led Social Work England | Knowledge, skills and behaviours Our plan to bring new curriculum guidance into regulation for qualifying social work courses By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 14:19:35 +0000 The post Social Work England | Knowledge, skills and behaviours Our plan to bring new curriculum guidance into regulation for qualifying social work courses was curated by information for practice. Full Article Grey Literature
led Enhancing the science–policy linkages using traditional and Indigenous knowledge By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 17:03:03 +0000 The post Enhancing the science–policy linkages using traditional and Indigenous knowledge was curated by information for practice. Full Article Grey Literature
led So-called ‘deaths of despair’ are rising in the UK. Labour must act on this silent epidemic By ifp.nyu.edu Published On :: Fri, 01 Nov 2024 13:48:44 +0000 Rates of suicide, alcohol and drug fatalities (collectively known as “deaths of despair”) have increased by 9%, 45% and 81% respectively in England and Wales over the last decade. Given that mortality rates for most other causes are stable or decreasing, this increase is deeply concerning. In total, in 2022 these three causes accounted for […] The post So-called ‘deaths of despair’ are rising in the UK. Labour must act on this silent epidemic was curated by information for practice. Full Article News
led New head of Quebec youth protection pledges to be ‘watchdog’ for children By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 11:54:28 +0000 Lesley Hill, newly named head of Quebec’s increasingly embattled youth protection department (DPJ), pledged Thursday to be a “watchdog” for the children of province, adding that she is ready to do what it takes to get to the bottom of the apparent dysfunction plaguing the agency. The post New head of Quebec youth protection pledges to be ‘watchdog’ for children was curated by information for practice. Full Article News
led Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial By ifp.nyu.edu Published On :: Sun, 03 Nov 2024 09:43:38 +0000 The post Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial was curated by information for practice. Full Article Open Access Journal Articles
led Participatory topological mapping: A novel approach for exploring and communicating situated knowledge of complex socio-ecological systems By ifp.nyu.edu Published On :: Sun, 03 Nov 2024 23:59:11 +0000 Methodological Innovations, Ahead of Print. Land use change impacts on Sámi reindeer husbandry are well-documented, but existing maps often fail to capture socio-ecological relationships between herders, reindeer and nature. Conventional Geographic Information Systems (GIS) simplify these relationships, lacking local context and excluding valuable knowledge due to their rigid structure. This paper introduces participatory topological mapping, […] The post Participatory topological mapping: A novel approach for exploring and communicating situated knowledge of complex socio-ecological systems was curated by information for practice. Full Article Open Access Journal Articles
led The B/1 by Toledano & Chan Brings the Beauty of Brutalism to Your Wrist By design-milk.com Published On :: Wed, 17 Jul 2024 13:00:58 +0000 Now you can wear your brutally honest love for architecture on your wrist with the B/1 watch by Toledano & Chan inspired by Marcel Breuer's NYC landmark. Full Article Main Style + Fashion Alfred Chan angular Brutalism Brutalist horology Marcel Breuer Met Breuer Phil Toledano timepiece Toledano & Chan Toledano and Chan watch watches wrist watch wristwatch
led Nike x Hyperice Tech-Enabled Boots Put the Squeeze on Muscle Fatigue By design-milk.com Published On :: Fri, 26 Jul 2024 14:00:10 +0000 Nike and sports technology brand Hyperice's new recovery boot and vest are each designed to squeeze, heat, and cool muscles. Full Article Main Style + Fashion Technology boot fitness fitness device fitness equipment fitness technology health technology Hyperice Nike recovery technology shoes sneakers
led Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 09:29:38 +0000 Volume 29, Issue 7, October 2024. Read the full article › The post Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations was curated by information for practice. Full Article Journal Article Abstracts
led Effects of creative movement, general movement, or seated play interventions on motor performance in children with autism spectrum disorder: A pilot randomized controlled trial By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 10:46:39 +0000 Publication date: January 2025 Source: Research in Autism Spectrum Disorders, Volume 119 Author(s): W.C. Su, S. Srinivasan, A.N. Bhat Read the full article › The post Effects of creative movement, general movement, or seated play interventions on motor performance in children with autism spectrum disorder: A pilot randomized controlled trial was curated by information for practice. Full Article Journal Article Abstracts
led Evidence & Policy | CfP – Exploring the Role of Youth-led Research in Policy Change (Interested authors should send a 300-word abstract by 30 Nov) By ifp.nyu.edu Published On :: Sun, 13 Oct 2024 22:33:39 +0000 The post Evidence & Policy | CfP – Exploring the Role of Youth-led Research in Policy Change (Interested authors should send a 300-word abstract by 30 Nov) was curated by information for practice. Full Article Calls & Consultations
led Why high prices toppled Democrats — and other governments around the world By www.npr.org Published On :: Tue, 12 Nov 2024 07:08:41 -0500 Voters really don't like inflation. In fact, whenever there's a sustained jump in the cost of living, the party in power often pays a price. Full Article
