I needed to get started on roughing out a story.

Writing and illustrating Sweet Pea Summer was a long process, as most books tend to me. There are a lot of images in the book, which is kind of graphic novelish in a way, with multiple images on some pages that follow a grid layout. Although I did preliminary character and setting sketches, I then spent time writing scene progressions and story boarding before I was ready to do the first full dummy.

I've found this saves me time in the long run, when I finally start to sketch I can be pretty certain I have the rudimentary story arc and length of book down. We had 2-3 edits and rehashes before my editors, art director and myself were all happy to go to finals. Finals are always the very long and arduous stage of the book for me. The first spark of story and hashing it out is the inspirational bit.

I did all the art for Sweet Pea in pencil and watercolor (usually I colour an under painting digitally), but I felt this book needed a traditional watercolour feel. It was a longer process for sure! Along the way I did a good amount of picture research especially on the landscapes and the flowers - plus the process of growing them, which features in the story. The parallel between the illness of the m/c's mom and the flowers failing to open was important to me. didn't want it to be too obvious to the reader.

My editor, Liz Bicknell at Candlewick Press, was very helpful, as always, keeping the story on track. Pam Consolazio was my art director, and her nickname was Sweet Pea as a child! it is lovely when you find unexpected connections. I scan my own artwork, which gives me the luxury of making any tweaks to the final art. I think the whole book took about 2 years, including edits etc.

It's wonderful when your book finally arrives in your mailbox! (Just like any birth, the pain recedes!) It was especially concerning in this time of the pandemic, but everything went well and the books arrived in time for publication.

Q. What advice do you have for young writers and illustrators?

My advice to young writers and illustrators is always work on stories that you love and feel an emotional response to whether, happy, sad, funny or just that you just love and know the subject. It will always show in your work!

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For more insights from book creators, see my Inkygirl interview archives.

 

Just read (and loved) a fun reimagining of the classic fairytale Goldilocks and the Three Bears: GOLDIBOOKS AND THE WEE BEAR, written by Troy Wilson and illustrated by Edwardian Taylor, published earlier this year by Running Press Kids.

Here is Troy Wilson's advice for young writers:

"My advice? Write badly. Badly, badly, badly. Include words and ideas that shouldn't be there. Leave out words and ideas that should be there. Put things in the wrong order. Have your protagonist act wildly out of character. Why? Because that is what your favorite author does.

"You don't see your favorite author's horrible first drafts. Or horrible second drafts. Or horrible third drafts. For that matter, you don't see their attempted books that never, ever turned out at all. (Some things are just dead ends, even for your favorite author.) No, you only see their final, super-duper-polished work, after they got lots and lots of great feedback.

"Everyone starts with bad writing. Every single writer, every single time - no matter how long they've been doing it. You can't avoid your own bad writing. You can't go around it or over it or under it. You have to go through it. Just get it onto the page or screen. You can always fix it later. Except if you let the bad writing - or the fear of bad writing - stop you from writing. Because you can't fix what isn't there."

Thanks, Troy! 

Related links:

Publisher page about Goldibooks and the Wee Bear

More about Troy Wilson at TroyStory.ca, Twitter and Facebook.

More about Edwardian Taylor at EdwardianTaylor.com, Twitter and Instagram.

-----

Find more advice for young writers and illustrators from children's book creators.

 

Twenty years ago the first edition of The Practice of System and Network Administration shipped! Since then there has been a 2nd and 3rd edition (2006 and 2014), plus a sequel book The Practice of Cloud System Administration, and many printings. (see the timeline here)

When we started the project we had no idea if it would be a success. There was a real chance it could be a flop. Many people told us that our proposal was illogical: How could you have a book about system administration that is vendor agnostic and talks about process and people instead of specific tools and operating systems? Well, to be honest, we took a deep breath and started writing anyway. It took 2+ years but in Sept/Oct 2001 the book finally shipped!

Instead of a flop, the reaction we got was very positive! It has sold tens of thousands of copies. Many universities have used the book and its future editions as text books. It received the Usenix LISA Outstanding Achievement Award. One DevOps pundit told me she considers it to be "the first devops book" which was quite humbling.

