The Search Engine Experiment gives you the results from Yahoo, MSN, and Google without saying which is which. Currently, 41% of those who have taken the test picked Google (33% Yahoo, 26% MSN).

Australian golfer Jeffrey Guan has lost sight in his left eye after being hit by a ball at a pro-am tournament.

Brummie painter tells Radio WM how Stephen knight came to commission his artwork

Aim/Purpose: This paper proposes a new approach to developing a deep learning-based prototyping wearable model which can assist blind and visually disabled people to recognize their environments and navigate through them. As a result, visually impaired people will be able to manage day-to-day activities and navigate through the world around them more easily. Background: In recent decades, the development of navigational devices has posed challenges for researchers to design smart guidance systems for visually impaired and blind individuals in navigating through known or unknown environments. Efforts need to be made to analyze the existing research from a historical perspective. Early studies of electronic travel aids should be integrated with the use of assistive technology-based artificial vision models for visually impaired persons. Methodology: This paper is an advancement of our previous research work, where we performed a sensor-based navigation system. In this research, the navigation of the visually disabled person is carried out with a vision-based 3D-designed wearable model and a vision-based smart stick. The wearable model used a neural network-based You Only Look Once (YOLO) algorithm to detect the course of the navigational path which is augmented by a GPS-based smart Stick. Over 100 images of each of the three classes, namely straight path, left path and right path, are being trained using supervised learning. The model accurately predicts a straight path with 79% mean average precision (mAP), the right path with 83% mAP, and the left path with 85% mAP. The average accuracy of the wearable model is 82.33% and that of the smart stick is 96.14% which combined gives an overall accuracy of 89.24%. Contribution: This research contributes to the design of a low-cost navigational standalone system that will be handy to use and help people to navigate safely in real-time scenarios. The challenging self-built dataset of various paths is generated and transfer learning is performed on the YOLO-v5 model after augmentation and manual annotation. To analyze and evaluate the model, various metrics, such as model losses, recall value, precision, and maP, are used. Findings: These were the main findings of the study: • To detect objects, the deep learning model uses a higher version of YOLO, i.e., a YOLOv5 detector, that may help those with visual im-pairments to improve their quality of navigational mobilities in known or unknown environments. • The developed standalone model has an option to be integrated into any other assistive applications like Electronic Travel Aids (ETAs) • It is the single neural network technology that allows the model to achieve high levels of detection accuracy of around 0.823 mAP with a custom dataset as compared to 0.895 with the COCO dataset. Due to its lightning-speed of 45 FPS object detection technology, it has become popular. Recommendations for Practitioners: Practitioners can help the model’s efficiency by increasing the sample size and classes used in training the model. Recommendation for Researchers: To detect objects in an image or live cam, there are various algorithms, e.g., R-CNN, Retina Net, Single Shot Detector (SSD), YOLO. Researchers can choose to use the YOLO version owing to its superior performance. Moreover, one of the YOLO versions, YOLOv5, outperforms its other versions such as YOLOv3 and YOLOv4 in terms of speed and accuracy. Impact on Society: We discuss new low-cost technologies that enable visually impaired people to navigate effectively in indoor environments. Future Research: The future of deep learning could incorporate recurrent neural networks on a larger set of data with special AI-based processors to avoid latency.

As evidenced by recent legislation and media attention, eradicating gender inequity in the workforce is of significant importance today. However, this interest in justice stands in bold contrast to the continued wage gap, the steady number of gender discrimination suits filed, and the plethora of cases exposed in the media. Previous data collected in 2006 suggests that university students do not perceive gender discrimination as a threat of major significance to themselves or others. University students tend to minimize or even disregard the likelihood that they will witness or experience gender bias or discrimination in their career. The current study serves as a continuation of and a comparison to the 2006 study, with the goal of determining whether the perspective of university students has shifted, or whether they continue to consider themselves to be immune to the injustice of gender discrimination at work. Our findings suggest that students in this cohort are not only more acutely aware of these issues, but that this awareness has expanded to include increased concern over gender discrimination against men as well. The reluctance of students to believe that they personally will be unaffected by gender discrimination has been and continues to be surprisingly high.

