Chantal (56) heeft coeliakie, hoe herken je de ziekte? “Ik kan nooit zomaar brood of koffiekoeken eten, elke kruimel zorgt voor krampen”  Het Laatste Nieuws

He'll just wait this one out. Cacti can't survive without water, right? ~NSHA

As part of their ongoing 3 day sale Meijer is giving 20k Mperks points, aka $20, when you buy at least $50 of certain gift cards.  If you buy the "One4All" gift card you can redeem it for Xbox or Playstation credit, or a bunch of other brands. 

I had the mperks points in my account within an hour, and just redeemed my $50 gc for PSN credit with no issues.  If you shop at Meijer anyway, this is 40% off Sony or MS credit if you do the minimum $50 gift card purchase.  If you put $70 on it that would be a new full price game for $50.  I believe this can only be used once per Mperks account.

I have only seen a hydrothermal vent once, during Dive 73 aboard the Monterey Bay Aquarium Research Institute’s Doc Ricketts. Unlike many deep-sea biologists, I…

The post A Journey to the Hottest Place on Earth: Hydrothermal Vents and the Resilient Pompeii Worm first appeared on Deep Sea News.

Dipshit billionaire Leon Musk, who we fondly refer to as that stupid fuck, isn't amused by Dana Carvey's impersonation of him on Saturday Night Live. So, he took his little fingers to Xitter, the once behemoth social site he destroyed only to influence the election to his audience of conspiracy theorists and far-right edge lords that use Peppy the Frog in their postings or avatars.

Well, Leon got quite a paycheck for promoting convicted felon and adjudicated rapist Donald Trump, so at least he's happy while the rest of us remain in shock over the election results.

SNL's cold open got under Leon's fragile narcissistic skin where the actors, sort of like him, pretended to be on Trump's side with solid support.

Dana Carvey – who previously played President Joe Biden, and we didn't bitch about it -- played the part of Leon. You can see Carey's part that shook Elon at around the 3:30 mark in the cold open, and below.

“Check it out, dark MAGA,” Carvey said while impersonating Musk in a black MAGA hat. “But seriously, I run the country now,” he added.

read more

In today's edition of FAFO (F*ck Around and Find Out) we have Nikki Haley (with an assist by Mike Pompeo) who is learning the hard way that MAGA loyalty only goes one way. They want your vote and your support, but won't do anything to make your life better. Once you kiss the ring and show your soft underbelly of weakness, you are no longer useful.

Nikki Haley threw her support behind Donald Trump, after running a fairly solid anti-Trump Republican campaign against him. But even after she gave up, he never forgave her. And on Saturday he put the knife in and twisted it even harder, publicly FIRING her (and Mike Pompeo) before he even takes office.

Her response was pathetic.

Recently saw this on YouTube, from a grandmaster competition shooter who is also in law enforcement. I agree with him. I’ve said for years that while a shooting match is not a gunfight, a gunfight most certainly is a shooting match. Competition experience makes shooting under pressure the norm. Wyatt Earp competed in the informal […]

The post The Craziest Wedding Competitions in Russia appeared first on English Russia.

1. Was das Ampel-Aus für die Medienbranche bedeutet (dwdl.de, Timo Niemeier) Timo Niemeier macht sich bei “DWDL” Gedanken darüber, wie sich das Ende der Ampel-Koalition auf die Medienbranche auswirken könnte. Die vorgesehene Reform der Filmförderung mit Elementen wie Steueranreizen und Investitionsverpflichtungen sei ohne FDP-Stimmen kaum durchsetzbar. Die geplante Reform des öffentlich-rechtlichen Rundfunks bleibe hingegen unberührt, […]

Come do Competitive Programming at Princeton! Improve your coding abilities. Increase your knowledge of algorithms and data structures. Learn problem solving skills.

Come do Competitive Programming at Princeton! Improve your coding abilities. Increase your knowledge of algorithms and data structures. Learn problem solving skills.

Come do Competitive Programming at Princeton! Improve your coding abilities. Increase your knowledge of algorithms and data structures. Learn problem solving skills.

Will a Patagonian cypress in Chile prove older than California’s most elderly bristlecone pine?

A pimenta, a cúrcuma e outras especiarias são frequentemente citadas como tendo benefícios para a nossa saúde ou até mesmo a capacidade de 'estimular nosso sistema imunológico'. Mas será que elas realmente oferecem algum benefício à nossa saúde ou nos ajudam a prevenir doenças?

The following article, EMBARRASSING: Big Election Misses by Never Trumpers and Others, was first published on The Black Sphere.

I love metaphorically rubbing my crotch in the faces of these smug Leftist pukes and know-it-alls after they get their asses handed to them.

