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Jesse Watters' mother, Anne Purvis, was a child psychologist. His dad, Stephen Hapgood Watters, was a teacher. Both parents came from a long line of achievers, and sent him to Penn Charter, a very liberal private Quaker school here in Philadelphia.

Despite his accomplished parents and his education, look how he turned out.

Every time he shows up on Twitter, I comment, "Your mother only talks to you so she can see her grandchildren."

Sounds like I was right, because Jesse's mother has disinvited him from the family Thanksgiving this year. Something about "scheduling." But she told him he could come the next day for leftovers.

He said no thanks, he would be at Best Buy.

Understand, this isn't just a difference of opinion. Jesse Watters is a horrible person who lies and distorts in ways that harm our country.

Time for karma, Jesse, you nasty piece of work. Guess you thought you got away with it, huh? After all, you're rich and famous!

Well, your own family doesn't want to be around you on the holiday that's all about family.

And your mom's bitten her tongue long enough.

read more

By Ryan Menezes Published: November 11th, 2024

I do in-house design work for my boss. I’ve worked with her for ten years and she swings wildly back and forth from being surprisingly design-savvy (not for a literal decade of trying on my part) and being a client from Hell. Today, she swung somewhere in the middle.

I have spent the entire time I’ve known her explaining how you cannot just pull photos from Google; I’ve explained copyright, public domain, etc. She refuses to buy photos 99% of the time, so I usually use free stock photos when possible. When she absolutely needs to buy a photo, she emails our web guy and has him buy one for her and add it to her next bill.

Me: “I see you got [Web Guy] to purchase the photo for the ad and forwarded me the email with the file. Unfortunately, the file is too small. Unless he sent you a separate email with a larger file, I will just email him for the correct one.”

Boss: “Maybe it’s how I sent it. I’ll try again.”

She forwards me the same email.

Me: “No, no, it’s not you. The file he sent you is labelled “thumbnail,” which is a preview file. He probably just sent the wrong one by accident. I have emailed him.”

Boss: “What about this one?”

She sends an email with the same photo attached.

Me: “That’s the same one. I have emailed [Web Guy]. Don’t worry about it. You don’t have the correct file.”

She forwards the same original email from [Web Guy].

Boss: “What about now?”

Me: “No, boss, I’ll get it from [Web Guy].”

She forwards the individual email she sent me.

Boss: “How about now?”

Me: “Boss, no.”

Closure: She now has a stock photo account that I have access to.

Client: “I need the number for Jack. Can you give me his number, please?”

Me: “Jack? Jack who?”

Client: “The manual for the modem said that I need to connect to Jack, so if you could give me his number, then I can connect with him.”

CHILL I Got This

In this episode I'm joined Clive Palmer to discuss Takehiro Tomiyasu signing a new deal, contract and salary management at the club in recent times, and how these contracts are linked to selling as well as player retention. We also talk about the Ben White story as he continues to get unjust criticism for his decision not to play for Gareth Southgate's England; reflect on the title race and the run-in, a new experience compared to our last Premier League win; Mikel Arteta as coach and the need to deliver silverware; and lots more.

Follow Clive @clivepafc

Get extra bonus content and help support Arseblog by becoming an Arseblog Member on Patreon: https://www.patreon.com/arseblog

Hosted on Acast. See acast.com/privacy for more information.

I’ve developed a survey to give to people who slipped me into their not-friend category. Since I’m a person with no ability to cope with nuance, answers to all questions are yes/no. 1. Were you ever my real friend?  I want to know if you needed me like I needed you, but I don’t want […]

The post Questionnaire for everyone who stopped talking to me appeared first on Penelope Trunk Careers.

The post They Said “Give Weapons To Everyone” appeared first on English Russia.

Come one, come all! nycdevops does its first virtual meetup! All are invited!

• Speaker: Adarsh Shah
• Topic: "Continuous Delivery for Machine Learning"
• Time: Thursday, September 17, 2020, 5-630 PM
• Link: https://www.meetup.com/nycdevops/events/272914068/

Hope to see you there!

Princeton's first alumni affinity conference since 2019 welcomed more than 600 alumni and guests to campus Sept. 19-21, for “Every Voice: Honoring and Celebrating Princeton’s LGBTQ+ Alumni.” 

As the James Webb Space Telescope delights stargazers with breathtaking images and groundbreaking discoveries, we connected with Princeton astrophysics luminaries Gillian “Jill” Knapp and Neta Bahcall, both contributors to a new book by women astronomers.

