if It is an offence: On Supreme Court clarification on online content on child sex abuse By www.thehindu.com Published On :: Wed, 25 Sep 2024 00:10:00 +0530 Court has done well to clarify law on online content showing child sex abuse Full Article Editorial
if Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:10:00 +0530 Actor Vijay seems to be targeting both the BJP and the DMK Full Article Editorial
if Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00257A, Research Article Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob AlamIn light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Recent advances from computer-aided drug design to artificial intelligence drug design By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00522H, Review ArticleKeran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei WangCADD and AIDD contribute to the drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00722K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice MangiatordiDeveloping sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
if Changes in train services notified due to demolition of old bridge near Tiruchi junction By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:30:53 +0530 Full Article Tiruchirapalli
if Agro-tourism push needs industry-specific policies, say farmers By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:37:41 +0530 Full Article Tiruchirapalli
if Plea to include ‘panneer karumbu’ in Pongal gift hamper By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:41:17 +0530 Full Article Tiruchirapalli
if Man attempts to end life, kills his wife and daughter By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:03:18 +0530 Full Article Tiruchirapalli
if Site identified for small-scale handloom park in Karur By www.thehindu.com Published On :: Sat, 09 Nov 2024 19:30:54 +0530 Full Article Tiruchirapalli
if 557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life By shoptalkshow.com Published On :: Mon, 20 Mar 2023 07:01:51 +0000 When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life. Full Article All Episodes AI chatgpt Conferences CSS fidgets
if 582: Lifetime Plan, Pricing #HotDrama, and CSS Resets By shoptalkshow.com Published On :: Mon, 11 Sep 2023 09:33:44 +0000 Getting tripped up on audio at conferences, announcing the ShopTalk Show Lifetime Plan, some Once pricing #hotdrama, remembering Molly Holzschlag, web components, Luro launch day thoughts, and a question about using a normalize or sanitize in 2023 prompts a run through of Andy Bell's Modern CSS Reset. Full Article All Episodes CSS CSS Resets Pricing
if 592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift By shoptalkshow.com Published On :: Mon, 20 Nov 2023 08:30:40 +0000 Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads. Full Article All Episodes markdown SEO Web Components
if 595: MedTalk Show, Plagiarism and Code Grifting, and How We’re Testing Code By shoptalkshow.com Published On :: Mon, 11 Dec 2023 09:03:30 +0000 Blood pressure, stress, and COVID highlight the MedTalk Show portion of this episode, a new "Did You Know" segment about dev tools in Chrome, 4 hour video on plagiarism and code grifters, typography, breaking out of CSS Grid, the oldest things Chris and Dave worked on, and what the testing process is like at Luro or CodePen. Full Article All Episodes css grid plagirism Testing Typography
if 611: React! TypeScript! Jobification! Drupal! By shoptalkshow.com Published On :: Mon, 15 Apr 2024 08:30:37 +0000 Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go? Full Article All Episodes Career Advice Drupal File System API p3
if A greener life By www.thehindu.com Published On :: Fri, 16 Jan 2015 15:01:25 +0530 Though it took many arguments and much labour, Anamika Mukherjee explains that the joy of growing your vegetables makes it all worth it Full Article Green Living
if The commodification of water By www.thehindu.com Published On :: Fri, 10 Apr 2015 21:20:54 +0530 Water purification systems in cities and villages may look attractive but do they actually benefit the needy? Full Article Green Living
if The green life By www.thehindu.com Published On :: Fri, 16 Oct 2015 14:50:34 +0530 At Sadhana Forest, on the outskirts of Auroville, a community plants trees and lives in rhythm with nature. Sujatha Shankar Kumar reports. Full Article Green Living
if New venture Zerofifty from ad veterans wants to simplify the agency model By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 10:46:58 +0530 ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model Full Article Marketing
if Shifting gift preferences By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:44:59 +0530 Employees today prefer personalised gifts, and India Inc is taking cognisance Full Article Corporate File
if Concussion: FIFA kicks off ‘suspect and protect’ drive By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:30:47 +0530 Campaign raises awareness that concussion is a traumatic brain injury and a risk to every player on the pitch Full Article Pulse
if Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Tue, 05 Nov 2024 13:00:21 +0530 Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed Full Article Delhi
if Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:19:07 +0530 Full Article Delhi
