chrome Google Chrome on iPhones gets new features with Drive, Maps integration - Business Standard By news.google.com Published On :: Wed, 13 Nov 2024 06:52:39 GMT Google Chrome on iPhones gets new features with Drive, Maps integration Business StandardStop Using Chrome On Your iPhone, Warns Apple—Millions Of Users Must Now Decide Forbes4 new Chrome improvements for iOS The KeywordChrome on iOS now lets you search using images and text at the same time TechCrunchGoogle rolls out new features in Chrome for iPhone users Moneycontrol Full Article
chrome Google Adds Some Nifty Features for Chrome on iOS Devices By phandroid.com Published On :: Tue, 12 Nov 2024 23:35:24 +0000 If you're an iPhone user, then you might want to check the Chrome app for new updates. The post Google Adds Some Nifty Features for Chrome on iOS Devices appeared first on Phandroid. Full Article Apps Devices Smartphones Google Chrome iOS iPhone
chrome Get some new tech on a budget with these discounted Chromebooks ahead of Black Friday By mashable.com Published On :: Mon, 11 Nov 2024 17:10:10 +0000 As of Nov. 11, Chromebook deals are aplenty ahead of Black Friday 2024. Check out our top picks from Lenovo, Asus, Samsung, and others. Full Article
chrome Effects of Compound Probiotics on Pharmacokinetics of Cytochrome 450 Probe Drugs in Rats [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Compound probiotics have been widely used and commonly coadministered with other drugs for treating various chronic illnesses, yet their effects on drug pharmacokinetics remain underexplored. This study elucidated the impact of VSL#3 on the metabolism of probe drugs for cytochrome P450 enzymes (P450s), specifically omeprazole, tolbutamide, midazolam, metoprolol, phenacetin, and chlorzoxazone. Male Wistar rats were administered drinking water containing VSL#3 or not for 14 days and then intragastrically administered a P450 probe cocktail; this was done to investigate the host P450’s metabolic phenotype. Stool, liver/jejunum, and serum samples were collected for 16S ribosomal RNA sequencing, RNA sequencing, and bile acid profiling. The results indicated significant differences in both α and β diversity of intestinal microbial composition between the probiotic and vehicle groups in rats. In the probiotic group, the bioavailability of omeprazole increased by 269.9%, whereas those of tolbutamide and chlorpropamide decreased by 28.1% and 27.4%, respectively. The liver and jejunum exhibited 1417 and 4004 differentially expressed genes, respectively, between the two groups. In the probiotic group, most of P450 genes were upregulated in the liver but downregulated in the jejunum. The expression of genes encoding metabolic enzymes and drug transporters also changed. The serum-conjugated bile acids in the probiotic group were significantly reduced. Shorter duodenal villi and longer ileal villi were found in the probiotic group. In summary, VSL#3 administration altered the gut microbiota, host drug–processing gene expression, and intestinal structure in rats, which could be reasons for pharmacokinetic changes. SIGNIFICANCE STATEMENT This study focused on the effects of the probiotic VSL#3 on the pharmacokinetic profile of cytochrome P450 probe drugs and the expression of host drug metabolism genes. Compared with previous studies, the present study provides a comprehensive explanation for the host drug metabolism profile modified by probiotics, combined here with the bile acid profile and histopathological analysis. Full Article
chrome The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa. The two most abundant cannabinoids (9-tetrahydrocannabinol and cannabidiol) have been governmentally approved to treat selected medical conditions; however, the plant produces over 100 cannabinoids, including cannabichromene (CBC). Although the cannabinoids share a common precursor molecule, cannabigerol, they are structurally and pharmacologically unique. These differences may engender differing therapeutic potentials. In this review, we will examine what is currently known about CBC with regards to pharmacodynamics, pharmacokinetics, and receptor profile. We will also discuss the therapeutic areas that have been examined for this cannabinoid, notably antinociceptive, antibacterial, and anti-seizure activities. Finally, we will discuss areas where new research is needed and potential novel medicinal applications for CBC. SIGNIFICANCE STATEMENT Cannabichromene (CBC) has been suggested to have disparate therapeutic benefits such as anti-inflammatory, anticonvulsant, antibacterial, and antinociceptive effects. Most of the focus on the medical benefits of cannabinoids has been focused on 9-tetrahydrocannabinol and cannabidiol. The preliminary studies on CBC indicate that this phytocannabinoid may have unique therapeutic potential that warrants further investigation. Following easier access to hemp, CBC products are commercially available over-the-counter and are being widely utilized with little or no evidence of their safety or efficacy. Full Article