Princeton Jazz Vocal Ensemble, directed by Michelle Lordi, presents a series of jazz pieces from the year 1959.

Nowadays, gas barbecues have supplanted standard charcoal flame broils in numerous family units. And happiness is when you find the Best gas grills under 300.

The post 15 Best Gas Grills Under 300 2024 – Propane Grills For Every Budget appeared first on Star Two.

We have great news for you! RSS Ground team is about to add a new set of tools to its arsenal. Our next big milestone is to implement integration with platforms that provide cross-service automation such as IFTTT, Zapier and Integrately. You will be able to connect to hundreds of online service providers and make […]

The post Quality Content From Everywhere To Anywhere appeared first on RSSground.com.

One small Ohio town designed a butterfly garden as a symbol of recovery for former flood land and for people who have struggled with addiction.

Think your website is fine the way it is? Think again. Even if you’re not seeing a decrease...

The post 10 Features Every Great Website Must Have appeared first on Ignition Media.

An anonymous reader quotes a report from BleepingComputer: VMware has announced that its VMware Fusion and VMware Workstation desktop hypervisors are now free to everyone for commercial, educational, and personal use. In May, the company also made VMware Workstation Pro and Fusion Pro free for personal use, allowing students and home users to set up virtualized test labs and experiment with other OSs by running virtual machines and Kubernetes clusters on Windows, Linux, and macOS devices. Starting this week, the Pro versions and the two products will no longer be available under a paid subscription model. "Effective immediately, both VMware Fusion and VMware Workstation will transition away from the paid subscription model, meaning you can now utilize these tools without any cost. The paid versions of these offerings -- Workstation Pro and Fusion Pro -- are no longer available for purchase," said Broadcom product marketing director Himanshu Singh. "If you're currently under a commercial contract, you can rest easy knowing that your agreement will remain in effect until the end of your term. You will continue to receive the full level of service and enterprise-grade support as per your contract." While the free versions will include all the features available in the paid products, Broadcom will no longer provide users with support ticketing for troubleshooting. Broadcom plans to continue developing new features and improvements and ensure that updates are rolled out promptly. "We're actively investing in new features, usability improvements, and other valuable enhancements," Singh added. "Our engineering teams are committed to maintaining our high standards for stability, with timely updates and reliable performance." You can download VMware Fusion and VMware Workstation here (sign-in required).

Read more of this story at Slashdot.

By Jason Cohen Former MSNBC host Chris Matthews on Wednesday criticized Democrats for their “open border” policy following Vice President Kamala Harris’ loss to former President Donald Trump. Trump clinched the required 270 electoral votes early Wednesday, winning Georgia, North Carolina and Pennsylvania, according to multiple forecasters. Matthews, on “Morning Joe,” argued that Democrats’ lenient […]

The post ‘A Lot Of People Are Very Angry’: Chris Matthews Unloads On Dems Over ‘Open Border’ Policy After Harris Loss appeared first on Liberty Unyielding.

Heather Hardy tells BBC Sport how she is adapting to life outside of boxing after the former world champion was left with a life-threatening injury.

Chief executive Guy Kinnings says the DP World Tour hopes "to have a different schedule in 2026" as golf's rulers continue to discuss a merger.

People in war-torn Gaza are already struggling with a deep humanitarian crisis but now they fear it will get much more difficult.

Adrian Newey tells BBC Sport's Joe Wilson "it is easy to become stale", but his "passion has always been for trying to find ways to make the car go faster" after joining Aston Martin.

The Magic Cottage was the epicentre of the blaze which broke out in Abergavenny on Sunday night.

Donald Trump's impending White House return poses questions once again about conflicts of interest related to his business empire, with new cryptocurrency and other ventures raising fresh concerns.

Taylor Swift has made a habit of cheering for the Kansas City Chiefs since she began dating NFL star Travis Kelce.

PORT LOUIS, Nov 10 - Mauritius was holding a parliamentary election on Sunday with Prime Minister Pravind Kumar Jugnauth and his main rivals all promising to tackle a cost of living crisis in the Indian Ocean archipelago.

Adjudicated rapist and convicted felon Donald Trump chose to politicize the Federal response to Hurricane Helene, demonstrating little concern about the actual devastation.