led R. Kelly ordered jailed on $1M bond at Chicago hearing By minnesota.publicradio.orghttps Published On :: Sat, 23 Feb 2019 15:15:00 -0600 A judge on Saturday gave R. Kelly a chance to go free while the R&B star awaits trial on charges that he sexually abused four people, including three minors, in a case that seemed likely to produce another #MeToo reckoning for a celebrity. Full Article
led Officials say rapper Nipsey Hussle shot and killed at 33 By minnesota.publicradio.orghttps Published On :: Mon, 01 Apr 2019 01:44:24 -0500 Nipsey Hussle, a respected rapper who earned a Grammy nomination this year for his major-label debut, was fatally shot outside his clothing store, authorities said. Full Article
led Why AP called Arizona for Trump By www.mprnews.org Published On :: Sun, 10 Nov 2024 14:58:09 +0000 The Associated Press declared President-elect Donald Trump the winner in Arizona on Saturday night after vote updates in Maricopa and other counties added to his overall lead, putting the state out of reach for Vice President Kamala Harris. Full Article
led Why high prices toppled Democrats — and other governments around the world By www.mprnews.org Published On :: Tue, 12 Nov 2024 12:08:41 +0000 Voters really don't like inflation. In fact, whenever there's a sustained jump in the cost of living, the party in power often pays a price. Full Article
led Twin brother of murdered Texas pastor wants suspect jailed as he laments pace of justice By www.christianpost.com Published On :: Mon, 04 Nov 2024 14:20:17 -0500 The Rev. Roland Mouton, the twin brother of the late East Bethel Missionary Baptist Church pastor the Rev. Ronald K. Mouton, who was fatally shot in the chest in June 2022 after a 10-second argument with an Uber driver in Houston, is calling for the suspect in his brother’s killing to be jailed for violating the terms of his bond as his laments the slow pace of justice for his family. Full Article
led Pastor who led double life, murdered girlfriend on wedding day, sees life conviction upheld By www.christianpost.com Published On :: Sun, 10 Nov 2024 11:11:10 -0500 The Georgia Supreme Court has upheld the life sentence of a pastor who led a double life and murdered his fiancée on their wedding day. Full Article
led Before leaving for Angola, missionary and wife charged with his murder shared troubled paths to Jesus By www.christianpost.com Published On :: Mon, 11 Nov 2024 15:03:32 -0500 Barely a year after the COVID-19 pandemic began in March 2021, and shortly before they would jet off to Angola in southern Africa with their five children to do missionary work, Beau Shroyer and his wife Jackie Shroyer who was recently charged in connection with his Oct. 25 murder, shared their troubled paths to Jesus and what made them so willing to dive into the mission field no matter the cost. Full Article
led Sean Rowe installed as new leader of Episcopal Church; stresses unity, need to ‘finish the job’ By www.christianpost.com Published On :: Mon, 04 Nov 2024 15:47:09 -0500 The Rt. Rev. Sean Rowe has taken over as the new leader of The Episcopal Church, declaring at his installation service that the denomination must unify and “finish the job” of witnessing to a “hurting world.” Full Article
led Iranian agents plotted to murder Trump, unsealed DOJ charges reveal By www.christianpost.com Published On :: Tue, 12 Nov 2024 17:01:00 -0500 The details of an unsealed Iranian murder-for-hire plot to kill President-elect Donald Trump raise questions about how the current administration will act, as President Joe Biden previously warned Iran that the United States would consider its targeting of the Republican nominee as an "act of war." Full Article
led Serial killer who cannibalised minors and killed over 30 sent to mental hospital By english.pravda.ru Published On :: Tue, 21 May 2024 16:41:00 +0300 The Kemerovo regional court ruled to send Alexander Spesivtsev, a resident of Novokuznetsk, to compulsory treatment, the regional Office of the Public Prosecutor said. The defendant, Alexander Spesivtsev, is a serial killer, who killed at least 34 victims and ate them during the 1990s. Spesivtsev will undergo treatment at a special psychiatric hospital. Full Article Society
led Chechen President Kadyrov pledges to send more airplanes with volunteers to Ukraine By english.pravda.ru Published On :: Tue, 29 Oct 2024 20:30:00 +0300 Chechnya should send volunteers to the zone of the special military operation in Ukraine more frequently, Chechen President Ramzan Kadyrov said. Kadyrov made this announcement after a Ukrainian drone struck the building of the University of Special Forces in Gudermes. "I urge real men to volunteer to fight to defend our land, our state and our people. We need to show that you can't play around with Chechnya and its people," Ramzan Kadyrov said. Airplanes with volunteers should be sent to the front lines every day, not just once a week, as is happening now, he added. Full Article World
led German Lillevali and tumbled pyramids of grand strategists By english.pravda.ru Published On :: Wed, 15 Sep 2021 20:55:00 +0300 How do famous film directors and athletes become baits for pyramid schemes? How are such prominent figures as Anatoly Karpov, Nikita Mikhalkov and other renowned personalities in Russia involved with the scammers from Anchor-Invest? Scarcely ever it is possible to catch and put into jail big-time operators of financial pyramids how it happened with Mavrodi, the famous "financier of Russia". Apart from Mavrodi, a variety of pyramids existed and continue to operate in Russia that have the same backbone; to take your money. Full Article Business