chrome Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism [Review Article] By pharmrev.aspetjournals.org Published On :: 2024-10-16T07:40:25-07:00 Our knowledge of the roles of individual cytochrome P450 (P450) enzymes in drug metabolism has developed considerably in the past 30 years, and this base has been of considerable use in avoiding serious issues with drug interactions and issues due to variations. Some newer approaches are being considered for "phenotyping" metabolism reactions with new drug candidates. Endogenous biomarkers are being used for noninvasive estimation of levels of individual P450 enzymes. There is also the matter of some remaining "orphan" P450s, which have yet to be assigned reactions. Practical problems that continue in drug development include predicting drug-drug interactions, predicting the effects of polymorphic and other P450 variations, and evaluating interspecies differences in drug metabolism, particularly in the context of "metabolism in safety testing" regulatory issues ["disproportionate (human) metabolites"]. Significance Statement Cytochrome P450 enzymes are the major catalysts involved in drug metabolism. The characterization of their individual roles has major implications in drug development and clinical practice. Full Article
chrome Cytochrome P450 Enzymes: The Old Pandoras Box with an Ever-Growing Hope for Therapy Optimization and Drug Development--Editorial [Editorial] By pharmrev.aspetjournals.org Published On :: 2024-10-16T07:40:25-07:00 Full Article
chrome Chrome for iOS now lets you add text to Google Lens visual searches By www.engadget.com Published On :: Tue, 12 Nov 2024 17:09:20 +0000 If you use Chrome on your iPhone, you’re about to see some features sliding over from the Android version. Google Lens will let you add text to your image searches, and you can save files and pictures directly to Google Drive and Photos. You can get “Shopping Insights” for products you’re browsing. Chrome for iOS now lets you add words to your Google Lens visual searches, allowing you to add nuance to your query or “perform more complex and specific searches,” as Chrome Product Manager Katia Muradyan wrote in a blog post. After activating Lens by tapping the camera icon in the Chrome search bar, you can ask questions about the object you’re snapping a pic of, and it will produce corresponding results. Google says AI Overviews will also appear for some of these search results. The feature shares some common ground with an Apple Intelligence feature for iPhone 16 owners in iOS 18.2, which is currently in beta. Visual Intelligence lets you point your camera at something and get info about it, including asking ChatGPT questions about it or searching for it on Google. Chrome for iPhone now has a feature that lets you save a file directly to Google Drive or Google Photos, sparing you from using your phone’s internal storage. When saving files from Chrome, you’ll see a new option to save the file to Drive. Similarly, when browsing a photo you want to save, long-press on it, and you’ll see a new “Save in Google Photos” option in the context menu. Of course, the feature requires you to be signed into a Google account. Chrome for iOS also adds a feature that pops up a mini-map when you click on an address. Look for an underlined link to specific addresses; clicking on it will take you to the mini-map without leaving the browser. Finally, Google is adding Shopping Insights for US users. The company frames it as a way to help you find great prices on items you’re shopping for, but it’s hard to imagine this feature exists strictly from the kindness of Google's heart. Regardless, you’ll soon see a “Good Deal Now” alert in Chrome’s address bar when browsing for products for which it’s available. You’ll see details like price history / tracking and buying options if you tap it.This article originally appeared on Engadget at https://www.engadget.com/mobile/smartphones/chrome-for-ios-now-lets-you-add-text-to-google-lens-visual-searches-170920556.html?src=rss Full Article Technology & Electronics Information Technology site|engadget provider_name|Engadget region|US language|en-US author_name|Will Shanklin
chrome 4 new Chrome improvements for iOS By blog.google Published On :: Tue, 12 Nov 2024 17:00:00 +0000 Here are four new Chrome iOS features making it even easier to use this browser across devices. Full Article Chrome
