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Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes

Org. Biomol. Chem., 2020, 18,3032-3037
DOI: 10.1039/D0OB00318B, Communication
Siddi Ramulu Meesa, Praveen Kumar Naikawadi, Kishan Gugulothu, K. Shiva Kumar
Catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C–H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Construction of pH sensitive smart glutathione peroxidase (GPx) mimics based on pH responsive pseudorotaxanes

Org. Biomol. Chem., 2020, 18,3125-3134
DOI: 10.1039/D0OB00122H, Paper
Jiaxi Li, Wenlong Jia, Ganghui Ma, Xiaoyin Zhang, Shaojie An, Tao Wang, Shan Shi
Two pH-sensitive smart glutathione peroxidase (GPx) mimics were developed by using pH-responsive pseudorotaxanes based on cucurbit[6]uril and organoselenium compounds.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Acylation of oxindoles using methyl/phenyl esters via mixed Claisen condensation – An access to 3-alkylideneoxindoles

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00789G, Communication
Ramdas Sreedharan, Purushothaman Rajeshwaran, Pradeep Kumar Reddy Panyam, Saurabh Yadav, C. M. Nagaraja, THIRUMANAVELAN GANDHI
Predominantly, aggressive acid chlorides and stoichiometric coupling reagents are employed in the acylating process for synthesizing carbonyl tethered heterocycles. Herein, we report simple acyl sources, viz. methyl and phenyl esters...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A silver-catalyzed radical ring-opening reaction of cyclopropanols with sulfonyl oxime ethers

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00055H, Paper
Xiaobao Zeng, Xin Wang, Yanan Zhang, Li Zhu, Yu Zhao
A simple and efficient method for the radical ring-opening reaction of cyclopropanols with sulfonyl oxime ethers catalyzed by AgNO3 is developed, affording γ-keto oxime ethers in moderate to good yields.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rhodium-Catalyzed ortho-Acrylation of Aryl Ketone O-Methyl Oximes with Cyclopropenones

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00064G, Communication
Yafeng Liu, Yuan Tian, Kexin Su, Xin Guo, Baohua Chen
An efficient Rh-catalyzed ortho-acrylation reaction for the synthesis of chalcones from O-methyl ketoximes and cyclopropenones via C–H bond activation has been described. This cross-coupling reaction exhibits high functional group tolerance...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of Glycosyl Sulfoximines by a Highly Chemo- and Stereoselective NH- and O-Transfer to Thioglycosides

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00647E, Paper
Arianna Tota, Claudia Carlucci, Luisa Pisano, Giuliano Cutolo, Guy James Clarkson, Giuseppe Romanazzi, Leonardo Degennaro, James A Bull, Patrick Rollin, Renzo Luisi
A synthesis of unprecedented and stable glycosyl sulfoximines is reported. The developed strategies represent the first examples of highly stereoselective sulfoximine formation directly from thioglycosides. X-ray analysis confirmed the structure...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of unsymmetrical benzils via palladium-catalysed α-arylation–oxidation of 2-hydroxyacetophenones with aryl bromides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00575D, Paper
Open Access
Takanori Matsuda, Souta Oyama
Unsymmetrical benzils are synthesised by a one-pot tandem palladium-catalysed α-arylation and oxidation of 2-hydroxyacetophenones with aryl bromides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Copper(I)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00546K, Paper
Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei, Er-Qing Li, Zheng Duan, François Mathey
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3'-oxindole]s in good yields with high ee.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00720J, Paper
Haibo Mei, Jiang Liu, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han
An unprecedented metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00535E, Communication
Xiao-Yu Lu, Run-Chuang Jiang, Jia-Mei Li, Chuang-Chuang Liu, Qing-Qing Wang, Hai-Pin Zhou
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Xiaomi launches Mi Box 4K streaming device in India, here's are the features, price

With the Mi Box 4K, Xiaomi is venturing into a segment dominated by Amazon with its Fire TV Stick.