Continue reading EMBARRASSING: Big Election Misses by Never Trumpers and Others ...

It was only a matter of time before House Republicans were going to file an ethics complaint against Rep. Adam Schiff (D) and anyone involved in the impeachment inquiry into President Trump.

The post Matt Gaetz files ethics complaint against Rep. Schiff over impeachment appeared first on Shark Tank.

While the growing majority of House Democrats support impeaching President Trump, and scheduled to take a vote to do so on Thursday, a new NY Times poll shows that while most Americans support an impeachment inquiry, Floridians do not suppose the potential measure.

The post Majority of Floridians oppose impeachment of President Trump appeared first on Shark Tank.

New Zealand's Maddy Green explains what led them to a maiden T20 World Cup title

Two big names from two remarkable stories in Test cricket are on the programme.

Saba Karim discusses the fall-out from New Zealand's historic Test series win in India.

BBC F1 correspondent Andrew Benson answers your questions following the Sao Paulo Grand Prix.

House Minority Leader Kevin McCarthy (R-CA) threatened to introduce a motion on the floor to oust House Speaker Nancy Pelosi (D-CA) as speaker if she attempts to impeach President Trump for “following the constitution” to slow down the Supreme Court confirmation process to fill the vacancy for the late Justice Ruth Bader Ginsburg. “I will […]

The post McCarthy Threatens Motion To Oust Pelosi If She Attempts Impeachment appeared first on Hispolitica.

Nearly 4 million people visited the ruins of the Roman city of Pompeii in 2023, a third more than the previous year.

Apple has spent the last few days trickling releases of new Mac hardware, debuting a revamped iMac with an M4 chip and new colors, a redesigned Mac Mini that is smaller in size and now has an M4 chip, and the MacBook Pro lineup has been revamped with M4 processors as well. Each of the ... Read More

Nvidia might have some serious competition in the AI chip space coming. Amazon is now seeking to bring its own… Continue reading Amazon readies new AI chip to compete with Nvidia

The post Amazon readies new AI chip to compete with Nvidia appeared first on ReadWrite.

Ignat V. Shilov
Sep 1, 2007; 6:1638-1655
Technology

Alzheimer's disease (AD) is characterized by neuronal loss and accumulation of β-amyloid-protein (Aβ) in the brain parenchyma. Sleep impairment is associated with AD and affects about 25–40% of patients in the mild-to-moderate stages of the disease. Sleep deprivation leads to increased Aβ production; however, its mechanism remains largely unknown. We hypothesized that the increase in core body temperature induced by sleep deprivation may promote Aβ production. Here, we report temperature-dependent regulation of Aβ production. We found that an increase in temperature, from 37 °C to 39 °C, significantly increased Aβ production in amyloid precursor protein-overexpressing cells. We also found that high temperature (39 °C) significantly increased the expression levels of heat shock protein 90 (Hsp90) and the C-terminal fragment of presenilin 1 (PS1-CTF) and promoted γ-secretase complex formation. Interestingly, Hsp90 was associated with the components of the premature γ-secretase complex, anterior pharynx-defective-1 (APH-1), and nicastrin (NCT) but was not associated with PS1-CTF or presenilin enhancer-2. Hsp90 knockdown abolished the increased level of Aβ production and the increased formation of the γ-secretase complex at high temperature in culture. Furthermore, with in vivo experiments, we observed increases in the levels of Hsp90, PS1-CTF, NCT, and the γ-secretase complex in the cortex of mice housed at higher room temperature (30 °C) compared with those housed at standard room temperature (23 °C). Our results suggest that high temperature regulates Aβ production by modulating γ-secretase complex formation through the binding of Hsp90 to NCT/APH-1.

Expert

Ricardo Bermudez-Otero and Tobias Galla discuss the mathematics describing the evolution of human languages. The sounds and structures of the world's approximately 7,000 languages never stop changing. Just compare the English in Romeo and Juliet or the Spanish in Don Quixote to the modern forms. But historical records give an incomplete view of language evolution. Increasingly, linguists draw upon mathematical models to figure out which features of a language change often and which ones change more rarely over the course of thousands of years. A new model inspired by physics assigns a "temperature" to many sounds and grammatical structures. Features with higher temperatures are less stable, so they change more often as time goes on. The linguistic thermometer will help researchers reconstruct how our languages came to be, and how they might change in future generations.

Marko Voutilainen, Lauri Viitasaari and Pauliina Ilmonen
Theor. Probability and Math. Statist. 111 (), 181-197.
Abstract, references and article information

A. Della Corte, M. Farotti and S. Rodríguez Martín
Proc. Amer. Math. Soc. 152 (), 5163-5173.
Abstract, references and article information