India blind cricket team players. — CABI/File

With the Blind T20 World Cup in Pakistan just days away, the Indian government has yet to clear its blind cricket team for participation, India Today reported.

Although the Sports Ministry has issued a No Objection Certificate for...

This undated photo shows Pakistan blind cricket team. — Pakistan Blind Cricket Council

ISLAMABAD: A 16-member squad led by Nasir Ali has been announced by the Pakistan Blind Cricket Council for the upcoming Blind T20 World Cup 2024, slated to be held in Pakistan from...

Joseph is legally blind, making the cleanup after Hurricane Milton particularly challenging. Operation Blessing provides a team of volunteers to restore his property and minister to his spirit. 

The preceding is the beginning of a song performed by Styx that was a hit in the ’80s. It describes the trials and tribulations that many people faced during that time by misusing a certain illegal white substance.

Because OSHA already considers a blind or blanking plate to be a lockout, how is the blind-flange lockout device a safety improvement?

You may not know the name for it, but if you drive at night, you’ve probably experienced situational night blindness. It can occur “when you are temporarily blinded by a bright light such as an oncoming car’s headlights,” the Texas Department of Insurance says.

Buskirk-Chumley Theater
Saturday, November 16, 2024, 7:30 – 10pm

The Blind Boys are known for crossing multiple musical boundaries with their remarkable interpretations of everything from traditional gospel favorites to contemporary spiritual material by songwriters such as Eric Clapton, Prince, and Tom Waits. They have appeared on recordings with many artists, including Lou Reed, Peter Gabriel, Bonnie Raitt, Willie Nelson, Aaron Neville, Susan Tedeschi, Ben Harper, Patty Griffin, and Taj Mahal.

Blind Boys of Alabama released 'Echoes Of The South’ on Aug 25, 2023, which finds the Gospel Music Hall of Fame inductees coming home to honor those they've lost on a bold declaration of how far they still plan to go. The eleven-song collection is a portrait of perseverance from a group well-versed in overcoming incredible odds - from singing for pocket change in the Jim Crow South to performing for three different American presidents, soundtracking the Civil Rights movement, and helping define modern gospel music as we know it. Recently, the group's decades-long mission of spreading light and love has taken on even deeper context as they've reckoned with the loss of two of their own, Paul Beasley and Benjamin Moore, both longtime members of the Blind Boys’ tight-knit family. 'Echoes Of The South' is released in their honor - as well as for the group's recently-retired leader, Jimmy Carter - and keeps the Blind Boys' long-held mission statement at its core: “As long as everybody gives all that they have to give and we sing songs that touch the heart, we'll live on forever.”

In 2022, the group had a collaborative recording with Béla Fleck, nominated for a Grammy. The nominated collaboration, "I Wish I Knew How It Would Feel to Be Free," powerfully reimagines the anthem of the Civil Rights Movement, originally made famous by Nina Simone. They also have had collaborative recordings and coinciding tours with both Marc Cohn and afro-pop duo Amadou & Mariam. In 2023, Blind Boys garnered another Grammy nomination for Best Americana Single for 'The Message' featuring Black Violin.

2024 started off the year with a return to the GRAMMY® Awards with three nominations and one win for Best Roots Gospel Album - 'Echoes Of The South.’ This was followed by a sold-out tour in Australia and a sizzling performance with Sir Tom Jones during the Bluesfest Byron Bay (Australia), where video of their rehearsal reached 750K + views in 48 hours on social platforms. The definitive book, titled Spirit of the Century, was released in March 2024. It’s an insider history of the Blind Boys of Alabama, the longest-running group in American music, and the untold story of their world written with band members and key musical colleagues.

Contact: BCT Box Office, boxoffice@buskirkchumley.org
Cost: $40 - $65
Ticket Phone: 812-323-3020
Ticket Web Link: buskirkchumley.org…
Communities: Bloomington

I must confess that I have never penned a column with a heavier heart. My beloved country, the United States of America, is in trouble.

Jack Smith’s prosecution (or was it “persecution”) of Gov. Bob McConnell was so overly zealous that it provided an extremely rare unanimous Supreme Court repudiation of it. Bob McConnell’s legal expenses amounted to a devastating $27 million.