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[ASAP] Controlling Surface Phase Transition and Chemical Reactivity of O3-Layered Metal Oxide Cathodes for High-Performance Na-Ion Batteries

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00700




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Concrete and durability of concrete structures: August 11-15, 2013, Cancun, Mexico / editors, L. E. Rendon Diaz Miron, N. Ramirez Salinas, B. Martinez Sanchez

Barker Library - TA439.S96 2013




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Recent advances in concrete technology and sustainability issues: proceedings of the fourteenth international conference, Beijing, China, October-November 2018 / [edited by] Tongbo Sui, Terence C. Holland, Ziming Wang, Xiaolong Zhao

Barker Library - TA439.I584 2018




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Big data in omics and imaging. Momiao Xiong

Online Resource




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Analysis and design of delayed genetic regulatory networks / Xian Zhang, Yantao Wang, Ligang Wu

Online Resource




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Peroxisomes: Biogenesis, Function, and Role in Human Disease / edited by Tsuneo Imanaka, Nobuyuki Shimozawa

Online Resource




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An Event Apart: Slow Design for an Anxious World

In his Slow Design for an Anxious World presentation at An Event Apart in Denver, Jeffrey Zeldman espoused the benefits of design that aims to increase comprehension and intentional use. Here's my notes from his talk:

  • We live in fast times and care a lot about making things faster for people. In this world, "slow" is often associated with friction. But some things are better slow.
  • Fast is best for transactional customer-service designs. We optimize our checkout flows for efficiency and our code for performance. Likewise, service-oriented content must be designed for speed of relevancy. Getting to content like driving directions, return policies, and more should be quick and easy for customers.
  • Slow is best for comprehension. Reading slowly helps us understand more of what we read and even transactional sites have some content that we want people to understand more deeply.
  • There's lots of resources for site optimization but few for slowing people down so they appreciate and understand our content.
  • Legibility means you can read what's on the page. Readability is where the art comes in. You don't need to be a graphic designer to improve readability. When focusing on readability you're focusing on absorption not conversion.
  • Improving readability means putting the focus on content and removing distractions. The service Readability optimized Web pages for this by removing ads, third party widgets, and more.
  • Considering different reading modes like in bed, at breakfast, on your lap, etc. can trigger ideas for layout and type for sites. For example, big fonts can help you lean back and take in content vs. leaning in and squinting.
  • Big type used to be a controversial design choice on the Web but now has been adopted by a number of sites like Medium, Pro Publica, and the New Yorker.
  • To be readable: use big type (16px should be your smallest size); use effective hierarchy for type; remove all extraneous elements in your layout; art direction helps you call attention to important content; make effective use of whitespace.
  • Art direction can bring unique emotion and resonance to articles online. In a world of templates and scalability, distinct art direction can help people take notice of intentional high value content.
  • Macro-whitespace is the bigger columns and padding around content we often associate with high-end luxury brands. Micro-whitespace is the space in between letter forms and between the lines of type. Consider both in your designs
  • Ensure your content is branded so it stands out. When all content looks like the same it all appears to have equal value. Have a brand that sticks out to be more trusted.
  • With all these techniques we're trying to get people to lean back and have a good "readable" experience on the Web.




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Lost in exile: The forgotten Chagos Islanders of West Sussex

A group of Indian Ocean islanders, forcibly removed from their homes 50+ years ago and deported to England, are still fighting for recognition and basic rights. By Alexi Demetriadi.




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The day Colombia’s FARC guerrilla ceases to exist as an armed group

The guerrillas are handing weapons over to the UN, but they are in fear. Thomas Mortensen reports from Urabá.




xi

Axis Bank to report Q4 earnings today; here's what analysts expect

Analysts at MOFSL believe the Mumbai-based bank's credit cost may stay elevated led by higher slippages. Besides, asset quality could witness some pressure along with modest loan growth.