When I visited Google in 2004 (a year before I considered joining) I was told everyone in the "systems operations" team was given a copy on their first day. The person giving me a tour then took me to a supply closet with 30 copies awaiting to be distributed to new hires.

However the real satisfaction comes from how it has helped others. Fans have related many heartwarming stories. Many fans have told us they felt like reading the book was a turning point in their life, that the book "turned me into a professional system administrator".

To thank our readers, our publisher is offering a special deal: 45% off the latest editions now until Oct 31, 2021 What? You still have the 2nd edition and haven't seen the dozens of chapters of new material in the 3rd edition? Or maybe you haven't heard of our Cloud book? Now is your chance to get the 3rd edition or the cloud sequel!

• Use this link: https://informit.com/tposa
• Use this coupon code: TPOSA

Thank you to everyone that gave us feedback on the early drafts! Thank you to all our readers! This book changed our lives and we hope it changed yours too!

P.S. We would love to hear from you! Please post a comment with reflections on the book.

Engage your students with science journalism about issues in their communities with the NOVA Science Studio program!

"No início da minha carreira, coisas como boas maneiras importavam e havia um nível esperado de decoro", disse Susan ao site Politico, descrevendo o partido Republicano como significativamente diferente do de várias décadas atrás.

Israel says its targets are legitimate, but critics say it is aiming at Hezbollah's social base.

Building the link to western Europe has become more urgent as the Baltics see Russia as a threat.

velocityconf: Call for speakers and registration is open for @webperfdays in Silicon Valley http://t.co/cJKBmynkjI June 22, Google HQ (cc @sfwebperf)

Trump has started filling key White House roles, starting with Susie Wiles as his chief of staff.

Elon Musk and Vivek Ramaswamy will lead the Department of Government Efficiency, also known as DOGE, under Donald Trump's administration, Trump said.

You’ve probably attended a webinar or two (or more), but are you using them effectively as part of your overall content plan? In this blog post, we teach you the basics of hosting a webinar and how to use them effectively as you build out your content strategy and grow your business.

In some parts of the capital, protesters negotiated with police. In other parts there was no talking.

Interactive Media Strategies (IMS) is a market research firm that follows streaming media. They discuss the news of Microsoft’s $8.5 billion acquisition of Skype, and the prospects for Skype to emerge as a viable platform for business video communications. 

Their research compares usage levels for a range of social media and communications applications, including Skype, YouTube and Facebook. Here is a link to the video.

They report that personal use of Facebook and YouTube is relatively high but that has not yet translated into comparable levels of corporate use. They believe this raises the question of whether YouTube and Facebook will be able to outgrow their focus on the consumer side of the business to compete in the enterprise market.

Usage levels for Skype are significantly lower overall, but Skype’s penetration in business communications is higher than they see for other communications apps online among young users most likely to experiment with emerging technologies.

IMS puts forth the opinion that if Microsoft could make it easier for technology laggards to embrace Skype - i.e. integrate Skype with the Microsoft Office suite - then Skype could achieve significant enterprise adoption.

Pro-Trump businessmen Elon Musk (the richest man in the world) and Vivek Ramaswamy have officially joined the incoming Trump administration. President-elect Donald Trump announced in a statement published Tuesday that […]

The post Breaking: Musk, Ramaswamy Officially Join Trump Administration - Their Job Is to Destroy Bureaucracy appeared first on The Western Journal.

The Indo-Pacific: Geostrategic Perspectives 2019-24 – Workshop 2 24 September 2019 — 9:00AM TO 2:00PM Anonymous (not verified) 4 September 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

The roundtable brought together stakeholders within the UK strategic and policymaking communities to explore British perceptions of evolving strategic shifts in the Indo-Pacific until 2024.

The roundtable took place at Chatham House in London. The report below contains a summary of the discussions.

Read a summary

The Indo-Pacific: Geostrategic Perspectives 2019-20 – Workshop 1 11 September 2019 — 10:00AM TO 2:30PM Anonymous (not verified) 4 September 2019 East-West Center, 1819 L St., NW, Suite 600, Washington, DC 20036, USA

The roundtable brought together stakeholders within the US strategic and policymaking communities to explore American perceptions of evolving strategic shifts in the Indo-Pacific until 2024. The roundtable was organized in cooperation with, and was held at, the East-West Center in Washington D.C.