led Retailers’ guide to navigating failed payments By www.retailtechnologyreview.com Published On :: By Brad Hyett, CEO at phos.With the news from UK Finance that 93% of all UK cards are now contactless, we cannot underestimate the importance of a reliable digital payment infrastructure. But what happens when traditional chip-and-pin machines fail? We all remember the recent tech outages across McDonald's, Tesco, and Sainsbury's, which forced the outlets to close down. Full Article EPoS Systems Retail Supply Chain Critical Issues Payment Technology
led Women in Green Business Awards: The top 20 women accelerating the UK’s net zero transition revealed ahead of Net Zero Festival 2024 By www.retailtechnologyreview.com Published On :: Tue, 13 Nov 2440 17:28:41 +0000 We Mean Business Coalition’s chief executive officer Maria Mendiluce, Zapmap’s co-founder and chief operating officer Melanie Shufflebotham, and co-leader of the Green Party England and Wales Carla Denyer are among those to have been awarded an inaugural Women in Green Business Award celebrating their work driving the UK's net zero transition. Full Article Retail Supply Chain Exhibitions and Events
led Russian general killed in special military operation zone By english.pravda.ru Published On :: Fri, 08 Nov 2024 20:34:00 +0300 Major General Pavel Klimenko was killed in the zone of the special military operation in Ukraine. He commanded the 5th separate motorized rifle brigade, which was previously part of the People's Militia of the Donetsk People's Republic. No circumstances of the general's death were provided. Pavel Klimenko held the title of Hero of the DPR, had two Orders of Courage, the Order of Alexander Nevsky and the Medal "For Bravery". Full Article Incidents
led Ukrainian truck driver killed in Germany for his remarks about Putin By english.pravda.ru Published On :: Mon, 11 Nov 2024 20:42:00 +0300 A Ukrainian truck driver was killed in Germany because of his words about Russian President Vladimir Putin, Bild wrote. "During a fight on a parking lot in front of a sawmill in Oberroth [in the federal state of Baden-Württemberg], three truck drivers apparently killed a colleague of theirs on Saturday evening at around 8:15 p.m. They were arguing about Russia's role in the conflict in Ukraine,” the newspaper said. The Ukrainian citizen was 34 years old. The men were drinking alcoholic beverages at the time when the incident occurred. The police detained three of his colleagues, each of whom is suspected of the murder. One of them is a citizen of Uzbekistan, two others are from Eastern European countries. Full Article Society
led For blood quality and men's health: which vegetables need to be boiled By english.pravda.ru Published On :: Wed, 19 Apr 2023 21:17:00 +0300 Margarita Koroleva, a professor at the Federal Medical and Biological Agency of Russia, a doctor of medical sciences and a dietician, shared her recommendations regarding the way of cooking vegetables to get the best of them. Some vegetables should be boiled to extract as many nutrients as possible. For example, boiled carrots are better absorbed by the body than raw ones, which allows us to obtain more vitamin A from this vegetable. When tomatoes and red peppers are thermally processed, lycopene, a wonderful antioxidant that is highly beneficial for tissue and blood health, is activated and better absorbed by the body. The specialist also advised people with digestive problems should consume boiled turnip and radish, as their nutrients are better digested by the human body if those vegetables are boiled. Full Article Health
led Yoon Pledges Efforts to Overcome Polarization Marking Halfway Point of Presidency By world.kbs.co.kr Published On :: Mon, 11 Nov 2024 14:38:54 +0900 [Politics] : President Yoon Suk Yeol pledged efforts to overcome polarization in South Korean society, as he passes the halfway point of his five-year presidency. According to presidential spokesperson Jeong Hye-jeon on Monday, Yoon, during a meeting with his aides, called for forward-looking efforts to resolve ...[more...] Full Article Politics
led S. Korean Military: Hwasong-19 a New Kind of Missile, Support from Russia Cannot Be Ruled Out By world.kbs.co.kr Published On :: Mon, 11 Nov 2024 15:39:34 +0900 [Inter-Korea] : The South Korean military believes the Hwasong-19, the intercontinental ballistic missile(ICBM) that North Korea test-fired on October 31, is a new model that Pyongyang may have developed with technological assistance from Moscow. In a report disclosed Monday by the office of ruling People Power Party ...[more...] Full Article Inter-Korea
led How to Volunteer to Help Disabled Veterans By money.howstuffworks.com Published On :: Sat, 11 Nov 2023 07:00:03 -0500 Would you like to volunteer to help disabled veterans? Visit HowStuffWorks to learn how to volunteer to help disabled veterans. Full Article
led NYT: US Official Confirms ‘Significant Number’ of N. Korean Troops Killed in Combat against Ukraine By world.kbs.co.kr Published On :: Wed, 06 Nov 2024 13:32:54 +0900 [International] : A high-level U.S. government official reportedly confirmed that many North Korean troops deployed to Russia have been killed in combat against Ukraine. On Tuesday, the New York Times quoted the official as saying “a significant number” were killed in action, with the exact time of the armed conflict ...[more...] Full Article International
