Addressing social drivers of health in medical education—through community engagement experiences—is essential for health equity and the development of future physicians. While this was written before the COVID-19 pandemic, these practices will gain even more importance as we come together to better understand its health and community implications in North Carolina and the United States.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Signing off after 30 years at the ABC, award-winning reporter Margot O'Neill writes about the thrill of the big scoop and gives an insight into the grinding slog of investigative journalism.

A court hears an Australian Federal Police officer told ABC lawyers he did not want to see "sensationalist headlines" prior to a raid of the broadcaster's Sydney headquarters this year.

ABC's "The Wonderful World of Disney" summer movie programming includes "Moana," "Thor: The Dark World," "Up" and "Big Hero 6."

Life sciences company LabCorp (LH) announced Tuesday that it has received an Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA) for its COVID-19 at-home test kit.

After penning a deal with Eli Lilly last month with the aim to have an antibody in the clinic within four months, Canadian-based AbCellera has been given a financial boost by its government.

Camille François is a leading investigator of disinformation campaigns and author of the well-known "ABC" or "Actor-Behavior-Content" disinformation framework, which has informed how many of the biggest tech companies tackle disinformation on their platforms. Here, she speaks with Lawfare's Quinta Jurecic and Evelyn Douek for that site's series on disinformation, "Arbiters of Truth." Earlier this…

The economic activity of the U.S. has plummeted in the wake of the coronavirus pandemic and unemployment has soared—largely the result of social distancing policies designed to slow the spread of the virus. The depth and speed of the decline will rival that of the Great Depression. But will the aftermath be as painful? Or…

Camille François is a leading investigator of disinformation campaigns and author of the well-known "ABC" or "Actor-Behavior-Content" disinformation framework, which has informed how many of the biggest tech companies tackle disinformation on their platforms. Here, she speaks with Lawfare's Quinta Jurecic and Evelyn Douek for that site's series on disinformation, "Arbiters of Truth." Earlier this…

The economic activity of the U.S. has plummeted in the wake of the coronavirus pandemic and unemployment has soared—largely the result of social distancing policies designed to slow the spread of the virus. The depth and speed of the decline will rival that of the Great Depression. But will the aftermath be as painful? Or…

Camille François is a leading investigator of disinformation campaigns and author of the well-known "ABC" or "Actor-Behavior-Content" disinformation framework, which has informed how many of the biggest tech companies tackle disinformation on their platforms. Here, she speaks with Lawfare's Quinta Jurecic and Evelyn Douek for that site's series on disinformation, "Arbiters of Truth." Earlier this…

The economic activity of the U.S. has plummeted in the wake of the coronavirus pandemic and unemployment has soared—largely the result of social distancing policies designed to slow the spread of the virus. The depth and speed of the decline will rival that of the Great Depression. But will the aftermath be as painful? Or…

The suit, brought in South Dakota court, seeks over a billion dollars in damages against ABC News -- even though ABC never originated the term and was just reporting what everyone else was calling it.

The concert will air on Sunday, May 17

The post ABC’s Concert Special Taylor Swift City of Lover Concert to Air May 17 appeared first on ComingSoon.net.

Hillary Clinton's lead over opponent Donald Trump has begun to stabilize as the Republican nominee's numbers hit their lowest point in ten days, according to the latest polls.

Malcolm Turnbull (pictured) says the media needs to be less elitist, following the election of Donald Trump as U.S. president-elect. The prime minister said his message on economic growth had resonated.

Ratings season may be over, but the fallout is continuing.

ABC is ‘Anything But China’! Yes, you heard it right. Anything But China. ABC.

Tom Gleeson's Gold Logie win came as a surprise to some, following his ruthless campaign against fellow nominees.

She shared a slideshow of images from her Easter with her three children during at-home quarantine amid the global COVID-19 pandemic. Kourtney included a sweet video of youngest son Reign.

Kylie Jenner had some fun while social distancing at home with her mother. The two enacted Kourtney Kardashian's infamous 'ABCDEFG' speech from an early Keeping Up With The Kardashians season.

The recording artist will play a popular rapper named Rich Youngsta who is employed by Anthony Anderson's Dre for a new advertising campaign.

It was announced last month that Katy Perry, Luke Bryan and Lionel Richie all will return as judges for the trailblazing reality competition show.

While season 28 has just wrapped, Dancing With The Stars execs have already began compiling their 2020 wish list, including actor Charlie Sheen.

I received my renewal quote from LV= and it was too much so I decided to switch to ABC. However, I found out ABC is owned by LV=. How can the prices be so different?

Matt Gutman (left), chief national correspondent for ABC News, was reporting live from the scene of the crash when he incorrectly said Kobe Bryant's other daughters (right) were on board the doomed flight.

Pop star Taylor Swift has announced an hour-long concert special "City of Lover" which will air on ABC. The announcement comes weeks after Swift was forced to cancel all of her 2020 live appearances and performances, including "Lover Fest East" and "Lover Fest West" , due to coronavirus pandemic. The special, which will air on May 17, was filmed in September at the L'Olympia Theater in Paris, where she performed in front of audiences from 37 countries. It will be available for streaming on Disney Plus and Hulu on May 18. "Excited to announce the City of Lover Concert! We filmed my show in Paris in September and thought it'd be fun to share it with you. May 17 at 10p ET on @abcnetwork and available the next day on @hulu and @disneyplus !#TaylorSwiftCityOfLover" the 30-year-old singer tweeted on Friday. The musical event gives fans unprecedented access to behind-the-scenes moments with the artist and marks her only concert performance this year, ABC Network said in a press ...

The main message that is going out to the masses is: use condoms. But this overlooks a fundamental reality about the values contained in that message, says Mirra Savara.

कोरोना वायरस संक्रमण के कारण देश के कई इलाकों में मास्क पहनने को अनिवार्य कर दिया गया है. वायरस से बचाव के लिए बाजार में कई तरह के फेस मास्क उपलब्ध हैं. मास्क को लेकर लोगों के मन में कई तरह की कंफ्यूजन है कि आखिरकार कौन सा मास्क पहना जाए, जो वायरस से बचाव कर सकता है. मास्क खरीदते वक्त ध्यान रहे कि इसकी रेटिंग N95 ही हो. इसके साथ ही मास्क का चेहरे पर फिट होना बहुत ज्यादा जरूरी है. आइए जानते हैं मास्क के बारे में...

ABC of coronavirus by Aavya Mishra

ABC of Coronavirus: As explained by the kids

ABC of coronavirus: 3 easy ways to save yourself

ABC of coronavirus: This little munchkin will show you how to make a mask

ABC of coronavirus: This little one has all the answers about coronavirus

ABC of coronavirus: This cute little munchkin explaining about coronavirus will make your day

ABC of Coronavirus: This little girl shares how to get through this tough time

Official Twitter of State of Israel responded to Varun Dhawan's tweet on coronavirus antidote with his 'ABCD 2' dialogue.

ABC News correspondent and Nightline co-anchor Dan Harris explains how meditation helped him feel better—and how corporations are using it for their workforce, too.​

Sedgley, Dawn J