Delaware State Treasurer Colleen Davis, alongside U.S. Senators Tom Carper and Chris Coons, celebrated the first-ever ABLE Savings Day, highlighting the importance of Achieving a Better Life Experience (ABLE) accounts. This new initiative aims to boost awareness and participation in ABLE accounts, which are instrumental in enhancing financial independence for individuals with disabilities. “ABLE accounts […]

The 2024-2025 school year marks the 20th anniversary of Poetry Out Loud®, an arts education program and dynamic poetry recitation competition for high school students that lifts poetry off the page, creating community and connection. A partnership of the National Endowment for the Arts (NEA), Poetry Foundation, and state and jurisdictional arts agencies, Poetry Out Loud takes place in all 50 states, American Samoa, District of Columbia, Guam, Puerto Rico, and the U.S. Virgin Islands.

The State of Delaware took a significant step towards a cleaner transportation future today, celebrating its receipt of 14.3 million thanks to the U.S. Environmental Protection Agency’s (EPA) “Climate Pollution Reduction Grant” (CPRG) program. This grant, the result of the Federal Inflation Reduction Act and the Biden-Harris Administration’s Investing in America agenda, will be used to […]

Governor John Carney and Delaware Secretary of Agriculture Michael T. Scuse, along with members of the General Assembly, the Aglands Preservation Board of Trustees, and other agricultural advocates, joined together at Shadybrook Farms, home of the Cartanza family, to unveil a new farm sign celebrating Delaware’s Agricultural Lands Preservation Program.

Children's Day, also known as 'Bal Diwas', is celebrated annually on November 14 in India. The day is celebrated to appreciate and acknowledge children as they are the future of the county.

The offer is valid across the US. Some of its international locations - the chain operates in 40 countries - also have World Kindness Day promotions planned.

On November 5, 2024, the Cadence Bangalore Toastmasters Club celebrated a significant milestone by hosting its 50th meeting. Established in December 2020, the club was created to provide a supportive environment for individuals looking to improve their communication and leadership skills. Over the years, the club has evolved into a vibrant community filled with success stories of personal development and newfound confidence. A testament to the club's dedication is its achievement of the "Select Distinguished Club" status during the 2023-2024 program year. By fulfilling 7 out of 10 distinguished goals, the club highlighted its commitment to excellence—a success driven by its vibrant members' relentless focus and perseverance. The strategic insight gained from regular Toastmasters committee meetings and the influential "Moments of Truth" sessions held in 2023 and 2024 are key to this success. Our club members have consistently demonstrated strong performance in various speech contests, with notable achievements across multiple levels. In 2023, members excelled in Evaluation and Table Topics contests, reaching the district level while advancing to the Division Level in the International Speech Contest. Continuing their success into 2024, members again qualified for area-level contests, securing third-place positions in the Evaluation and Table Topics categories, highlighting the club's dedication and competitive spirit. The 50th meeting was based on the theme of serendipity. It was not only a milestone celebration but also a vibrant festival of achievements and growth. The day buzzed with energy as activities like a spirited Treasure Hunt injected enthusiasm and camaraderie among attendees. Distinguished guests, including Kripa Venkitachalam and Madhavi Rao, enriched the occasion with inspiring speeches. Madhavi reignited the club's spirit, while Kripa's discourse on the Growth Mindset and the "Power of Yet" encouraged members to pursue continuous self-improvement. The Cadence Bangalore Toastmasters Club is enthusiastic about its promising future and is committed to creating an environment that promotes personal and professional growth. Many members are close to completing their Toastmasters levels and pathways, and this term, a new group of approximately 30 individuals has joined, bringing the total membership to 52. This vibrant community is just beginning its journey and is eager to reach new milestones together through mutual support and a shared commitment to excellence. The transformations experienced by many club members are truly compelling. They often share how the club has significantly improved their communication skills and boosted their confidence. One member recalls, "Before joining, I found public speaking intimidating. Now, I embrace every opportunity to share my ideas." Another member highlights how the club's supportive environment helped him overcome his fear of public speaking, propelling his career to new heights. This culture of constructive feedback and continuous improvement has inspired countless members to pursue their dreams with renewed determination and optimism. The Cadence Bangalore Toastmasters Club's journey is a living testament to the power of community and the potential within each of us to grow and achieve greatness. As the club continues to evolve and inspire, it serves as a beacon for those aspiring to transform their skills and seize their moment in the spotlight. Learn more about life at Cadence.

