GUJARAT, INDIA – HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today opened an exclusive premium showroom for its high-end, Luxury Audio range of products in Ahmedabad, Gujarat. This is the company’s fifth luxury audio showroom* in India and offers the most advanced high-performance audio systems available in the country.

Title: Could a Cellular Tweak Someday 'Switch Off' Gray Hair?
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM

Title: Menopause May Someday Disappear as Women Postpone Pregnancy: Study
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

BACKGROUND:

Pediatric subspecialists routinely provide procedural sedation outside the operating room. No large study has reported trends in outpatient pediatric procedural sedation. Our purpose in this study was to identify significant trends in outpatient procedural sedation using the Pediatric Sedation Research Consortium.

Erin Gorrell, Ashley Shemery, Jesse Kowalski, Miranda Bodziony, Nhlalala Mavundza, Amber R. Titus, Mark Yoder, Sarah Mull, Lydia A. Heemstra, Jacob G. Wagner, Megan Gibson, Olivia Carey, Diamond Daniel, Nicholas Harvey, Meredith Zendlo, Megan Rich, Scott Everett, Chaitanya K. Gavini, Tariq I. Almundarij, Diane Lorton, and Colleen M. Novak

Non-shivering thermogenesis can promote negative energy balance and weight loss. In this study, we identified a contextual stimulus that induces rapid and robust thermogenesis in skeletal muscle. Rats exposed to the odor of a natural predator (ferret) showed elevated skeletal muscle temperatures detectable as quickly as 2 min after exposure, reaching maximum thermogenesis of >1.5°C at 10–15 min. Mice exhibited a similar thermogenic response to the same odor. Ferret odor induced a significantly larger and qualitatively different response from that of novel or aversive odors, fox odor or moderate restraint stress. Exposure to predator odor increased energy expenditure, and both the thermogenic and energetic effects persisted when physical activity levels were controlled. Predator odor-induced muscle thermogenesis is subject to associative learning as exposure to a conditioned stimulus provoked a rise in muscle temperature in the absence of the odor. The ability of predator odor to induce thermogenesis is predominantly controlled by sympathetic nervous system activation of β-adrenergic receptors, as unilateral sympathetic lumbar denervation and a peripherally acting β-adrenergic antagonist significantly inhibited predator odor-induced muscle thermogenesis. The potential survival value of predator odor-induced changes in muscle physiology is reflected in an enhanced resistance to running fatigue. Lastly, predator odor-induced muscle thermogenesis imparts a meaningful impact on energy expenditure as daily predator odor exposure significantly enhanced weight loss with mild calorie restriction. This evidence signifies contextually provoked, centrally mediated muscle thermogenesis that meaningfully impacts energy balance.

BACKGROUND:Electrical impedance tomography (EIT) is a noninvasive, portable lung imaging technique that provides functional distribution of ventilation. We aimed to describe the relationship between the distribution of ventilation by mode of ventilation and level of oxygenation impairment in children who are critically ill. We also aimed to describe the safety of EIT application.METHODS:A prospective observational study of EIT images obtained from subjects in the pediatric ICU. Images were categorized by whether the subjects were on intermittent mandatory ventilation (IMV), continuous spontaneous ventilation, or no positive-pressure ventilation. Images were categorized by the level of oxygenation impairment when using SpO2/FIO2. Distribution of ventilation is described by the center of ventilation.RESULTS:Sixty-four images were obtained from 25 subjects. Forty-two images obtained during IMV with a mean ± SD center of ventilation of 55 ± 6%, 14 images during continuous spontaneous ventilation with a mean ± SD center of ventilation of 48.1 ± 11%, and 8 images during no positive-pressure ventilation with a mean ± SD center of ventilation of 47.5 ± 10%. Seventeen images obtained from subjects with moderate oxygenation impairment with a mean ± SD center of ventilation of 59.3 ± 1.9%, 12 with mild oxygenation impairment with a mean ± SD center of ventilation of 52.6 ± 2.3%, and 4 without oxygenation impairment with a mean ± SD center of ventilation of 48.3 ± 4%. There was more ventral distribution of ventilation with IMV versus continuous spontaneous ventilation (P = .009), with IMV versus no positive-pressure ventilation (P = .01) cohorts, and with moderate oxygenation impairment versus cohorts without oxygenation impairment (P = .009). There were no adverse events related to the placement and use of EIT in our study.CONCLUSIONS:Children who had worse oxygen impairment or who received controlled modes of ventilation had more ventral distribution of ventilation than those without oxygen impairment or the subjects who were spontaneously breathing. The ability of EIT to detect changes in the distribution of ventilation in real time may allow for distribution-targeted mechanical ventilation strategies to be deployed proactively; however, future studies are needed to determine the effectiveness of such a strategy.

