We have prepared a major update for one of the most popular automated posters in RSS Ground – LinkedIn Poster. LinkedIn poster can make continuous posts to your LinkedIn personal feed or LinkedIn company pages. And now you can control what content you wish to post. Find a list of new Advanced settings in the […]

The post LinkedIn Automated Poster Major Update appeared first on RSSground.com.

Due to recent changes on Twitter, our Twitter Poster and Twitter Feeds features have been temporarily suspended. We are excited to announce a significant update to the Twitter Poster. Your immediate action is required to ensure the continuity of your posting campaigns! The primary change in our new X (Twitter) Poster involves the necessity of […]

The post RSS Ground X (Twitter) Poster Major Update appeared first on RSSground.com.

We are glad to introduce some interface updates and improvements. In the Feeds Box you can now see a new Filter icon. Click to filter your content feeds by type, source and status and to use search option.  You can also change the number of feeds per page. We have also added the Reset filters option […]

The post Interface updates and improvements. appeared first on RSSground.com.

Your feedback matters to us, and we’ve been working hard on our Personal Feeds based on what you told us in our ongoing survey. We’re excited to show off a cleaner, user-friendly update – a straightforward, refreshed look that makes creating and editing personal feeds simple and efficient.   The feed title is now prominently […]

The post You asked – we listened: Personal Feeds interface update appeared first on RSSground.com.

We continue our updates and improvements based on your recent suggestions. This time, we have enhanced some interface options as well as Personal Feeds functionality. Please enjoy! Pagination has been added to the bottom of all RSS Ground lists (tables). We have also added an “attention seeker” bouncing effect for the Filters icon. It will […]

The post Another set of updates for personal feeds and more appeared first on RSSground.com.

By Ireland Owens Toyota’s North American Chief Operating Officer (COO) Jack Hollis criticized U.S. policies promoting electric vehicle adoption (EV) on Friday, according to Bloomberg. The Toyota COO said that electric vehicle policies are “de facto mandates” that are not in sync with consumer demand, according to Bloomberg. Hollis also said that EV mandates such as […]

The post Major Automaker Exec Flatly Says Liberals’ EV ‘Mandates’ Are ‘Impossible’ To Meet appeared first on Liberty Unyielding.

The vice-president failed to make the case that she would be different from her boss, President Joe Biden.

Gun barrels are made of metal, and like any other metal object, they just love to get rusty. After you use the gun for a while, they start acting like a toddler who needs nonstop attention. If you leave them unattended for a while, you’ll come back to see that the shiny barrel is cluttered […]

The post How To Remove Rust From A Gun Barrel? [Updated 2023] appeared first on Patriot Outdoor News.

President Trump tweeted a four-minute video message updating the American public Saturday evening on his progress since being tested positive with the coronavirus, saying that he “feels much better now” but the next few days is going to be “the real test.” pic.twitter.com/gvIPuYtTZG — Donald J. Trump (@realDonaldTrump) October 3, 2020 “I came here, wasn’t […]

The post Trump Delivers Video Update From Walter Reed: ‘I Feel Much Better Now’ appeared first on Hispolitica.

President Trump tweeted a second video update from Walter Reed Medical Center on Sunday, stating his personal positive diagnosis have been a “very interesting journey,” and that he learned a lot about COVID-19. pic.twitter.com/0Bm9W2u1x7 — Donald J. Trump (@realDonaldTrump) October 4, 2020 “So it’s been a very interesting journey. I learned a lot about COVID. […]

The post Trump In Second Video Update Says He ‘Learned A Lot’ About Covid Since Being Diagnosed appeared first on Hispolitica.

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

Apple has released macOS Sonoma 14.7.1 and MacOS Ventura 13.7.1 for Mac users who have not yet updated to MacOS Sequoia, of which MacOS Sequoia 15.1 with Apple Intelligence was just released. macOS Sonoma 14.7.1 and macOS Ventura 13.7.1 both contain many security fixes, making them important updates to install for Mac user who are ... Read More

Though not common, some Mac users are encountering a strange error message that says “Failed to personalize the software update. Please try again.” when attempting to update their Mac to MacOS Sequoia, and sometimes even with other MacOS software updates too. This is a frustrating error since it prevents the installation of a major system ... Read More

The ChatGPT app for Mac is a fantastic AI tool and LLM that makes for a great addition to many Mac users workflows, whether you’re extremely tech savvy, or just a novice. One thing that some users have wondered is how to keep the ChatGPT app for Mac updated, and how to install updates to ... Read More

Marilyn Chinitz has worked with celebs like Tom Cruise, Michael Douglas, and Wendy Williams. She has been happily married for 38 years.

