Ahead of her arrival, Delhi Chief Minister Arvind Kejriwal had tweeted to welcome her. "@FLOTUS will attend happiness class in our school today. Great day for our teachers, students and Delhiites. For centuries, India has taught spirituality to the world. Am happy that she will take back the msg of happiness from our school," Kejriwal said.

A proteomic study reveals wide-ranging protein differences among brain cells treated with various concentrations of PBDE-99.

To investigate the effect of high-energy X-rays on site-specific radiation-damage, low-dose diffraction data were collected from radiation-sensitive crystals of the metal enzyme cytochrome c oxidase. Data were collected at the Structural Biology I beamline (BL41XU) at SPring-8, using 30 keV X-rays and a highly sensitive pixel array detector equipped with a cadmium telluride sensor. The experimental setup of continuous sample translation using multiple crystals allowed the average diffraction weighted dose per data set to be reduced to 58 kGy, and the resulting data revealed a ligand structure featuring an identical bond length to that in the damage-free structure determined using an X-ray free-electron laser. However, precise analysis of the residual density around the ligand structure refined with the synchrotron data showed the possibility of a small level of specific damage, which might have resulted from the accumulated dose of 58 kGy per data set. Further investigation of the photon-energy dependence of specific damage, as assessed by variations in UV-vis absorption spectra, was conducted using an on-line spectrometer at various energies ranging from 10 to 30 keV. No evidence was found for specific radiation damage being energy dependent.

The local Fourier-space relation between diffracted intensity I, diffraction wavevector q and dose D, ilde I(q,D), is key to probing and understanding radiation damage by X-rays and energetic particles in both diffraction and imaging experiments. The models used in protein crystallography for the last 50 years provide good fits to experimental I(q) versus nominal dose data, but have unclear physical significance. More recently, a fit to diffraction and imaging experiments suggested that the maximum tolerable dose varies as q−1 or linearly with resolution. Here, it is shown that crystallographic data have been strongly perturbed by the effects of spatially nonuniform crystal irradiation and diffraction during data collection. Reanalysis shows that these data are consistent with a purely exponential local dose dependence, ilde I(q,D) = I0(q)exp[−D/De(q)], where De(q) ∝ qα with α ≃ 1.7. A physics-based model for radiation damage, in which damage events occurring at random locations within a sample each cause energy deposition and blurring of the electron density within a small volume, predicts this exponential variation with dose for all q values and a decay exponent α ≃ 2 in two and three dimensions, roughly consistent with both diffraction and imaging experiments over more than two orders of magnitude in resolution. The B-factor model used to account for radiation damage in crystallographic scaling programs is consistent with α = 2, but may not accurately capture the dose dependencies of structure factors under typical nonuniform illumination conditions. The strong q dependence of radiation-induced diffraction decays implies that the previously proposed 20–30 MGy dose limit for protein crystallography should be replaced by a resolution-dependent dose limit that, for atomic resolution data sets, will be much smaller. The results suggest that the physics underlying basic experimental trends in radiation damage at T ≃ 100 K is straightforward and universal. Deviations of the local I(q, D) from strictly exponential behavior may provide mechanistic insights, especially into the radiation-damage processes responsible for the greatly increased radiation sensitivity observed at T ≃ 300 K.

This study relates to the INFN project SYRMA-3D for in vivo phase-contrast breast computed tomography using the SYRMEP synchrotron radiation beamline at the ELETTRA facility in Trieste, Italy. This peculiar imaging technique uses a novel dosimetric approach with respect to the standard clinical procedure. In this study, optimization of the acquisition procedure was evaluated in terms of dose delivered to the breast. An offline dose monitoring method was also investigated using radiochromic film dosimetry. Various irradiation geometries have been investigated for scanning the prone patient's pendant breast, simulated by a 14 cm-diameter polymethylmethacrylate cylindrical phantom containing pieces of calibrated radiochromic film type XR-QA2. Films were inserted mid-plane in the phantom, as well as wrapped around its external surface, and irradiated at 38 keV, with an air kerma value that would produce an estimated mean glandular dose of 5 mGy for a 14 cm-diameter 50% glandular breast. Axial scans were performed over a full rotation or over 180°. The results point out that a scheme adopting a stepped rotation irradiation represents the best geometry to optimize the dose distribution to the breast. The feasibility of using a piece of calibrated radiochromic film wrapped around a suitable holder around the breast to monitor the scan dose offline is demonstrated.

An intuitive method is presented for detecting pseudosymmetries in Z' > 1 cases as a complement to well-proven strategies already available in the literature. It is based in the simple idea that the mid-points between equivalent atoms in symmetrically related mol­ecules are disposed according to simple well-known patterns, which are easily recognizable by optical inspection. A number of Z' = 4 cases in the literature are analyzed, which allows some of the potentialities of the method to be revealed.