Responsible leaders who care about the people they govern do not leap into every photo opportunity they can find. — Read the rest

The post Trump lies, sows division, and wastes recovery resources as Americans suffer appeared first on Boing Boing.

October 1 was officially "International Raccoon Appreciation Day," for those of you who love to love the adorable trash panda. Around here, honestly, every day is raccoon appreciation day, so it's an "International Day" I can genuinely get behind.

National Day Calendar explains the origins of the day:

In 2002, a young girl in California wanted to highlight the good points about the raccoon instead of the bad ones.

— Read the rest

The post Every day should be raccoon appreciation day appeared first on Boing Boing.

The advertising world is uncomplicated at its core, and utterly bewildering when seen from the outside. The easy bit stems from a simple axiom: Wherever you can find the attention of potential customers, you pay to get your message in front of them. That’s the essence of advertising: paying for attention. It gets complicated by … Continue reading "Ads, Ads Everywhere"

We've all met some of those 'precious moments' type Christians who are far too 'holy' to involve themselves in such trivialities as politics.

The post This Biblical Passage is VERY Political (Eph.1:20-23) appeared first on Clash Daily.

There's a reason Hitler holds a special place of disgrace in public memory. He combined the ambition and destruction of Attila The Hun with the personal malice of a serial killer.

The post The REAL Harm Done By Calling Everyone You Don’t Like ‘Hitler’ Is BIGGER Than Lefties Think appeared first on Clash Daily.

Whichever candidate is sworn into office this January is the President who will be making decisions about how America and her legacy is remembered.

The post AMERICA’S BIG BIRTHDAY: An Election Argument Everyone Seems To Be Missing appeared first on Clash Daily.

Funding Ukraine’s recovery 15 October 2024 — 2:00PM TO 3:30PM Anonymous (not verified) 24 September 2024 Online

The expert panel explores the role of the private sector in financing recovery projects.

Despite the ongoing war, recovery and reconstruction is under way in Ukraine. The question of how to push and finance the pipeline of the recovery projects remains one of the key challenges for the Ukrainian government. Most importantly, there is an outstanding question about how foreign investors can participate in the process.

Energy, together with access to finance and uninterrupted export routes is one of the key pillars of Ukraine’s wartime economy. In the coming months, Ukraine faces an ultimate test on its capacity to implement energy projects to restore energy generation. It is a test case for how effectively Kyiv raises public and private funds and delivers results to mitigate destruction as the war continues.

This expert panel discusses key questions including:

• What funding streams and mechanisms are currently in place?
• What does the new Ukraine Investment Framework offer?
• How successful is the energy sector in generating necessary funding?
• What role for private-public partnerships? Do we have examples?

This event is organised in partnership with Ukrainian project ‘The Recovery Spending Watchdog’ financed by the EU. The project is a joint effort of the Centre for Economic Strategy, the Institute for Economic Research and Policy Consulting, and the NGO ‘Technologies for Progress’.

Policy for Recovery in Africa: Rethinking Energy Solutions for Universal Electricity Access 10 December 2020 — 5:00PM TO 6:00PM Anonymous (not verified) 20 November 2020 Online

Approximately three quarters of Africa’s population do not have access to clean cooking fuel and face costs to their health. Speakers explore policy opportunities to bridge this gap, the key barriers that remain and the transformative potential of energy transition in delivering sustainable access for all.

Speakers explore policy opportunities to bridge the energy access gap, the key barriers that remain and the transformative potential of energy transition in delivering sustainable access for all.

African countries face an uphill battle as they confront the shocks of the coronavirus pandemic, seeking recovery in the context of global socio-economic difficulty and fragmented geopolitics.

With deficits in terms of governance, public health systems, social protection, and basic service delivery presenting challenges even before the outbreak, careful analysis and creative evidence-based policy solutions, as well as emphasis on implementation, will be crucial if Africa is to progress towards the SDGs and Agenda 2063.

The Policy for Recovery in Africa series brings together expert speakers and decision makers to examine and exchange on key challenges, potential solutions, and approaches for implementation.

The energy access gap in Africa presents one of the most serious obstacles to the long-term pandemic recovery effort, with almost half of the continent’s population estimated to still lack access to electricity, creating a negative annual GDP impact estimated to be over 25 billion USD.