The report below contains a summary of the discussions and an essay by Satu Limaye, Vice President and Director of the East-West Center in Washington, DC.

Read a summary report and essay

The Indo-Pacific: Geostrategic Perspectives to 2024 - Workshop 3 17 October 2019 — 9:30AM TO 2:00PM Anonymous (not verified) 14 October 2019 Institut Francais des Relations Internationales, 27 rue de la Procession, 75740 Paris Cedex 15, France

The roundtable brought together stakeholders within the French strategic and policymaking community to explore French perceptions of evolving strategic shifts in the Indo-Pacific until 2024. The roundtable was organized in cooperation with, and was held at, the Institut français des relations internationals in Paris.

The report below contains a summary of the discussions and an essay by Céline Pajon, Research Fellow, Center for Asian Studies, Institut français des relations internationals.

Read a summary and essay

The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4 26 November 2019 — 9:30AM TO 12:00PM Anonymous (not verified) 9 January 2020 Gateway House, Stevens Street, Colaba

The roundtable brought together stakeholders within India’s strategic and policymaking communities to explore Indian perceptions of evolving strategic shifts in the Indo-Pacific until 2024. The roundtable was organized in cooperation with, and was held at, Gateway House in Mumbai.

The report below contains a summary of the discussions and an essay by the International Security Studies Programme at Gateway House.

Read a summary and essay

The Indo-Pacific: Geostrategic Outlook From Now to 2024 - Workshop 5 18 February 2020 — 12:00PM TO 4:30PM Anonymous (not verified) 17 February 2020 Langafonua Centre

The roundtable brought together stakeholders within Tonga’s strategic and policymaking communities to explore Tongan perceptions of evolving strategic shifts in the Indo-Pacific until 2024. The roundtable took place in Nuku’alofa and was co-hosted by the Royal Oceania Institute in Tonga.

The report below contains a summary of the discussions and an essay by Lady Fane Fakafanua, Director of Operations at the Royal Oceania Institute.

Read a summary and essay

The Indo-Pacific: Geostrategic Perspectives until 2024 – Japanese perceptions 24 February 2020 — 9:00AM TO 1:00PM Anonymous (not verified) 22 March 2021 Chatham House

The roundtable brought together stakeholders within Japan’s strategic and policymaking communities to explore Japanese perceptions of evolving strategic shifts in the Indo-Pacific until 2024. The roundtable took place in Tokyo and was organized in partnership with the Indo-Pacific Studies Group.

The report below contains a summary of the discussions and an essay by Hiroki Sekine, Visiting Fellow, Asia-Pacific Programme, Chatham House.

Read a summary and essay

Offsetting the North Korean strategic challenge 16 March 2023 — 9:30AM TO 10:30AM Anonymous (not verified) 8 March 2023 Online

This event explores what balance between pressure and dialogue is most likely to incentivise North Korea to limit its provocations.

With North Korea having steadily increased its nuclear and conventional security capabilities over the course of recent months, the speakers explore practical options for lowering tensions on the Korean peninsula.

They consider how best to re-engage diplomatically with North Korea, including the role of key actors such as the US, South Korea, Japan, and European states, in advancing a constructive resolution of current tensions.

The discussion explores finding a balance between pressure and dialogue which is most likely to incentivise North Korea to limit its provocations, assess the risks of a possible seventh nuclear test, and consider the viability of multilateral cooperation in enhancing regional security in north-east Asia.

This event forms part of the Korea Foundation Korea Fellowship, funded by the Korea Foundation and Taejae Academy.

US and Europe Strategic Security Cooperation: The View from Washington 27 March 2023 — 9:00AM TO 10:00AM Anonymous (not verified) 9 March 2023 Chatham House

As the US prepares to enter the next presidential election cycle, can the transatlantic alliance stay the course, especially against a deepening Russia-China partnership?

Thank you for your interest in joining our event. Please plan to arrive at Chatham House from 08:45 GMT as the event will begin promptly at 09:00.

The Biden administration’s response to Russia’s war in Ukraine and the rise of a globally assertive China, as articulated in the 2022 US national strategy, is to ‘constrain Russia and out-compete China’. It needs Europe as a partner and ally for both – yet Europe is also an object and a battleground in this era of strategic competition.