Celebrating National Hispanic Heritage Month reminds us how the wide range of perspectives and experiences among our employees makes us stronger both as a company and as a steward of the internet. In honor of this month, we are proud to recognize the stories of three of our Hispanic employees, and the positive impact they […]

The post Verisign Celebrates Hispanic Heritage Month appeared first on Verisign Blog.

Ten years ago I was posted to South Korea to cover news.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Chris Evans hopes to become a great dad somedayChris Evans has recently discussed about fatherhood and marital relation with Alba Baptista. Speaking at upcoming Red One movie premiere on November 11, Evans responded to the question about becoming a superhero father like his co-star Dwayne Johnson...

Anne Hathaway is being grateful to everyone who contributed to a wonderful last year in her life, and looks forward to a better year ahead as she turns 42.Hathaway celebrated turning 42 on Tuesday, Nov. 12, by posting a special video clip on Instagram, beginning with a cheerful wave from bed and...

Musing on John Lewis-Stempel's latest book, England: A natural history, James McConnachie marks the flowering of other, more diverse voices in nature writing

A mouse's tumours, scales from a butterfly's wings and a smiling cross-section of a bracken fern are some of the incredible images from the Nikon Small World photography competition

See some of the top entries to this year's Mangrove Photography Awards, showing the beauty and fragility of these unique ecosystems

Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking. With the Department of Physiology and Pharmacology now celebrating its 75-year anniversary, we wanted to take this as an opportunity to showcase recent research achievements and how they paved the way for current activities at the department. We emphasize examples from preclinical and clinical research where the dpartment's integrative environment and robust infrastructure have successfully facilitated the translation of findings into clinical applications and patient benefits. The close collaboration between preclinical scientists and clinical researchers across various disciplines, along with a strong network of partnerships within the department and beyond, positions us to continue leading world-class pharmacological research at the Department of Physiology and Pharmacology for decades to come.

Hearing disorders pose significant challenges to individuals experiencing them and their overall quality of life, emphasizing the critical need for advanced pharmacological approaches to address these conditions. Current treatment options often focus on amplification devices, cochlear implants, or other rehabilitative therapies, leaving a substantial gap regarding effective pharmacological interventions. Advancements in our understanding of the molecular and cellular mechanisms involved in hearing disorders induced by noise, aging, and ototoxicity have opened new avenues for drug development, some of which have led to numerous clinical trials, with promising results. The development of optimal drug delivery solutions in animals and humans can also enhance the targeted delivery of medications to the ear. Moreover, large genome studies contributing to a genetic understanding of hearing loss in humans combined with advanced molecular technologies in animal studies have shown a great potential to increase our understanding of the etiologies of hearing loss. The auditory system exhibits circadian rhythms and temporal variations in its physiology, its vulnerability to auditory insults, and its responsiveness to drug treatments. The cochlear clock rhythms are under the control of the glucocorticoid system, and preclinical evidence suggests that the risk/benefit profile of hearing disorder treatments using chronopharmacological approaches would be beneficial. If translatable to the bedside, such approaches may improve the outcome of clinical trials. Ongoing research into the molecular and genetic basis of auditory disorders, coupled with advancements in drug formulation and delivery as well as optimized timing of drug administration, holds great promise of more effective treatments.

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular homeostasis. Reduced NO production or increased scavenging during disease conditions with oxidative stress contribute to endothelial dysfunction and NO deficiency. In addition to the classical enzymatic NO synthases (NOS) system, NO can also be generated via the nitrate-nitrite-NO pathway. Dietary and pharmacological approaches aimed at increasing NO bioactivity, especially in the cardiovascular system, have been the focus of much research since the discovery of this small gaseous signaling molecule. Despite wide appreciation of the biological role of NOS/NO signaling, questions still remain about the chemical nature of NOS-derived bioactivity. Recent studies show that NO-like bioactivity can be efficiently transduced by mobile NO-ferroheme species, which can transfer between proteins, partition into a hydrophobic phase, and directly activate the soluble guanylyl cyclase-cGMP-protein kinase G pathway without intermediacy of free NO. Moreover, interaction between red blood cells and the endothelium in the regulation of vascular NO homeostasis have gained much attention, especially in conditions with cardiometabolic disease. In this review we discuss both classical and nonclassical pathways for NO generation in the cardiovascular system and how these can be modulated for therapeutic purposes.

The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD_1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.