The results of the seventh blind test of crystal structure prediction are presented, focusing on structure generation methods.

The results of the seventh blind test of crystal structure prediction are presented, focusing on structure ranking methods.

Accurate modeling of conformational energies is key to the crystal structure prediction of conformational polymorphs. Focusing on molecules XXXI and XXXII from the seventh blind test of crystal structure prediction, this study employs various electronic structure methods up to the level of domain-local pair natural orbital coupled cluster singles and doubles with perturbative triples [DLPNO-CCSD(T1)] to benchmark the conformational energies and to assess their impact on the crystal energy landscapes. Molecule XXXI proves to be a relatively straightforward case, with the conformational energies from generalized gradient approximation (GGA) functional B86bPBE-XDM changing only modestly when using more advanced density functionals such as PBE0-D4, ωB97M-V, and revDSD-PBEP86-D4, dispersion-corrected second-order Møller–Plesset perturbation theory (SCS-MP2D), or DLPNO-CCSD(T1). In contrast, the conformational energies of molecule XXXII prove difficult to determine reliably, and variations in the computed conformational energies appreciably impact the crystal energy landscape. Even high-level methods such as revDSD-PBEP86-D4 and SCS-MP2D exhibit significant disagreements with the DLPNO-CCSD(T1) benchmarks for molecule XXXII, highlighting the difficulty of predicting conformational energies for complex, drug-like molecules. The best-converged predicted crystal energy landscape obtained here for molecule XXXII disagrees significantly with what has been inferred about the solid-form landscape experimentally. The identified limitations of the calculations are probably insufficient to account for the discrepancies between theory and experiment on molecule XXXII, and further investigation of the experimental solid-form landscape would be valuable. Finally, assessment of several semi-empirical methods finds r2SCAN-3c to be the most promising, with conformational energy accuracy intermediate between the GGA and hybrid functionals and a low computational cost.

The seventh blind test of crystal structure prediction (CSP) methods substantially increased the level of complexity of the target compounds relative to the previous tests organized by the Cambridge Crystallographic Data Centre. In this work, the performance of density-functional methods is assessed using numerical atomic orbitals and the exchange-hole dipole moment dispersion correction (XDM) for the energy-ranking phase of the seventh blind test. Overall, excellent performance was seen for the two rigid molecules (XXVII, XXVIII) and for the organic salt (XXXIII). However, for the agrochemical (XXXI) and pharmaceutical (XXXII) targets, the experimental polymorphs were ranked fairly high in energy amongst the provided candidate structures and inclusion of thermal free-energy corrections from the lattice vibrations was found to be essential for compound XXXI. Based on these results, it is proposed that the importance of vibrational free-energy corrections increases with the number of rotatable bonds.

A seventh blind test of crystal structure prediction has been organized by the Cambridge Crystallographic Data Centre. The results are presented in two parts, with this second part focusing on methods for ranking crystal structures in order of stability. The exercise involved standardized sets of structures seeded from a range of structure generation methods. Participants from 22 groups applied several periodic DFT-D methods, machine learned potentials, force fields derived from empirical data or quantum chemical calculations, and various combinations of the above. In addition, one non-energy-based scoring function was used. Results showed that periodic DFT-D methods overall agreed with experimental data within expected error margins, while one machine learned model, applying system-specific AIMnet potentials, agreed with experiment in many cases demonstrating promise as an efficient alternative to DFT-based methods. For target XXXII, a consensus was reached across periodic DFT methods, with consistently high predicted energies of experimental forms relative to the global minimum (above 4 kJ mol−1 at both low and ambient temperatures) suggesting a more stable polymorph is likely not yet observed. The calculation of free energies at ambient temperatures offered improvement of predictions only in some cases (for targets XXVII and XXXI). Several avenues for future research have been suggested, highlighting the need for greater efficiency considering the vast amounts of resources utilized in many cases.