As the US prepares to enter the next presidential election cycle, can the transatlantic alliance stay the course, especially against a deepening Russia-China partnership? Can Europeans, in particular, move from deepening dependency to greater agency and self-reliance? What is the role for Germany – and for the UK?

Ivan Matic
Jan 1, 2008; 7:132-144
Research

Lys234 is one of the residues present in class A β-lactamases that is under selective pressure due to antibiotic use. Located adjacent to proton shuttle residue Ser130, it is suggested to play a role in proton transfer during catalysis of the antibiotics. The mechanism underpinning how substitutions in this position modulate inhibitor efficiency and substrate specificity leading to drug resistance is unclear. The K234R substitution identified in several inhibitor-resistant β-lactamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxicillin to overcome β-lactamase–mediated antibiotic resistance. Here we show that for CTX-M-14 β-lactamase, whereas Lys234 is required for hydrolysis of cephalosporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin. Further, by determining the acylation and deacylation rates for cefotaxime hydrolysis, we show that both rates are fast, and neither is rate-limiting. The K234R substitution causes a 1500-fold decrease in the cefotaxime acylation rate but a 5-fold increase in kcat for ampicillin, suggesting that the K234R enzyme is a good penicillinase but a poor cephalosporinase due to slow acylation. Structural results suggest that the slow acylation by the K234R enzyme is due to a conformational change in Ser130, and this change also leads to decreased inhibition potency of clavulanic acid. Because other inhibitor resistance mutations also act through changes at Ser130 and such changes drastically reduce cephalosporin but not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin rather than penicillin would impede the evolution of resistance.

This article is by Toni Šušnjar.

Strategy and Enemies

The structure of an army will depend on the strategy, as strategy will determine the army’s role and tasks. A state which carries out expansion through outright territorial conquest will have large numbers of heavy infantry, combat engineers and artillery, and possibly some heavy cavalry as well (e.g. Roman Empire, 10th century Byzantine Empire). If conquest is done by slowly destroying an opponent’s economic and social structures through constant raiding (such as chevauchee or razzia / ghazw), then majority of the army will be light cavalry, with some heavy cavalry support (e.g. Seljuk and Ottoman Empires), and light infantry will be used if terrain is unsuitable for cavalry. If a state is defending against cavalry raids, then light cavalry will be dominant (e.g. 15th century Hungary), whereas heavy cavalry will predominate if enemy raiders are primarily infantry. If enemy armies are too powerful to face in the field, light and heavy cavalry will be used to harass the invading army and cut off its supplies and foraging. In terrain unsuitable for cavalry operations, heavy infantry will be used instead.

Raiding — as a strategy — is generally preferred against a peer opponent, especially if a state cannot have a developed logistical support system.

Continue reading Building a Fantasy Army — Strategy & Organization at Mythic Scribes.

AUKUS reveals much about the new global strategic context Expert comment NCapeling 17 September 2021

The new AUKUS partnership as well as the furore in Paris surrounding its announcement says a lot about the new geopolitical landscape.

The growing diplomatic drama surrounding the announcement of the new Australia-UK-US (AUKUS) risks concealing rather than highlighting what the deal reveals about profound changes in the global strategic context. Several elements stand out.

First, Australia’s decision to break off the $66 billion contract it signed with France in 2016 to purchase a new fleet of diesel electric submarines underscores the heightened level of concern in Canberra about China’s growing naval capabilities.

Despite all the industrial, legal, and diplomatic disruption, the Australian government has decided only the stealthy nuclear-powered submarines developed by Britain with US support can provide the genuine naval capability it needs long-term.

Next, in helping Australia resolve this conundrum, the British government has revealed the versatility of its new foreign policy. Part of the reason UK prime minister Boris Johnson eschewed the concept of a formal foreign policy and security treaty in the post-Brexit deal with the European Union (EU) was to pursue freely new ventures such as the recent ‘G7-plus’ summit in Cornwall, and enhanced cooperation among the Five Eyes allies. AUKUS reveals that this approach can produce real results.

