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In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. One of our previous blog series, Looking for Truth in All the Wrong Places, strongly emphasizes those doctrines. The following entry from that series originally appeared on June 21, 2017. -ed.

If God is still speaking to His people today—particularly through mental impressions and premonitions—how can believers exercise discernment when it comes to interpreting and applying these divine messages? Put simply, how is following the private, subjective “leading” of the Lord any more reliable than gazing into a crystal ball?

As we saw last time, biblical discernment runs contrary to the kind of subjective mysticism many promote in the church today. Without any objective criteria, there is no means for determining truth from error. Such blithe subjectivity leaves people at the mercy of whatever mystical “voice” they’re listening to.

Upper Abdominal Distress

It is therefore ironic that advocates of mysticism inevitably treat discernment itself as if it were some kind of subjective, mystical ability. One author speaks of discernment as “a spiritual function,” by which he evidently means that discernment does not involve the intellect. ^[1] William DeArteaga, Quenching the Spirit (Lake Mary, FL: Creation House, 1992), 55. For a further discussion of DeArteaga’s work, see chapter 6 of Reckless Faith. In one of my earlier books I quoted Bill Hamon, one of the leading proponents of modern revelatory prophecy. Hamon’s recipe for discernment is a classic case of mystical anti-intellectualism. He believes prophecies can be properly evaluated only by people willing to set reason and logic aside:

I have sometimes heard people say, “I did not witness with that prophecy.” But after questioning them, I discovered that what they really meant was that the prophecy did not fit their theology, personal desires or goals, or their emotions reacted negatively to it. They failed to understand that we do not bear witness with the soul—the mind, emotions or will.

Our reasoning is in the mind, not the spirit. So our traditions, beliefs and strong opinions are not true witnesses to prophetic truth. The spirit reaction originates deep within our being. Many Christians describe the physical location of its corresponding sensation as the upper abdominal area.

A negative witness—with a message of “no,” “be careful” or “something’s not right”—usually manifests itself with a nervous, jumpy or uneasy feeling. There is a deep, almost unintelligible sensation that something is wrong. This sense can only be trusted when we are more in tune with our spirit than with our thoughts. If our thinking is causing these sensations, then it could be only a soulish reaction.

On the other hand, when God’s Spirit is bearing witness with our spirit that a prophetic word is right, is of God and is according to His will and purpose, then our spirit reacts with the fruit of the Holy Spirit. We have a deep, unexplainable peace and joy, a warm, loving feeling—or even a sense of our spirit jumping up and down with excitement. This sensation lets us know that the Holy Spirit is bearing witness with our spirit that everything is in order, even though we may not understand everything that is being said, or our soul may not be able to adjust immediately to all the thoughts being presented. ^[2] Bill Hamon, “How to Receive a Personal Prophecy,” Charisma (April 1991), 68 (emphasis added).

Notice that Hamon’s emphasis is entirely on feeling, while he derides the intellect, theology, reason, understanding, and by implication, true biblical wisdom. A reaction in the upper abdominal region is supposed to be a more reliable gauge of truth than all those things.

But that is superstition, not discernment. How your upper abdomen feels about a thing is certainly no measure of truth or falsehood. Neither is “a nervous, jumpy, or uneasy feeling” apart from any rational cause. “A deep, unexplainable peace and joy, a warm, loving feeling—or even a sense of [your] spirit jumping up and down with excitement” is no proof that a supposed prophecy is reliable. Those who practice this sort of “discernment” epitomize reckless faith.

And those who seek truth by analyzing inner feelings are likely to wind up with nothing but confusion.

Dueling Prophets

My editor once attended a service at the Anaheim Vineyard where two “prophets” gave contradictory prophecies. It happened in a Sunday morning worship service. When the congregational singing was over, John Wimber stepped to the platform. Before he could say anything, a young man in the congregation stood and began loudly to prophesy judgment against the leaders of the church. “Jerusalem! Jerusalem!” he began, echoing Luke 13:34, “you persecute My prophets and stone My messengers. My displeasure burns hot toward the leadership of this church for the way you have scorned My prophets and ignored My prophecies. . . .” and so on. The man evidently was disgruntled at the treatment he had received at the hands of church leaders, and this “prophecy” seemed to be his way of striking back. He prophesied in that manner for five minutes or more, earnestly calling the elders of the church to repentance. His entire message was in first person as if from God.

Immediately when he finished, before John Wimber could respond, another “prophet” from the other side of the congregation popped up and began to prophesy exactly the opposite message. This prophet began with a loose paraphrase of Jeremiah 29:11: “Oh, pastors and leaders of this church, I know My thoughts toward you—thoughts of mercy, and not of judgment. I have loved you with an everlasting love and have laid up for you a crown in heaven, My beloved. You have done according to all My good pleasure, and henceforth all men will rise up and call you blessed. . . .” etcetera, etcetera.