led Operator of Japan’s Crippled Fukushima Nuclear Plant Retrieves Sample of Fuel Debris By world.kbs.co.kr Published On :: Thu, 07 Nov 2024 15:32:27 +0900 [International] : The operator of Japan’s Fukushima Daiichi nuclear power plant said it retrieved a small amount of melted fuel from one of the reactors for the first time since a major earthquake and tsunami crippled the nuclear facility in 2011. According to Japanese media outlets on Thursday, the Tokyo Electric Power ...[more...] Full Article International
led Position-independent product increase rate in a shaker mill revealed by position-resolved in situ synchrotron powder X-ray diffraction By journals.iucr.org Published On :: The position- and time-resolved monitoring of a mechanochemical reaction using synchrotron powder X-ray diffraction revealed a position-independent increase rate of product in the jar of a shaker mill. Full Article text
led Position-independent product increase rate in a shaker mill revealed by position-resolved in situ synchrotron powder X-ray diffraction By journals.iucr.org Published On :: 2024-11-08 We investigated the position and time dependence of a mechanochemical reaction induced by ball milling using in situ synchrotron powder X-ray diffraction with changing X-ray irradiation position. The mechanochemical reduction of AgCl with Cu was monitored in situ with the X-rays incident at two different vertical positions on the jar. Our previously developed multi-distance Rietveld method was applied to analyze the in situ diffraction data with a 1 min resolution. Both the vertical and the horizontal sample positions were determined using the sample-to-detector distances from the in situ data. Position dependence was found in the powder spreading and induction time. We reveal that the increase rate of the product is independent of the sample position when measured with a 1 min time resolution, confirming the validity of in situ monitoring of part of the space in a milling jar for a gradual mechanochemical reaction. Full Article text
led In situ/operando plug-flow fixed-bed cell for synchrotron PXRD and XAFS investigations at high temperature, pressure, controlled gas atmosphere and ultra-fast heating By journals.iucr.org Published On :: 2024-01-01 A plug-flow fixed-bed cell for synchrotron powder X-ray diffraction (PXRD) and X-ray absorption fine structure (XAFS) idoneous for the study of heterogeneous catalysts at high temperature, pressure and under gas flow is designed, constructed and demonstrated. The operating conditions up to 1000°C and 50 bar are ensured by a set of mass flow controllers, pressure regulators and two infra-red lamps that constitute a robust and ultra-fast heating and cooling method. The performance of the system and cell for carbon dioxide hydrogenation reactions under specified temperatures, gas flows and pressures is demonstrated both for PXRD and XAFS at the P02.1 (PXRD) and the P64 (XAFS) beamlines of the Deutsches Elektronen-Synchrotron (DESY). Full Article text
led A thermal deformation optimization method for cryogenically cooled silicon crystal monochromators under high heat load By journals.iucr.org Published On :: 2024-01-22 A method to optimize the thermal deformation of an indirectly cryo-cooled silicon crystal monochromator exposed to intense X-rays at a low-emittance diffraction-limited synchrotron radiation source is presented. The thermal-induced slope error of the monochromator crystal has been studied as a function of heat transfer efficiency, crystal temperature distribution and beam footprint size. A partial cooling method is proposed, which flattens the crystal surface profile within the beam footprint by modifying the cooling contact area to optimize the crystal peak temperature. The optimal temperature varies with different photon energies, which is investigated, and a proper cooling strategy is obtained to fulfil the thermal distortion requirements over the entire photon energy range. At an absorbed power up to 300 W with a maximum power density of 44.8 W mm−2 normal incidence beam from an in-vacuum undulator, the crystal thermal distortion does not exceed 0.3 µrad at 8.33 keV. This method will provide references for the monochromator design on diffraction-limited synchrotron radiation or free-electron laser light sources. Full Article text
led Modelling the power threshold and optimum thermal deformation of indirectly liquid-nitrogen cryo-cooled Si monochromators By journals.iucr.org Published On :: 2024-04-09 Maximizing the performance of crystal monochromators is a key aspect in the design of beamline optics for diffraction-limited synchrotron sources. Temperature and deformation of cryo-cooled crystals, illuminated by high-power beams of X-rays, can be estimated with a purely analytical model. The analysis is based on the thermal properties of cryo-cooled silicon crystals and the cooling geometry. Deformation amplitudes can be obtained, quickly and reliably. In this article the concept of threshold power conditions is introduced and defined analytically. The contribution of parameters such as liquid-nitrogen cooling efficiency, thermal contact conductance and interface contact area of the crystal with the cooling base is evaluated. The optimal crystal illumination and the base temperature are inferred, which help minimize the optics deformation. The model has been examined using finite-element analysis studies performed for several beamlines of the Diamond-II upgrade. Full Article text
