The 2022 IRE kicks off ABC Supply’s 40th anniversary celebration happening throughout 2022.

JobNimbus has collaborated with ABC Supply to enhance roofing contractors' material management, pricing, estimates, direct ordering, and timely notifications accessible through both JobNimbus and myABCsupply accounts.

ABC Supply continues to invest in its people, technology and communities. Learn more in this exclusive Q&A with RC.

Family-owned PABCO Roofing Products is celebrating a rich history of creating high-quality shingles during the 2024 International Roofing Expo.

The new partnership aims to provide ABC contractor members with the tools and insights to improve project outcomes and maximize profitability.

Assyrian ABCs Alphabet App

The former California congressman, consummate Donald Trump lackey and Trump Media chief executive is being accused of mismanagement and cronyism.

Seis expertos en negociación apuntaron que es necesario reconocer las necesidades del otro, así como identificar los liderazgos para avanzar en la negociación.

Seis expertos en negociación apuntaron que es necesario reconocer las necesidades del otro, así como identificar los liderazgos para avanzar en la negociación.

En Caracol Radio estuvo Hernán Penagos, registrador nacional del Estado Civil, explicando cómo la entidad ha estado trabajando para brindar nuevos servicios.

Todo lo que debe saber sobre la ley de financiamiento 

Natasha Avendaño, gerente del Acueducto, junto al alcalde Galán, anunciaron las nuevas medidas para entender el comportamiento de falta de lluvias en el Sistema Chingaza

BE Solar’s Director of Sales Joanna Frith has obtained the North American Board of Certified Energy Practitioners [NABCEP] PV Associate Certificate, with the company noting that she is the first woman in Bermuda to accomplish this. A spokesperson said, “BE Solar’s Director of Sales, Joanna Frith is the first woman in Bermuda to obtain the NABCEP […]

1. Brisbane Broncos star Ezra Mam charged over head-on collision, allegedly failing second drug test  ABC News
2. Brisbane news live: Broncos’ Ezra Mam charged over drug test result after crash | Stab victim’s widower wants knife checks in schools | Dog rescued near abandoned boat  Brisbane Times
3. Broncos player charged after car crash: 9News Latest Stories Season 2024, Short Video  9Now
4. Ezra Mam issued court notice after allegedly failing secondary drug test  Fox Sports
5. Club Statement: Ezra Mam  Broncos

Nesia Daily Afternoon Edition  ABC News

1. Wages growth slows faster than expected but still exceeds inflation  ABC News
2. Real wages are growing at highest rate since 2020. But it’s unlikely to last  Sydney Morning Herald
3. SBS On the Money: Wages growth slows but real wages turn positive  SBS News

1. Outback Queensland residents spend thousands on flights, grapple with Qantas service changes  ABC News
2. Airlines that love competition: Do you see pigs fly?  Sydney Morning Herald
3. Predictably, domestic airfares surged after the collapse of Rex. There aren’t many good solutions  The Conversation
4. Report finds just how much airfares spiked since end of Rex. One route doubled  The Canberra Times
5. Qantas’ single excuse for fare price hike  news.com.au

1. Beijing and Washington stops provide clues for Indonesia's direction under Prabowo Subianto  ABC News
2. Prabowo pledges co-operation with Trump  The Australian Financial Review
3. Indonesian president meets Biden and speaks with Trump  The Canberra Times
4. At White House, Indonesia's new leader straddles US-China rivalry  VOA Asia
5. Will Prabowo Subianto cosy up to Donald Trump or to China?  The Economist

1. Germany to hold snap election in February after government's coalition collapse  ABC News
2. The briefcase, the Porsche and the collapse of the German government – podcast  The Guardian
3. Germany set for snap election following collapse of Olaf Scholz’s coalition  The Conversation
4. President calls German early election plan 'realistic'  DW (English)

1. Cindy Crossthwaite's estranged husband faces Supreme Court murder trial over mother of three's death  ABC News
2. 'Deep-seated hatred' for estranged wife led to killing, jury told  9News
3. 'Deep-seated hatred' for estranged wife led to killing, court hears  9News

1. Legitimacy of two Victorian local government elections in question after duplicate votes detected  ABC News
2. Victorian council election results 2024 LIVE updates: Suspected postal vote tampering in council elections  Sydney Morning Herald
3. VEC investigates potential vote tampering in two Melbourne councils  The Age

Michael Dean
Jul 1, 2001; 42:1007-1017
Thematic Reviews

Martin Prescher
Dec 1, 2020; 61:1605-1616
Research Articles

ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates PC-lipids from the cytoplasmic to the extracellular leaflet. ABCB4 is an ATP-dependent transporter that reduces the harsh detergent effect of the bile salts by counteracting self-digestion. To do so, ABCB4 provides PC lipids for extraction into bile. PC lipids account for 40% of the entire pool of lipids in the canalicular membrane with an unknown distribution over both leaflets. Extracted PC lipids end up in so-called mixed micelles. Mixed micelles are composed of phospholipids, bile salts, and cholesterol. Ninety to ninety-five percent of the phospholipids are members of the PC family, but only a subset of mainly 16.0-18:1 PC and 16:0-18:2 PC variants are present. To elucidate whether ABCB4 is the key discriminator in this enrichment of specific PC lipids, we used in vitro studies to identify crucial determinants in substrate selection. We demonstrate that PC-lipid moieties alone are insufficient for stimulating ABCB4 ATPase activity, and that at least two acyl chains and the backbone itself are required for a productive interaction. The nature of the fatty acids, like length or saturation has a quantitative impact on the ATPase activity. Our data demonstrate a two-step enrichment and protective function of ABCB4 to mitigate the harsh detergent effect of the bile salts, because ABCB4 can translocate more than just the PC-lipid variants found in bile.