The Carboniferous Bowland Shale Formation of the UK is a proven hydrocarbon source rock and currently a target for shale gas exploration. Most existing analysis details lithofacies and geochemical assessment of a small number of boreholes. Given a paucity of relevant borehole cores, surface samples provide a valuable contribution to the assessment of this unconventional gas source. This study reviews existing literature on the formation's hydrocarbon geochemistry and provides new lithological descriptions of seven lithofacies, XRD mineralogy and hydrocarbon-specific geochemical data for 32 outcrop localities within the Craven and Edale basins, respectively in the northern and southern parts of the resource area. Low oxygen indices suggest that the majority of samples are relatively unaltered (in terms of hydrocarbon geochemistry), and therefore suitable for the characterization of the shale organic character. Total organic carbon (TOC) ranges from 0.7 to 6.5 wt%, with highest values associated with maximum flooding surfaces. Mean T_max values of 447 and 441°C for the Edale and Craven basins, respectively, suggest that nearly all the samples were too immature to have generated appreciable amounts of dry gas. The oil saturation index is consistently below the >100 mg g^–1 TOC benchmark, suggesting that they are not prospective for shale oil.

Supplementary material: A table summarizing the location, geological description and age of all of the samples in this paper is available at https://doi.org/10.6084/m9.figshare.c.4444589

Yuta Sakae, Akira Oikawa, Yuki Sugiura, Masatoshi Mita, Shuhei Nakamura, Toshiya Nishimura, Makoto Suematsu, and Minoru Tanaka

The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal. Metabolomic and RT-qPCR analyses indicated that pantothenate metabolism was suppressed by starvation. Consistently, inhibiting the pantothenate metabolic pathway caused sex reversal. The final metabolite in this pathway is coenzyme A, an essential factor for lipogenesis. Inhibiting fatty acid synthesis, the first step of lipogenesis, also caused sex reversal. The expression of dmrt1, a critical gene for male development, was suppressed by starvation, and a dmrt1 (13) mutant did not show sex reversal under starvation. Collectively, these results indicate that fatty acid synthesis is involved in female-to-male sex reversal through ectopic expression of male gene dmrt1 under starvation.

Background and objectives

Bioelectrical impedance analysis (BIA) devices can help assess volume overload in patients receiving maintenance peritoneal dialysis. However, the effects of BIA on the short-term hard end points of peritoneal dialysis lack consistency. This study aimed to test whether BIA-guided fluid management could improve short-term outcomes in patients on peritoneal dialysis.

"This government has failed to show any self-criticism whatsoever, when it is glaringly obvious to everybody that big mistakes have been made."

Cassie may not have any arms to work with, but that doesn’t keep it from juggling a ball on its head

Some plants, like soybean, are known to possess an innate defense machinery that helps them develop resistance against insects trying to feed on them. However, exactly how these plants recognize signals from insects has been unknown until now. Scientists have now uncovered the cellular pathway that helps these plants to sense danger signals and elicit a response, opening doors to a myriad of agricultural applications.

Kim Yuna's stunning win at last month's Winter Games will not only boost the career of the Olympic figure skating champion, it should help add several billion dollars to the South Korean economy.

Nearly 100 children who were being targeted online by child abusers were saved by police in London during the first four weeks of the lockdown, Scotland Yard revealed today.

Cybertip.ca, an online sexual exploitation of children tipline, says it saw a 66 per cent spike in reports in April.

In the late afternoon session, the scrip was being traded at 20.61 pounds, down by 5.50 per cent on the LSE. Vedanta opened on a positive note, but soon swung into the red.

The procedural move gives attorneys for House Democrats until May 18 to respond. They say they're owed access to confidential evidence and other materials. No, argues the Trump administration.

The comic essayist on crying over Olive Kitteridge, his love for Richard Yates and the books that make him laugh

The book I am currently reading
Hidden Valley Road. It’s a nonfiction book about a family with 12 children, half of whom turn out to be schizophrenic. In the opening pages the mother sews a live bird’s eyes shut. And she’s one of the few who isn’t mentally ill!

The book that changed my life
Kurt Vonnegut’s Breakfast of Champions. A friend read it out aloud to me when we were hitchhiking across America in 1976, and it made me think: “That’s right – books!” After high school I had forgotten about them. As soon as I got a stable address, I secured a library card, and started making up for lost time.

As the US deals with a Covid-19 catastrophe in its meatworks, the Melbourne factory points to the potential for outbreaks in Australia

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Working in an abattoir at the best of times is tough. The hours are long, the labour is intensive and, for rank and file labourers, the pay is low.

