Nearly 200 nations have gathered at the annual U.N. climate summit in Baku, focused this year on raising hundreds of billions of dollars to fund a global transition to cleaner energy sources and limit the climate damage caused by carbon emissions

Community is more than just a mere word, it defines our existence

A portrait of English mathematician Alan Turing became the first artwork by a humanoid robot to be sold at auction, fetching $1,320,000

The pair hopes to stimulate the immune system to tackle tumors bearing mutant KRas proteins, one of cancer’s toughest targets

At the third meeting of GP-write, researchers decide to create virus-resistant human cells

Naturally occurring compound inhibits replication of Zika virus in living cells

Naturally occurring compound inhibits replication of Zika virus in living cells

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Princeton University-based researchers have found that machine-learning programs can acquire the cultural biases embedded in the patterns of wording, from a mere preference for flowers over insects, to discriminatory views on race and gender.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

This volume, by a former senior counsel to the 9/11 Commission, argues that the U.S. approach to immigration and border security is off-kilter and not keeping pace with the scope and complexity of people’s movement around the world, nor with expectations regarding freedom of movement.

A new imaging technique may give researchers fresh insights into brain development, function, and disease

The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.

These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

In the summer of 2013, a South African member of OM Czech Republic returned to her home country to lead anti-trafficking training and awareness seminars.

Human trafficking grows like a cancer in Ecuador. Boris and Fernanda Salinas are destined to fight it.

Coronavirus COVID 19 vaccine news, latest update, human trials: Sanofi's Pasteur division has an established track record in influenza vaccines. Last month it had teamed with its British rival GSK to produce a vaccine candidate hoping that it will be ready in 2021.

In another release, the ministry said the Institute of Genomics and Integrative Biology (CSIR-IGIB) and Tata Sons have signed a licensing agreement for a paper strip-based test called Feluda for Covid 19's rapid diagnosis.

A recent incident where a Hong Kong citizen forced his maid to travel abroad with him has opened up a wide discussion on the issue of human trafficking. The outcome of the incident has seen a rather curious scenario develop, wherein Hong Kong holidaymakers…

1. Human urine could help make concrete on moon, says European Space Agency  Times Now
2. Human urine could be used to make concrete on moon in the future  Economic Times
3. Ever thought of urine for lunar concrete?  NEWS9 live
4. You Can Now Buy a Piece of the Moon for $2.5 Million  Beebom
5. European Space Agency: Human urine could help make concrete on Moon  The New Indian Express
6. View Full coverage on Google News

Trillions of dollars will be invested in renewable energy over the next 25 years, driving some of the most profound changes yet in how humans get their electricity. That's according to a new forecast by Bloomberg New Energy Finance that plots out global power markets to 2040. 

Trillions of dollars will be invested in renewable energy over the next 25 years, driving some of the most profound changes yet in how humans get their electricity. That's according to a new forecast by Bloomberg New Energy Finance that plots out global power markets to 2040. 

Realisation of security by mortgagees is a hot topic in current economic circumstances, and Horsham Properties Group Ltd v Clark is a case that underlines that mortgagees' powers can sometimes appear draconian. In this case, the mortgagee appointed...

Wondering whether the collaboration with the state by spiritual leaders might not be a betrayed of faith in the power of God to reign over the virus

Islamabad : Reduced human activities outside due to COVID-19 lockdown has not only contributed to the revival of nature through lowering pollution level and limiting human interference but also provided an opportunity to the migratory birds to fly freely without any threat of poaching.World...

07/11/12 - the OECD and the International Coordinating Committee of National Human Rights Institutions concluded a Memorandum of Understanding to promote respect by multinational enterprises of the new human rights chapter of the OECD Guidelines for Multinational Enterprises and the UN Guiding Principles for Business and Human Rights upon which the OECD Guidelines are based.

70 years after the Universal Declaration of Human Rights, our recognition of the “inherent dignity of all members of the human family as the foundation of freedom, justice and peace in the world” has further strengthened the alignment between responsible business conduct and human rights.

The truth is that human rights are not sustainable, or in some places even possible, in today’s networked society unless public and private actors take responsibility. Governments and corporations alike must commit to design, manage, and govern technologies in a manner that is consistent with international human rights standards.

This report summarizes major policy and practical issues discussed by international and Asian experts at the 4th Roundtable on Labour Migration (ADBI/OECD/ILO, Tokyo, 27-28 January 2014). The report outlines the trends in labor migration within Asia and between Asia and some OECD countries. It reviews the links between migration and human capital development and presents the impact of migration on family members "left behind".

The current humanitarian crisis is unprecedented with an appalling and unacceptable human cost. This issue of Migration Policy Debates looks at the most recent developments in the humanitarian migration crisis and what makes this crisis different from previous ones.

This edition of Migration Policy Debates scrutinises the factors that facilitate human trafficking, as well as the smuggling routes to OECD countries. It synthesises available evidence and reviews existing policy tools for tackling such crime.

OECD recommendations for the integration of Humanitarian migrants

Natural resources provide essential raw materials and other commodities, and are an important source of income and jobs. They also support the provision of ecosystem services necessary to develop human and social capital.

The global economic crisis has had a profound impact on people’s well-being, reaching far beyond the loss of jobs and income, and affecting citizens’ satisfaction with their lives and their trust in governments, according to a new OECD report.

These country notes profile public sector human resource practices and policies, covering issues including legal frameworks; age and gender composition of workers; public sector restructuring; management practices; industrial relations and reforms.

Skills for growth: human capital composition and economic performance

Colombia and Mexico are a step closer to beneffiting from cross border tax co-operation and information sharing. Colombia has signed, and Mexico has deposited its instrument of ratification for the Multilateral Convention on Mutual Administrative Assistance in Tax Matters.

To pursue economic growth, Russia must develop its human capital, which requires structural reforms in education, healthcare and pensions. These, in turn, must respond to major trends in service provision, including the increasing role of individual choice, the need to deliver lifelong learning and healthcare, and the risk that Russians will increasingly buy services abroad, rather than work to develop their own national systems.

The Indonesian economy has enjoyed strong and stable growth over the past decade and a half, leading to impressive reductions in poverty and major improvements in living standards. But challenges remain to continue to converge towards higher-income countries, according to the latest OECD Economic Survey of Indonesia.

US Environmental Protection Agency derived the Human health benchmarks for pesticides by applying the health effects data from pesticide registrations to the typical methods used for developing drinking water health advisories. It was developed to enable states, water systems and the public to better determine whether the detection of a pesticide in drinking water or source waters for drinking water may indicate a potential health risk.

The OECD has just published two new Test Guidelines on human health hazard endpoint skin sensitisation. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).

The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. Every year new and updated Test Guidelines are adopted to meet the regulatory needs in OECD member countries. The most recent Test Guidelines were adopted in July 2016.

Taipei’s MRT is the only underground railway where someone has offered to tie up my shoelace

Deliberately infecting volunteers could accelerate research but raises ethical questions

MailOnline will board a Boeing 787 Dreamliner at London Heathrow tomorrow that will then fly non-stop to Sydney - a distance of 11,060 miles that'll take 19-and-a-half hours to cover.

Manjari Singh reports on the opening of the Lucknow branch of Sheroes Hangout, a café run and managed by acid attack survivors under the guidance of the humanitarian organisation “Stop Acid Attacks”