Pneumatic product manufacturer sees more than 80 percent increase in 3D model downloads in first two months

Minister of Communications and Digital Technologies Solly Malatsi has said his department will look into scrapping luxury tax on smartphones.

[COSATU] The Congress of South African Trade Unions (COSATU) is deeply concerned by the Minister for Communications and Digital Technologies, Mr. S. Malatsi's sudden withdrawal of the South African Broadcasting Corporation (SABC) SOC Ltd Bill from Parliament where it was being engaged upon by the National Assembly's Portfolio Committee: Communications and Digital Technologies.

Hi All,

I'm using a code (abConvertPolygonToPath.ils) that I found in other posts to convert a rect object to a path object inside a pcell code, but when I try to run a DRC, the layout export fails due to a warning message, here is the log message

*WARNING* (DB-270001): Pcell evaluation for 18A_asaavedr/lay_mesh_BM0_BM4_3p6_3p6/layout has the following error(s):

*WARNING* (DB-270002): ("eval" 0 t nil ("*Error* eval: undefined function" abConvertPolygonToPath))

ERROR (XOASIS-231): Pcell evaluation failed for '18A_asaavedr/lay_mesh_BM0_BM4_3p6_3p6/layout' because the Pcell SKILL code contains either a syntax error or an unsupported XOasis function. Check the standard output or the Virtuoso log file for more information. Cadence recommends correcting the Pcell SKILL code to resolve the issue. However, to ignore these errors and continue the translation, you may use the 'ignorePcellEvalFail' option.

INFO (XOASIS-282): Translation Failed. '1' error(s) and '3' warning(s) found.

And when compile the code I get the following message:

*WARNING* defgeneric function already defined - abConvertPolygonToPath

I will aprreciate any help in how to waive this error, or fix it.

Thank you

ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a membrane-bound transporter responsible for the efflux of various xenobiotics and endobiotics, including protoporphyrin IX (PPIX), an intermediate in the heme biosynthesis pathway. Certain genetic mutations and chemicals impair the conversion of PPIX to heme and/or increase PPIX production, leading to PPIX accumulation and toxicity. In mice, deficiency of ABCG2 protects against PPIX-mediated phototoxicity and hepatotoxicity by modulating PPIX distribution. In addition, in vitro studies revealed that ABCG2 inhibition increases the efficacy of PPIX-based photodynamic therapy by retaining PPIX inside target cells. In this review, we discuss the roles of ABCG2 in modulating the tissue distribution of PPIX, PPIX-mediated toxicity, and PPIX-based photodynamic therapy.

A quick primer on how to manage all that rich organic waste your home generates

Just out of college and looking for a job? Some tips on professional etiquette.

How do we tackle pests without synthetic pesticides? How can we get a huge haul of vegetables without resorting to chemical fertilisers? A workshop series teaches us organic gardening step-by-step

Plants dying mysteriously in your kitchen garden? It could be root disease, says Hema Vijay

Learn the ABCs of RSS Feeds

1. Barack Obama labels Donald Trump's coronavirus response a 'chaotic disaster'  ABC News
2. Barack Obama labels Donald Trump’s coronavirus response ‘absolute chaotic disaster’  NEWS.com.au
3. Obama lashes out at Trump in call with supporters  Sydney Morning Herald
4. Coronavirus update: Barack Obama calls Donald Trump's coronavirus response a 'chaotic disaster'  ABC News
5. 'Chaotic disaster': Barack Obama unloads on Donald Trump's response to coronavirus  SBS News
6. View Full coverage on Google News

1. WA coronavirus restriction easing not enough for pubs, beauticians, tourism industry  ABC News
2. Coronavirus crisis: Weekends in Esperance back on the cards  The West Australian
3. WA's decision to keep its mines open amid coronavirus may have saved Australia's economy | ABC News  ABC News (Australia)
4. View Full coverage on Google News

1. Jackie Trad resigns as Queensland's Deputy Premier and Treasurer, Steven Miles and Cameron Dick to take on portfolios  ABC News
2. Poster girl’s fall a shock for the left of politics  The Australian
3. Corruption investigation into Queensland Deputy Premier Jackie Trad has potential to unravel Labor Government's five-year reign  ABC News
4. Editorial: Premier, Queensland needs a new treasurer now  Courier Mail
5. Analysis: Latest investigation not a good look for Jackie Trad  Courier Mail
6. View Full coverage on Google News

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Archives, Room Use Only - HE7676.C53 1919

School's nearly back in session, but the seven young lions at the Smithsonian's National Zoo have been working hard through the summer months!

The post Lion cub summer school: Instead of learning their ABCs, the National Zoo’s lion cubs are learning behaviors that will help animal care staff evaluate their health. appeared first on Smithsonian Insider.

Plus: NBC's 'Parenthood' wins green seal.

Dr. Rabchevsky has been endorsed by Marquis Who's Who as a leader in the field of physiology

Labcon ViewPoint™ thermochromic tubes offer real-time temperature signaling to indicate temperature excursions above and below 0-4° C.