Too much fluoride can make your teeth brown, but getting a little bit is a dentist's dream. Here's the complete history of fluoridated water.

Kenya's candidate for the top job at the African Union said on Saturday that if US president-elect Donald Trump does not want to work with Africa, the continent has "other friends".

PORT LOUIS, Nov 10 - Mauritius was holding a parliamentary election on Sunday with Prime Minister Pravind Kumar Jugnauth and his main rivals all promising to tackle a cost of living crisis in the Indian Ocean archipelago.

Continuing to set records, Pepe Unchained recently achieved a new milestone after reaching $26 million. The project’s presale has now… Continue reading As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU

The post As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU appeared first on ReadWrite.

The latest investment insights and market developments.

There is a reason Joe Rogan became the world's largest podcaster. He doesn't take his audience -- or his guests -- for granted. He wants MEANINGFUL conversations.

The post Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet appeared first on Clash Daily.

The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday.

In their comment (1) on our publication (2), the authors make two points: (i) they raise concerns about the possible effect of residual NONOate in our study, and (ii) they promote nitrosylcobalamin (NOCbl) supplied by their own company. Both points lack merit for the following reasons. The authors make the astonishing claim that the spectra of nitric oxide (NO•) and cobalamins overlap. Unlike NO•, cobalamin absorbs in the visible region, permitting unequivocal spectral assignment of NOCbl as reported (3). We demonstrated that whereas NOCbl is highly unstable in solution, it is stabilized by the B12 trafficking protein CblC. So even if present, residual NONOate (which is unstable at neutral pH and is removed during the work-up (3)) could not account for the observed difference.The authors then misrepresent our synthetic method, claiming that anaerobic conditions were used to generate nitrocobalamin (NO2Cbl), which results in the transient formation of NOCbl. We synthesized NO2Cbl aerobically using nitrite as described (4); NOCbl is not an intermediate in this ligand exchange reaction. The aerobic instability of NOCbl has been rigorously described by inorganic chemists (3, 5) and raises obvious questions about its purported biological effects as exemplified by the authors' own 2003 JBC publication, which was later withdrawn.As to promoting NOCbl from their company, the authors refer to a synthetic route from a mixture of NO• gas and aquocobalamin. The authors' method (6) has been described as “dubious” by chemists (5). Whereas DEAE NONOate used in our method is widely known as an NO• donor,...

After a thorough read of this paper (1), we wish to clarify that the authors' anaerobic method of synthesis for the production of nitrocobalamin results in the transient formation of nitrosylcobalamin, an unstable intermediate upon exposure to air. We concur that the authors' method results in the production of nitrocobalamin based on the UV-visible data as shown. The authors' adapted anaerobic method consists of mixing hydroxocobalamin hydrochloride with diethylamine NONOate diethylammonium salt in aqueous solution. Of concern, the UV spectrum of nitric oxide overlaps that of all cobalamin species under anaerobic conditions, making any assignments of the binding of nitric oxide to hydroxocobalamin suspect (2). Additionally, the use of acetone to precipitate the authors' product causes precipitation of diethylamine NONOate, resulting in an impure product. As a result, its utility for drawing experimental conclusions is faulty.The product from the authors' anaerobic synthetic method has not been assessed for purity, and the synthetic method itself has not been validated using a stability-indicating method as required by the International Conference on Harmonization (ICH) (ICH Q2B, Validation of Analytical Procedures) methodology, which is a hallmark for analytical characterization. Our nitrosylcobalamin synthesis involves reacting nitric oxide gas with hydroxocobalamin acetate as a heterogeneous mixture in a non-electron-donating solvent followed by rotary evaporation. Our nitrosylcobalamin product is stable in air, releases nitric oxide gas in situ (3), and meets ICH stability guidelines (4). Additionally, our nitrosylcobalamin product demonstrates biological activity, which has not been observed for nitrocobalamin (3, 5).