chrome 10 Best Chrome Extensions That Are Perfect for Everyone By techncruncher.blogspot.com Published On :: Mon, 31 Jan 2022 10:56:00 +0000 Are you a great Chrome user? That’s nice to hear. But first, consider whether or not there are any essential Chrome extensions you are currently missing from your browsing life, so here we're going to share with you 10 Best Chrome Extensions That Are Perfect for Everyone. So Let's Start.1. LastPassWhen you have too several passwords to remember, LastPass remembers them for you.This chrome extension is an easy way to save you time and increase security. It’s a single password manager that will log you into all of your accounts. you simply ought to bear in mind one word: your LastPass password to log in to all or any your accounts.FeaturesSave usernames and passwords and LastPasswill log you in automatically.Fill the forms quickly to save your addresses, credit card numbers and more.2. MozBarMozBar is an SEO toolbar extension that makes it easy for you to analyze your web pages' SEO while you surf. You can customize your search so that you see data for a particular region or for all regions. You get data such as website and domain authority and link profile. The status column tells you whether there are any no-followed links to the page.You can also compare link metrics. There is a pro version of MozBar, too.3. GrammerlyGrammarly is a real-time grammar checking and spelling tool for online writing. It checks spelling, grammar, and punctuation as you type, and has a dictionary feature that suggests related words. if you use mobile phones for writing than Grammerly also have a mobile keyboard app.4. VidlQVidIQ is a SaaS product and Chrome Extension that makes it easier to manage and optimize your YouTube channels. It keeps you informed about your channel's performance with real-time analytics and powerful insights.FeaturesLearn more about insights and statistics beyond YouTube AnalyticsFind great videos with the Trending tab.You can check out any video’s YouTube rankings and see how your own video is doing on the charts.Keep track the history of the keyword to determine when a keyword is rising or down in popularity over time.Quickly find out which videos are performing the best on YouTube right now.Let this tool suggest keywords for you to use in your title, description and tags.5. ColorZillaColorZilla is a browser extension that allows you to find out the exact color of any object in your web browser. This is especially useful when you want to match elements on your page to the color of an image.Features Advanced Color Picker (similar to Photoshop's)Ultimate CSS Gradient GeneratorThe "Webpage Color Analyzer" site helps you determine the palette of colors used in a particular website.Palette Viewer with 7 pre-installed palettesEyedropper - sample the color of any pixel on the pageColor History of recently picked colorsDisplays some info about the element, including the tag name, class, id and size.Auto copy picked colors to clipboardGet colors of dynamic hover elements Pick colors from Flash objectsPick colors at any zoom level 6. HoneyHoney is a chrome extension with which you save each product from the website and notify it when it is available at low price it's one among the highest extensions for Chrome that finds coupon codes whenever you look online.FeaturesBest for finding exclusive prices on Amazon.A free reward program called Honey Gold.Searches and filters the simplest value fitting your demand. Instant notifications.7. GMass: Powerful Chrome Extension for Gmail MarketersGMass (or Gmail Mass) permits users to compose and send mass emails using Gmail. it is a great tool as a result of you'll use it as a replacement for a third-party email sending platform. you will love GMass to spice up your emailing functionality on the platform.8. Notion Web Clipper: Chrome Extension for GeeksIt's a Chrome extension for geeks that enables you to highlight and save what you see on the web.It's been designed by Notion, that could be a Google space different that helps groups craft higher ideas and collaborate effectively.FeaturesSave anything online with just one click Use it on any deviceOrganize your saved clips quicklyTag, share and comment on the clipsIf you are someone who works online, you need to surf the internet to get your business done. And often there is no time to read or analyze something. But it's important that you do it. Notion Web Clipper will help you with that.9. WhatFont: Chrome Extension for identifying Any Site FontsWhatFont is a Chrome extension that allows web designers to easily identify and compare different fonts on a page. The first time you use it on any page, WhatFont will copy the selected page.It Uses this page to find out what fonts are present and generate an image that shows all those fonts in different