Paperback – November 21, 2023

By Eli Yudin Published: November 10th, 2024

As someone who practically grew up with ABBA’s “Dancing Queen” as my childhood soundtrack (thanks, Dad!), I couldn’t be more excited to share this news: IKEA launched an album! IKEA just dropped the mic with their first-ever global talent show, and let me tell you, it’s not about building furniture – it’s about building harmony. Earlier this year, they turned the spotlight on their musically gifted co-workers, and did they deliver. Picture this: 150 talented IKEA co-workers from 21 countries, […]

The post Move Over Billy, IKEA’s Got a New Greatest Hit appeared first on IKEA Hackers.

California-based Greatfill makes zero waste easy. With a variety of refillable household products, the company’s focus is on health for the home, humans and the environment.[...]

I was saddened to be told of the recent death of my old friend Ed Lovette. He had a long and distinguished career in military, law enforcement, and the CIA. Ed was a thinking man’s instructor. We took each other’s classes. He went through my LFI-I course back in the day , and about thirty […]

The post Russian Designer Creates Realistic Images of Great Historical Figures appeared first on English Russia.

Records show how the Egyptians built the Great Pyramid more than 4500 years ago.

Think your website is fine the way it is? Think again. Even if you’re not seeing a decrease...

The post 10 Features Every Great Website Must Have appeared first on Ignition Media.

The trains could be charged in a matter of minutes before setting off on their journeys

A UK law allowing gene-edited food has been paused and some British scientists fear being overtaken.

Ayrton Senna, Michael Schumacher, Lewis Hamilton and Max Verstappen have all mastered treacherous conditions to win F1 races - but which was the best?

The former Rangers and Liverpool star said charity fundraising allowed people to see "the real me".

Ducati North America CEO Jason Chinnock enlisted in the US Army out of high school and served with the Third Armored Division in Desert Storm.

It's been just over a year since director Macon Blair premiered his new reboot of The Toxic Avenger at Fantastic Fest in Austin, Texas. The new film stars Peter Dinklage as the eponymous hideously deformed creature of superhuman size and strength, along with Elijah Wood, Kevin Bacon, and more—but has unfortunately struggled to find support for a wider distribution, according to The Hollywood Reporter. — Read the rest

The post The new TOXIC AVENGER comic book is great appeared first on Boing Boing.

Former Kaizer Chiefs legend Brian Baloyi says that holding the Kaizer Chiefs No 1 jersey requires a hardened mentality, but he is upbeat over Amakhosi's chances this season.

The Implication of Greater Use of Investment Screening 26 June 2020 — 9:00AM TO 10:30AM Anonymous (not verified) 11 February 2021 Online

What is driving the trend towards greater use of investment screening by nation states and regional economic groupings?

• How is the COVID-19 crisis affecting this trend?
• What will the economic implications be?
• Will this help or hinder inclusivity and transparency in investment governance?
• Is there a role for international safeguards and/or international coordination of national/regional approaches to investment screening?

This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world.

Thoracic great vessels such as the aorta and subclavian arteries are formed through dynamic remodeling of embryonic pharyngeal arch arteries (PAAs). Previous work has shown that loss of a basic helix-loop-helix transcription factor Hey1 in mice causes abnormal fourth PAA development and lethal great vessel anomalies resembling congenital malformations in humans. However, how Hey1 mediates vascular formation remains unclear. In this study, we revealed that Hey1 in vascular endothelial cells, but not in smooth muscle cells, played essential roles for PAA development and great vessel morphogenesis in mouse embryos. Tek-Cre–mediated Hey1 deletion in endothelial cells affected endothelial tube formation and smooth muscle differentiation in embryonic fourth PAAs and resulted in interruption of the aortic arch and other great vessel malformations. Cell specificity and signal responsiveness of Hey1 expression were controlled through multiple cis-regulatory regions. We found two distal genomic regions that had enhancer activity in endothelial cells and in the pharyngeal epithelium and somites, respectively. The novel endothelial enhancer was conserved across species and was specific to large-caliber arteries. Its transcriptional activity was regulated by Notch signaling in vitro and in vivo, but not by ALK1 signaling and other transcription factors implicated in endothelial cell specificity. The distal endothelial enhancer was not essential for basal Hey1 expression in mouse embryos but may likely serve for Notch-dependent transcriptional control in endothelial cells together with the proximal regulatory region. These findings help in understanding the significance and regulation of endothelial Hey1 as a mediator of multiple signaling pathways in embryonic vascular formation.

17 September 2020

Toma Keser
Dec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433
Research

Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. The method does not require isolation of AGP with antibodies and affinity chromatography, but AGP is enriched by acid precipitation from 5 μl of bloodplasma in a 96 well format. After trypsinization, AGP glycopeptides are purified using a hydrophilic interaction chromatography based solid-phase extraction and analyzed by RP-LC-ESI-MS. We used our method to show for the first time that AGP N-glycan profile is stable in healthy individuals (14 individuals in 3 time points), which is a requirement for evaluation of its diagnostic potential. Furthermore, we tested our method on a population including individuals with registered hyperglycemia in critical illness (59 cases and 49 controls), which represents a significantly increased risk of developing type 2 diabetes. Individuals at higher risk of diabetes presented increased N-glycan branching on AGP’s second glycosylation site and lower sialylation of N-glycans on AGP’s third and AGP1’s fourth glycosylation site. Although this should be confirmed on a larger prospective cohort, it indicates that site-specific AGP N-glycan profile could help distinguish individuals who are at risk of type 2 diabetes.