File: (L-R) "The Sarah Silverman Program" writer Harris Wittels, comedian Sarah Silverman, executive producer/head writer Dan Sterling and actress Laura Silverman, arrive at Comedy Central's Emmy Awards party at the STK restaurant Sept. 21, 2008 in Los Angeles.; Credit: Ethan Miller/Getty Images

Harris Wittels, a comedy writer who worked on "Parks & Recreation," has died at 30, the Los Angeles Police Department's Jane Kim tells KPCC.

Wittels was discovered by his assistant around 12 p.m., Kim said, and was already dead. Kim said that Wittels' death was a possible overdose, but that the Coroner's Office would determine the cause of death. Wittels had attended drug rehab twice.

Comedy Central, where Wittels worked on "The Sarah Silverman Program" and "Secret Girlfriend," confirmed Wittels' death, as did the comedy show he appeared at Wednesday night.

Comedy Central tweet

Meltdown Show tweet

Wittels was also well known for his @Humblebrag Twitter account and later book, helping to popularize the idea online of the false modesty of bragging while trying not to look like you're bragging.

Wittels had spoken about his struggles with addiction in places including Pete Holmes's podcast "You Made It Weird" in a November episode.

"I just really stopped caring about my life," Wittels said on "You Made It Weird," explaining how he got into doing drugs. "I just really started to think, well, if I'm only here for 80 years, then who cares if I spend it high or not?"

Wittels received his first big break when Sarah Silverman saw him performing comedy and gave him a job writing for her Comedy Central show.

Wittels also wrote for HBO's "Eastbound & Down," several MTV awards shows and the American Music Awards. He had a recurring role on "Parks & Recreation" and was a regular guest on the "Comedy Bang Bang" podcast.

Comedians, actors and fans mourned Wittels' death online.

Harris Wittels Storify

See Wittels in a scene from "Parks & Recreation":

Wittels on Parks & Recreation

Listen to Wittels on "Comedy Bang Bang":

Wittels on Comedy Bang Bang

This story has been updated.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies.

A new report by the National Academies of Sciences, Engineering, and Medicine proposes a strategy that the U.S. Environmental Protection Agency (EPA) should use to evaluate the evidence of adverse human health effects from low doses of exposure to chemicals that can disrupt the endocrine system.

Covid-19 crisis has seen a surge in demand for the roles of CISOs and CDOs, while the CIO role seems to be headed for an on-demand model among the small and medium enterprises.

Covid-19 crisis has seen a surge in demand for the roles of CISOs and CDOs, while the CIO role seems to be headed for an on-demand model among the small and medium enterprises.

Non-target aquatic wildlife species may be more vulnerable to pesticides’ effects, with repeated exposure to low doses over the long-term, if they compete with other species for food, according to a recent study. Understanding how this process occurs can help those undertaking risk assessments and managing pesticides in the natural environment.

Setting cycle and footpaths further back from the road can significantly lower the amount of air pollution that cyclists and pedestrians inhale, suggests new research. While wide gaps are not always practical, the study shows that even small increases in distance could substantially reduce the dose of pollution.

In Mexico, a drug cartel is extorting money from avocado producers and killing those who won’t pay. There’s no perfect way to avoid buying them.

The latest Pinterest-worthy food trend further solidifies the avocado as one of the world's most versatile and beloved fruits.

Make sure your knives are sharpened and spice rack is stocked so time in the kitchen this holiday season goes more smoothly.

Food news and items of interest from around the Web — Giada de Laurentiis, Jersey Girl Cooks and weeknight dinner parties.

New Hampshire distillery Tamworth turns the healthy spice into a tribute to Alexander Von Humboldt, the "forgotten father of environmentalism."

Study participants on higher doses of statins were 15 percent more likely to develop diabetes than those on lower doses.

Using a single-pixel camera, a patterned light source and some computer processing, researchers have demonstrated a cheap way to do X-rays with "ghost images."

Researchers find that more than 10 percent of patients may be taking aspirin unnecessarily, and the risks may outweigh the benefits.

Once considered a dead zone for green building, Miami Beach will soon be getting its first LEED Platinum home in the form of 2020 Alton Road, a super-sleek, sup

Enjoy this year's abundance of avocados and try one of these tasty recipes that go beyond guacamole.

When it comes to plastic especially, it seems like a no-brainer to at least pick up some of it when you’re out in nature.

When people think of avocados, they think of guacamole, but there's more to these nutritious fruits than meets the chip.

Sustanon is a very popular steroid which is highly appreciated by its users since it offers several advantages when compared to other testosterone compounds. Sustanon is a mixture of four different testosterones which...