led Developing an in situ LED irradiation system for small-angle X-ray scattering at B21, Diamond Light Source By journals.iucr.org Published On :: 2024-05-31 Beamline B21 at the Diamond Light Source synchrotron in the UK is a small-angle X-ray scattering (SAXS) beamline that specializes in high-throughput measurements via automated sample delivery systems. A system has been developed whereby a sample can be illuminated by a focused beam of light coincident with the X-ray beam. The system is compatible with the highly automated sample delivery system at the beamline and allows a beamline user to select a light source from a broad range of wavelengths across the UV and visible spectrum and to control the timing and duration of the light pulse with respect to the X-ray exposure of the SAXS measurement. The intensity of the light source has been characterized across the wavelength range enabling experiments where a quantitative measure of dose is important. Finally, the utility of the system is demonstrated via measurement of several light-responsive samples. Full Article text
led Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals By journals.iucr.org Published On :: 2024-07-25 Advances in structural biology have relied heavily on synchrotron cryo-crystallography and cryogenic electron microscopy to elucidate biological processes and for drug discovery. However, disparities between cryogenic and room-temperature (RT) crystal structures pose challenges. Here, Cryo2RT, a high-throughput RT data-collection method from cryo-cooled crystals that leverages the cryo-crystallography workflow, is introduced. Tested on endothiapepsin crystals with four soaked fragments, thaumatin and SARS-CoV-2 3CLpro, Cryo2RT reveals unique ligand-binding poses, offers a comparable throughput to cryo-crystallography and eases the exploration of structural dynamics at various temperatures. Full Article text
led STEM SerialED: achieving high-resolution data for ab initio structure determination of beam-sensitive nanocrystalline materials By journals.iucr.org Published On :: 2024-01-01 Serial electron diffraction (SerialED), which applies a snapshot data acquisition strategy for each crystal, was introduced to tackle the problem of radiation damage in the structure determination of beam-sensitive materials by three-dimensional electron diffraction (3DED). The snapshot data acquisition in SerialED can be realized using both transmission and scanning transmission electron microscopes (TEM/STEM). However, the current SerialED workflow based on STEM setups requires special external devices and software, which limits broader adoption. Here, we present a simplified experimental implementation of STEM-based SerialED on Thermo Fisher Scientific STEMs using common proprietary software interfaced through Python scripts to automate data collection. Specifically, we utilize TEM Imaging and Analysis (TIA) scripting and TEM scripting to access the STEM functionalities of the microscope, and DigitalMicrograph scripting to control the camera for snapshot data acquisition. Data analysis adapts the existing workflow using the software CrystFEL, which was developed for serial X-ray crystallography. Our workflow for STEM SerialED can be used on any Gatan or Thermo Fisher Scientific camera. We apply this workflow to collect high-resolution STEM SerialED data from two aluminosilicate zeolites, zeolite Y and ZSM-25. We demonstrate, for the first time, ab initio structure determination through direct methods using STEM SerialED data. Zeolite Y is relatively stable under the electron beam, and STEM SerialED data extend to 0.60 Å. We show that the structural model obtained using STEM SerialED data merged from 358 crystals is nearly identical to that using continuous rotation electron diffraction data from one crystal. This demonstrates that accurate structures can be obtained from STEM SerialED. Zeolite ZSM-25 is very beam-sensitive and has a complex structure. We show that STEM SerialED greatly improves the data resolution of ZSM-25, compared with serial rotation electron diffraction (SerialRED), from 1.50 to 0.90 Å. This allows, for the first time, the use of standard phasing methods, such as direct methods, for the ab initio structure determination of ZSM-25. Full Article text
led Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SEC-SWAXS, NMR and molecular simulation By journals.iucr.org Published On :: 2024-08-08 The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a small EDRK-rich factor 1a (SERF1a) in promoting Httex1 fibrillization through interactions with its N terminus. By establishing an integrated approach with size-exclusion-column-based small- and wide-angle X-ray scattering (SEC-SWAXS), NMR, and molecular simulations using Rosetta, the analysis here reveals a tight binding of two NT17 fragments of Httex1 (comprising the initial 17 amino acids at the N terminus) to the N-terminal region of SERF1a. In contrast, examination of the complex structure of SERF1a with a coiled NT17-polyQ peptide (33 amino acids in total) indicates sparse contacts of the NT17 and polyQ segments with the N-terminal side of SERF1a. Furthermore, the integrated SEC-SWAXS and molecular-simulation analysis suggests that the coiled NT17 segment can transform into a helical conformation when associated with a polyQ segment exhibiting high helical content. Intriguingly, NT17-polyQ peptides with enhanced secondary structures display diminished interactions with SERF1a. This insight into the conformation-dependent binding of NT17 provides clues to a catalytic association mechanism underlying SERF1a's facilitation of Httext1 fibrillization. Full Article text
