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It is an offence: On Supreme Court clarification on online content on child sex abuse

Court has done well to clarify law on online content showing child sex abuse




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​Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference  

Actor Vijay seems to be targeting both the BJP and the DMK 




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Agro-tourism push needs industry-specific policies, say farmers




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Plea to include ‘panneer karumbu’ in Pongal gift hamper




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Man attempts to end life, kills his wife and daughter




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Site identified for small-scale handloom park in Karur




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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582: Lifetime Plan, Pricing #HotDrama, and CSS Resets

Getting tripped up on audio at conferences, announcing the ShopTalk Show Lifetime Plan, some Once pricing #hotdrama, remembering Molly Holzschlag, web components, Luro launch day thoughts, and a question about using a normalize or sanitize in 2023 prompts a run through of Andy Bell's Modern CSS Reset.




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592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift

Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads.




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595: MedTalk Show, Plagiarism and Code Grifting, and How We’re Testing Code

Blood pressure, stress, and COVID highlight the MedTalk Show portion of this episode, a new "Did You Know" segment about dev tools in Chrome, 4 hour video on plagiarism and code grifters, typography, breaking out of CSS Grid, the oldest things Chris and Dave worked on, and what the testing process is like at Luro or CodePen.




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611: React! TypeScript! Jobification! Drupal!

Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go?




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A greener life

Though it took many arguments and much labour, Anamika Mukherjee explains that the joy of growing your vegetables makes it all worth it




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The commodification of water

Water purification systems in cities and villages may look attractive but do they actually benefit the needy?




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The green life

At Sadhana Forest, on the outskirts of Auroville, a community plants trees and lives in rhythm with nature. Sujatha Shankar Kumar reports.




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New venture Zerofifty from ad veterans wants to simplify the agency model

ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model




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Shifting gift preferences

Employees today prefer personalised gifts, and India Inc is taking cognisance




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Concussion: FIFA kicks off ‘suspect and protect’ drive 

Campaign raises awareness that concussion is a traumatic brain injury and a risk to every player on the pitch




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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge

Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed




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Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge




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Delhi HC permits man to buy The Satanic Verses after Centre fails to produce notification banning the book

India was one of the first countries to ban the book’s import and sale, citing concerns over its content being offensive to the Muslim community




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BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife




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2024 Pacificon Inspires Next Generation of Radio Amateurs




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Rare California Island to be Activated for Armed Forces Day, First Time in 53 Years

On Armed Forces Day, May 1971, 53 years ago, two amateur operators working as WZ6SNI, activated San Nicolas Island, IOTA NA-066. At 61 miles, San Nicolas is the most remote of the Channel Islands off the coast of Southern California and is owned by the US Navy.

Now, weather permitting, Will Costello, WC6DX, has been authorized to be active from San Nicolas Island November 8 - 12, 2024. He is tak...




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Desecration of a way of life

A story of how China ripped into the genteel charm of the traditional Buddhist society in Tibet




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Into the life of a billionaire-philanthropist

The book covers Wipro founder Azim Premji’s journey without pulling any punches




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Demystifying ECBs

India Inc must tap foreign funds with caution




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The economics of everyday life

An economics book shorn of jargon, equations and graphs




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Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta

The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves 




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Rahul Bajaj: An Extraordinary Life 

The anecdotes, the historical context, and the business learnings make this book a perfect homage to Bajaj




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Mango growers demand uniform relief of ₹30,000 per acre, fixed prices at tripartite meeting in Krishnagiri




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Paddy MSP up 5.35% to ₹2,300 per quintal as Cabinet clears MSP hikes for 14 kharif crops

MSPs for bajra, arhar dal, maize offer highest margins above production costs; Cabinet nod for Varanasi airport expansion, new Maharashtra port, wind energy projects in Gujarat and T.N., forensic infrastructure development




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Eyebrows raised as Central team visits Anantapur to assess rabi drought during rainy kharif

The team choosing mandals like Vidapanakallu and Vajrakarur which received excessive rain in June, draws flak from farmers and district officials alike; farmers worry as to how to present their drought woes to the officials who are visiting their fields which are now rain-fed and green




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First International Dairy Federation Asia-Pacific summit in Kochi from June 26 to 28




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When Tamil Nadu police opened fire at farmers protesting against power tariff increase in 1970

Tamil Nadu’s history of free power supply for farming led to violent agitations, political backtracking, and eventual implementation in phases




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Home cooks in Thiruvananthapuram are championing artificial additive-free jams, preserves, juice, ethnic eats and more

Four home cooks in Thiruvananthapuram are turning fruits into value-added products without using artificial flavours or preservatives




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Annoyed over tardy paddy lifting, farmers block roads in Punjab

The AAP and the BJP sparred over who was to be assigned blame for the delays in procurement 





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SAT pulls up Sebi for lack of uniformity in penalising market players




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RPG Life Sciences to sell biotech unit to Intas Pharma




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China slowdown ‘a significant risk’ for global economy

There has been a sharp contraction in China’s imports over the past year