In my last blog, Getting Your Existing SiP File Into Virtuoso RF, I talked about the new enhancements in ICADVM20.1 ISR25 for Virtuoso RF Solution. At the end of the blog, I told you about the Fully Assisted Roundtrip flow, which includes importing SiP files that are compatible with the Virtuoso RF Solution assisted import flow into the Virtuoso platform. Let's examine how the Fully Assisted Roundtrip flow works in this blog.(read more)

This blog introduces the new Voltus-XFi Custom Power Integrity Solution, a transistor-level EM-IR tool that enables designers to complete comprehensive analysis and debugging easily and quickly.(read more)

This blog informs about the new badge certification available for Cadence Certus Closure Solution, that grants credit to your proficiency.(read more)

Poland’s quickening transition to clean energy opens up supply opportunities for Australian METS companies.

In a session led by Chairman Sadiq Sanjrani, the Senate approved a resolution concerning the recent Supreme Court decision on military courts. Senator Dilawar Khan, presenting the resolution, expressed concerns about the court’s interference with Parliament’s legislative authority. The resolution stressed the importance of using military courts, operational since 1967, for actions against terrorists, suggesting ... Read more

The post Senate Passes Resolution Objecting Supreme Court’s Ruling on Military Courts appeared first on Pakistan Tribune.

Two decades of failed negotiations, perpetual conflict and an expanded occupation should encourage an alternative to the two-state solution.

[Nile Post] Energy Minister, Ruth Nankabirwa, has called for sustainable clean cooking solutions to support Uganda's extensive refugee population and safeguard the country's forests.

[UNHCR] UNHCR, the UN Refugee Agency has just concluded a three-day event, hosting partners and Governments from the East and Horn of Africa, Great Lakes Region and Yemen, to review strategies for comprehensive solutions to the ongoing displacement crisis in Somalia. The meeting brought together representatives from Uganda, Yemen, Djibouti, Ethiopia and Kenya, as well as the regional body, Intergovernmental Authority on Development (IGAD) and provided a platform for sharing insights and aligning efforts among

The Arab region is among the most water-scarce areas globally, as nearly 392 million people live in countries facing water scarcity or absolute water scarcity. So dire is the situation that, of the 22 Arab countries, 19 fall below the annual threshold for water scarcity in renewable resources, defined as 1,000 cubic meters per person. […]

Armenia’s Crossroads of Peace initiative offers a vision of peace and stability through improved infrastructure and trade. It is also a great opportunity to build sustainable infrastructure, improve customs clearance, and promote green trade. Key reforms in road safety and foreign direct investment are essential for long-term success, positioning Armenia as a strategic hub for regional trade.

Extreme heat is an invisible but increasingly tangible climate risk. It varies by time and place and has wide-reaching but unequal impacts, particularly to women and vulnerable people. As global temperatures rise, extreme heat events (heat waves) are becoming more frequent and severe.

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This brochure outlines how nature is being rapidly degraded and shows how ADB-designed nature-based solutions (NBS) can help protect vulnerable communities and ecosystems to make countries in Asia and the Pacific more climate resilient.

When it comes to the survival of animals living in the wild, the characteristics of the group can matter as much as the traits of the individual, according to a study in marmots

Our Future Chronicles column explores an imagined history of inventions and developments yet to come. In our latest glimpse into the near future, Rowan Hooper tells how seaweed was a game changer when it came to getting carbon out of the atmosphere in the 2030s

When it comes to the survival of animals living in the wild, the characteristics of the group can matter as much as the traits of the individual, according to a study in marmots

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.

Caenorhabditis elegans is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression and tissue patterning in animals. An invaluable tool in modern gene expression research is the presence of a high-resolution ribosome structure, though no such structure exists for C. elegans. Here, we present a high-resolution single-particle cryogenic electron microscopy (cryo-EM) reconstruction and molecular model of a C. elegans ribosome, revealing a significantly streamlined animal ribosome. Many facets of ribosome structure are conserved in C. elegans, including overall ribosomal architecture and the mechanism of cycloheximide, whereas other facets, such as expansion segments and eL28, are rapidly evolving. We identify uL5 and uL23 as two instances of tissue-specific ribosomal protein paralog expression conserved in Caenorhabditis, suggesting that C. elegans ribosomes vary across tissues. The C. elegans ribosome structure will provide a basis for future structural, biochemical, and genetic studies of translation in this important animal system.

BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

BACKGROUND AND PURPOSE:

Incidental findings on brain MRI and variations of the circle of Willis (CoW) are relatively common among the general population. Ethnic differences have been described before, but few studies have explored the prevalence of incidental intracranial cerebrovascular findings and CoW variants in the setting of a single multiethnic cohort. The purpose of this investigation was to describe both incidental cerebrovascular findings and the morphology of the CoW on high-resolution 3T TOF-MRA in a UK tri-ethnic population-based cohort and to present updated prevalence estimates and morphologic reference values.

The diagnosis of maturity-onset diabetes of the young (MODY), a monogenic form of diabetes mellitus caused by a mutation in a single gene, is often uncertain until genetic testing is performed. We report a 13-yr-old Korean boy who was initially diagnosed with type 2 diabetes (T2DM). MODY was suspected because of his nonobese body habitus and family history of multiple affected members. Targeted panel sequencing of all MODY-related genes was performed using the NextSeq 550Dx platform (Illumina). Sanger sequencing was performed using blood samples from the parents, siblings, and other relatives. A frameshift variant in the 3' region of the last exon of PDX1 was detected in the patient and his family members with diabetes. PP1_Moderate criterion was applied and this variant was confirmed to be the genetic cause of diabetes in the family and classified as likely pathogenic. The study highlights the importance of genetic testing for nonobese, early-onset diabetic patients with multiple affected family members. Increased awareness and aggressive genetic testing for MODY are needed.

