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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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Organic/inorganic heterostructures templated by interfacial instability-driven BCP colloids in deformable emulsion droplets

Soft Matter, 2024, 20,8174-8180
DOI: 10.1039/D4SM00921E, Communication
Yuqing Song, Nan Yan, Lingli Wan, Jingjing Li, Ye Gao
Core–shell colloids are self-assembled in emulsion droplets driven by interfacial instability, which serve as excellent scaffolds for designing organic/inorganic heterostructures.
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Revisiting the density profile of the fuzzy sphere model for microgel colloids

Soft Matter, 2024, 20,8181-8184
DOI: 10.1039/D4SM01045K, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Frank Scheffold
Microgel density profiles evaluated with the complementary error function and the popular fuzzy sphere model are not compatible with each other.
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Co-encapsulation of organic polymers and inorganic superparamagnetic iron oxide colloidal crystals requires matched diffusion time scales

Soft Matter, 2024, 20,8312-8325
DOI: 10.1039/D4SM00935E, Paper
Open Access
Brian K. Wilson, Robert K. Prud’homme
Composite nanoparticles co-encapsulate organic materials with inorganic primary colloids. Producing “stoichiometric NPs”, where all NPs contain organic and inorganic species at similar ratios, requires matched diffusion-aggregation time scale.
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Coupled dynamics in binary mixtures of model colloidal Yukawa systems

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01123F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Daniel Weidig, Joachim Wagner
Self- and collective dynamics in mixtures of highly charged binary colloidal particles is analyzed by Brownian dynamics simulations. For equally charged, but differently sized particles coupling effects in their long-time dynamics are observed.
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Understanding Polymer-Colloid Gels: A Solvent Perspective Using Low-Field NMR

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01098A, Communication
Léo Hervéou, Gauthier Legrand, Thibaut Divoux, Guilhem Pablo Baeza
The present work emphasizes the relevance of low-field NMR relaxometry to investigate colloid-polymer hydrogels by probing water dynamics across a wide range of formulations between 10°C and 80°C. By examining...
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Pairing-specific microstructure in depletion gels of bidisperse colloids

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00811A, Paper
Open Access
Rony A. Waheibi, Lilian C. Hsiao
We report the ensemble-averaged and pairing-specific network microstructure formed by short-range depletion attractions in bidisperse hard sphere-like colloidal systems.
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Magnetic colloidal single particles and dumbbells on a tilted washboard moir'e pattern in a precessing external field

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01183J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Farzaneh Farrokhzad, Nico C. X. Stuhlmüller, Piotr Kuswik, Maciej Urbaniak, Feliks Stobiecki, Sapida Akhundzada, Arno Ehresmann, Daniel de las Heras, Thomas M. Fischer
We measure the dynamical behavior of colloidal singlets and dumbbells on an inclined magnetic moir'e pattern, subject to a precessing external homogeneous magnetic field. At low external field strength single...
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Editorial. Industrial township plan should avoid earlier errors

The institutional arrangements and market linkages must be worked out beforehand. The biggest hurdle pertains to land acquisition. The implementing agency is expected to provide “developed land parcels” for industries to operate in ‘plug and play’ mode. But this is easier said than done




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Zardozi Embroidery

A pantheon of craftsmen and their art are on display at Kaivalam, under way in Chennai. Rashmi R.D. introduces us to some Living Legends of Indian crafts. Meet Mohammad Bilal




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Total synthesis of spiro Ganoderma meroterpenoids spiroapplanatumines B, D, F, and H

Org. Chem. Front., 2024, 11,6333-6339
DOI: 10.1039/D4QO01147C, Research Article
Jia-Hao Zhang, Wen-Cai Luo, Wen-Tao Chen, Yu-Tao He, Ya-Jian Hu
The first total synthesis of spiroapplanatumines B, D, F, and H as well as the possibly undiscovered natural product spiroapplanatumine R has been achieved.
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A safe and efficient synthesis of N-Boc-β3-amino acid methyl esters from α-amino acids: applications in the formal synthesis of sedum alkaloids

