Virus-like-particle (VLP) influenza vaccines can be given intramuscularly (i.m.) or intranasally (i.n.) and may have advantages over split-virion formulations in the elderly. We tested a plant-made VLP vaccine candidate bearing the viral hemagglutinin (HA) delivered either i.m. or i.n. in young and aged mice. Young adult (5- to 8-week-old) and aged (16- to 20-month-old) female BALB/c mice received a single 3-μg dose based on the HA (A/California/07/2009 H1N1) content of a plant-made H1-VLP (i.m. or i.n.) split-virion vaccine (i.m.) or were left naive. After vaccination, humoral and splenocyte responses were assessed, and some mice were challenged. Both VLP and split vaccines given i.m. protected 100% of the young animals, but the VLP group lost the least weight and had stronger humoral and cellular responses. Compared to split-vaccine recipients, aged animals vaccinated i.m. with VLP were more likely to survive challenge (80% versus 60%). The lung viral load postchallenge was lowest in the VLP i.m. groups. Mice vaccinated with VLP i.n. had little detectable immune response, but survival was significantly increased. In both age groups, i.m. administration of the H1-VLP vaccine elicited more balanced humoral and cellular responses and provided better protection from homologous challenge than the split-virion vaccine.

Background:

Energy balance–related factors, such as body mass index (BMI), diet, and physical activity, may influence colorectal cancer etiology through interconnected metabolic pathways, but their combined influence is less clear.

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Your weekly selection of awesome robot videos

A new two-way teleoperation system sends your motions to the robot and the robot's motions to you

This uncanny story of preppy drug dealers has a touch of Heathers and a bit of Bret Easton Ellis, and an intriguing take on what high school is really like

Tayarisha Poe, like her partial namesake, has a gift for the uncanny. She is the photographer and film-maker behind this feature debut, which began as an online multimedia project and was developed as a conventional movie through the Sundance screenwriters and directors labs. What has emerged is an intriguing, opaque, tonally elusive story that seems weirdly unfinished. It is set in a privileged high school – a world of ivy-covered stone buildings and shady quadrangles where rich kids are separated into malign and mutually hostile cliques. It has a touch of Donna Tartt and Bret Easton Ellis, a hint of Heathers and a bit of the elegant, disdainful satire of Dear White People.

Somehow, though, it is odder, more stylised and contrived, always holding out the possibility that it is set in the future, or in an alternative present on some other planet, or inside the head of one of its characters who is having a disturbing dream – the kind that ends just as it is about to give up its meaning. Right until the closing credits, I half-expected the face of each person on screen to flip upwards, revealing a Stepford-like set of dials.

Modern Games is a new studio working to create games that combine physical and digital play. The company was founded by husband-and-wife team Justin and Amanda Kifer — serial entrepreneurs who previously launched companies including Citizen Local (acquired by MyLife in 2011) and Fidgetly, a fidget spinner company that also created a motion controller for […]

New Zealand is on track to eliminate covid-19 altogether, but keeping the virus out for good will be a challenge, and the economic impacts are likely to hurt

Alf Ingve Berntsen, who worked with the teenage striker at Byrne FK, believes a heavyweight European outfit should already have signed the Norwegian

Measuring tiny differences in mass between different quantum states provides new insights into heavy atoms.

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Memorial services will be held in Australia and New Zealand this week to mark Anzac Day.

Services around the world have been disrupted due to the coronavirus crisis

Military-style semi-automatic weapons and assault rifles will be banned in New Zealand from next month under tough new laws announced today by Prime Minister Jacinda Ardern.

New Zealand moves to ease strict lockdown measures after successfully containing coronavirus outbreak

People headed to the beach and fast food outlets after New Zealand lifted its strict lockdown rules that were put in place to limit the spread of coronavirus.

New Zealand has recorded no new coronavirus cases for the first day since a national lockdown came into force more than a month ago.

The record is filled with soaring vocals, melodic guitar work, stomping grooves and more

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Balancing home, office work takes toll on mental health  Deccan Chronicle

Alex Ronan

The post Just Because It’s Natural Doesn’t Mean It’s Moral: A Conversation With Alan Levinovitz appeared first on The Nation.