sizes. Besides the apparent websites like Google or Amazon, you'll conjointly use it on sites wherever embedded fonts ar used. 10. SimilarWeb: Traffic Rank & Website Analysis ExtensionSimilar Web is an SEO add on for both Chrome and Firefox.It allows you to check web site traffic and key metrics for any web site, as well as engagement rate, traffic ranking, keyword ranking, and traffic source. this is often a good tool if you are looking to seek out new and effective SEO ways similarly as analyze trends across the web.FeaturesDiscover keyword trendsKnow fresh keywordsGet benefit from the real traffic insightsAnalyze engagement metricsExplore unique visitors dataAnalyze your industry's categoryUse month to date dataHow to Install chrome Extension in AndroidI know everyone knows how to install extension in pc but most of people don't know how to install it in android phone so i will show you how to install it in android1. Download Kiwi browser from Play Store and then Open it. Advertisement Continue reading below 2. Tap the three dots at the top right corner and select Extension. 3. Click on (+From Store) to access chrome web store or simple search chrome web store and access it.4. Once you found an extension click on add to chrome a message will pop-up asking if you wish to confirm your choice. Hit OK to install the extension in the Kiwi browser.5. To manage extensions on the browser, tap the three dots in the upper right corner. Then select Extensions to access a catalog of installed extensions that you can disable, update or remove with just a few clicks.Your Chrome extensions should install on Android, but there’s no guarantee all of them will work. Because Google Chrome Extensions are not optimized for Android devices.Final SayingWe hope this list of 10 best chrome extensions that is perfect for everyone will help you in picking the right Chrome Extensions. We have selected the extensions after matching their features to the needs of different categories of people. Also which extension you like the most let me know in the comment section Full Article Chrome Extension
chrome Google rolls out new features in Chrome for iPhone users - Moneycontrol By news.google.com Published On :: Wed, 13 Nov 2024 03:41:56 GMT Google rolls out new features in Chrome for iPhone users Moneycontrol4 new Chrome improvements for iOS The KeywordStop Using Chrome On Your iPhone, Warns Apple—Millions Of Users Must Now Decide ForbesChrome 131 for iOS adding new Google Drive, Maps integrations 9to5GoogleChrome for iOS now lets you add text to Google Lens visual searches Engadget Full Article
chrome Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function By pubs.rsc.org Published On :: Mol. Syst. Des. Eng., 2024, Advance ArticleDOI: 10.1039/D3ME00196B, PaperYan-Yan Li, Yu Feng, Lu Yu, Shuang-Shuang Long, Shu-Qin Gao, Ying-Wu LinAn artificial disulfide bond was rationally constructed in human cytochrome c (hCyt c) via double mutations (A51C/G77C), which weakened the coordination of Met80 to the heme iron and enhanced the peroxidase activity of hCyt c.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
chrome Chrome on Android to support third-party autofill services natively By developers.googleblog.com Published On :: Chrome on Android will soon natively support third-party autofill services, providing a smoother user experience. Full Article
chrome DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35 By www.html5rocks.com Published On :: Thu, 26 Jun 2014 00:00:00 +0000 Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more. Full Article
chrome Tab Discarding in Chrome: a Memory-Saving Experiment By developers.google.com Published On :: Tue, 01 Sep 2015 00:00:00 +0000 Full Article
chrome Smart RSS Reader is a feed reader extension for Firefox and Chrome By www.rss-specifications.com Published On :: Fri, 1 Jan 2021 12:31:44 -0500 Smart RSS Reader is a feed reader extension for Firefox and Chrome. Install the add-on and click its toolbar icon to open a new tab with the extension's RSS reader. It has three panes, each of which has a toolbar at the top. The left pane is the feeds pane and lists all RSS feeds that you are subscribed too. Selecting a feed displays the title of the articles published by the site in the center pane. It also displays the author's name and the date when the article went live. Full Article
chrome 631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome By shoptalkshow.com Published On :: Mon, 02 Sep 2024 08:01:07 +0000 Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers. Full Article All Episodes Chrome LLM notion second brain
