The lack of a legislature and regional autonomy in Ladakh has led to the current protests

Hyderabad-based Abhishek Duttagupta on how he scaled Mt Kun, Mt Kang Yatse and completed the Ladakh ultra marathon back-to-back

The mission will simulate life in an interplanetary habitat to tackle the challenges of a base station beyond the earth

The unique appeal of Pouranic verse drama came alive in the staging of ‘Bhaktha Prahlada’.

The government needs to answer the critical question of whether it has accepted any restrictions on its infrastructure creation activities, asserts Ajai Shukla.

Mohd Ali, Haji Anayat Ali of Kargil and their assistants Shero Ali and Nazir Ahmad of Kathua had gone to the higher reaches of Warwan in J-K's Kishtwar district to purchase livestock in August 1998 but did not return to their homes.

'While my generation carries with it the memory of the Chinese perfidy of 1962, this generation will carry the memory of Chinese perfidy in Galwan.'

What happens when you take nine Tata UVs including Hexa and Harrier and put them on the road to the world's highest motorable road? Come, witness, how this epic journey unfolded over a course of 10 days.

Islamabad :” The Patron-in-Chief of Supreme Shia Ulema Board and Quaid-i-Millat Jafariya Agha Syed Hamid Ali Shah Moosavi has said that enemies of the religion are looting the wealth of Muslims by creating differences amongst them and by sowing the seeds of hatred, says a press release.He...

Living amidst the hustle and bustle of urban life, people often feel the need for a long journey away from their busy routine.

The title compound exhibits exceptionally weak inter­molecular C—H⋯π hydrogen bonding of the ethynyl groups, with the corresponding H⋯π separations [2.91 (2) and 3.12 (2) Å] exceeding normal vdW distances. This bonding compliments distal contacts of the CH (aliphatic)⋯π type [H⋯π = 3.12 (2)–3.14 (2) Å] to sustain supra­molecular layers.

The title compound, C14H16, exhibits exceptionally weak intermolecular C—H...π hydrogen bonding of the ethynyl groups, with the corresponding H...π separations [2.91 (2) and 3.12 (2) Å] exceeding normal vdW distances. This bonding complements distal contacts of the CH (aliphatic)...π type [H...π = 3.12 (2)–3.14 (2) Å] to sustain supramolecular layers. Hirshfeld surface analysis of the title compound suggests a relatively limited significance of the C...H/H...C contacts to the crystal packing (24.6%) and a major contribution from H...H contacts accounting 74.9% to the entire surface.

Derek take a closer look at a 70's classic.

Lada is a brand of cars manufactured by Russian automobile manufacturer AvtoVAZ (originally VAZ). The Lada brand appeared in 1973,...

Barcelona native Leonardo Balada’s creative style has been labelled ‘Dalí’s surrealism in music’—an aspect of his work explored in this programme through the technique of ‘sound transformation’ in which abstract musical materials become familiar melody. Fusing traditional and contemporary elements, Caprichos Nos. 6 and 7 engage intimately with Spanish culture and history, while the virtuoso Double Concerto, heard here in an arrangement for flute, clarinet and piano, blends well-known Mexican folk tunes with the composer’s distinctive avant-garde style.

La compañía energética BP anunció el lanzamiento de su aplicación móvil BPme, desarrollada con capacidades de inteligencia artificial (IA) de IBM Watson, buscando mejorar constantemente la experiencia de los usuarios de las estaciones de servicio de BP en México.

