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Electrochemical aptasensor based on silver-thiolated graphene for high-sensitive detection of Pb2+

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00322E, Paper
Jie Zhou, Changchun Hu, Shuo Li, Chuanxiang Zhang, Yuan Liu, Zhu Chen, Song Li, Hui Chen, Yan Deng
The presence of lead ions (Pb2+) not only leads to environmental contamination but also poses a significant risk to public health through their migration into food and drinking water. Therefore,...
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Rapid and green quantification of phloridzin and trilobatin in Lithocarpus litseifolius (Hance) Chun (sweet tea) using an online pressurized liquid extraction high-performance liquid chromatography at equal absorption wavelength method

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00170B, Paper
Zhengming Qian, Qinggui Lei, Dan Tang, Guoying Tan, Qi Huang, Fucai Zhou, Wenhao Wang
Sweet tea is a functional herbal tea with anti-inflammatory, anti-diabetic, and other effects, in which phloridzin and trilobatin are two functional compounds.
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Near-infrared responsive gold nanorods for highly sensitive colorimetric and photothermal lateral flow immuno-detection of SARS-CoV-2

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00347K, Paper
Xiaohui Liu, Jingwen Li, Kun Wang, Xiang Li, Shenming Wang, Gengchen Guo, Qiaowen Zheng, Maosheng Zhang, Jingbin Zeng
We developed a colorimetric and photothermal dual-mode LFIA platform for sensitive and selective SARS-CoV-2 N protein detection based on gold nanorods.
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00333K, Paper
David Ulisses Tega, Luan Felipe Campos Oliveira, Patrick Cesar Ferreira, Bruna Beatriz Soldera, Heliara Dalva Lopes Nascimento, Marcos Nogueira Eberlin, Alessandra Sussulini
Optimization of a LC-V-EASI-MS system. Employment of LC-V-EASI-MS and online SPE to enhance analytical performance for caffeine determination reaching 90 s per sample.
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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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Antibody-labeled Gold Nanoparticles Based Resonance Rayleigh Scattering Detection of S100B

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00335G, Paper
tiantian Wang, yonghui Wang, junbo Li
Traumatic brain injury (TBI) is a sudden brain injury due to an external force that causes a large number of deaths and permanent disabilities every year. S100B has been recognized...
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Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2278-2285
DOI: 10.1039/D3AY02261G, Paper
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Development of an off-line LC-SFc-MS method, separation of sterol isomers in algal unsaponifiable fractions, elution pattern helping in the reduction of structural candidates.
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On-chip light sheet illumination for nanoparticle tracking in microfluidic channels

By pubs.rsc.org
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Anal. Methods, 2024, 16,2229-2240
DOI: 10.1039/D3AY02290K, Communication
Théo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu Loumaigne
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
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A highly selective probe engineered to detect polarity and distinguish normal cells and tumor cells in tissue sections

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00438H, Paper
Sai Zhu, Lixuan Dai, Xiaoli Zhong, Weiying Lin
We have designed a polarity fluorescent probe (DCI-Cou-polar) with high selectivity for diagnosing cancer.
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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

By www.thehindu.com
Published On :: Fri, 13 Sep 2024 00:20:00 +0530

Extension of free health coverage to all over 70 years is good, but more needs to be done  


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A fair share: On the concerns of high performing States

By www.thehindu.com
Published On :: Thu, 19 Sep 2024 00:10:00 +0530

The Sixteenth Finance Commission must address the concerns of high-performing States


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Staying the course: On the fight against air pollution in the Indo-Gangetic plains

By www.thehindu.com
Published On :: Sat, 28 Sep 2024 00:10:00 +0530

The Centre and the States need to fight air pollution together 


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​Tough task: On the battle lines in the Jharkhand Assembly election

By www.thehindu.com
Published On :: Wed, 30 Oct 2024 00:20:00 +0530

Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand


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Alia-Ranbir's Daughter Raha Turns 2

By www.rediff.com
Published On ::

Alia Bhatt and Ranbir Kapoor's little girl Raha turned two on November 6, and we were treated to the most adorable pictures on social media.


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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:30:58 +0530


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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:10:58 +0530

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive


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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:56:40 +0530

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa


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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 19:20:03 +0530

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand


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Man attempts to end life, kills his wife and daughter

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:03:18 +0530


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554: Jamstack Thoughts with Brian Rinaldi

By shoptalkshow.com
Published On :: Mon, 27 Feb 2023 20:50:01 +0000

Brian Rinaldi joins us to talk about the state of Jamstack in 2023, acronym confusion, SPA confusion, developing common tools of understanding, why Netlify bought Gatsby, and the state of developer conferences.


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562: Podcast Apps, Zaraz, Future CSS Thoughts, and Arc

By shoptalkshow.com
Published On :: Mon, 24 Apr 2023 08:01:44 +0000

What if Taylor Swift lyrics hold the answers to web dev questions? Podcast app thoughts, using Cloudflare Zaraz, what we're excited about with CSS, Arc browser updates, and are we even developers or are we specialized systems whisperers?