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Axis Bank reports net loss of Rs 1,388 cr in Q4FY20; NII at Rs 6,808 cr

The private lender's net interest income (NII) came in at Rs 6,808 crore for the period under review




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Axis Bank reports Rs 1,878-crore pre-tax loss in Q4 on Covid-19 provisions

the bank reported a 17 per cent increase in its operating profit at Rs 5,851 crore in the March quarter




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[ASAP] Carbon Nanotubes Modulate Activity of Cytotoxic Compounds via a Trojan Horse Mechanism

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00370




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[ASAP] Identifying Cysteine, <italic toggle="yes">N</italic>-Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00488




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[ASAP] Computational Approaches to Identify Structural Alerts and Their Applications in Environmental Toxicology and Drug Discovery

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00006




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[ASAP] The Role of Cyclooxygenases-2 in Benzo(<italic toggle="yes">a</italic>)pyrene-Induced Neurotoxicity of Cortical Neurons

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00451




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[ASAP] Surface Functionalization of Pegylated Gold Nanoparticles with Antioxidants Suppresses Nanoparticle-Induced Oxidative Stress and Neurotoxicity

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00368




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[ASAP] Systems Toxicology Approaches Reveal the Mechanisms of Hepatotoxicity Induced by Diosbulbin B in Male Mice

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00503




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[ASAP] Triiodothyronine Attenuates Silica-Induced Oxidative Stress, Inflammation, and Apoptosis via Thyroid Hormone Receptor a in Differentiated THP-1 Macrophages

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00018




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[ASAP] Synergy between Experiments and Computations: A Green Channel for Revealing Metabolic Mechanism of Xenobiotics in Chemical Toxicology

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00448




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[ASAP] <italic toggle="yes">In Vitro</italic> Toxicity and Chemical Characterization of Aerosol Derived from Electronic Cigarette Humectants Using a Newly Developed Exposure System

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00490




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[ASAP] Neurotoxicology of Nanomaterials

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00050




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[ASAP] Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00517




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[ASAP] The Urine Proteome in Toxicology

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00126




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[ASAP] Toxicity and Gene Expression Profiling of Copper- and Titanium-Based Nanoparticles Using Air–Liquid Interface Exposure

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00489




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[ASAP] Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00055




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[ASAP] Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of Metals and Polycyclic Aromatic Hydrocarbons

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00007




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[ASAP] Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00139




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[ASAP] Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00040




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The Toxic Cloud-Emitting Portable Dry Ice Maker

The Toxic Cloud-Emitting Portable Dry Ice Maker in action.




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Tesla Taxi

Damon Lavrinc and Tesla Model S owner Konstantin Othmer are using the Sidecar App to pick up passengers around San Francisco and get their first impressions of the car.




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Calexico - Station to Station

Members of the band Calexico play an acoustic version of Crystal Frontier in Frank Lloyd Wright’s Taliesin West.




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Gadget Lab - PlayStation 4: Unboxing the New Game Console

We got the PlayStation 4! Sony’s new console comes out on November 15 in the US, but we went to Sony’s Tokyo HQ and asked engineering director Yasuhiro Ootori to give WIRED an exclusive look inside the new system—literally. Like, he takes it apart piece by piece and explains what all the parts do, and how they fit together.




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Think Like a Tree - How Coral Reefs and Carbon Dioxide Can Change the Future

Most people think of carbon dioxide as a poison, but in nature it’s a building block. Find out how we can imitate coral reef by using CO2 as a raw material for the creation of concrete.




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Hacker Lexicon: A Guide to Ransomware, the Scary Hack That’s on the Rise

Ransomware is a rising type of malware that locks your keyboard or computer until you pay a ransom, typically in Bitcoin. Find out how the sophisticated hacks happen and learn what you can do to avoid falling victim to them.




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Absurd Creatures | The Fennec Fox and Its Giant Ears Are Too Cute to Possibly Exist

The Fennec fox is the smallest, and arguably the cutest, fox on earth. Its enormous ears make it look like a cartoon character and help it hear prey and keep cool.




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We Drive an All-Electric Ferrari, the Car that Shouldn’t Exist

Ferrari boss Sergio Marchionne is on record as saying an electric Ferrari is an obscene concept, but that didn't stop a group of guys in California from turning the 308 GT into an EV.




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Explore a Mysterious Deep Reef That Shouldn’t Exist

A new exhibit shows off the undersea creatures who populate one of the most mysterious, poorly understood parts of the ocean.