When the second man finished, a woman stood and sang a song, another person spoke in tongues, and one or two others quoted Bible verses or shared something brief. Then the service continued with Wimber making announcements. No reference was made to the two contradictory prophecies. No attempt was made to explain the dilemma or interpret either prophecy. Members of the congregation were simply left to draw their own conclusions about which, if either, of the two prophecies was correct.

That illustrates the impossible situation that arises when people are encouraged to voice their own subjective impressions as if they were divine prophecy. And it also reveals the predicament we are placed in if we must allow a sensation in our upper abdominal area to determine the truth or falsehood of a prophetic message.

Notice that both prophets’ messages echoed biblical terminology. Both of them were delivered with great conviction. Both of them employed first-person pronouns, as if God Himself were doing the speaking. Yet they flatly contradicted each other. They might both be false prophecies, but there is no way they could both be true. How were the people in the congregation supposed to determine which, if either, was correct? If they followed the gut-feeling approach, all the disgruntled people in the church undoubtedly opted for the first prophecy, believing they now had a word from the Lord to confirm their displeasure with their leaders.

The obvious fact is that once we stray into the realm of subjectivity, we have no way to determine what is really true.

(Adapted from Reckless Faith.)

CARICOM-CUBA SUMMIT Toward the indispensable political, economic and social integration of Latin America and the Caribbean Key remarks by President Raúl Castro opening the Fifth CARICOM-Cuba Summit in Havana, December 8, 2014

ISLAMABAD: The Foreign Office on Friday said it had summoned a senior Indian diplomat to register a strong protest over the Indian ceasefire violations along the Line of Control .The statement by the FO said that in the unprovoked Indian firing across the LoC in Nezapir and Rakchikri sectors, six...

ISLAMABAD: The Foreign Office on Friday said it had summoned a senior Indian diplomat to register a strong protest over the Indian ceasefire violations along the Line of Control .The statement by the FO said that in the unprovoked Indian firing across the LoC in Nezapir and Rakchikri sectors, six...

It's easy and fun to make hand-pulled noodles, especially if you understand how gluten is acting inside the dough to make it stretch y and elastic, says Sam Wong

Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA-damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 patients with CRPC treated with platinum chemotherapy by RNA sequencing (RNA-seq) of metastatic biopsy tissue (n = 27) and/or immunofluorescence in circulating tumor cells (CTC; n = 20). Cox regression and Kaplan–Meier methods were used to evaluate the association of SLFN11 expression with radiographic progression-free survival (rPFS) and overall survival (OS). Multivariate analysis included tumor histology (i.e., adenocarcinoma or neuroendocrine) and the presence or absence of DNA repair aberrations. Patient-derived organoids with SLFN11 expression and after knockout by CRISPR-Cas9 were treated with platinum and assessed for changes in dose response. Patients were treated with platinum combination (N = 38) or platinum monotherapy (N = 3). Median lines of prior therapy for CRPC was two. Median OS was 8.7 months. Overexpression of SLFN11 in metastatic tumors by RNA-seq was associated with longer rPFS compared with those without overexpression (6.9 vs. 2.8 months, HR = 3.72; 95% confidence interval (CI), 1.56–8.87; P < 0.001); similar results were observed for patients with SLFN11-positive versus SLFN11-negative CTCs (rPFS 6.0 vs. 2.2 months, HR = 4.02; 95% CI, 0.77–20.86; P = 0.002). A prostate-specific antigen (PSA) decline of ≥50% was observed in all patients with SLFN11 overexpression. No association was observed between SLFN11 expression and OS. On multivariable analysis, SLFN11 was an independent factor associated with rPFS on platinum therapy. Platinum response of organoids expressing SLFN11 was reduced after SLFN11 knockout. Our data suggest that SLFN11 expression might identify patients with CRPC with a better response to platinum chemotherapy independent of histology or other genomic alterations. Additional studies, also in the context of PARP inhibitors, are warranted.

Microtubule-associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl) kinase, has an important role in the regulation of mitosis. By inhibiting protein phosphatase 2A (PP2A), it plays a crucial role in activating one of the most important mitotic kinases, known as cyclin-dependent kinase 1 (CDK1). MASTL has been seen to be upregulated in various types of cancers and is also involved in tumor recurrence. It is activated by CDK1 through phosphorylations in the activation/T-loop, but the complete mechanism of its activation is still unclear. Here, we report that AKT phosphorylates MASTL at residue T299, which plays a critical role in its activation. Our results suggest that AKT increases CDK1-mediated phosphorylation and hence the activity of MASTL, which, in turn, promotes mitotic progression through PP2A inhibition. We also show that the oncogenic potential of AKT is augmented by MASTL activation, since AKT-mediated proliferation in colorectal cell lines can be attenuated by inhibiting and/or silencing MASTL. In brief, we report that AKT plays an important role in the progression of mitosis in mammalian cells and that it does so through the phosphorylation and activation of MASTL.