chrome 633: Thomas Steiner on AI in Chrome and the Web By shoptalkshow.com Published On :: Mon, 16 Sep 2024 09:30:53 +0000 Thomas Steiner from Project Fugu talks with us about AI in Chrome, the small large language model in use, how features like this are rolled out, the ethics and concerns around sending and sharing data, on device vs web APIs, and ideas for use cases and ways to explore AI on the web. Full Article All Episodes AI Chrome Fugu
chrome Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35215-35219DOI: 10.1039/D4RA05941G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Antonia Behnsen, Gesa Hertrampf, Sandra Vojnović, Jasmina Nikodinović-Runić, Tobias A. M. GulderThe myxocoumarins are natural products with strong antibiotic activity. We herein explored structural simplification of the myxocoumarins while aiming to retain their antibacterial properties. This led to the discovery of potent myxochromene diones.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
chrome Mediated electron transfer in a photo-bioreactor: continuous flow hydroxylation using cytochrome P450 BM3 in NADPH-free conditions By pubs.rsc.org Published On :: React. Chem. Eng., 2024, 9,803-815DOI: 10.1039/D3RE00569K, PaperAli Fendri, Donya Valikhani, Joelle N. PelletierWe designed a proof-of-concept photo-bioreactor enabling continuous flow NADPH-free activation of cytochrome P450 BM3 via mediated electron transfer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
chrome Nanoscopic visualization of microgel-immobilized cytochrome P450 enzymes and their local activity By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20194-20201DOI: 10.1039/D4NR03435J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lukas Schubert, Chiara Nenninger, Maximilian Nöth, Thomke Belthle, Robert Dirk de Lange, Andrij Pich, Ulrich Schwaneberg, Dominik WöllThe distribution and local catalytic activity of Cytochrome P450 enzymes immobilized in microgels by electrostatic interaction has been determined with a combination of in situ super-resolution fluorescence microscopy experiments.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
chrome Asus launches ExpertBook CX54 Chromebook Plus with 14th gen Intel Core Ultra 7 By www.thehindu.com Published On :: Thu, 17 Oct 2024 13:13:54 +0530 The Taiwanese company claims that ExpertBook CX54 Chromebook Plus got the MIL-STD-810H standards for durability Full Article Gadgets
chrome IFA Berlin 2022: Lenovo launches new 16-inch Chromebook, tablets By www.thehindubusinessline.com Published On :: Thu, 01 Sep 2022 17:14:21 +0530 New devices focus on making the most of gadgets at home and work Full Article Other Gadgets
chrome Google Chromebook Now Available for $299 By labnol.tumblr.com Published On :: Tue, 22 Nov 2011 05:50:59 +0530 Google Chromebook Now Available for $299 Full Article
chrome Google Chromebook Now Available for $299 By labnol.tumblr.com Published On :: Tue, 22 Nov 2011 21:42:29 +0530 Google Chromebook Now Available for $299 Full Article
chrome Chrome Has A Different Take On Certificate Revocation By packetstormsecurity.com Published On :: Tue, 22 Apr 2014 15:09:19 GMT Full Article headline privacy flaw google ssl chrome cryptography
chrome Video hands-on with Google's new $249 Chromebook By feeds.reuters.com Published On :: Thu, 18 Oct 2012 13:02:57 -0400 Google’s newest Chromebook, made by Samsung, only costs $249 and offers the same general performance of ChromeOS is a smaller, lighter package. How’d they do it? This model uses the same chip type that powers smartphones and tablets. Take a look at my hands-on thoughts. Full Article
chrome For $199, is Acer's C7 Chromebook worth it? By feeds.reuters.com Published On :: Wed, 14 Nov 2012 14:54:01 -0500 Google surprised many with the launch of a $199 Chromebook this week. So what's the Acer C7 like? Overall the quality and performance is better than I expected for the price and it even has a 320 GB hard drive for those who want local storage. Full Article
chrome How impressive is the Chromebook Pixel? Very! By feeds.reuters.com Published On :: Sat, 23 Feb 2013 17:33:57 -0500 I've been using a Chromebook Pixel for the past two days and a single phrase comes to mind: blown away. Is it worth $1,299 or more? Take a look to see and then stack it up against your mobile computing needs. Full Article
chrome Multitasking with Chrome OS and Linux on the Chromebook Pixel By feeds.reuters.com Published On :: Tue, 05 Mar 2013 17:51:59 -0500 Google's Chromebook Pixel is quite versatile after all. I can run Chrome OS and Linux at the same time, and switch between the two, allowing me to use Skype and other third party apps! Full Article
chrome High def video gaming on the Chromebook Pixel: Thank you Steam! By feeds.reuters.com Published On :: Wed, 03 Apr 2013 17:21:25 -0400 While the Chrome browser takes full advantage of the Chromebook Pixel's hardware, I thought it would interesting to see how video gaming works on the device. Quite well, with just a few small issues, it turns out. Full Article