Alison M. Kurimchak
Dec 1, 2020; 19:2068-2089
Research

Prabuddha Dey
Dec 1, 2020; 61:1556-1564
Reviews

Gerhard Liebisch
Dec 1, 2020; 61:1539-1555
Special Report

You encounter this issue when the table metadata matches the data source. In this scenario, no metadata update is required.

Phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and regulates the synthesis of membrane phospholipids. There is much interest in this enzyme because it controls the cellular levels of its substrate, phosphatidate (PA), and product, DAG; defects in the metabolism of these lipid intermediates are the basis for lipid-based diseases such as obesity, lipodystrophy, and inflammation. The measurement of PAP activity is required for studies aimed at understanding its mechanisms of action, how it is regulated, and for screening its activators and/or inhibitors. Enzyme activity is determined through the use of radioactive and nonradioactive assays that measure the product, DAG, or P_i. However, sensitivity and ease of use are variable across these methods. This review summarizes approaches to synthesize radioactive PA, to analyze radioactive and nonradioactive products, DAG and P_i, and discusses the advantages and disadvantages of each PAP assay.

A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase therapeutic avenues for EC, we profiled the kinome of endometrial tumors and normal endometrial tissues using Multiplexed Inhibitor Beads and Mass Spectrometry (MIB-MS). Our proteomics analysis identified a network of kinases overexpressed in tumors, including Serine/Arginine-Rich Splicing Factor Kinase 1 (SRPK1). Immunohistochemical (IHC) analysis of endometrial tumors confirmed MIB-MS findings and showed SRPK1 protein levels were highly expressed in endometrioid and uterine serous cancer (USC) histological subtypes. Moreover, querying large-scale genomics studies of EC tumors revealed high expression of SRPK1 correlated with poor survival. Loss-of-function studies targeting SRPK1 in an established USC cell line demonstrated SRPK1 was integral for RNA splicing, as well as cell cycle progression and survival under nutrient deficient conditions. Profiling of USC cells identified a compensatory response to SRPK1 inhibition that involved EGFR and the up-regulation of IGF1R and downstream AKT signaling. Co-targeting SRPK1 and EGFR or IGF1R synergistically enhanced growth inhibition in serous and endometrioid cell lines, representing a promising combination therapy for EC.

Ramaphosa Must Act Fast With New Mandate in South Africa Expert comment sysadmin 23 May 2019

In the wake of South Africa’s election, political constraints will ebb momentarily. The president should seize the opportunity to deliver meaningful change.

On 25 May, Cyril Ramaphosa will be inaugurated as president of South Africa, having dragged the African National Congress (ANC) over the line in the 8 May election. The ANC gained a 57 per cent majority, its lowest vote since 1994, its status as national liberator deeply eroded by successive corruption scandals. Only Ramaphosa’s personal popularity stopped it haemorrhaging more support.

His sustained action against corrupt public servants and promises of job-creating economic growth has attracted support from beyond the ANC’s base, including a significant minority of white voters, and generated significant international goodwill. Ramaphosa now has a short window of opportunity to reset social democracy in South Africa before the political cycle of municipal, party and national elections from 2021 to 2024 forces his attention back to party politics.

Defining ‘Ramaphosa-ism’

But personal popularity is fickle, and goodwill alone will not turn around the ailing economy. To attract investment and keep the electorate on side, Ramaphosa’s government needs to move beyond pragmatic crisis responses and articulate a clear, shared vision for how market intervention can allow the economy to grow while simultaneously delivering social transformation.

Growth will be hard to achieve in the short term. The economy is expected to grow 1.2% in 2019 and 1.5% in 2020, according to the IMF. Consumer confidence remains subdued, and a decade of declining GDP per capita and increasing inequality has put a strain on households. A ‘fiscal stimulus’ in 2018 delivered very little new government spending, and over the past 10 years, the government wage bill has increased three times higher than the rate of inflation.

Eskom, the state electricity provider, has debts equating to the GDP of Latvia and is not the only state-owned enterprise (SOE) that has required bailing out by the government. There are plans to break up Eskom into three separate entities but calls for deeper reform – or even privatization – are growing.

The president’s responses to these challenges will go a long way to defining ‘Ramaphosa-ism’ and the role of government in pursuing equitable economy growth.

Economic expectations under Ramaphosa

Ramaphosa was a champion of the introduction of a minimum wage and a proponent of the National Development Plan, which relies on growth to drive job creation. His support for land reform is an individual conviction as much as it is a party line, although his views are softer than many in the party, with state-owned land being the initial target.