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573: Google Reader, Sticky and Overflow, and Figma Thoughts

By shoptalkshow.com
Published On :: Mon, 10 Jul 2023 08:01:45 +0000

Chris breaks out his banjo, some thoughts on making music vs recording music, what happened to Google Reader and social reading, what black box properties can't Dave or Chris remember, follow up for dev teams communicating with designers, and what's Adobe going to do about Figma?


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590: Twisting Through Websites

By shoptalkshow.com
Published On :: Mon, 06 Nov 2023 10:08:50 +0000

The excitement of launching Luro, changes in social media platforms, different seasons for coding and marketing, embedded social media post weight, CSS thoughts from Web Unleashed, focus state issues, and fact checking and updating old posts on your blog.


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596: The Year of AI, Arc, and Being Mad About the Right Thing

By shoptalkshow.com
Published On :: Mon, 18 Dec 2023 09:03:32 +0000

Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing.


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599: Fighting the Algorithm With RSS, Blogging, and the IndieWeb

By shoptalkshow.com
Published On :: Mon, 22 Jan 2024 10:30:04 +0000

Dave and Chris discuss indie web culture, the role of social media in today's society, and the challenges and strategies of freelancing. Additionally, they discuss a range of topics from content moderation, coding and refining tech skills, to emerging startups and the future of web technology.


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620: Cloudflare #HotDrama, Auth, and Prototyping Thoughts

By shoptalkshow.com
Published On :: Mon, 17 Jun 2024 08:27:24 +0000

Show DescriptionWe dive a bit deeper into the Cloudflare drama of the past couple of weeks, Instagram ads vs Cara art, what to do about Auth in your app, pre-negging any sponsorships, prototyping and feedback on projects, and ideas for future topics. Listen on Website →Links Cloudflare took down our website after trying to force […]


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623: Assigning Weight Dynamically, CoPilot vs Other AI, and Monorepos

By shoptalkshow.com
Published On :: Mon, 08 Jul 2024 08:34:45 +0000

We're talking about assigning a weight to items in a layout, differentiating between banger posts and regular blog posts, using social engineering to get PR's accepted, monorepo thoughts, using CoPilot vs other AI programming support bots, has TypeScript benefited from AI, and what happens if you turn off CoPilot?


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631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome

By shoptalkshow.com
Published On :: Mon, 02 Sep 2024 08:01:07 +0000

Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.


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638: Q&A About Copyright, Jekyll, Joomla, Statamic, and More!

By shoptalkshow.com
Published On :: Mon, 21 Oct 2024 08:38:43 +0000

Dave's designing a new tshirt, questions for lawyers about copyrights for code projects, what does the copyright in the footer actually do, what do Dave and Chris require for personal web projects, does Jekyll get updated anymore, the Bob from Hell UX pattern, viewing ads on CNN, what about Joomla or Statamic, and how do paid fonts on the web work?


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Your space, your right

By www.thehindu.com
Published On :: Fri, 17 Apr 2015 14:58:35 +0530

Ask for specified parking slots in your new home.


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The fight against encroachment

By www.thehindu.com
Published On :: Fri, 04 Sep 2015 16:58:16 +0530

No one has the right to use precious road space as their private storage yard.


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Site and foresight

By www.thehindu.com
Published On :: Fri, 18 Dec 2015 18:56:46 +0530

If people could design, build and live happily as per site contexts for thousands of years, why do we need to destroy the rules of nature today?


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Give high priority to fire safety

By www.thehindu.com
Published On :: Fri, 08 Jan 2016 16:39:57 +0530

In majority of high-rise buildings, power supply distribution and meter panels are located in the basement floors making them vulnerable to fire mishaps, writes Avala Buchi Reddy


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A ‘shadow ban’ in plain sight

By www.thehindubusinessline.com
Published On :: Mon, 21 Oct 2024 17:02:24 +0530

The confusion and stigma surrounding the ‘morning after’ pill puts women’s health at risk


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Spotlight on ways to end violence against children

By www.thehindubusinessline.com
Published On :: Sun, 03 Nov 2024 19:24:25 +0530


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‘Focused on building a high-conviction portfolio’

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 20:33:15 +0530

How fund house Cactus Partners ensures its capital goes toward growth rather than just keeping operations running


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Founders who firefight non-stop, risking their mental health 

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 20:54:27 +0530

There is unbelievable pressure on entrepreneurs as they work hard non-stop to create bigger, better, faster businesses


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IAF Mig-29 fighter crashes near Agra, pilot ejects to safety

By www.thehindu.com
Published On :: Mon, 04 Nov 2024 17:26:14 +0530

An enquiry has been ordered by the IAF, to ascertain the cause of the accident


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CVC has sought report from CPWD over CM House renovation: Delhi LoP

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 01:03:54 +0530


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Yamuna highly toxic, says Delhi HC, bins plea to allow Chhath Puja rituals on riverbanks

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 01:08:00 +0530

Court dismisses petition against order prohibiting Chhath Puja rituals on Yamuna’s banks, says it can’t let devotees fall sick; have made ample arrangements at 1,000 ghats: Delhi govt. counsel; 4-day festival dedicated to Sun God began on Tuesday


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