led Neural network analysis of neutron and X-ray reflectivity data incorporating prior knowledge By journals.iucr.org Published On :: 2024-03-31 Due to the ambiguity related to the lack of phase information, determining the physical parameters of multilayer thin films from measured neutron and X-ray reflectivity curves is, on a fundamental level, an underdetermined inverse problem. This ambiguity poses limitations on standard neural networks, constraining the range and number of considered parameters in previous machine learning solutions. To overcome this challenge, a novel training procedure has been designed which incorporates dynamic prior boundaries for each physical parameter as additional inputs to the neural network. In this manner, the neural network can be trained simultaneously on all well-posed subintervals of a larger parameter space in which the inverse problem is underdetermined. During inference, users can flexibly input their own prior knowledge about the physical system to constrain the neural network prediction to distinct target subintervals in the parameter space. The effectiveness of the method is demonstrated in various scenarios, including multilayer structures with a box model parameterization and a physics-inspired special parameterization of the scattering length density profile for a multilayer structure. In contrast to previous methods, this approach scales favourably when increasing the complexity of the inverse problem, working properly even for a five-layer multilayer model and a periodic multilayer model with up to 17 open parameters. Full Article text
led Directors Guild finds TV diversity hiring stalled By www.scpr.org Published On :: Wed, 17 Sep 2014 12:38:26 -0700 In this Saturday, Sept. 6, 2014 file photo, Paris Barclay attends the LA Premiere Screening of "Sons Of Anarchy" at TCL Chinese Theatre, in Los Angeles. A new guild study says that women and minorities were largely shut out of the ranks of TV directors again last season. In a Wednesday, Sept. 17, 2014 statement, Directors Guild President Barclay said it can be "shockingly difficult" to persuade those who control industry hiring to make even small improvements.; Credit: Paul A. Hebert/Paul A. Hebert/Invision/AP A new guild study says women and minorities were largely shut out of the ranks of TV directors again last season. The Directors Guild of America report released Wednesday said employers have made no significant improvement in diversity hiring for TV series in the last four years. According to the study, white males directed the vast majority of the 3,500 cable, broadcast and high-budget online episodes made for the 2013-14 season. The same holds true for the three previous years, according to guild findings. In a statement, Directors Guild President Paris Barclay said it can be "shockingly difficult" to persuade those who control industry hiring to make even small improvements. Full Article
led 'Red Band Society' ads pulled from LA buses amid complaints of racism, sexism By www.scpr.org Published On :: Fri, 19 Sep 2014 08:56:27 -0700 "Red Band Society," premieres on Fox September 17th, starring Octavia Spencer, Charlie Rowe and Nolan Sotillo.; Credit: Fox Television Studios The Los Angeles County Metropolitan Transportation Authority is pulling ads for the Fox television show "Red Band Society" from nearly 200 buses amid complaints they are racist and offensive to women. The ads show the ensemble cast's members in front of a wall with graffiti describing their characters. A denigrating word for a woman is used to describe the show's star, Octavia Spencer's character. The Los Angeles Times reports transit officials began pulling the ads on Wednesday. They had been up for five weeks. The Red Band Society also shared the ad on its Facebook page in August. Facebook: #RedBandSociety ad But it's since edited it to look like this. Photo: New ad via Facebook Protesters who attended Thursday's transit agency board meeting complained the depiction of Spencer's character is racist and offensive to women. The actress, who plays a nurse in the hospital drama, is black. She won a supporting actress Oscar for her role in "The Help." Full Article
led The Pandemic Led To The Biggest Drop In U.S. Life Expectancy Since WWII, Study Finds By www.scpr.org Published On :: Wed, 23 Jun 2021 17:40:11 -0700 A COVID-19 vaccination clinic last month in Auburn, Maine. A drop in life expectancy in the U.S. stems largely from the coronavirus pandemic, a new study says.; Credit: Robert F. Bukaty/AP Allison Aubrey | NPRA new study estimates that life expectancy in the U.S. decreased by nearly two years between 2018 and 2020, largely due to the COVID-19 pandemic. And the declines were most pronounced among minority groups, including Black and Hispanic people. In 2018, average life expectancy in the U.S. was about 79 years (78.7). It declined to about 77 years (76.9) by the end of 2020, according to a new study published in the British Medical Journal. "We have not seen a decrease like this since World War II. It's a horrific decrease in life expectancy," said Steven Woolf of the Virginia Commonwealth University School of Medicine and an author of the study released on Wednesday. (The study is based on data from the National Center for Health Statistics and includes simulated estimates for 2020.) Beyond the more than 600,000 deaths in the U.S. directly from the coronavirus, other factors play into the decreased longevity, including "disruptions in health care, disruptions in chronic disease management, and behavioral health crisis, where people struggling with addiction disorders or depression might not have gotten the help that they needed," Woolf said. The lack of access to care and other pandemic-related disruptions hit some Americans