Middle East and great power competition 28 November 2022 — 12:00PM TO 1:00PM Anonymous (not verified) 25 October 2022 Chatham House and Online

Experts discuss how the Middle East is changing in a fast-moving geopolitical environment.

The war in Ukraine and great power competition define not only global politics but also regional ones. The Middle East is a microcosm for observing how the great power rivalry informs regional affairs.

OPEC+’s decision to reduce oil supply to international markets and many regional states’ balancing act between the West and Russia, for that matter China as well, are only a few recent policy choices that clearly illustrate how the global and regional levels interact with each other.

Plus this is now a region in which the US has downsized its security commitments, whereas Russia has increased its footprint in regional security and China in economy.

This event tries to unpack how the great power rivalry and the war in Ukraine affect regional politics and how the Middle East adjusts itself to this new phase in global politics.

Earlier this month, the United States and the Republic of Korea reached an agreement on greater cooperation on civil nuclear energy projects, the U.S. Department of Energy said this week.

New cross-species research suggests a theory of mind is one thing that sets humans apart from apes

TED Fellow and composer Sahba Aminikia brings the healing power of dance, storytelling, music and performance to some of the most dangerous places on Earth. By celebrating children and their communities with beauty and joy, he shows how to cultivate hope, connection and love — even in conflict zones. "The ultimate power is in unity," Aminikia says.

Kenzie Lalonde will become the first woman play-by-play announcer for an NHL team's TV broadcasts in Canada. Reactions and endorsements have poured in.

Emma Lingan and Eric Cruikshank discuss Washington Capitals center Dylan Strome, the Bruins and Red Wings coaches, Kirill Kaprizov's next contract and much more.

With new CFP rankings having Indiana at No. 5, it's a clear sign from the Playoff committee: wins matter.

Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems.

In between trips to archaeology digs around the world, scientist Bruno Frohlich uses 3-D imaging to uncover what makes a great stringed instrument. Read more at: https://www.smithsonianmag.com/smithsonian-institution/scanning-a-stradivarius-13807009/

Learn about this often misunderstood creature

Lonnie Bunch, the director of the National Museum of African American History and Culture, discusses the Martin Luther King, Jr. memorial, one of America's greatest monuments.

Photographer Drew Gardner has a passion for history. His long-term project, “The Descendants,” (https://www.drewgardner.com/descendants)  wherein he recreates famous portraits of historical figures featuring their direct offspring, is his most visible expression of this interest. But like a lot of people who study history, Gardner has in recent years begun to contemplate more deeply the question of whose stories have been judged worthy of preservation, and whose have been allowed to fade into obscurity. That was how he decided to shift his specific focus to locating and photographing Black American descendants of Civil War veterans. You can take a look at Gardner’s photographs and read magazine editor Jennie Rothenberg Gritz’s exploration of their meaning here (https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/) . On the latest episode of the Smithsonian podcast “There’s More to That,” (https://www.smithsonianmag.com/podcast)  I speak with Janisse Flowers and her 9-year-son, Neikoye, who are descended from the Civil War drummer boy David Miles Moore Jr. After some reflection, Janisse and her husband decided to grant Gardner’s request to photograph Neikoye dressed in a replica of Moore’s Union Army uniform. Both Janisse and Neikoye share their surprise over how this experience made them more conscious of their heritage. I’m also joined by Gardner himself, who describes the challenges—and, he hopes, the potential benefits—of asking Black Americans to revisit one of the most painful chapters of America’s history by (almost) literally stepping into their ancestors’ shoes. You can learn more about Drew and his work at his website (https://www.drewgardner.com/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

In 1858, the mountain was named for a Confederate general. Now, it will once again be known as "Kuwohi"

"Transforming Energy," the artist's first museum show in China, focuses on "artworks and objects that actively engage the audience"

Authorities have not yet identified the cause of death for the 12.5-foot-long shark, which was named Koala

A Port Hawkesbury woman has long imagined a Remembrance Day with her great-uncle's war medals. It will happen this year for the first time thanks to some sleuthing and the kindness of her great-uncle's foster family.

Families are grappling with the consequences of growing gun violence in Hamilton and across the Greater Toronto Area this year. Several of the region's police forces have warned of an alarming rise in shootings since January.

God transforms the hearts of teens from two people groups, who normally do not interact, to bring them together for worship, Bible study and friendship.

Automation of time-consuming analysis tasks and support for popular CAD programs gives designers and engineers a safety net for experimenting with new product designs

Focus on Speed and Collaboration Enables Design Teams to Work More Productively and Profitably

Apple's new M4 24-inch iMac shows that the all-in-one desktop computer still has a loyal fanbase, with every reviewer also relishing the more vibrant colors of the new model.

Since joining OM’s Namana Project, one couple has developed a successful business, built their own home and can give their children an education.

Kuching, Malaysia :: The Logos Hope family celebrates Easter day together onboard.

On 19 March, OM Australia moved into their new home, a place that will help mobilise more people and finances into missions.

A group from the U.S. demonstrated God’s love during OM Costa Rica’s city outreach, which focused primarily on working within the slums of San José.