Mr. Dubash has been endorsed by Marquis Who's Who as a leader in the pharmaceutical industry

Surgery Technique Produces Life-Changing Results For Patients With Extreme Back Pain

Dr. El Deeb has been endorsed by Marquis Who's Who as a leader in the field of oral and maxillofacial surgery

GRAFEX Super Fullerene's new coconut oil powder-based capsule eliminates dependence on oil-based delivery for C60.

Originally, the products were given space in 77 Sally's Beauty Supply stores nationally, as well as, 298 location under the Target grocery chain.

For dog and cat lovers who love their martinis shaken, not stirred or wine connoisseurs expecting their Cabernet or Chablis poured just so, Paws4Claws offers the top product cat and dog themed products to bring sure to bring holiday cheer!

Monica Vavilala, MD, discusses her recent article published in the May issue of Pediatric Critical Care Medicine.

Mike Dimoff, the new race caller at Ruidoso Downs in New Mexico, spent his first day in the track's announcer's booth on May 6 calling schooling works races as preparations are under way for the opening day of the 2020 meet on May 22. “It feels very comfortable,” Dimoff said, stepping away from the microphone […]

The post New Ruidoso Announcer Dimoff Tunes Up In Schooling Races appeared first on Horse Racing News | Paulick Report.

‘Kudos’ is an interesting word.

The Daily Record columnist claims it's a deflection from the club's failures on the pitch this season

DALLAS, 1 de abril del 2020 — Algunos cardiólogos de Wuhan, China y otros países recomiendan a los pacientes con hipertensión arterial que continúen tomando sus medicamentos, aunque los efectos de algunos se hayan visto afectados por las infecciones ...

DALLAS, 2 de abril del 2020 – La American Heart Association, la organización voluntaria líder mundial dedicada a un mundo con vidas más duraderas y saludables, anunció hoy que se otorgarán más de $14 millones en becas de investigación científica a cuatro...

Aspectos destacados de las declaraciones: Los factores sociales adversos, como el estado de los seguros, la inseguridad alimentaria, la falta de fondos para medicamentos y otros, pueden causar resultados clínicos negativos de la insuficiencia...

DALLAS, 3 de abril del 2020 – Debido al esfuerzo de médicos, científicos e investigadores de todo el mundo por comprender la pandemia del coronavirus (COVID-19), la American Heart Association está desarrollando un nuevo registro para agregar datos y...

  DALLAS, 23 de abril del 2020 — A medida que el distanciamiento social mantiene a las familias separadas, es posible que muchos de los que cuidan de un padre o un ser querido que padece insuficiencia cardíaca se pregunten cómo...

CEDAR RAPIDS — A Dubuque woman who helped her boyfriend and another person buy heroin that later led to a fatal overdose was convicted Thursday in federal court. Jacqueline M. Birch, 23,...

CEDAR RAPIDS — A Dubuque woman who helped her boyfriend and another person buy heroin that later led to a fatal overdose was convicted Thursday in federal court.

Jacqueline M. Birch, 23, pleaded guilty in U.S. District Court to one count of aiding and abetting the distribution of a controlled substance.

During the plea hearing, Birch admitted she knew that another person was going to illegally distribute a drug last May, and she aided in that distribution.

Evidence at a previous hearing showed that Birch drove her boyfriend, Mateusz Syryjczyk, 29, of Rockford, Ill., and another person, not identified in court documents, to a residence in Dubuque on May 27. Birch and the other person went into the residence and bought heroin from a dealer. The three drove to a hotel in Dubuque and all used the heroin.

The other person began to overdose in the room, but Birch and Syryjczyk didn’t immediately call 911, according to evidence. Over many hours, Birch occasionally would perform CPR on the person to restore some breathing function, though the person never regained consciousness.

Eventually, Birch and Syryjczyk decided to call 911, and Syryjczyk took the remaining drug paraphernalia from the room to prevent law enforcement from finding it, according to court documents. Birch and Syryjczyk also made false statements to police about the cause of the person’s condition.

Court documents showed the overdose victim died at the scene. An autopsy later determined the cause of death was use of heroin, fentanyl and valeryl fentanyl.

Syryjczyk previously pleaded to misprision of a felony and remains free on bond pending sentencing.

Birch faces up to 20 years in federal prison, a $1 million fine and supervised release for life following her prison term.

Sentencing will be set after a presentencing report is prepared.

The case was investigated by the Dubuque Drug Task Force and is being prosecuted by Assistant U.S. Attorney Dan Chatham.

Comments: (319) 398-8318; trish.mehaffey@thegazette.com

A way to formulate prasterone to both increase its oral bioavailability, and decrease the variability of its oral bioavailability. In contrast to the approach taught by the prior art, the instant approach is amenable to scale-up to commercial scale. Further, the resulting product is amenable to analysis using standard, known quantitative analytical techniques; thus, unlike the prior art approach, the instant approach may be used to manufacture a product in conformity with applicable regulatory standards.

Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.