Climate change could mean mosquitoes that can carry diseases like dengue, zika and yellow fever become established in southern Europe within 10 years.

It’s been 10 years since electronic cigarettes hit the shelves in a big way - and since there controversy has reigned about their health effects - are they less unhealthy than smoking traditional tobacco cigarettes, and will they increase nicotine dependence? Its to that last point that new research, published on BMJ.com is looking into -...

PORT OF SPAIN, Trinidad, CMC – The Trinidad-based Caribbean Public Health Agency (CARPHA) is urging people in the region to remember that despite the coronavirus (COVID-19) pandemic, they must be mindful that other public health threats still...

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H42RA) exhibited a significant loss of global H2Bub1. H42RA mutant yeast strains also displayed chemotoxin sensitivities similar to, but less severe than, strains containing a complete loss of H2Bub1. We found that the H4 basic patch regulates H2Bub1 levels independently of interactions with chromatin remodelers and separately from its regulation of H3K79 methylation. To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool, the light-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1. The ability of Bre1 to ubiquitylate H2B was unaffected in the H42RA mutant. In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp10, increased in the H42RA mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.

It’s a conviction that was published in the November issue of The Journal of the American Dental Association and the basis for the October 2019 forum that Dr. Francisco Ramos-Gomez fostered, where dentists, physicians, nurses and public health and public policy experts proposed, discussed and recommended solutions for preventing early childhood caries through the lens of social justice, health equity and human rights.

New Zealand drew global attention for its unity and support for the Muslim community targeted during the horrific Christchurch attacks. Yet the country's road to inclusion has been far from straightforward, and amid rising diversity it is grappling with the best way to achieve inclusion for its multiethnic population, including indigenous Māori peoples and migrants. This article outlines the opportunities and challenges to fostering multiculturalism against a backdrop of bicultural policies.

The state's "Influence 100" project includes a leadership development program that will give aspiring district leaders a hands-on opportunity to work through an equity issue in their home districts.

Educators are changing instructional priorities, altering lessons, and working on ways to help teachers grow professionally, all in an effort to raise math achievement.

Michael Sentance abruptly resigns less than a year after being hired to oversee Alabama's schools and as board members were preparing to decide his fate after a brutal evaluation.

Educators are changing instructional priorities, altering lessons, and working on ways to help teachers grow professionally, all in an effort to raise math achievement.

Three Oregon school employees sued their union in federal court last week, arguing it's unfair that the teachers' union only lets members drop out and stop paying dues during the month of September.

Ubiquity Press is an open access publisher of peer-reviewed, academic journals and books. It was founded by researchers at University College London (UCL) in 2012.

The Flyers have had quite a bit of luck when drafting players from the Brandon Wheat Kings. Could they keep their streak alive with Braden Schneider in the first round of the 2020 NHL draft? By Brooke Destra

Controversy over an intiative aimed a reducing inequities in Lee's Summit, Mo., schools led the police department to provide security protection for the district's first African-American superintendent. Now the school board has reversed course.

Items recovered include fossils, paintings, ancient coins, ceramics and jewelry

Equities are likely to keep trading in volatile ranges until the many conflicting narratives in the market give way to a singular message for investors.

Equities have rallied since 2017 and yet the expected growth in dividends has declined since then. Is the fall in long-term interest rates to be blamed?

Information technology, health care, and consumer discretionary stocks that outperformed in the last decade have done well in the first four months of 2020.

Robbyn Plumb tried to balance a career in the public service with looking after two kids, one with special needs. When the pandemic hit she finally hit a wall and decided to stop working. She writes about how hard it is for parents trying to do it all during COVID-19.

Equities are likely to keep trading in volatile ranges until the many conflicting narratives in the market give way to a singular message for investors.

Equities have rallied since 2017 and yet the expected growth in dividends has declined since then. Is the fall in long-term interest rates to be blamed?

Information technology, health care, and consumer discretionary stocks that outperformed in the last decade have done well in the first four months of 2020.

Bank of Finland Research Discussion Papers by Gonçalo Faria and Fabio Verona

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below.

The rates will be effective after the close of business on April 22, 2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory in the link below. Please email any questions to Clearing.RiskManagement@cmegroup.com

The rates will be effective after the close of business on Friday, April 24, 2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below. Please email any questions to Clearing.RiskManagement@cmegroup.com

The rates will be effective after the close of business on Friday, May 8, 2020.

For the full text of this advisory, please click here.

New data tools allow users to see how public schools fall short when it comes to providing all students the resources they need to meet their highest potential.

Educational equity is more than just a philosophy to embrace—it is a goal realized through concrete actions.

We need a way to radically reimagine the mindset and the methodology of working toward equity. The concept of "street data," which allows for real-time feedback loops rooted in the voices and experiences of students, staff, and families, is key to this transformation.

New data tools allow users to see how public schools fall short when it comes to providing all students the resources they need to meet their highest potential.

As some districts try to dismantle racist and biased policies and practices, they are creating high-profile positions to lead that public, sometimes hostile, reckoning.

As superintendents, we must make the system work for all students—however socially, politically, and professionally dangerous it may be, writes Demond A. Means.

A group of testing experts says that opt-out could jeopardize the ability to target educational resources appropriately.

More than half of the state plans fail to publicly report data on educator equity gaps, the National Council of Teacher Quality found in its analyses.

Educators are changing instructional priorities, altering lessons, and working on ways to help teachers grow professionally, all in an effort to raise math achievement.

Technology can fuel innovation, foster creativity, and create engaging learning environments. Ineffective edtech and instruction, however, can punish our poorest and most vulnerable students--especially students of color and those living in rural areas. This post explores strategies for avoiding thi

Adolescents show mixed opinions over gender equality in recent survey.

As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in south East Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could lead to prospective interventions to contain resistance and prevent the eventual spread to other malaria endemic regions. Artemisinin reduced susceptibility in South East Asia (SEA) has been primarily linked to mutations in P. falciparum Kelch-13, which is currently widely recognised as a molecular marker of artemisinin resistance. However, 2 mutations in a ubiquitin hydrolase, UBP-1, have been previously associated with artemisinin reduced susceptibility in a rodent model of malaria and some cases of UBP-1 mutation variants associating with artemisinin treatment failure have been reported in Africa and SEA. In this study, we have employed CRISPR-Cas9 genome editing and pre-emptive drug pressures to test these artemisinin susceptibility associated mutations in UBP-1 in P. berghei sensitive lines in vivo. Using these approaches, we have shown that the V2721F UBP-1 mutation results in reduced artemisinin susceptibility, while the V2752F mutation results in resistance to chloroquine and moderately impacts tolerance to artemisinins. Genetic reversal of the V2752F mutation restored chloroquine sensitivity in these mutant lines while simultaneous introduction of both mutations could not be achieved and appears to be lethal. Interestingly, these mutations carry a detrimental growth defect, which would possibly explain their lack of expansion in natural infection settings. Our work has provided independent experimental evidence on the role of UBP-1 in modulating parasite responses to artemisinin and chloroquine under in vivo conditions.