Investor uncertainty on land tenure and regulations in mining will need to be addressed through passing key pieces of legislation on land reform and the revised Mining and Petroleum Resources Development Act.

Where Ramaphosa differs from his predecessors is his links with business. Thabo Mbeki enjoyed a relationship of mutual respect with business; this disintegrated under Jacob Zuma. Ramaphosa, however, is part of South Africa’s business community, having founded the Shanduka Group, with investments in multiple sectors including retail, telecoms and extractives, and served as chairman of MTN and Bidvest. As president, he has surrounded himself with close economic advisers from business and banking.

In the short term, anti-corruption measures and competent appointments will ease investor woes. In the long term, there is a need to improve the ease of doing business, including labour market reforms, and to make South Africa a more competitive business environment by reducing the hold of large conglomerates on the economy. Ramaphosa may also make greater use of public-private partnerships for large projects.

Political constraints

Ramaphosa faces few immediate political challenges. The ANC is still deeply divided, but although Ramaphosa does not enjoy the ideological support of the entire party, his opponents are leaderless post-Zuma, and have been unable to offer a coherent alternative. ANC Secretary General Ace Magashule has fallen into the role of interim figurehead of this faction, and allegations of corruption would make it difficult for him to aspire to national leadership.

The need to avoid splits before the election meant Ramaphosa had to make concessions, and his first cabinet in February 2018 included opponents and those accused of corruption or incompetence, such as Malusi Gigaba and Bathabile Dlamini. Such concessions to political opponents are unlikely to continue after the election.

Meanwhile, opposition parties made some advances in the election, but where Zuma was an easy target, they are still grappling with how to confront Ramaphosa. The party with the biggest gains was the Economic Freedom Fighters, whose increase of just over 4 points from the last election gave it 11 per cent of the vote this time. They will likely continue to be an effective disruptor. Ramaphosa may also be challenged by trade unions on his reforms, notably over any break-up of SOEs.

But the biggest and most immediate external political challenge for Ramaphosa will be rebuilding trust between government and society, in a context where social protest has become an alternative form of political participation. A turnout of 65 per cent may be considered normal in Western democracies but is a notable drop for a country as politicized as South Africa, driven by frustration and a sense of exclusion as much as apathy. Turnout by young people was even lower.

Achieving the vision

South Africa has all the platforms it needs to project its renewal and attract vital external investment – it is a non-permanent member of the UN Security Council, it will take over as chair of the African Union in 2020, it is a member of BRICS and it is the only African member of the G20. But in the recent past, it has struggled to tell a coherent story about its vision for the future and offer to the world.

In the immediate wake of the election, internal and external political constraints will ebb. Ramaphosa must act fast to deliver results before the election cycle starts again. To attract much needed investment stimulus, he will not only need to articulate and market his vision for South Africa, but also outline how he plans to achieve it.

What can be achieved using applications such as AI/ML, Deep Learning, and Big Data Analytics has been revolutionized by Magnum IO GPUDirect Storage’s capabilities. Agencies have invested in these solutions […]

The post Accelerating GPU Based Applications with NVIDIA Validated Magnum IO GPUDirect Storage and Pavilion appeared first on HPCwire.

Waiting is the hardest part. In the fall of 2023, HPCwire wrote about the new diverging Xeon processor strategy from Intel. Instead of a on-size-fits all approach; Intel has opted […]

The post Granite Rapids HPC Benchmarks: I’m Thinking Intel Is Back (Updated) appeared first on HPCwire.

Montana Superintendent Elsie Arntzen offers practical advice to schools that could open as early as May 7, even as she says "how they open schools and how learning takes place is up to them."

The law passed after parent groups lobbied for it and will require schools to provide 20 consecutive minutes of recess daily for students in kindergarten through 6th grade.

Any discussion in politics of the future of education in Ohio inevitably turns to the Electronic Classroom of Tomorrow.

"It has become clear over time that [the edTPA] caused unintended barriers and burdens for teachers entering the profession," Georgia's state superintendent said.

Republican gubernatorial nominee Ron DeSantis is renewing a political trend that had fallen dormant: calling for the end of the use of the shared standards.

A state appellate court indicated it was likely to side with Florida Gov. Ron DeSantis and his administration's emergency order requiring schools to open for brick-and-mortar instruction.