A seventh blind test of crystal structure prediction was organized by the Cambridge Crystallographic Data Centre featuring seven target systems of varying complexity: a silicon and iodine-containing molecule, a copper coordination complex, a near-rigid molecule, a cocrystal, a polymorphic small agrochemical, a highly flexible polymorphic drug candidate, and a polymorphic morpholine salt. In this first of two parts focusing on structure generation methods, many crystal structure prediction (CSP) methods performed well for the small but flexible agrochemical compound, successfully reproducing the experimentally observed crystal structures, while few groups were successful for the systems of higher complexity. A powder X-ray diffraction (PXRD) assisted exercise demonstrated the use of CSP in successfully determining a crystal structure from a low-quality PXRD pattern. The use of CSP in the prediction of likely cocrystal stoichiometry was also explored, demonstrating multiple possible approaches. Crystallographic disorder emerged as an important theme throughout the test as both a challenge for analysis and a major achievement where two groups blindly predicted the existence of disorder for the first time. Additionally, large-scale comparisons of the sets of predicted crystal structures also showed that some methods yield sets that largely contain the same crystal structures.

Se-Kure Domes and Mirrors is a true Made in America manufacturer of mirrored safety products. Full 360-degree domes from 18” to 60” in diameter, 180 & 90-degree domes are also available.

Erik Weihenmayer, billed as a world-class blind adventurer, delivered the traditional opening day motivational speech at this year’s NSC Congress & Expo.

Free eye screenings, eye health awareness activities and services for the blind and visually impaired community being offered at a Vision Fair at Cal State Los Angeles, Lot 5, on October 15, 2022.

"Work Comp Matters" - the central location for all your workers' compensation, employment and labor law matters. Steve Appell hosts this weekly podcast from sunny southern California - presenting some…

“From alarms and task chunking to time-estimation exercises, the strategies below can help you develop a more ‘ACCURATE’ sense of time.”

Motivated both by rising energy costs and sustainability concerns related to climate change, consumers have grown more desirous of energy-efficient living.

Vision damage from a complication of premature birth can be halted if it’s caught soon enough — and a California Perinatal Quality Care (CPQCC) and Stanford Medicine-led study shows the state’s screening process is helping close racial gaps.

The post California excels at screening babies for main cause of childhood blindness appeared first on Scope.

El líder del PSE-EE reúne en un acto solemne en el palacio de Miramar a los consejeros socialistas, parlamentarios y altos cargos de Gipuzkoa para conjurarse en la defensa del Estatuto de Gernika. Califica de "adorno" al 'nuevo estatus' en vísperas de reunirse con Andoni Ortuzar. Leer

La maniobra ha hecho emerger uno de los reproches más repetidos a Marlaska: las dos varas de medir que le atribuyen en los dos cuerpos de seguridad Leer

Una sentencia, dictada tras los fallos del TC, defiende que el reparto de fondos públicos incumplía todos los procedimientos, incluido el declarado legal por el tribunal de garantías Leer

The fusiform face area (FFA) responds to touching faces in people born blind.

Location: Main Media Collection - Video record 42302 DVD

Tudor Grange date for visually impaired swimmers.

Young swimmers compete and learn at Tudor Grange.

Escuche el programa de este martes 13 de agosto. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

El gobierno del alcalde Jaume Collboni está trazando un muy complicado plan para blindar el distrito de Ciutat Vella contra los monocultivos comerciales. via Pocket

Thomas uit ‘Blind getrouwd’ over de klik met Karlien: “Ik ben nu eenmaal geen doorsnee persoon”  Het Laatste Nieuws

Willem-Alexander says Jewish people must feel safe in the Netherlands after Israeli football supporters come under attack.

Food system transformation: A blind spot for climate and biodiversity action? 20 October 2022 — 12:00PM TO 1:00PM Anonymous (not verified) 5 October 2022 Chatham House and Online

How can COP27 and COP15 accelerate the agenda for sustainable food systems and land use?

Tackling the dual crises of climate change and biodiversity loss requires extraordinary levels of action at an unprecedented speed. Agriculture is the biggest user of land, the biggest source of methane emissions, a major contributor to total greenhouse gas emissions and the leading driver of biodiversity loss.