much harder than others. And it's been well documented that the death rate for Black Americans was twice as high compared with white Americans. The disparity is reflected in the new longevity estimates. "African Americans saw their life expectancy decrease by 3.3 years and Hispanic Americans saw their life expectancy decrease by 3.9 years," Woolf noted. "These are massive numbers," Woolf said, that reflect the systemic inequalities that long predate the pandemic. "It is impossible to look at these findings and not see a reflection of the systemic racism in the U.S.," Lesley Curtis, chair of the Department of Population Health Sciences at Duke University School of Medicine, told NPR. "This study further destroys the myth that the United States is the healthiest place in the world to live," Dr. Richard Besser, president of the Robert Wood Johnson Foundation (an NPR funder), said in an email. He said wide differences in life expectancy rates were evident before COVID-19. "For example, life expectancy in Princeton, NJ—a predominantly White community—is 14 years higher than Trenton, NJ, a predominantly Black and Latino city only 14 miles away," Besser said. Life expectancy in the U.S. had already been declining — albeit slowly — in the years leading up to the pandemic. And the U.S. has been losing ground compared with other wealthy countries, said Magali Barbieri of the University of California, Berkeley, in an editorial published alongside the new study. The study estimates that the decline in life expectancy was .22 years (or about one-fifth of a year) in a group of 16 peer countries (including Austria, Finland, France, Israel, the Netherlands and the United Kingdom) compared with the nearly two-year decline in the United States. "The U.S. disadvantage in mortality compared with other high income democracies in 2020 is neither new nor sudden," Barbieri wrote. It appears the pandemic has magnified existing vulnerabilities in U.S. society, she added. "The range of factors that play into this include income inequality, the social safety net, as well as racial inequality and access to health care," Duke's Curtis said. So, what's the prognosis going forward in the United States? "I think life expectancy will rebound," Woolf of Virginia Commonwealth said. But it's unlikely that the U.S. is on course to reverse the trend entirely. "The U.S. has some of the best hospitals and some of the greatest scientists. But other countries do far better in getting quality medical care to their population," Woolf said. "We have big gaps in getting care to people who need it most, when they need it most." Copyright 2021 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
led COVID-19 AMA: LA County’s New COVID-19 Cases Have Doubled, Vaccinated People Who Got Infected Carry Less Virus, CDC Researchers Say And More By www.scpr.org Published On :: Thu, 01 Jul 2021 09:19:33 -0700 Facemasks remain worn as firefighter paramedic Jorge Miranda, holding syringe, speaks with Eduardo Vasquez, who has lived homeless on the streets of Los Angeles since 1992, before administering the one-shot Johnson and Johnson' Janssen Covid-19 vaccine as part of outreach to the homeless by members of the Los Angeles Fire Department's Covid Outreach unit on June 14, 2021 in Los Angeles.; Credit: FREDERIC J. BROWN/AFP via Getty Images James Chow | AirTalkIn our continuing series looking at the latest medical research and news on COVID-19, Larry Mantle speaks with UCSF’s Dr. Peter Chin-Hong. Topics today include: Two weeks after reopening, LA County’s new COVID-19 cases have doubled CDC: Infected vaccinated people carry less COVID-19 virus Delta variant is now detected in all 50 states J&J: “At present, there is no evidence to suggest need for a booster dose to be administered” Novavax claims vaccine’s overall efficacy is 89.7% Another respiratory virus is spreading in the U.S. Curevac’s final trial show shot is far less effective than other vaccines Can we now live with the coronavirus? Israel scrambles to curb rising COVID-19 infection rates Is it time to rethink “one-size-fits-all” approach for masking? Guest: Peter Chin-Hong, M.D., infectious disease specialist and professor of medicine at the UCSF Medical Center; he tweets @PCH_SF This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
led Burning Man Canceled: 'Relief' As Burners, Locals See Bright Side Of Informal Events By www.scpr.org Published On :: Thu, 29 Apr 2021 19:00:10 -0700 The pandemic has once again felled Burning Man. Some burners still plan to gather for informal events on the dusty Black Rock Desert Playa this summer.; Credit: Bernard Friel/Education Images/Universal Images Group via Getty Images Emma Bowman | NPRAnd so it goes: Burning Man 2021 is canceled. It's the second year in a row, the popular arts festival won't be held in Nevada's Black Rock Desert due to the pandemic. "We have decided to set our sights on Black Rock City 2022," event officials announced in a blog post on Tuesday. In a frequently-asked-questions section, organizers added: "We've heard from many who don't feel ready to come to Black Rock City. While we're confident in our ability to get a permit and to safeguard public health, we know that co-creating Black Rock City in 2021 would put tremendous strain on our community while we are still ironing out uncertainty." Many would-be attendees praised the decision in comments on the Burning Man website and on social media as a safe one; others are anxiously anticipating a bigger and better 2022 Burn. But the cancellation has put many people in the event's host community at ease. Wary of a trend of rising coronavirus