RSC Adv., 2024, 14,36016-36021
DOI: 10.1039/D4RA07506D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bohua Long, Lijie Ren, Mengmeng Jiang, Shengquan Hu, Qianqian Jiang, Limin Li, Xuanluan Chen, Zhengzhi Wu
β3-Amino acids are essential components in the synthesis of biologically active compounds.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Avoid arresting boys who go on a date, says Uttarakhand High Court

PIL petition cites gender discrimination in teenage dating




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Can India avoid defeat in Bengaluru Test?

India were in danger of suffering their first home test loss to New Zealand since 1988, despite Sarfaraz Khan's 150 and Rishabh Pant's 99, when the tourists bowled them out for 462 on the fourth day of their rain-interrupted series opener on Saturday.




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Android or Alangudi




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Of coruscating celluloid

The cameras back then captured raw, real, and unadulterated images




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Prioritise celebrating Diwali with lights to avoid noise and air pollution: BMC issues new guidelines for firecracker use during festivities




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Are we paranoid about security?




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Zydus Lifesciences gets WHO prequalification for Typhoid Vi conjugate vaccine

Zydus Lifesciences’ ZyVac TCV receives WHO prequalification, eligible for U.N. procurement, combating typhoid fever in high-risk regions




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Leadership void at DUK and KTU: Administrative challenges persist amid Vice-Chancellor vacancies




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Campaign against British tabloids gathers momentum

The ‘Stop Funding Hate’ campaign is urging companies to stop advertising with tabloids




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Pain, the opioid epidemic, and depression [electronic resource] / Jeffrey F. Scherrer, editor ; Jane C. Ballantyne, co-editor.

New York, NY : Oxford University Press , 2024.




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‘The Romans are unavoidable,’ says Mary Beard about the ancient civilisation

Roman writers had an anxiety about one-man rule. But there was little opposition to the system, says the author of ‘Emperor of Rome: Ruling the Ancient Roman World’




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Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females

Food Funct., 2024, 15,10782-10794
DOI: 10.1039/D4FO02681K, Paper
Open Access
Josh Thorley, Abrar Alhebshi, Ana Rodriguez-Mateos, Zicheng Zhang, Stephen J. Bailey, Neil R. W. Martin, Nicolette C. Bishop, Tom Clifford
Supplementation with a curcuminoid-based formulation for four days did not augment nuclear factor erythroid 2-related factor 2 (NRF2) activity in peripheral blood mononuclear cells at rest and after strenuous plyometric exercise.
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Correction: A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice

Food Funct., 2024, 15,10913-10914
DOI: 10.1039/D4FO90102A, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tian Liu, Xue Wang, Yan-Ming Wang, Feng-Rong Sui, Xue-Ying Zhang, Hai-Di Liu, Dong-Yue Ma, Xiao-Xiao Liu, Shou-Dong Guo
The content of this RSS Feed (c) The Royal Society of Chemistry




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Alleviating effect of whey protein supplementation on oxidative stress in hypothyroidism

Food Funct., 2024, 15,11158-11168
DOI: 10.1039/D4FO03186E, Paper
Ann Liya Sajan, Jenat Pazheparambil Jerom, Bhagyasree Rajasekharan Nair, Devanandana Dileep Kumar Sajitha, Reshma Soman, Ajmal Jalal, Raveendran Harikumaran Nair
Supplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.
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Human Milk Metals and Metalloids Shape Infant Microbiota

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO01929F, Paper
Open Access
Eduard Flores Ventura, Manuel Bernabeu, Belén Callejón Leblic, Raúl Cabrera-Rubio, Laxmi Yeruva, Javier Estañ-Capell, Cecilia Martínez-Costa, Tamara García-Barrera, Maria Carmen Collado
Background: The profile of metal (loid)s in human milk is essential for infant growth and development, yet its impact on the development of the infant microbiota remains unclear. Elements such...
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Correction: Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO90094D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xianli Wang, Yuxin Jing, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhengyang Wu, Ruihong Ge, Wei Cheng, Yuanyuan Yan, Shilong Jiang, Jianguo Sun, Jingquan Li, Qinggang Xie, Xiaoguang Li, Hui Wang
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Avoiding digital arrest

Stay informed, don’t share personal information




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Science for All | What are Trojan asteroids?