Now, in the Covid-19 crisis, workers have one more thing to worry about – around the world their factories have proved to be a hotbed of infection. As Australia moves to ease lockdown laws, meat workers may still be at the frontline of exposure and infection.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

Graeme Souness landed the latest blow in his feud with Manchester United star Paul Pogba as he declared: "Put your medals on the table!"

Paul Pogba vs Graeme Souness is the feud that keeps on giving after the two exchanged barbs again on Tuesday.

Spain's Copa del Rey final could take place in 2021 after the Spanish Football Federation (RFEF) agreed to calls from Athletic Club and Real Sociedad for the match to be played in front of fans.

Some plants, like soybean, are known to possess an innate defense machinery that helps them develop resistance against insects trying to feed on them. However, exactly how these plants recognize signals from insects has been unknown until now. In a new study, scientists in Japan have uncovered the cellular pathway that helps these plants to sense danger signals and elicit a response, opening doors to a myriad of agricultural applications.

Some predators, including red foxes, move into burnt areas after fires pass through. But what about other predators?

Mohammed Abdullah Warsame, a 35-year-old resident of Minneapolis, has pleaded guilty to one count of conspiring to provide material support and resources to al-Qaeda.

A 35-year-old Minneapolis man was sentenced today in federal court on one count of conspiring to provide material support and resources to al-Qaeda. In Minneapolis, U.S. District Court Judge John Tunheim sentenced Mohammed Abdullah Warsame to 92 months in prison and three years of supervised release.

The Department has reached a settlement agreement with the Alameda County, Calif., Sheriff’s Office, under which it will provide sign language interpreters and other auxiliary aids and services to arrestees, detainees, suspects, victims, witnesses, complainants and visitors who are deaf, hard of hearing or deaf-blind at two jails.

Among other things, Zazi admitted that he brought TATP [Triacetone Triperoxide] explosives to New York on Sept. 10, 2009, as part of plan to attack the New York subway system.

Raja Lahrasib Khan was charged with two counts of providing material support to terrorism in a criminal complaint that was filed yesterday in U.S. District Court in Chicago and unsealed today following his arrest.

"This plot, as well as others we have encountered, makes clear we face a continued threat from al-Qaeda and its affiliates overseas," said Attorney General Holder.

The Justice Department today announced charges against five members of an al-Qaeda plot to attack targets in the United States and United Kingdom.

"The Medal of Valor is the highest honor awarded to public safety officers in the country," said Attorney General Holder. "And today’s recipients are part of a select group,"

Farooque Ahmed, 34, of Ashburn, Va., was arrested today for attempting to assist others whom he believed to be members of al-Qaeda in planning multiple bombings at Metrorail stations in the Washington, D.C., area.

Farooque Ahmed, 35, of Ashburn, Va., was sentenced today to 23 years in prison, followed by 50 years of supervised release, after pleading guilty to charges stemming from his attempts to assist others whom he believed to be members of al-Qaeda in planning bombings at Metrorail stations in the Washington, D.C., area.

The Civil Rights Division and the U.S. Attorney’s Office for the Northern District of California announced today an agreement with Alameda County, Calif., to ensure compliance with provisions of the Voting Rights Act that require the county to provide election materials and information in Spanish and Chinese.

Earlier today, following a four-week trial, Adis Medunjanin, 28, a Queens, N.Y., resident who joined al-Qaeda and plotted to commit a suicide terrorist attack, was found guilty of multiple federal terrorism offenses.

Deputy Attorney General James M. Cole paid tribute to four individuals today during the National Missing Children’s Day ceremony at the Justice Department’s Great Hall.

Earlier today, Adis Medunjanin, age 34, a Queens, N.Y., resident who joined al-Qaeda, then plotted and attempted to commit suicide terrorist attacks, was sentenced in the Eastern District of New York to life in prison for multiple federal terrorism offenses.

Vice President Joe Biden and Attorney General Eric Holder today awarded the Public Safety Officer Medal of Valor to 18 public safety officers who exhibited exceptional courage in saving and protecting others and whose heroic actions were above and beyond the call of duty.

"Through these selfless acts – and through the service you render to your communities and fellow citizens every day – each of you has earned the deepest thanks of a grateful nation. And all of you have incurred a debt of gratitude that this country can only hope to repay," said Attorney General Holder.

"We’re here to recognize 18 extraordinary individuals for their quick thinking, selflessness, and exceptional courage. They are law enforcement and corrections officers and firefighters who went beyond the call of duty to risk – and in some cases, to give – their lives for their fellow citizens and colleagues," said Acting Assistant Attorney General Leary.

The International Competition Network (ICN) adopted new recommended practices for predatory pricing analysis and competition assessment, and approved new work product on international merger enforcement cooperation, confidentiality protections during investigations, leniency policy and digital evidence gathering.

Takeda in global licensing agreement with ProThera to develop plasma-based therapies for inflammatory conditions.