Anything short of a food system transformation puts climate and biodiversity objectives in peril. However, governments have not yet produced credible pathways and strong policies for tackling our growing ‘foodprint’ – the negative impacts of what we grow and eat.

In advance of COP27 in Sharm El-Sheikh for climate and COP15 in Montreal for biodiversity, Chatham House has published a new briefing paper which examines aligning food systems with climate and biodiversity targets.

The paper reviews the climate and biodiversity policy landscape to 2030, with a focus on land-based aspects and the inclusion of food and agriculture. The paper highlights serious conflicts between the impacts of the food system and goals to protect and restore biodiversity and mitigate climate change.

In light of this, opportunities for joined-up action on food, climate and biodiversity are identified, including three key steps for countries to take this decade to produce suitably ambitious and effective policies across the climate–biodiversity–food nexus.

This event brings together leading voices from the international policy arenas for climate and biodiversity to react to the briefing paper and discuss how COP27 and COP15 can accelerate the agenda for sustainable food systems and land use.

Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging from rod dysfunction to rod and cone degeneration. We tested how the mutations causing recessive congenital stationary night blindness (CSNB), recessive Leber's congenital amaurosis (LCA1), and dominant cone–rod dystrophy-6 (CORD6) affected RetGC1 activity and regulation by RetGC-activating proteins (GCAPs) and retinal degeneration-3 protein (RD3). CSNB mutations R666W, R761W, and L911F, as well as LCA1 mutations R768W and G982VfsX39, disabled RetGC1 activation by human GCAP1, -2, and -3. The R666W and R761W substitutions compromised binding of GCAP1 with RetGC1 in HEK293 cells. In contrast, G982VfsX39 and L911F RetGC1 retained the ability to bind GCAP1 in cyto but failed to effectively bind RD3. R768W RetGC1 did not bind either GCAP1 or RD3. The co-expression of GUCY2D allelic combinations linked to CSNB did not restore RetGC1 activity in vitro. The CORD6 mutation R838S in the RetGC1 dimerization domain strongly dominated the Ca2+ sensitivity of cyclase regulation by GCAP1 in RetGC1 heterodimer produced by co-expression of WT and the R838S subunits. It required higher Ca2+ concentrations to decelerate GCAP-activated RetGC1 heterodimer—6-fold higher than WT and 2-fold higher than the Ser838-harboring homodimer. The heterodimer was also more resistant than homodimers to inhibition by RD3. The observed biochemical changes can explain the dominant CORD6 blindness and recessive LCA1 blindness, both of which affect rods and cones, but they cannot explain the selective loss of rod function in recessive CSNB.

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human retina: Cav1.4 splice variants with or without exon 47 (Cav1.4+ex47 and Cav1.4Δex47, respectively), and the auxiliary subunits, β2X13 and α2δ-4. We find that IT caused both Cav1.4 splice variants to activate at significantly more negative voltages and with slower deactivation kinetics than the corresponding WT channels. These effects of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in channels lacking exon 47. The weaker ion selectivity caused by IT led to hyperpolarizing shifts in the reversal potential and large outward currents that were evident in channels containing the auxiliary subunits β2X13 and α2δ-4 but not in those with β2A and α2δ-1. We conclude that the IT mutation stabilizes channel opening and alters ion selectivity of Cav1.4 in a manner that is strengthened by exclusion of exon 47 and inclusion of β2X13 and α2δ-4. Our results reveal complex actions of IT in modifying the properties of Cav1.4 channels, which may influence the pathological consequences of this mutation in retinal photoreceptors.

Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN)

Learn more about color blindness: https://www.smithsonianmag.com/smithsonian-institution/ask-smithsonian-how-does-world-look-the-color-blind-180960415/ Have a question in mind? It's your turn to Ask Smithsonian: https://www.smithsonianmag.com/smithsonian-institution/ask-smithsonian/ask-form/

Some of the brightest minds in the world gathered at Smithsonian's "The Future is Here" conference to discuss the great triumphs and future innovations in science and technology http://www.smithsonianmag.com/ideas-innovations/The-Future-is-Here.html

The viewfinders are outfitted with special lenses that help people with red-green colorblindness distinguish between hues