chrome Update your Google Chrome browser immediately: CERT-In By Published On :: Update your Google Chrome browser immediately: CERT-In Full Article
chrome Low-dose X-ray structure analysis of cytochrome c oxidase utilizing high-energy X-rays By scripts.iucr.org Published On :: 2019-06-14 To investigate the effect of high-energy X-rays on site-specific radiation-damage, low-dose diffraction data were collected from radiation-sensitive crystals of the metal enzyme cytochrome c oxidase. Data were collected at the Structural Biology I beamline (BL41XU) at SPring-8, using 30 keV X-rays and a highly sensitive pixel array detector equipped with a cadmium telluride sensor. The experimental setup of continuous sample translation using multiple crystals allowed the average diffraction weighted dose per data set to be reduced to 58 kGy, and the resulting data revealed a ligand structure featuring an identical bond length to that in the damage-free structure determined using an X-ray free-electron laser. However, precise analysis of the residual density around the ligand structure refined with the synchrotron data showed the possibility of a small level of specific damage, which might have resulted from the accumulated dose of 58 kGy per data set. Further investigation of the photon-energy dependence of specific damage, as assessed by variations in UV-vis absorption spectra, was conducted using an on-line spectrometer at various energies ranging from 10 to 30 keV. No evidence was found for specific radiation damage being energy dependent. Full Article text
chrome The crystal structure of the heme d1 biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo By journals.iucr.org Published On :: The crystal structure of the c-type cytochrome NirC from Pseudomonas aeruginosa has been determined and reveals the simultaneous presence of monomers and 3D domain-swapped dimers in the same asymmetric unit. Full Article text
chrome 3-(4-Iodophenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one By scripts.iucr.org Published On :: 2020-01-31 In the title compound, C19H13IO2, the dihedral angle between the naphthyl ring system and the pendant iodophenyl ring is 72.48 (11)°. In the crystal, C—H⋯π interactions and I⋯O [3.293 (2) Å] halogen bonds are observed, which combine to generate a herringbone packing motif. Full Article text
chrome 6-Methyl-4-{[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]methyl}-2H-chromen-2-one By scripts.iucr.org Published On :: 2020-04-03 In the title compound, C16H19N3O2Si, the dihedral angle between the coumarin ring system (r.m.s. deviation = 0.031 Å) and the triazole ring is 73.81 (8)°. In the crystal, molecules are linked into [010] chains by weak C—H⋯O interactions. Full Article text
chrome Crystal structure and Hirshfeld surface analysis of 2-[(2-oxo-2H-chromen-4-yl)oxy]acetic acid dimethyl sulfoxide monosolvate By scripts.iucr.org Published On :: 2019-07-09 The title compound, C11H8O5·(CH3)2SO, is a new coumarin derivative. The asymmetric unit contains two coumarin molecules (A and B) and two dimethylsulfoxide solvent molecules (A and B). The dihedral angle between the pyran and benzene rings in the chromene moiety is 3.56 (2)° for molecule A and 1.83 (2)° for molecule B. In molecule A, the dimethyl sulfoxide sulfur atom is disordered over two positions with a refined occupancy ratio of 0.782 (5):0.218 (5). In the crystal, molecules are linked by O—H⋯O hydrogen bonds, forming chains running along the c-axis direction. The chains are linked by C—H⋯O hydrogen bonds, forming layers parallel to the ac plane. In addition, there are also C—H⋯π and π–π interactions present within the layers. The intermolecular contacts in the crystal have been analysed using Hirshfeld surface analysis and two-dimensional fingerprint plots, which indicate that the most important contributions to the packing are from H⋯H (33.9%) and O⋯H/H⋯O (41.2%) contacts. Full Article text
chrome Crystal structures of two new isocoumarin derivatives: 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one By scripts.iucr.org Published On :: 2019-07-09 The title compounds, 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one, C22H17NO2, (I), and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one, C14H17NO2, (II), are new isocoumarin derivatives in which the isochromene ring systems are planar. Compound II crystallizes with two independent molecules (A and B) in the asymmetric unit. In I, the two phenyl rings are inclined to each other by 56.41 (7)° and to the mean plane of the 1H-isochromene ring system by 67.64 (6) and 44.92 (6)°. In both compounds, there is an intramolecular N—H⋯O hydrogen bond present