Fauci and Birx could storm out and publicly speak their minds, but then they'd lose any influence they have on President Trump.

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Teaching students to read is the first job of our schools. How can we help all students become strong, confident readers? Literacy for All: Equitable Practices for Reading and Dyslexia was held on February 20, 2020 in Annapolis, Maryland. The event was hosted by National Center on Improving Literacy (NCIL), Decoding Dyslexia Maryland (DD-MD), and community partners. Reading experts from NCIL shared best practices in early screening and interventions supported by decades of reading research.

Teaching students to read is the first job of our schools. How can we help all students become strong, confident readers? Literacy for All: Equitable Practices for Reading and Dyslexia was held on February 20, 2020 in Annapolis, Maryland. The event was hosted by National Center on Improving Literacy (NCIL), Decoding Dyslexia Maryland (DD-MD), and community partners. Reading experts from NCIL shared best practices in early screening and interventions supported by decades of reading research.

Teaching students to read is the first job of our schools. How can we help all students become strong, confident readers? Literacy for All: Equitable Practices for Reading and Dyslexia was held on February 20, 2020 in Annapolis, Maryland. The event was hosted by National Center on Improving Literacy (NCIL), Decoding Dyslexia Maryland (DD-MD), and community partners. Reading experts from NCIL shared best practices in early screening and interventions supported by decades of reading research.

Many homeowners have built up wealth in their homes. Owners’ balance sheets remained strong in the first quarter across the U.S., a new report shows.

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H42RA) exhibited a significant loss of global H2Bub1. H42RA mutant yeast strains also displayed chemotoxin sensitivities similar to, but less severe than, strains containing a complete loss of H2Bub1. We found that the H4 basic patch regulates H2Bub1 levels independently of interactions with chromatin remodelers and separately from its regulation of H3K79 methylation. To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool, the light-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1. The ability of Bre1 to ubiquitylate H2B was unaffected in the H42RA mutant. In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp10, increased in the H42RA mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.

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