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HARI SREENIVASAN: President Xi Jinping opened China’s twice-per-decade Communist Party Congress today with a lengthy list of his achievements during his first five-year term, and his vision of where he hopes to take his nation.

But beyond the words, Xi is asserting power like no Chinese leader in decades.

William Brangham reports.

WILLIAM BRANGHAM: The applause, the music, it was a reception befitting the commanding role that Xi Jinping has taken since being named party leader five years ago.

He opened today’s proceedings by hailing reforms he’s put in place, and proclaiming a — quote — “new era for China.”

PRESIDENT XI JINPING, China (through interpreter): The Chinese nation has realized a great leap, from declining in modern history to twisting its fate fundamentally and continuously moving to prosperity.

WILLIAM BRANGHAM: Over 3.5 hours, Xi laid out his vision to shape the nation of 1.4 billion people into what he called a — quote — “great modern socialist country” over the next three decades.

PRESIDENT XI JINPING (through interpreter): Achieving the great rejuvenation of the Chinese nation will be no walk in the park, and it will take more than drumbeating and gong-clanging to get there. The whole party must be prepared to make more arduous, strenuous efforts.

WILLIAM BRANGHAM: Susan Shirk is chair of the 21st Century China Center at the University of California, San Diego.

SUSAN SHIRK, University of California, San Diego: Xi Jinping has a vision of China’s role in the world that is much more ambitious than anything we have seen before, talking about China kind of moving toward the center of the world and having a lot more influence than it did before.

WILLIAM BRANGHAM: In his address, Xi largely ignored the question of political reforms in China, and he didn’t mention President Trump or North Korea’s nuclear weapons program.

But in a rare move, he did acknowledge that with global demand weakening, there were challenges facing China’s export-driven economy.

PRESIDENT XI JINPING (through interpreter):  While China’s overall productive forces have significantly improved and in many areas our production capacity leads the world, the more prominent problem is that our development is unbalanced and inadequate.

WILLIAM BRANGHAM: Xi was one of the first foreign leaders to meet with President Trump.

PRESIDENT DONALD TRUMP: The relationship developed by President Xi and myself, I think, is outstanding.

WILLIAM BRANGHAM: That was decidedly warmer than Mr. Trump’s past criticism of China and its economic and trade policies.

But other U.S. officials are more critical of Beijing’s actions.

REX TILLERSON, Secretary of State: China, while rising alongside India, has done so less responsibly.

WILLIAM BRANGHAM: Secretary of State Rex Tillerson today criticized China’s aggressive displays of economic and military power, particularly its expansion on man-made islands in the South China Sea.

REX TILLERSON: We will not shrink from China’s challenges to the rules-based order, and where China subverts the sovereignty of neighboring countries and disadvantages the U.S. and our friends.

SUSAN SHIRK: I think there are things to worry about in Chinese foreign policy that are mostly related to these maritime sovereignty issues and to a kind of bullying in Asia, but the global ambition could turn out to be positive.

WILLIAM BRANGHAM: Susan Shirk says China has filled a vacuum left by the United States’ withdrawal from global agreements like the Trans-Pacific Partnership and the Paris climate accords.

Perhaps the most important thing to watch for in the next few days is who Xi establishes as his likely successor.

SUSAN SHIRK: That is why there is a lot of speculation now that he may be trying, much like Putin, to stay on beyond his normal term or to rule behind the scenes even after he retires.

WILLIAM BRANGHAM: President Trump will be traveling to Beijing to meet Xi next month.

For the PBS NewsHour, I’m William Brangham.

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REVERB features 17 audiovisual installations including new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory celebrates art and sound with immersive exhibition at 180 Studios appeared first on Fact Magazine.

Beloved roguelike traumatic-childhood-em-up The Binding Of Issac: Rebirth turned 10 yesterday, and it’s half off on Steam to celebrate. What’s more, maker Edmund McMillen has announced that the foretold online co-op update is due on the 18th of this month, alongside a “considerable” balance update. Consider me considering the considerability of said considerable update!

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Four decades after the first IEEE International Conference on Robotics and Automation (ICRA) in Atlanta, robotics is bigger than ever. Next week in Rotterdam is the IEEE ICRA@40 conference, “a celebration of 40 years of pioneering research and technological advancements in robotics and automation.” There’s an ICRA every year, of course. Arguably the largest robotics research conference in the world, the 2024 edition was held in Yokohama, Japan back in May.

