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PUNE: Across the city, the rush to pay the annual property tax in advance and avail the discount has swelled the Pune Municipal Corporation coffers. Over 4.50 lakh property owners, who paid the tax before May 31 and availed of the 10% discount, helped the civic body collect Rs 400 crore in two months. “More than 50% of property owners paid the tax in the first two months of the new financial year. The good response to the scheme is due to the awareness programmes the administration undertook. The efforts to provide bills at the doorstep of residents helped boost collection. A maximum number of bills were sent to the […]

CBS News anchor Walter Cronkite hosted a special broadcast on the very first Earth Day on April 22, 1970 to report on the nationwide protests that took place that day.

Title: Cat Allergy Doesn't Have to Mean Giving Up Kitty
Category: Health News
Created: 4/23/2010 2:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: There Aren't Enough Coronavirus Test Kits to Safely Reopen America, Experts Warn
Category: Health News
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic KIT mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was highly specific for GIST cell labeling in vitro. Functionally, the KIT aptamer bound extracellular KIT in a manner similar to KIT mAb staining, and was trafficked intracellularly in vitro. The KIT aptamer bound dissociated primary human GIST cells in a mutation agnostic manner such that tumors with KIT and PDGFRA mutations were labeled. In addition, the KIT aptamer specifically labeled intact human GIST tissue ex vivo, as well as peritoneal xenografts in mice with high sensitivity. These results represent the first use of an aptamer-based method for targeted detection of GIST in vitro and in vivo.

Transcription factors (TFs) enact precise regulation of gene expression through site-specific, genome-wide binding. Common methods for TF-occupancy profiling, such as chromatin immunoprecipitation, are limited by requirement of TF-specific antibodies and provide only end-point snapshots of TF binding. Alternatively, TF-tagging techniques, in which a TF is fused to a DNA-modifying enzyme...

⁶⁸Ga-labeled urea-based inhibitors of the prostate-specific membrane antigen (PSMA), such as ⁶⁸Ga-PSMA-11, are promising small molecules for targeting prostate cancer (PCa). Although this radiopharmaceutical was produced mostly by means of manual synthesis and automated synthesis modules, a sterile cold kit was recently introduced. The aim of our study was to evaluate the image quality of ⁶⁸Ga-PSMA-11 PET/CT (PSMA-PET) in a population of PCa patients after the injection of comparable activities of ⁶⁸Ga-PSMA-11 obtained with the 2 different synthetic procedures. A secondary aim was to identify secondary factors that may have an impact on image quality and, thus, final interpretation. Methods: Two different groups of 100 consecutive PCa patients who underwent PSMA-PET were included in the study. The first group of patients was imaged with ⁶⁸Ga-PSMA-11 obtained using synthesis modules, whereas the second group’s tracer activity was synthesized using a sterile cold kit. All PET images were independently reviewed by 2 nuclear medicine diagnosticians with at least 2 y of experience in PSMA-based imaging and unaware of the patients’ clinical history. The 2 reviewers independently rated the quality of each PSMA-PET scan using a 3-point Likert-type scale. In cases of discordance, the operators together reviewed the images and reached a consensus. Performance was evaluated on the basis of the expected biodistribution, lesion detection rate, and physiologic background uptake. Results: Overall, 104 of 200 (52%) PSMA-PET scans were positive for PCa-related findings. No significant differences in image quality between cold kits and synthesis modules were found (P = 0.13), although a higher proportion of images was rated as excellent by the observers for kits than for modules (45% vs. 34%). Furthermore, after image quality had been dichotomized as excellent or not excellent, multivariate regression analysis found several factors to be significantly associated with a not-excellent quality: an increase in patient age (+5 y: odds ratio [OR], 1.40; 95% confidence interval [CI], 1.12–1.75), an increase in patient weight (+5 kg: OR, 1.89; 95% CI, 1.53–2.32), an increase in ⁶⁸Ga-PSMA-11 uptake time (+10 min: OR, 1.45; 95% CI, 1.08–1.96), and a decrease in injected activity (–10 MBq: OR, 1.28; 95% CI, 1.07–1.52). Conclusion: No significant differences were identified between the 2 groups of patients undergoing PSMA-PET; therefore, we were not able to ascertain any significant influences of tracer production methodology on final scan quality. However, increased patient age, increased patient weight, decreased injected activity, and increased ⁶⁸Ga-PSMA-11 uptake time were significantly associated with an overall poorer image quality.

One of the most dramatic changes you can make to effectively boost value of your home is giving your kitchen some renovations.