Expert

Expert

Animals can sense the presence of microbes in their tissues and mobilize their own defenses by recognizing and responding to conserved microbial structures (often called microbe-associated molecular patterns (MAMPs)). Successful host defenses may kill the invaders, yet the host animal may fail to restore homeostasis if the stimulatory microbial structures are not silenced. Although mice have many mechanisms for limiting their responses to lipopolysaccharide (LPS), a major Gram-negative bacterial MAMP, a highly conserved host lipase is required to extinguish LPS sensing in tissues and restore homeostasis. We review recent progress in understanding how this enzyme, acyloxyacyl hydrolase (AOAH), transforms LPS from stimulus to inhibitor, reduces tissue injury and death from infection, prevents prolonged post-infection immunosuppression, and keeps stimulatory LPS from entering the bloodstream. We also discuss how AOAH may increase sensitivity to pulmonary allergens. Better appreciation of how host enzymes modify LPS and other MAMPs may help prevent tissue injury and hasten recovery from infection.

2 July 2020

14 August 2020

Toma Keser
Dec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433
Research

The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl chains in distinct biological processes; moreover, they may play different roles in disease states and possibly even act as prognostic markers. We now demonstrate that the half-life, or turnover rate, of ceramides containing diverse N-acyl chains is different. By means of a pulse-labeling protocol using stable-isotope, deuterated free fatty acids, and following their incorporation into ceramide and downstream SLs, we show that very-long-chain (VLC) ceramides containing C24:0 or C24:1 fatty acids turn over much more rapidly than long-chain (LC) ceramides containing C16:0 or C18:0 fatty acids due to the more rapid metabolism of the former into VLC sphingomyelin and VLC hexosylceramide. In contrast, d16:1 and d18:1 ceramides show similar rates of turnover, indicating that the length of the sphingoid LCB does not influence the flux of ceramides through the biosynthetic pathway. Together, these data demonstrate that the N-acyl chain length of SLs may not only affect membrane biophysical properties but also influence the rate of metabolism of SLs so as to regulate their levels and perhaps their biological functions.

Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. The method does not require isolation of AGP with antibodies and affinity chromatography, but AGP is enriched by acid precipitation from 5 μl of bloodplasma in a 96 well format. After trypsinization, AGP glycopeptides are purified using a hydrophilic interaction chromatography based solid-phase extraction and analyzed by RP-LC-ESI-MS. We used our method to show for the first time that AGP N-glycan profile is stable in healthy individuals (14 individuals in 3 time points), which is a requirement for evaluation of its diagnostic potential. Furthermore, we tested our method on a population including individuals with registered hyperglycemia in critical illness (59 cases and 49 controls), which represents a significantly increased risk of developing type 2 diabetes. Individuals at higher risk of diabetes presented increased N-glycan branching on AGP’s second glycosylation site and lower sialylation of N-glycans on AGP’s third and AGP1’s fourth glycosylation site. Although this should be confirmed on a larger prospective cohort, it indicates that site-specific AGP N-glycan profile could help distinguish individuals who are at risk of type 2 diabetes.

Economic Reform and Recovery in Zimbabwe 8 October 2018 — 2:30PM TO 3:30PM Anonymous (not verified) 4 October 2018 Chatham House, London

Public Service, Accountability and Delivery in Malawi 17 October 2018 — 12:00PM TO 1:00PM Anonymous (not verified) 11 October 2018 Chatham House, London

Zimbabwe Futures 2030: A Vision for Inclusive Long-Term Economic Recovery 10 October 2019 — 10:00AM TO 12:15PM Anonymous (not verified) 5 September 2019 Harare, Zimbabwe

In its Vision 2030, the government of Zimbabwe committed itself to facilitating an open market and stable economy through strategies such as the Transitional Stabilization Programme (TSP) and new industrialization policy. The private sector is pivotal to these objectives and creating an environment conducive to inclusive and job-creating economic growth. Economic growth can only be achieved with a conducive policy environment and government support to underpin markets with provision of public goods, entrepreneurial incentives and protect contract enforcement and dispute resolution mechanisms.

This event will launch a new Chatham House Africa Programme publication on Zimbabwe’s Vision 2030. The paper is the culmination of an inclusive research process that has drawn on senior private sector expertise, civil society, academics, technocratic elements of government and other experts to develop policy recommendations that will support inclusive economic growth in Zimbabwe.

This event is held in partnership with the Zimbabwe Business Club and Konrad Adenauer Stiftung (KAS). It is supported by KAS and the Dulverton Trust.