30/01/2013 –The first update to the third generation of the QSAR Toolbox (version 3.1) has now been released containing improved search functionalities, interface improvement, a new database for observed rat in vivo metabolism; updated auto oxidation and metabolism simulators; updated DNA binding profiler and additional ways of expressing mixtures composition.

11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for genetic toxicity and genotoxic carcinogenicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.

11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for acute aquatic toxicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.

This toolbox is a compilation of resources relevant to chemical substitution and alternatives assessments. Alternative assessments are processes for identifying, comparing and selecting safer alternatives to replace hazardous chemicals with the objective of promoting sustainable production and consumption.

The new version of the IOMC Toolbox for Decision Making in Chemicals Management provides a set of interactive features allowing governments to use it as a platform for collaboration among ministries, agencies, and other stakeholders such as industry. Users can save their information, add comments, and share and discuss issues with colleagues and partners.

New features of the QSAR Toolbox version 4.3 include: 2 New Databases, 5 New Profilers, 2D parameters, 159 new (Q)SAR models including pre-calculated online Danish QSAR DB models and new pKa models, Toolbox Application Program Interface (API) is now publicly available.

Propagation-based phase-contrast X-ray imaging is by now a well established imaging technique, which – as a full-field technique – is particularly useful for tomography applications. Since it can be implemented with synchrotron radiation and at laboratory micro-focus sources, it covers a wide range of applications. A limiting factor in its development has been the phase-retrieval step, which was often performed using methods with a limited regime of applicability, typically based on linearization. In this work, a much larger set of algorithms, which covers a wide range of cases (experimental parameters, objects and constraints), is compiled into a single toolbox – the HoloTomoToolbox – which is made publicly available. Importantly, the unified structure of the implemented phase-retrieval functions facilitates their use and performance test on different experimental data.

Sustainable consumption and production (SCP) programmes are frameworks to systemically develop sustainability. New research has analysed three national SCP programmes in the UK, Sweden and Finland and concluded that, rather than provide a strong roadmap for sustainability, they tend to be a toolbox of good but scattered initiatives.

Clickbank Super Affiliates Toolbox Helps You Jolt Your Clickbank Commissions And Sales In Record Speed... Using Over-Used, Yet Highly-Powerful Tactics That Work!

Project management for podcasters is now available! Podcaster's Toolbox combines podcasting tools for show notes, interviews, social-media promotion, scheduling, automation, and more!

This paper presents a new open source Python framework for causal discovery from observational data and domain background knowledge, aimed at causal graph and causal mechanism modeling. The cdt package implements an end-to-end approach, recovering the direct dependencies (the skeleton of the causal graph) and the causal relationships between variables. It includes algorithms from the `Bnlearn' and `Pcalg' packages, together with algorithms for pairwise causal discovery such as ANM.

The Xenopus oocyte is a unique model system, allowing both the study of complex biological processes within a cellular context through expression of exogenous mRNAs and proteins, and the study of the cell, molecular, and developmental biology of the oocyte itself. During oogenesis, Xenopus oocytes grow dramatically in size, with a mature oocyte having a diameter of ~1.3 mm, and become highly polarized, localizing many mRNAs and proteins. Thus, the mature oocyte is a repository of maternal mRNAs and proteins that will direct early embryogenesis prior to zygotic genome transcription. Importantly, the Xenopus oocyte also has the capacity to translate exogenous microinjected RNAs, which has enabled breakthroughs in a wide range of areas including cell biology, developmental biology, molecular biology, and physiology. This introduction outlines how Xenopus oocytes can be used to study a variety of important biological questions.

Hi, I’m Mike Dady, Application Engineer for Alignex. As many of you probably know, the Toolbox Add-In is a database that allows for the quick addition of fasteners and other hardware to a SOLIDWORKS Assembly. However, many don’t realize that

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Molar element ratio analysis of element concentrations consists of four basic tools that provide substantial insight into the lithogeochemistry (and mineralogy) of rocks under examination. These tools consist of: (1) conserved element ratio analysis; (2) Pearce element ratio analysis; (3) general element ratio analysis; and (4) lithogeochemical mineral mode analysis. Conserved element ratio analysis is useful in creating a chemostratigraphic model for the host rocks to mineral deposits, whereas Pearce element ratio analysis and general element ratio analysis are primarily used to identify mineralogical and metasomatic controls on rock compositions and to investigate and quantify the extent of the material transfers that formed the host rocks and mineralization. Lithogeochemical mineral mode analysis converts element concentrations into mineral concentrations using a matrix-based change-of-basis operation, allowing lithogeochemical data to be interpreted in terms of mineral modes. It can be used to provide proper names to rocks, an important activity for an exploration geologist because of the implications that rock names have on genetic processes and mineral deposit models.

This paper provides a review of the theoretical foundations of each of these four tools and then illustrates how these techniques have been used in a variety of exploration applications to assist in the search for, evaluation and planning of, and the mining of mineral deposits. Examples include the evaluation of total digestion lithogeochemical datasets from mineral deposits hosted by igneous and sedimentary rocks and formed by hydrothermal and igneous processes. In addition, this paper illustrates a more recent geometallurgical application of these methods, whereby the mineral proportions determined by lithogeochemical mineral mode analysis are used to predict rock properties and obtain the ore body knowledge critical for resource evaluation, mine planning, mining and mine remediation.

Thematic collection: This article is part of the Exploration 17 collection available at: https://www.lyellcollection.org/cc/exploration-17

New method enables timely diagnosis and treatment of urological cancer which includes prostate, bladder and kidney cancers. Biomarkers are biological

Online resource to help implement the OECD Recommendation on Public Procurement. This website provides policy tools, country examples and indicators to measure public procurement systems.

McQuarrie, Edward F

Never again will mankind have to look for RSS info in more than one place...ok, we're kidding, but we've aimed to create a near comprehensive list of all the RSS readers, tools, browser plugins, tips, hacks and directories available on the web.

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This steel toolbox from Japanese brand Trusco adds a double-hinged lid and some slick design to the classic form.