The Trump administration is working on placing a temporary ban on the issuance of some work-based visas like H-1B, which are popular among highly-skilled Indian IT professionals, as well as students visas and work authorisation that accompanies them, as unemployment levels

The young budding fashionista Janhvi Kapoor has absolutely impressed us with her sartorial picks. It's so amazing to see the way the actress's fashion has evolved. From lehengas to gowns, she has been slaying in each outfit and making stunning

Kajol's sister and Bollywood-South Indian film actress Tanishaa Mukerji has been doing rounds on the internet these days. She has been treating her fans with her beautiful pictures one after the other and her recent traditional look is what we

A few days ago, Vijay Deverakonda expressed his anger against websites publishing fake news about him. For those who are unversed, in a recent video, angry Vijay revealed that some websites spread fake news against his charitable trust, which gained all

While Kareena Kapoor Khan celebrated Mother's Day with Taimur, Karisma Kapoor shared an image with Babita and Kareena

Gauri too had shared a collage of pictures on her Instagram in the morning featuring Aryan, Suhana, and AbRam and a picture with her mother.

1. Vitamin D-deficient Patients Twice As Likely To Develop Severe COVID-19 Symptoms  Green Prophet
2. Researchers Have Discovered a Strong Correlation Between Severe Vitamin D Deficiency and COVID-19 Mortality Rates  Technology Networks
3. If your body has low levels of this, you have a higher chance of dying from COVID-19  Ladders
4. New study links low vitamin D levels with high COVID-19 death rate  Gulf News
5. Vitamin D is associated with a low COVID-19 death rate  Tech Explorist
6. View Full coverage on Google News

LIKE A BOSS!

LIKE A BOSS level: epic

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

Coronavirus reopening: more beaches and parks

A low-pressure trough pushing into Northern California from the Pacific will bring widespread showers to the part of the state most in need of rain.

Comparing “Likes” with “Tweets” of the Most Shared Stories

Flying in Canada during the time of COVID-19 requires a lot extra care, and CTV Senior Political Correspondent Glen McGregor gives a first-hand account on CTVNews.ca.

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Christina shares about the love between a refugee man and his disabled son, whom she met while volunteering in Šid, Serbia.

Twice a week Lourie Ferreira heads out into rural Zambian communities to show God's love through dentistry.

“Seeing how these boys lived…put my own life into perspective,” said Anne Davidson, after spending time with youth living on the streets of Lusaka.

"Wow! Roohi, What a classic performance we are giving," said Karan Johar

"Wow! Roohi, What a classic performance we are giving," said Karan Johar

The BMW 310 twins might not have a features upgrade or riding modes compared to the updates the TVS Apache RR310 got.

Royal Enfield Meteor 350 Fireball is expected to come with multiple optional accessories. Very recently, images that appear to be the screenshots of the official configurator have leaked on the web revealing some juicy details.

FY21/22e EPS lowered by 22-33/9-13%; softer LNG prices a positive; GUJGA and MGL are to be preferred.

Small cardamom exports to Saudi Arabia are likely to increase during the current Ramadan season with the Saudi authorities agreeing to accept the globally accepted Codex Food Standards of the United Nations.

A Barclays report estimates that the central government’s revenue benefit from the additional hikes in fuel taxes could be as much as Rs 1.4 lakh crore on an annual basis.

The National Stock Exchange (NSE) on Wednesday said it was working to equip its systems to handle crises such as that caused by the crash in crude prices.

Capturing a still image or recording a special moment is among the best ways to preserve a memory. However, to truly enjoy the experience, the quality of the digital image is paramount, and so, it is important to get yourself a device with an amazing camera.

Interview: Mrutyunjay Mahapatra, deputy MD and chief information officer, State Bank of India.

Kotak Mahindra Bank on Thursday reported a surge in its first quarter net profit while maintaining the asset quality.

Government orders on waiver of rents impinge on contractual rights.

Corona will worsen world hunger, while malnutrition facilitates increased vulnerability to the pandemic.

In India, which is the biggest democracy in the world with over 1.3 billion people, the question of public health has never been debated in public.

Israel has just reported a potent monoclonal antibody (mAb) against SARS CoV-2. Firms in South Korea, the US are leading mAb trials.

Three children, including a five-year-old boy, have died of a mysterious inflammatory syndrome resembling Kawasaki disease or a toxic shock, Governor Andrew Cuomo said, as the state authorities began an inquiry into the cases.
Read Full Article at RT.com

With Sales Accelerator, Del Monte can 'tweak the levers' during a campaign to boost reach and revenu

The discipline is projected to mature into a rich blend of social media and mobile engagement.

The record excise duty hike on petrol and diesel will not help the government bridge the fiscal gap as planned, nor will it help boost economic growth as consumption demand will further be crippled, warns a report. Despite crude prices trading at a two decades low, the government had earlier this week hiked excise duty […]

The minister also added that the result will be announced with a period of four to six weeks after entire examination gets complete.

Ease of Doing Business for MSMEs: Retailers, architects, town planners have suggested Nitin Gadkari to allow malls resume operations, e-commerce operations for non-essential items, relief in rentals for retailers, extend moratorium period to nine months and more.

1. Centre issues guidelines for restarting factories post lockdown, says treat first week like test run  Zee News
2. After Vizag gas leak, new MHA guidelines on restarting manufacturing units insist on safety  Moneycontrol
3. Centre issues guidelines for manufacturing units post lockdown  ETAuto.com
4. View Full coverage on Google News