The Hindu’s weekly Science for All newsletter explains all things Science, without the jargon.




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Photomanipulatable colloidal clusters from the aggregation of azo molecular glass spheres

Nanoscale, 2024, 16,20060-20066
DOI: 10.1039/D4NR03618B, Communication
Bo Tang, Lier Wang, Xitong Ai, Chuyi Liao, Zhiyuan Xiong, Yaning He, Xiaogong Wang
Controllable fabrication of photoresponsive colloidal clusters with a wide range of adjustable sizes and complex architectures are fabricated through the aggregation, fusion and photoinduced deformation of azo colloidal spheres.
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Optimization of hair follicle spheroids for hair-on-a-chip

Biomater. Sci., 2024, 12,1693-1706
DOI: 10.1039/D3BM02012F, Paper
Subin Jeong, Hyeon-Min Nam, Gun Yong Sung
We report spheroids prepared by injecting LEF1 and Wnt1 into DPCs via transfection and then adding KCs and HUVECs. Through SEM, we observed a part extending outward from the TK and TKH surfaces, as indicated by white arrows.
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Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Biomater. Sci., 2024, 12,1801-1821
DOI: 10.1039/D3BM01688A, Paper
Manju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti Panda
The graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.
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Google announces new Android features at MWC 2024

The focus is on easier AI-assisted communication




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Endocrinology plays a vital role in diagnosing, managing and preventing lifestyle disorders like diabetes and thyroid, says Venkaiah Naidu




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Embroidery of Dreams: Deepika Khatri’s journey to Cannes

Designer Deepika Khatri made news when actor Rebecca Kunikowski wore her work on the red carpet. She talks about her life and how it brought her to Cannes




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Watch: Women artisans in Lucknow keep Chikankari embroidery alive




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Ace embroiderer Annie Titus Mammen crafts an independent line of embellished pashmina stoles

Chennai-based Annie Titus Mammen, who does embroidery for Chanel, Balenciaga and Louis Vuitton, has launched Tambour’s first Independent product line of embellished pashmina stoles in Delhi




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Take recovery from ‘avoidance transactions’ seriously, IBBI tells creditors. 

Recovery for creditors could go up at least 10 per cent on such approach, says IBBI Chief Mital; Till Sep 2024, total clawback on avoidance transactions applications stood at ₹7,516 crore




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Google working on making Gemini take calls and send messages when Android phone is locked: Report

Currently, Gemini can reply to texts and take calls when a phone is locked, but only Google Assistant can do these tasks when the phone is unlocked




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OnePlus 13 launched with Snapdragon 8 Elite and Android 15. Price, specs

OnePlus 13 gets up to 24 GB RAM and up to 1 TB storage in its home market




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Avoid polluting indoors

Interior design options are aplenty today, but are such energy-guzzling materials healthy?




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First artwork by humanoid robot sells for $1.3 million

A portrait of English mathematician Alan Turing became the first artwork by a humanoid robot to be sold at auction, fetching $1,320,000




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EU to ban neonicotinoid pesticides outdoors

Move follows report by food safety agency on health risks to bees




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Escient launches to tackle itching and anaphylactoid drug targets

The startup raised $40 million to target a class of GPCRs called Mas-related G-protein receptors, to treat neuroimmune and inflammatory conditions




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Should You Avoid High-Cost Funds?

Investors should match their investment horizon with the fund's portfolio duration.




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Infinix launches Android X3 smart TVs in India

The smart TVs will be available in 32-inch and 43-inch variants for pre-booking from March 12-16