Nigel Farage has become the butt of mocking jokes online after sharing his Clap for Carers effort.

The 84-year-old star of 'M*A*S*H' is working harder now than ever before. Ellen McCarthy spoke to him about his life, his acting career and his new work to get the world communicating more clearly

'Talking Heads' was first broadcast in 1988 and 1998

Apprentice host shared post falsely claiming that Covid-19 was manufactured in a Wuhan laboratory

The comic essayist on crying over Olive Kitteridge, his love for Richard Yates and the books that make him laugh

The book I am currently reading
Hidden Valley Road. It’s a nonfiction book about a family with 12 children, half of whom turn out to be schizophrenic. In the opening pages the mother sews a live bird’s eyes shut. And she’s one of the few who isn’t mentally ill!

The book that changed my life
Kurt Vonnegut’s Breakfast of Champions. A friend read it out aloud to me when we were hitchhiking across America in 1976, and it made me think: “That’s right – books!” After high school I had forgotten about them. As soon as I got a stable address, I secured a library card, and started making up for lost time.

The retro runner has made (another) comeback

As new actors revive the Talking Heads TV monologues, the poignant tales they tell will resonate more than ever with viewers in lockdown

The decision, announced last week by BBC Drama, to revive and recast Alan Bennett’s landmark Talking Heads series was driven as much by necessity as sentiment. Monologue, delivered to camera, is just about the only form of acting possible at the moment. But, still, there will be a special poignancy in hearing how the mini-dramas sound a generation later in their new voices – Imelda Staunton instead of Patricia Routledge, Kristen Scott Thomas in place of Eileen Atkins, Tamsin Greig for Penelope Wilton, Jodie Comer instead of Julie Walters.

Bennett wrote the first of the monologues in 1987, giving voice, in his 50s, to lives that in several cases were facing their last act. He himself turns 86 next week, about the same age as Thora Hird was when he cast her so memorably in Waiting for the Telegram in the last of the second series of monologues in 1998.

Related: Jodie Comer to star in new BBC production of Alan Bennett's Talking Heads

Manchester United are yet to offer Odion Ighalo a permanent deal with Ole Gunnar Solskjaer undecided over his plans to sign a striker this summer.

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Borussia Dortmund striker Erling Haaland is an attractive option for any club in Europe, believes former Real Madrid defender and assistant coach Aitor Karanka.

Paul Pogba claims unfinished business lured him back to Manchester United as Real Madrid and Juventus line up to prise him away again this summer.

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Welcome to the Evening Standard's live blog covering the latest transfer news and rumours from the Premier League and beyond.

Real Madrid should have signed young striker Erling Haaland before he moved to Borussia Dortmund, their former winger Luis Figo believes.

Manchester United must target signing all three of Harry Kane, Jadon Sancho and Jack Grealish in order to compete for silverware, says Alan Shearer.

Alan Pardew insists he will not take a bonus from ADO Den Haag after the Dutch outfit avoided relegation from the Eredivisie.

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ADO Den Haag have announced that Alan Pardew and his coaching team have left the club by mutual consent after four months in charge.

Borussia Dortmund striker Erling Haaland is "made for Real Madrid", according to former coach Stanislav Macek.

What’s needed after Covid-19 is a bigger, smarter state, with more devolved decisions, a greener economy and a stronger safety net

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The words are straining to come out. Boris Johnson hero worships Winston Churchill so it is obvious how the prime minister will pitch this week’s announcement of the plan to get Britain out of lockdown.

In late 1942, victory in the north African desert had suggested that the tide of the war might have turned but Churchill was cautious. “Now this is not the end,” he said in a speech at London’s Mansion House. “It is not even the beginning of the end. But it is, perhaps, the end of the beginning.”

Old rivals Australia and New Zealand produce another netball classic, with the Silver Ferns edging out the Diamonds to take a lead in the Constellation Cup series.

Just say "no" to mom guilt.

Measuring tiny differences in mass between different quantum states provides new insights into heavy atoms.