ICRA@40 is not just a second ICRA conference in 2024. Next week’s conference is a single track that promises “a journey through the evolution of robotics and automation,” through four days of short keynotes from prominent roboticists from across the entire field. You can see for yourself, the speaker list is nuts. There are also debates and panels tackling big ideas, like: “What progress has been made in different areas of robotics and automation over the past decades, and what key challenges remain?” Personally, I’d say “lots” and “most of them,” but that’s probably why I’m not going to be up on stage.

There will also be interactive research presentations, live demos, an expo, and more—the conference schedule is online now, and the abstracts are online as well. I’ll be there to cover it all, but if you can make it in person, it’ll be worth it.

Forty years ago is a long time, but it’s not that long, so just for fun, I had a look at the proceedings of ICRA 1984 which are available on IEEE Xplore, if you’re curious. Here’s an excerpt of the forward from the organizers, which included folks from International Business Machines and Bell Labs:

The proceedings of the first IEEE Computer Society International Conference on Robotics contains papers covering practically all aspects of robotics. The response to our call for papers has been overwhelming, and the number of papers submitted by authors outside the United States indicates the strong international interest in robotics.
The Conference program includes papers on: computer vision; touch and other local sensing; manipulator kinematics, dynamics, control and simulation; robot programming languages, operating systems, representation, planning, man-machine interfaces; multiple and mobile robot systems.
The technical level of the Conference is high with papers being presented by leading researchers in robotics. We believe that this conference, the first of a series to be sponsored by the IEEE, will provide a forum for the dissemination of fundamental research results in this fast developing field.

Technically, this was “ICR,” not “ICRA,” and it was put on by the IEEE Computer Society’s Technical Committee on Robotics, since there was no IEEE Robotics and Automation Society at that time; RAS didn’t get off the ground until 1987.

Tech expert Kurt “CyberGuy" Knutsson helps you honor our heroes with these powerful podcasts, audiobooks and documentaries this Veterans Day.

ALEXIS SANCHEZ returns to former club Arsenal tonight - and Manchester United fans are desperate to see him celebrate if he scores at the Emirates..

Alienware was born in a garage near Miami in 1996. The first Aurora arrived in 2004.

In his latest book, The Blue on Fire: Hawaii, photographer Enzo Barracco hopes to inspire the world to protect the ocean.

<a href="https://bluetechker.com/" rel="nofollow ugc">Blue Techker</a> naturally like your web site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I find it very bothersome to tell the truth on the other hand I will surely come again again.

Tickets for the event will go on sale on November 10, 2024, via BookMyShow

Santhosh Kana’s ‘A Musical Pilgramage’ containing 8 select poems combines soothing narration with Indian classical music.

As part of the National Pharmacy Week (NPW) celebration, the Kerala Private Pharmacist Association (KPPA) is organizing a high─impact webinar series from November 17th to 23rd, connected by the common

Founded in 1924 as J&G Hardie, Hardie Polymers, the Glasgow-based polymer supplier, celebrates its 100th anniversary.

As a group of friends circled a hearse, chants were heard. Then, they stopped and bowed to the portrait displayed at the front of the vehicle. This was not a typical Buddhist funeral, but rather the unconventional birthday celebration of a funeral director, reported Shin Min Daily News. According to the Chinese evening daily, a video circulating online showed the friends chanting a birthday song. The hearse's interior had been decorated with balloons and a birthday banner, with the man even laying inside for photos. The clip garnered criticism from netizens, with some deeming it overboard and disrespectful to the funeral industry. In an interview with Shin Min, director of Xin An Funeral Services Chen Weisong (transliteration) explained that he had celebrated his birthday at the company's premises with his friends and family last week. Halfway through the performances by singers, his employees and business partners had surprised him with the birthday-themed hearse bearing his portrait. Chen told 8world he was not angry and did not think it was taboo. "I was too embarrassed to turn down their gesture," he said. 

Celebrate My Drive� thanks all who committed to drive safe!

European Business Award Teaser 2015

Eden Party by Perrier-Jou�t

Former star or ABC�s The Bachelorette Ali Fedotowsky and [ yellow tail ], America�s go-to holiday wine, team up to Spread Holiday Cheer in New York City to kick-off [yellow tail ] wine�s 12 Days of Giveaways. Starting Tuesday, Dec. 8, 2015, people can visit Facebook.com/yellowtail to find out more ways to win exciting prizes.

Las Vegas Convention and Visitors Authority interviews Tina Sinatra

Al Maryah Island lights up Abu Dhabi with Spectacular New Year�s Eve Celebrations