Here, we highlight the case of a 31-yr-old man who had clinical features of primary hypertrophic osteoarthropathy (PHOAR) and harbored a homozygous variant (c.38C > A, p.Ala13Glu) in the HPGD gene, as indicated by whole-exome sequencing (WES). This variant has been previously classified by our laboratory as a variant of uncertain significance (VUS). However, another patient with the same phenotype and the same homozygous variant in HPGD was subsequently reported. In reassessing the variant, the absence of this variant in the gnomAD population database, supporting computational predictions, observation in homozygosity in two probands, and specificity of the phenotype for HPGD, all provide sufficient evidence to reclassify the HPGD c.38C > A, p.Ala13Glu variant as likely pathogenic.

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December 31, 2020 at 11.59 pm – across the world there was a collective sigh of relief that the ‘lost year’ is truly behind us. The end of a year, ...

The post Start 2021 Fresh With These 12 New Year Resolutions appeared first on Star Observer.

Trelleborg Medical Solutions showcases its comprehensive polymer-based solutions and capabilities for the medical technology and biopharmaceutical industries at Compamed 2024 in Dusseldorf from November 11 to 14, at stand F02 in hall 8A.

Peytant has announced that the U.S. Food and Drug Administration (FDA) granted marketing authorisation (clearance to market in the United States as a Class II device) for the AMStent Tracheobronchial Covered Stent System, a therapy platform.

Oct 10, 2023

Michael Toffel, Senator John Heinz Professor of Environmental Management and Professor of Business Administration at Harvard Business School (HBS), discusses the many ways in which business and governments can and are working together to address climate change in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” The podcast is produced by the Harvard Environmental Economics Program.

Jun 5, 2024

The war in Gaza has accelerated a major shift in Tunisia’s foreign policy. One of the first Arab countries to advocate for a two-state solution, Tunisia has now abandoned it. That shift has left Tunisia more isolated geopolitically, prompting it to now court Iran, China, and Russia.

When it comes to the survival of animals living in the wild, the characteristics of the group can matter as much as the traits of the individual, according to a study in marmots

Highlights: Keto diet promotes gut bacteria that reduce inflammation in autoimmune diseases UC San Francisco stu

Fortified foods and supplements help meet nutrient needs but could lead to excessive vitamin B6 intake in a small portion of users.

Scientists have created a groundbreaking novel bioinspired adhesive patch, "Dental Tough Adhesive (DenTAI)" with robust mechanical properties for the treatment of common oral health disorders.

Smallholder farmers are embracing climate-adaptive agriculture, innovations and partnerships.

The post Cultivating change: Sri Lanka’s smallholder farmers explore climate-resilient solutions first appeared on International Water Management Institute (IWMI).

On World Water Day, IWMI Director General Mark Smith is hopeful about progress for the world’s pressing water challenges.

The post Wicked water problems: Facing challenges, finding solutions first appeared on International Water Management Institute (IWMI).

Nature-based Solutions (NbS) are a hot topic in environment and landscape planning networks. But are they a silver bullet for solving the climate crisis?

The post Greening gray infrastructure: uncovering the complexity of Nature-based Solutions first appeared on International Water Management Institute (IWMI).

Understanding water system risks in fragile and conflict-affected communities is crucial for developing anticipatory action and peace.

The post Waters of vulnerability and transformative solutions first appeared on International Water Management Institute (IWMI).

Unified action for preparedness and response can help communities to build resilience

The post Zambia’s thirst for solutions in the face of drought first appeared on International Water Management Institute (IWMI).

In celebration of International Youth Day, IWMI and BongoHive hosted a Demonstration Day in partnership with the Accelerating Impacts of CGIAR Climate Research in Africa (AICCRA) project in Zambia.

The post Youth seek climate-smart agri-solutions in innovation challenge first appeared on International Water Management Institute (IWMI).

IWMI's work in Sri Lanka has helped to restore marshes, enhance biodiversity and improve livelihoods in partnership with government departments and local communities.

The post How nature-based solutions can build urban resilience first appeared on International Water Management Institute (IWMI).

Smallholder farmers are embracing climate-adaptive agriculture, innovations and partnerships.

The post Cultivating change: Sri Lanka’s smallholder farmers explore climate-resilient solutions first appeared on International Water Management Institute (IWMI).

Matthew McCartney commented on IWMI's work to rectify the dearth of agroecological research focusing on water management and aquatic foods.

The post Sri Lanka sources integrated solutions to land and water-based challenges first appeared on International Water Management Institute (IWMI).

Mohsin Hafeez discusses the potential of nature-based solutions in dealing with climate shocks faced by vulnerable people in the twin cities of Islamabad and Rawalpindi.

The post Role of nature-based solutions for improving urban water security first appeared on International Water Management Institute (IWMI).

Ismahane Elouafi, CGIAR’s Executive Managing Director, discusses the global research consortium’s vital role in transforming food, land, and water systems.

The post CGIAR EMD Ismahane Elouafi discusses food security and climate solutions on Agro América first appeared on International Water Management Institute (IWMI).