forming an S(6) ring motif. In the crystal of I, molecules are linked by N—H⋯π interactions, forming chains along the b-axis direction. A C—H⋯π interaction links the chains to form layers parallel to (100). The layers are then linked by a second C—H⋯π interaction, forming a three-dimensional structure. In the crystal of II, the two independent molecules (A and B) are linked by N—H⋯O hydrogen bonds, forming –A–B–A–B– chains along the [101] direction. The chains are linked into ribbons by C—H⋯π interactions involving inversion-related A molecules. The latter are linked by offset π–π interactions [intercentroid distances vary from 3.506 (1) to 3.870 (2) Å], forming a three-dimensional structure. Full Article text
chrome Crystal structures and Hirshfeld surface analyses of (E)-N'-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice ene By scripts.iucr.org Published On :: 2019-09-03 The crystal structures of the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide, C20H18N2O6·0.5C2H6OS, and (E)-N'-benzylidene-2-oxo-2H-chromene-3-carbohydrazide, C17H12N2O3 (4: R = C6H5), are discussed. The non-hydrogen atoms in compound [4: R = (3,4,5-MeO)3C6H2)] exhibit a distinct curvature, while those in compound, (4: R = C6H5), are essential coplanar. In (4: R = C6H5), C—H⋯O and π–π intramolecular interactions combine to form a three-dimensional array. A three-dimensional array is also found for the hemi-DMSO solvate of [4: R = (3,4,5-MeO)3C6H2], in which the molecules of coumarin are linked by C—H⋯O and C—H⋯π interactions, and form tubes into which the DMSO molecules are cocooned. Hirshfeld surface analyses of both compounds are reported, as are the lattice energy and intermolecular interaction energy calculations of compound (4: R = C6H5). Full Article text
chrome The crystal structures and Hirshfeld surface analysis of 6-(naphthalen-1-yl)-6a-nitro-6,6a,6b,7,9,11a-hexahydrospiro[chromeno[3',4':3,4]pyrrolo[1,2-c]thiazole-11,11'-indeno[1,2-b]quinoxaline] and 6'-(naphthalen-1-yl)-6a By scripts.iucr.org Published On :: 2019-09-27 The title compounds, 6-(naphthalen-1-yl)-6a-nitro-6,6a,6 b,7,9,11a-hexahydrospiro[chromeno[3',4':3,4]pyrrolo[1,2-c]thiazole-11,11'-indeno[1,2-b]quinoxaline], C37H26N4O3S, (I), and 6'-(naphthalen-1-yl)-6a'-nitro-6',6a',6b',7',8',9',10',12a'-octahydro-2H-spiro[acenaphthylene-1,12'-chromeno[3,4-a]indolizin]-2-one, C36H28N2O4, (II), are new spiro derivatives, in which both the pyrrolidine rings adopt twisted conformations. In (I), the five-membered thiazole ring adopts an envelope conformation, while the eight-membered pyrrolidine-thiazole ring adopts a boat conformation. An intramolecular C—H⋯N hydrogen bond occurs, involving a C atom of the pyran ring and an N atom of the pyrazine ring. In (II), the six-membered piperidine ring adopts a chair conformation. An intramolecular C—H⋯O hydrogen bond occurs, involving a C atom of the pyrrolidine ring and the keto O atom. For both compounds, the crystal structure is stabilized by intermolecular C—H⋯O hydrogen bonds. In (I), the C—H⋯O hydrogen bonds link adjacent molecules, forming R22(16) loops propagating along the b-axis direction, while in (II) they form zigzag chains along the b-axis direction. In both compounds, C—H⋯π interactions help to consolidate the structure, but no significant π–π interactions with centroid–centroid distances of less than 4 Å are observed. Full Article text
chrome Crystal structures of two 4H-chromene derivatives: 2-amino-3-cyano-4-(3,4-dichlorophenyl)-7-hydroxy-4H-benzo[1,2-b]pyran 1,4-dioxane monosolvate and 2-amino-3-cyano-4-(2,6-dichlorophenyl)-7-hydroxy-4H-benzo[ By scripts.iucr.org Published On :: 2019-09-27 In the title compounds, C16H9Cl2N2O2·C4H8O2 and C16H9Cl2N2O2, the bicyclic 4H-chromene cores are nearly planar with maximum deviations of 0.081 (2) and 0.087 (2) Å. In both structures, the chromene derivative molecules are linked into centrosymmetric dimers by pairs of N—H⋯O hydrogen bonds, forming R22(16) motifs. These dimers are further linked in the 3,4-dichlorophenyl derivative by N—H⋯N hydrogen bonds into double layers parallel to (100) and in the 2,6-dichlorophenyl derivative by O—H⋯N hydrogen bonds into ribbons along the [1overline{1}0] direction. In the 3,4-dichlorophenyl derivative, the 1,4-dioxane solvent molecules are connected to the chromene molecules via O—H⋯O hydrogen bonds. Full Article text
chrome Crystal structures of 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene By scripts.iucr.org Published On :: 2019-10-31 Two thiochromene compounds containing Br and F atoms, namely 2-(2-bromo-5-fluorophenyl)-8-ethoxy-3-nitro-2H-thiochromene (C17H13BrFNO3S, A) and 2-(2-bromo-5-fluorophenyl)-7-methoxy-3-nitro-2H-thiochromene (C16H11BrFNO3S, B), were prepared via the condensation reaction between 2-mercaptobenzaldehyde and nitrostyrene derivatives. In both compounds, the thiochromene plane is almost perpendicular to the phenyl ring. In the structure of A, molecules are assembled via π–π stacking and C—H⋯O and C—F⋯π interactions. In the crystal packing of B, molecules are linked by C—H⋯F, C—H⋯O, C—H⋯π and π–π interactions. Full Article text
