Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI00513A, Research Article

Qiuyuan Feng, Jialong Wang, Changyou Liu, Qun Jing, Xiaoyu Dong
The novel NaVSeO5 birefringent crystals were successfully synthesized using a multifunctional group synergistic strategy, which combines a two-dimensional layered structure, consisting of stereochemically active lone pairs [SeO3], and anomalous [VO6]...
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Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI00605D, Research Article

Xiaoxue Ma, Xin Li, Xueke Han, Lu Zhang, Ronghua Liu, Hongguo Hao, Hui Yan, Xin Zhao, Xiangjin Kong, Huawei Zhou, Xia Li, Hongjie Zhu, Suna Wang, Yunwu Li, Dichang Zhong, Fangna Dai
Two outstanding proton conducting materials have been obtained by loading TFA molecules onto/into the surface or pores of MOFs. After post-treatment, their proton conductivity values are greatly increased under the same conditions.
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Chem. Sci., 2024, 15,18031-18047
DOI: 10.1039/D4SC02408G, Edge Article

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David Kreutter, Jean-Louis Reymond
Integrating enzymatic reactions into computer-aided synthesis planning (CASP) should help devise more selective, economical, and greener synthetic routes.
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Chem. Sci., 2024, 15,17881-17891
DOI: 10.1039/D4SC04630G, Edge Article

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Shi Xuan Leong, Sergio Pablo-García, Zijian Zhang, Alán Aspuru-Guzik
Leveraging multimodal large language models (MLLMs) to process multimodal data inputs and complex inter-modality data dependencies for automated (electro)chemical data mining from scientific literature.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06060A, Edge Article

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Yipeng You, Xue-Jie Zhang, Wen Xiao, Thittaya Kunthic, Zheng Xiang, Chen Xu
A unified synthetic strategy for drimane meroterpenoids was developed by combining heterologous biosynthesis, enzymatic oxidation, and transition metal catalysis. Six drimane meroterpenoids were synthesized in a concise and enantiospecific manner.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04174G, Edge Article

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Run-Zhou Liu, Zhihan Zhang, Min Li, Lihan Zhang
A metabologenomics workflow using mass defect filtering (MDF) and bioinformatics-based structural prediction was established for rapid screening of modular polyketide natural products, and led to the identification of 22 polyketides.
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Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06324D, Edge Article

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Lotte L. Metz, Rens Ham, Eduard Bobylev, Kelly J. H. Brouwer, Alfons van Blaaderen, Rim van de Poll, Victor Drozhzhin, Emiel J. M. Hensen, Joost N. H. Reek
Controlled preparation of ultrafine metal nanoclusters (<2 nm) is challenging, yet important as the properties of these clusters are inherently linked to their size and local microenvironment. In the present...
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05482B, Edge Article

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Gongming Yang, Shangde Liu, Shujie Ji, Xingsen Wu, Jian Wang
The unprecedented non-enzymatically atroposelective synthesis of planar-chiral macrocycles via a Pd/NHC sequential catalytic intermolecular macrocyclization is reported.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC02262A, Edge Article

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Samantha Hollands, Julia Tasch, David J. Simon, Dimah Wassouf, Isobel Barber, Arne Gessner, Andreas Bechthold, David L. Zechel
The noncanonical biosynthesis of curacozole by Streptomyces curacoi is shown to be dependent on the bldA-encoded Leu-tRNA^UUA. The minimal biosynthetic gene cluster is defined, and the functions of key biosynthetic enzymes are established in vitro.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06369D, Edge Article

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Xiao Jing Lv, Chun Zhi Ai, Li Rong Zhang, Xiu Xiu Ma, Juan Juan Zhang, Jia Peng Zhu, Ren Xiang Tan
BruN and BTG13 cleave chrysophanol hydroquinone into monodictyphenone and cephalanone F, respectively, with the regioselectivities found tunable via the key amino acid (AA) substitution strategy.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05499G, Edge Article

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Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. Burkart
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06335J, Edge Article

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Leibing Wang, Zhongyu Feng, Zhen Luo, Zihao Guo, Jieping Wang, Wenbin Yi
The one-step direct synthesis of N-perfluoro-tert-butyl secondary amines utilizes TMSCF₃ as the sole CF₃ source and the starting material N-CF₃ secondary amine itself as the hydrogen source. PFtB amines can be effectively employed in ¹⁹F MRI.
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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05707D, Perspective

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Naoki Ogiwara, Wei Zhou, Sayaka Uchida
Al oxo-hydroxide clusters are formed through the hydrolysis of Al³⁺-containing solutions, exhibiting a diversity of sizes and shapes. The assembly of these clusters demonstrates functional applications, such as adsorption and heterogeneous catalysis.
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Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05977H, Edge Article

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Junjie Zhang, Yulin Liu, Yuxiang Zhao, Siyu Zhang, Feng Xu, Fei Li
Ischemic stroke and reperfusion injury result in neuronal damage and dysfunction associated with oxidative stress, leading to overproduction of cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). In...
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Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper

Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
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RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article

Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article

Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-Abl^T315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article

Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
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RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article

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Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
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RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article

Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
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RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article

Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
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RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article

Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
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RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article

Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article

Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article

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Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article

Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article

Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article

Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article

Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00541D, Research Article

Mikhail N. Anisimov, Maksim A. Boichenko, Vitaly V. Shorokhov, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Ilya A. Lifshits, Andrey Yu. Plodukhin, Ivan A. Andreev, Nina K. Ratmanova, Sergey S. Zhokhov, Elena A. Tarasenko, Daria A. Ipatova, Alexander R. Pisarev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Nikita B. Gudimchuk
New 1,5-disubstituted pyrrolidin-2-ones 1, 2 and 5-aryl-3,3a,4,5-tetrahydropyrrolo[1,2-a]quinoline-1(2H)-ones 3 were explored as inhibitors of tubulin polymerization.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article

Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction

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Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article

Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article

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Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article

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Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article

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Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article

Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article

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Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article

Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article

Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article

YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article

Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article

Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article

Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H₂S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article

Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article

Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00528G, Paper

Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kroger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg
This paper presents a coarse-grained molecular dynamics simulation study of the synthesis, mechanics, and thermal actuation of nematic phase main-chain liquid crystal elastomers (LCEs), a type of soft, temperature-responsive, polymeric...
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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01619J, Review Article

Wenli Tong, Jie-Ping Wan, Jianchao Liu
This review highlights the recent progress in palladium-catalyzed C-glycosylation reactions for the synthesis of C-glycosides.
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