cases in some parts of the region, Washoe County's district health officer Kevin Dick said "the right call was made," in order to lower the risk of spreading infection. "The event draws thousands of people from all over the world," Dick said in an email. "We are seeing large outbreaks of COVID-19 occurring in a number of countries, areas where very contagious COVID-19 variants of concern are prevalent and where low rates of vaccination are occurring." The head of a local Paiute tribe is also feeling less burdened knowing there won't be the annual pilgrimage. The main highway to get to the Black Rock Desert playa, which normally draws tens of thousands of people to the summer event, cuts through tribal lands. "For us it is a sigh of relief," said Janet Davis, chairwoman of the Pyramid Lake Paiute Tribe. Although the event — which brings in about $63 million to the state annually — gives the tribal community a welcome financial boost, Davis said. "We don't know who's vaccinated and who's not," she said. "We've been trying to keep our reservation safe and that happening was too soon for us to open." As with last year, the organization will offer virtual programming during Burn Week, from Aug. 29 through Sept. 7, an experience they say drew 165,000 participants in 2020. In response to a request for more details on the reasons for the cancellation, Burning Man organizers declined to comment further. Earlier this month, though, CEO Marian Goodell said the organization was "weighing the gravity" of implementing a vaccination requirement that she said challenged "radical inclusion," one of the group's 10 principles. Still, for many burners, the news won't extinguish their plans to trek to the desert in droves. Just like last year, revelers are preparing to hold unofficial gatherings on public land in place of the annual event. Last summer, those events — the so-called "rogue" and "free" burns or, unmistakably, "Not Burning Man" — drew an estimated 3,000 people to Black Rock Desert during the time Burning Man is normally held, according to the Bureau of Land Management, the federal agency that approves the organization's permits each year. Kevin Jervis, one such attendee who now lives in Gerlach — a tiny desert town near the event site — welcomed this year's cancellation. He called it "more of a relief than anything. ... A lot of us liked it better the way it happened last year." During the informal festivities, Jervis spent a few days between the playa and its outskirts. He said he and his fellow burners felt like it represented the festival's freewheeling roots. "I've had friends that have been going since '94 and they said it was a lot more like it used to be. We didn't have to go by regulations," he said. "We could have guns, dogs ... it was a lot freer." Even before the pandemic, burners increasingly saw an annual gathering under siege. Event-goers who adhere to Burning Man's counterculture beginnings say the festival's explosion in popularity in the past decade has welcomed a host of bad actors who trash the desert and surrounding communities and disregard the event's founding principles, including "decommodification" and the eco-friendly philosophy of "leave no trace." Some of those perceived threats come from festival officials themselves, he said. A ticket to the main event alone cost over $400 in 2019 — a financial hurdle critics say goes against another tenet long espoused, that "everyone is invited." "People that have never been before came out last year because they either couldn't get a ticket other years or they were just kind of curious. Or they didn't have the money to go to the actual Burn," said Jervis. As for the Pyramid Lake Paiute community, with the reservation largely closed during that period last year, Davis said, "we really didn't see the impact" from a public health standpoint. "You're not talking about 65 — 75,000 people." While there was more traffic, she said, "they moseyed on through and moseyed on out." In the years leading up to the pandemic, BLM had been cracking down on the event's growth. Were the festival to return this year, Burning Man organizers said they would have had to meet a population cap of 69,000, down from its 80,000 limit for previous events. Jervis says he won't miss what he describes as organizers' leniency toward "elites" who set up VIP areas at their camps and hire out to construct their art creations instead of making their own. "A lot of people have gotten sick of what Burning Man's kind of become," he said. Even if this year was a go, he said, burners would still be setting up their own Burning Man-adjacent happenings. Following the announcement of the event's cancellation, people are taking to Facebook groups to reminisce about last year's unsanctioned burns and discuss preparations for their own this summer. "So it seems that as of today there isn't going to be an official [Burning Man Ceremony] this year," James Zapata wrote. "So who's joining me in the dust?" Copyright 2021 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
led Assistant County Manager Dewey Harris earns international Credentialed Manager distinction. By www.catawbacountync.gov Published On :: Thu, 29 Nov 2012 16:00:00 EST Catawba County Assistant County Manager Dewey Harris has earned the International City/County Management Association's (ICMA) Credentialed Manager designation. Established in 2002, the ICMA Credentialed Manager program recognizes professional government managers whom the ICMA certifies as having a "commitment to continuous learning and professional development". Full Article News Release FYI Please Choose