Europe or the Indo-Pacific

During this week’s Polish-British Belvedere Forum in Warsaw, one of the main Polish concerns was that this ‘tilt’ to the Indo-Pacific could overstretch Britain’s scarce resources when it should be focusing on Europe, where they are most needed.

But AUKUS does not over-extend Britain. There is no military commitment involved in the agreement. The UK also remains outside the Quad – made up of the US, India, Japan, and Australia. And the ongoing stately voyage of its new aircraft carrier from the Mediterranean into the South China Sea provides better insight into the substance of the UK’s Indo-Pacific tilt.

Much derided for not carrying enough of its own aircraft – and for depending on US and Dutch escort vessels – the UK has in fact managed to coalesce a flexible group of allies around the Queen Elizabeth while enabling it to fly the British flag in Asian waters and strengthening interoperability with its allies for future joint operations.

Despite the hype, Britain’s main defence investments and deployments remain firmly focused in Europe, as laid out by the recent Integrated Review. And the decision to draft a new NATO Strategic Concept – midwifed by Britain at the 70th anniversary NATO summit hosted in London in December 2019 and confirmed during Joe Biden’s visit to NATO headquarters in June – will give Britain’s role in European security a new purpose and focus in the coming years.

Alone on the strategic landscape

For France, of course, the cancellation of its submarine deal is a painful humiliation, and a severe blow to thousands of workers in its hi-tech defence industry. It also comes at a sensitive moment politically, with Emmanuel Macron keen to demonstrate his international standing ahead of the 2022 presidential election. Instead, France now looks rather lonely on the strategic landscape alongside the more homogeneous and collectively powerful AUKUS trio.

But, rather than take the high road, a furious French reaction has compared Biden to Donald Trump and argued that this defence industrial failure for France should drive an acceleration towards European – for which, read EU – strategic autonomy.

This implies France sees European strategic autonomy as protecting and extending its own sovereign power and industrial interests rather than as a process for EU members to achieve more together in security and foreign policy than they can alone – thereby undermining rather than enhancing its case.

The gap between European strategic rhetoric and practical action was further highlighted by the AUKUS partnership being announced the evening before the EU launched its own Indo-Pacific strategy, and on the same day as China refused to allow a German frigate its first planned port visit to Shanghai.

America is still back

There is still a long way to go before the new submarine deal becomes reality. Australia needs to extricate itself from the French deal, decide how to secure the highly enriched uranium to power its new nuclear submarines, decide with the US and UK the division of labour and technology transfer of production, and assuage the International Atomic Energy Agency’s concerns about the precedent this deal sets. The fruits of this dramatic announcement will, therefore, be a long time in coming.

But, however the details play out, 15 September 2021 was a consequential day. The AUKUS announcement showed that China’s growing hard power is now eliciting a genuinely tough and structural political-military reaction.

Across the Atlantic, it also allowed President Biden – flanked ‘virtually’ by the British and Australian prime ministers – to send the global message that America is indeed back, just three weeks after the ignominious retreat from Afghanistan and chaotic exit from Kabul. And it offered him the opportunity to remind the world that the Indo-Pacific is where the US will be putting its main effort in the future.

For many in China, AUKUS now confirms their belief that the US and its principal allies are determined to contain China’s rise in its own ‘backyard’, where it believes it has the right to flex its muscles. For others, it will confirm Xi Jinping has overreached and China is now paying the price of his more assertive strategy. Either way, the Chinese are on notice that the ambivalent nature of the Obama pivot to Asia has given way to a more determined pivot under Biden.

While the US is stepping up, the UK has shown it is in the mix, leveraging opportunities as they arise. For example, the goodwill the UK has generated in Tokyo with this new partnership with Australia could help its case as it pursues membership of the Transpacific Partnership trade area in 2022.

The EU looks like a bystander in comparison and ill-equipped for the geopolitical competition inherent in this new strategic context. It is essential, therefore, once the dust has settled from these fraught few days, that the US and UK reach out to find ways to involve France and its EU partners in a meaningful, shared transatlantic approach to the Indo-Pacific.

New Strategic Partnership with the Robert Bosch Stiftung News Release jon.wallace 23 November 2020

The Robert Bosch Stiftung becomes a founding donor to Chatham House’s second century.