One of our favorite consumer drones gets an FPV upgrade

She’s also learning to iron.

There are all sorts of ways the home cook can help conserve precious energy, this recipe for vegan coconutty ‘cheesecake’ being a case in point

Reducing waste in the kitchen isn’t just about saving food: the time and energy it takes to cook food are also important resources that are easily squandered.

The best way to save energy, besides loving your leftovers, is by cooking less: swap out a cooked element of your meal for a nutritious vegetable salad or raw dish (such as today’s coconut and lemon “cheesecake”); or make one-pot wonders that don’t use multiple cooker rings. And when you do need to cook more, make extra portions for the freezer.

Follow our live coronavirus updates HERE Coronavirus: the symptoms

Live coronavirus updates here

Some hospitals face running out of personal protection equipment this weekend amid growing concerns over supplies amid the coronavirus outbreak.

Three kittens rescued from a garden have been named after key figures from NHS history.

Doctors at the London hospital at the centre of the coronavirus outbreak today told how they rapidly came up with innovative solutions when it ran out of vital life-saving equipment.

https://www.bestbuy.com/site/promo/nintendo-labo-offer

Includes Variety Kit, Robot Kit, Vehicle Kit, and VR Starter Kit.

Celebrity TV chef from MKR has been repeatedly criticised by scientific and medical groups over his views on health and nutrition

The controversial reality TV chef Pete Evans will exit My Kitchen Rules, Seven’s defining show of the decade which slumped badly in the ratings this year.

Evans, a self-styled health guru held one of the most lucrative jobs in television despite a series of controversies related to his views on health and nutrition.

'Here Kitty Kitty' references Exotic's claim that Carole Baskin killed her late husband and fed him to a tiger

Finlay was married to Joe Exotic during filming of 'Tiger King'

A sweet way to quell any Friday night boredom

Vodafone's new thermal detection cameras will help businesses scan the temperature of people entering the building

Chelsea fans have been almost unanimous in their condemnation of a 'leaked' shirt for next season after a model posed in the strip and posted it on social media.

Liverpool are set to be the best-looking team in the Premier League and across Europe next season if these concept kit designs are anything to go by.

Ivan Rakitic has warned Barcelona he wants to be "where he is valued" amid growing transfer speculation.

Ivan Rakitic has made 299 appearances for Barcelona in all competitions and remains the only midfielder to score for the Catalan club in a European Cup final. At Camp Nou, his name is still cheered by fans.

A number of Liverpool fans have been left disappointed by a 'leaked' shirt for next season after pictures showing what appear to be the new Nike kit were posted on social media.

Liverpool will begin the 2020-21 season with Nike as their new shirt sponsor after parting ways with New Balance last year.

Manchester United fans seem far from pleased with what, according to a 'leaked' picture on social media, will be their new home strip for next season.

Manchester City defender Aymeric Laporte has purchased kit worn by late French boxer Alexis Vastine auction to raise money for French healthcare workers.

It's the season of the leaked kits, and while we've seen a number of shirt designs across the Internet, Bleacher Report have now brought them to life... well, to Fifa 20.

It seems football is as much about looking the part is it is playing the part these days, and as such there is always plenty of excitement and speculation around kits at this time of year.

Manchester United are among the clubs to have their possible new shirt designs for the 2020-21 season leaked online.

Tottenham fans appear to be divided over a 'leaked' away shirt for next season after pictures emerged on social media.

Former Premier League striker Dave Kitson has announced his bid to end Gordon Taylor's near four-decade run as chief executive of the Professional Footballers' Association (PFA).

Barcelona midfielder Ivan Rakitic says he is ready take the risk of contracting coronavirus by returning to action following six weeks of inactivity due to Covid-19.

Former Arsenal and England striker Ian Wright has become the latest member of the football community to hit out at Dave Kitson's bid to become the new chief of the PFA.

Tottenham are reportedly looking for midfield reinforcements this summer, with Barcelona's Ivan Rakitic the latest name linked.

Dave Kitson has apologised for using "clumsy language" when assessing the racial abuse suffered by Raheem Sterling at Chelsea back in 2018.

Ivan Rakitic plans to see out his contract at Barcelona.

High-quality tool kits come in a variety of sizes and styles for your home repair needs. Just a hammer and a flathead screwdriver won't cut it.

CHURCHGOERS who bake cakes for charity are celebrating a victory for “common sense’’ after a council backflip on plans to subject their kitchens to annual health inspections.