if Delhi HC permits man to buy The Satanic Verses after Centre fails to produce notification banning the book By www.thehindu.com Published On :: Thu, 07 Nov 2024 20:30:42 +0530 India was one of the first countries to ban the book’s import and sale, citing concerns over its content being offensive to the Muslim community Full Article India
if BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife By www.thehindu.com Published On :: Tue, 12 Nov 2024 16:17:13 +0530 Full Article Delhi
if 2024 Pacificon Inspires Next Generation of Radio Amateurs By www.arrl.org Published On :: Thu, 24 Oct 2024 14:03:00 -0500 Full Article
if Rare California Island to be Activated for Armed Forces Day, First Time in 53 Years By www.arrl.org Published On :: Fri, 08 Nov 2024 13:40:00 -0600 On Armed Forces Day, May 1971, 53 years ago, two amateur operators working as WZ6SNI, activated San Nicolas Island, IOTA NA-066. At 61 miles, San Nicolas is the most remote of the Channel Islands off the coast of Southern California and is owned by the US Navy.Now, weather permitting, Will Costello, WC6DX, has been authorized to be active from San Nicolas Island November 8 - 12, 2024. He is tak... Full Article
if Desecration of a way of life By www.thehindubusinessline.com Published On :: Sun, 06 Sep 2020 19:34:08 +0530 A story of how China ripped into the genteel charm of the traditional Buddhist society in Tibet Full Article Books
if Into the life of a billionaire-philanthropist By www.thehindubusinessline.com Published On :: Sun, 22 Nov 2020 21:46:39 +0530 The book covers Wipro founder Azim Premji’s journey without pulling any punches Full Article Books
if Demystifying ECBs By www.thehindubusinessline.com Published On :: Sun, 14 Feb 2021 21:19:41 +0530 India Inc must tap foreign funds with caution Full Article Books
if The economics of everyday life By www.thehindubusinessline.com Published On :: Sun, 28 Mar 2021 21:03:31 +0530 An economics book shorn of jargon, equations and graphs Full Article Books
if Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta By www.thehindubusinessline.com Published On :: Wed, 02 Feb 2022 17:42:46 +0530 The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves Full Article Book Reviews
if Rahul Bajaj: An Extraordinary Life By www.thehindubusinessline.com Published On :: Sun, 10 Apr 2022 09:47:38 +0530 The anecdotes, the historical context, and the business learnings make this book a perfect homage to Bajaj Full Article Books
if Mango growers demand uniform relief of ₹30,000 per acre, fixed prices at tripartite meeting in Krishnagiri By www.thehindu.com Published On :: Fri, 07 Jun 2024 20:46:06 +0530 Full Article Coimbatore
if Paddy MSP up 5.35% to ₹2,300 per quintal as Cabinet clears MSP hikes for 14 kharif crops By www.thehindu.com Published On :: Wed, 19 Jun 2024 20:17:45 +0530 MSPs for bajra, arhar dal, maize offer highest margins above production costs; Cabinet nod for Varanasi airport expansion, new Maharashtra port, wind energy projects in Gujarat and T.N., forensic infrastructure development Full Article India
if Eyebrows raised as Central team visits Anantapur to assess rabi drought during rainy kharif By www.thehindu.com Published On :: Wed, 19 Jun 2024 20:31:59 +0530 The team choosing mandals like Vidapanakallu and Vajrakarur which received excessive rain in June, draws flak from farmers and district officials alike; farmers worry as to how to present their drought woes to the officials who are visiting their fields which are now rain-fed and green Full Article Andhra Pradesh
if First International Dairy Federation Asia-Pacific summit in Kochi from June 26 to 28 By www.thehindu.com Published On :: Tue, 25 Jun 2024 20:35:17 +0530 Full Article Kerala
if When Tamil Nadu police opened fire at farmers protesting against power tariff increase in 1970 By www.thehindu.com Published On :: Thu, 05 Sep 2024 23:46:17 +0530 Tamil Nadu’s history of free power supply for farming led to violent agitations, political backtracking, and eventual implementation in phases Full Article Tamil Nadu
if Home cooks in Thiruvananthapuram are championing artificial additive-free jams, preserves, juice, ethnic eats and more By www.thehindu.com Published On :: Wed, 16 Oct 2024 13:42:08 +0530 Four home cooks in Thiruvananthapuram are turning fruits into value-added products without using artificial flavours or preservatives Full Article Features
if Annoyed over tardy paddy lifting, farmers block roads in Punjab By www.thehindu.com Published On :: Fri, 25 Oct 2024 16:51:12 +0530 The AAP and the BJP sparred over who was to be assigned blame for the delays in procurement Full Article Punjab
if If it was not for Pandya... By www.rediff.com Published On :: Thu, 03 Dec 2020 14:04:28 +0530 Purnendu Maji and Srinivas Bhogle list the Most Valuable Players during the India-Australia ODI series. Full Article ODI MVPI Steve Smith Hardik Pandya Jasprit Bumrah Glenn Maxwell IMAGE Purnendu Maji Srinivas Bhogle Yuzvendra Chahal Ravindra Jadeja Australia-India Australia Aslam Rediff India-Australia
if SAT pulls up Sebi for lack of uniformity in penalising market players By www.thehindu.com Published On :: Wed, 25 May 2016 00:00:00 +0530 Full Article Mumbai Capital
if RPG Life Sciences to sell biotech unit to Intas Pharma By www.thehindu.com Published On :: Fri, 27 May 2016 00:00:00 +0530 Full Article Mumbai Capital
if China slowdown ‘a significant risk’ for global economy By www.thehindu.com Published On :: Fri, 27 May 2016 00:00:00 +0530 There has been a sharp contraction in China’s imports over the past year Full Article Mumbai Capital