Anne Jörns
Apr 1, 2020; 69:624-633
Islet Studies

Approximately 10% of patients with type 2 diabetes suffer from latent autoimmune diabetes in adults (LADA). This study provides a systematic assessment of the pathology of the endocrine pancreas of patients with LADA and for comparison in a first rat model mimicking the characteristics of patients with LADA. Islets in human and rat pancreases were analyzed by immunohistochemistry for immune cell infiltrate composition, by in situ RT-PCR and quantitative real-time PCR of laser microdissected islets for gene expression of proinflammatory cytokines, the proliferation marker proliferating cell nuclear antigen (PCNA), the anti-inflammatory cytokine interleukin (IL) 10, and the apoptosis markers caspase 3 and TUNEL as well as insulin. Human and rat LADA pancreases showed differences in areas of the pancreas with respect to immune cell infiltration and a changed ratio between the number of macrophages and CD8 T cells toward macrophages in the islet infiltrate. Gene expression analyses revealed a changed ratio due to an increase of IL-1β and a decrease of tumor necrosis factor-α. IL-10, PCNA, and insulin expression were increased in the LADA situation, whereas caspase 3 gene expression was reduced. The analyses into the underlying pathology in human as well as rat LADA pancreases provided identical results, allowing the conclusion that LADA is a milder form of autoimmune diabetes in patients of an advanced age.

The European Medicines Agency (EMA) has embraced a new model of drug testing and marketing called “adaptive pathways”, allowing new drugs for “unmet medical needs” to be launched on the market faster, on the basis of fewer data. While industry claims this is necessary, an analysis on thebmj.com looks at the assumptions underlying the new pathway,...

OBJECTIVE

The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region.

RESEARCH DESIGN AND METHODS

Chromosome 6 was imputed using SNP2HLA, with conditional analysis performed in type 1 diabetes case subjects (n = 1,985) and control subjects (n = 2,219). The same approach was applied to a LADA cohort (n = 1,428) using population-based control subjects (n = 2,850) and in a separate replication cohort (656 type 1 diabetes case, 823 LADA case, and 3,218 control subjects).

RESULTS

The strongest associations in the MHC class II region (rs3957146, β [SE] = 1.44 [0.05]), as well as the independent effect of MHC class I genes, on type 1 diabetes risk, particularly HLA-B*39 (β [SE] = 1.36 [0.17]), were confirmed. The conditional analysis in LADA versus control subjects showed significant association in the MHC class II region (rs3957146, β [SE] = 1.14 [0.06]); however, we did not observe significant independent effects of MHC class I alleles in LADA.

CONCLUSIONS

In LADA, the independent effects of MHC class I observed in type 1 diabetes were not observed after conditioning on the leading MHC class II associations, suggesting that the MHC class I association may be a genetic discriminator between LADA and childhood-onset type 1 diabetes.

Gelada Monkey staring into the sunset

Our photo of the day comes from "The Wild Place Project."

[To be published in the Gazette of India, Extraordinary, Part II, Section 3, Sub-section (i)] Government of India Ministry of Finance

Revised GSTR-3B for UT of J&K and Ladakh...

In the first world of first world-liest problems, a problem I would love to be having this very week when I’m shivering again (despite many suggestions of spring on the near horizon) is that when in my life I’ve been lucky enough to decamp to a tropical location for a vacation, and wish to do what one does on tropical vacations — I mean, aside from wearing such buckets of SPF that when I return people comment, “I thought you went to the beach?” — and that is ordering a piña colada. Possibly at a swim-up bar. In a hurricane glass with a tacky paper umbrella in it, a fluorescent maraschino cherry, and a creamy-tart balance that is unfettered vacation bliss with each sip. The problem is that they’re very often…. terrible, tinny and artificially-flavored. I mean, I drink it; I’m not a barbarian. But every time I do (daily, at 4:30pm, please), I vow that when I get home, I’m going to make a real and proper and perfect one to set things right again.

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The pristine and idyllic pictures of Ladakh do not tell the true story. In recent past Ladakh has been losing its rich cultural heritage and natural resources, and sadly there has been no sincere concentrated official effort to stop this deterioration. But hope is on its way, says Ashish Kothari who visited the region recently.

Ashvin Kumar recalls he had no budget to pay Irrfan Khan, but the actor voluntarily supported his film.

International Conference on Mathematical Physics (15th : 2006 : Rio de Janeiro, Brazil)

Online Resource

Online Resource

Coladarci, Theodore, author

Dewey Library - JF1525.L4 A63 2019

Berlin ; New York : Springer, 2006

Rotch Library - JQ1850.A91 P65 2017