chrome Crystal structures and Hirshfeld surface analyses of (E)-N'-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N'-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice ene By scripts.iucr.org Published On :: 2019-11-29 In the paper by Gomes et al. [Acta Cryst. (2019), E75, 1403–1410], there was an error and omission in the author and affiliation list. Full Article text
chrome Crystal structure of a new polymorph of 3-acetyl-8-methoxy-2H-chromen-2-one By scripts.iucr.org Published On :: 2019-11-15 A new polymorphic form of the title compound, C12H10O4, is described in the orthorhombic space group Pbca and Z = 8, as compared to polymorph I, which crystallizes in the monoclinic space group C2/c and Z = 8 [Li et al. (2012). Chin. J. Struct. Chem. 31, 1003–1007.]. In polymorph II, the coumarin ring system is almost planar (r.m.s. deviation = 0.00129 Å). In the crystal, molecules are connected by Csp3—H⋯O and Car—H⋯O hydrogen bonds, forming molecular sheets linked into zigzag shaped layers along the b-axis direction. The three-dimensional lattice is assembled through stacking of the zigzag layers by π–π interactions with a centroid-to-centroid distance of 3.600 (9) Å and antiparallel C=O⋯C=O interactions with a distance of 3.1986 (17) Å, which give rise to a helical supramolecular architecture. Full Article text
chrome The crystal structure of the heme d1 biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo By scripts.iucr.org Published On :: 2020-03-25 Monoheme c-type cytochromes are important electron transporters in all domains of life. They possess a common fold hallmarked by three α-helices that surround a covalently attached heme. An intriguing feature of many monoheme c-type cytochromes is their capacity to form oligomers by exchanging at least one of their α-helices, which is often referred to as 3D domain swapping. Here, the crystal structure of NirC, a c-type cytochrome co-encoded with other proteins involved in nitrite reduction by the opportunistic pathogen Pseudomonas aeruginosa, has been determined. The crystals diffracted anisotropically to a maximum resolution of 2.12 Å (spherical resolution of 2.83 Å) and initial phases were obtained by Fe-SAD phasing, revealing the presence of 11 NirC chains in the asymmetric unit. Surprisingly, these protomers arrange into one monomer and two different types of 3D domain-swapped dimers, one of which shows pronounced asymmetry. While the simultaneous observation of monomers and dimers probably reflects the interplay between the high protein concentration required for crystallization and the structural plasticity of monoheme c-type cytochromes, the identification of conserved structural motifs in the monomer together with a comparison with similar proteins may offer new leads to unravel the unknown function of NirC. Full Article text
chrome Remove the Power App Chrome Extension By www.bleepingcomputer.com Published On :: Mon, 28 Oct 2019 17:05:22 EDT Power App is a Google Chrome extension that has a description of "This extension configures your Default Search to Power App (searchpowerapp.com)". This article was published first at Remove the Power App Chrome Extension Full Article Spyware Removal Virus Removal Malware Removal Security Power App Chrome Extension Browser Extensions and Add-ons
chrome Remove the Flash App+ Chrome Extension By www.bleepingcomputer.com Published On :: Thu, 13 Feb 2020 17:11:21 EST Flash App+ is a Google Chrome extension that has a description of "This extension configures your Default Search to Flash App+ (searchpowerapp.com)". This article was published first at Remove the Flash App+ Chrome Extension Full Article Spyware Removal Virus Removal Malware Removal Security Flash App+ Chrome Extension Browser Extensions and Add-ons
chrome Remove the Wisip Chrome Extension By www.bleepingcomputer.com Published On :: Fri, 13 Mar 2020 15:27:02 EDT Wisip is a Google Chrome extension that has a description of "This extension configures your Default Search to Smash Search (srchus.xyz)". This article was published first at Remove the Wisip Chrome Extension Full Article Spyware Removal Virus Removal Malware Removal Security Wisip Chrome Extension Browser Extensions and Add-ons
chrome is Vista, using a Chrome browser, safe to surf the web? By www.bleepingcomputer.com Published On :: 2019-08-31T16:34:47-05:00 Full Article
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