Dynamic regulation of the mitochondrial network by mitofusins (MFNs) modulates energy production, cell survival, and many intracellular signaling events, including calcium handling. However, the relative importance of specific mitochondrial functions and their dependence on MFNs vary greatly among cell types. Osteoclasts have many mitochondria, and increased mitochondrial biogenesis and oxidative phosphorylation enhance bone resorption, but little is known about the mitochondrial network or MFNs in osteoclasts. Because expression of each MFN isoform increases with osteoclastogenesis, we conditionally deleted MFN1 and MFN2 (double conditional KO (dcKO)) in murine osteoclast precursors, finding that this increased bone mass in young female mice and abolished osteoclast precursor differentiation into mature osteoclasts in vitro. Defective osteoclastogenesis was reversed by overexpression of MFN2 but not MFN1; therefore, we generated mice lacking only MFN2 in osteoclasts. MFN2-deficient female mice had increased bone mass at 1 year and resistance to Receptor Activator of NF-κB Ligand (RANKL)-induced osteolysis at 8 weeks. To explore whether MFN-mediated tethering or mitophagy is important for osteoclastogenesis, we overexpressed MFN2 variants defective in either function in dcKO precursors and found that, although mitophagy was dispensable for differentiation, tethering was required. Because the master osteoclastogenic transcriptional regulator nuclear factor of activated T cells 1 (NFATc1) is calcium-regulated, we assessed calcium release from the endoplasmic reticulum and store-operated calcium entry and found that the latter was blunted in dcKO cells. Restored osteoclast differentiation by expression of intact MFN2 or the mitophagy-defective variant was associated with normalization of store-operated calcium entry and NFATc1 levels, indicating that MFN2 controls mitochondrion–endoplasmic reticulum tethering in osteoclasts.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Interferon-regulated myxovirus resistance protein B (MxB) is an interferon-induced GTPase belonging to the dynamin superfamily. It inhibits infection with a wide range of different viruses, including HIV-1, by impairing viral DNA entry into the nucleus. Unlike the related antiviral GTPase MxA, MxB possesses an N-terminal region that contains a nuclear localization signal and is crucial for inhibiting HIV-1. Because MxB previously has been shown to reside in both the nuclear envelope and the cytoplasm, here we used bioinformatics and biochemical approaches to identify a nuclear export signal (NES) responsible for MxB's cytoplasmic location. Using the online computational tool LocNES (Locating Nuclear Export Signals or NESs), we identified five putative NES candidates in MxB and investigated whether their deletion caused nuclear localization of MxB. Our results revealed that none of the five deletion variants relocates to the nucleus, suggesting that these five predicted NES sequences do not confer NES activity. Interestingly, deletion of one sequence, encompassing amino acids 505–527, abrogated the anti-HIV-1 activity of MxB. Further mutation experiments disclosed that amino acids 515–519, and Pro-515 in particular, regulate MxB oligomerization and its binding to HIV-1 capsid, thereby playing an important role in MxB-mediated restriction of HIV-1 infection. In summary, our results indicate that none of the five predicted NES sequences in MxB appears to be required for its nuclear export. Our findings also reveal several residues in MxB, including Pro-515, critical for its oligomerization and anti-HIV-1 function.

Objective

To study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4⁺ T cells in experimental autoimmune encephalomyelitis (EAE) and human peripheral blood mononuclear cells (PBMCs).

Previous studies indicated that circular RNAs (circRNA) played vital roles in the development of non–small cell lung cancer (NSCLC). Although hsa_circ_0014130 might be a potential NSCLC biomarker, its function in NSCLC remains unknown. Thus, this study aimed to investigate the role of hsa_circ_0014130 in the progression of NSCLC. The levels of hsa_circ_0014130 in NSCLC tissues and adjacent normal tissues were determined by qRT-PCR. In addition, the expressions of Bcl-2 and cleaved caspase-3 in A549 cells were detected with Western blot analysis. Meanwhile, the dual luciferase reporter system assay was used to determine the interaction of hsa_circ_0014130 and miR-136-5p or Bcl-2 and miR-136-5p in NSCLC, respectively. The level of hsa_circ_0014130 was significantly upregulated in NSCLC tissues. Downregulation of hsa_circ_0014130 markedly inhibited the proliferation and invasion of A549 cells via inducing apoptosis. In addition, downregulation of hsa_circ_0014130 inhibited the tumorigenesis of subcutaneous A549 xenograft in mice in vivo. Meanwhile, mechanistic analysis indicated that downregulation of hsa_circ_0014130 decreased the expression of miR-136-5p–targeted gene Bcl-2 via acting as a competitive "sponge" of miR-136-5p. In this study, we found that hsa_circ_0014130 was upregulated in NSCLC tissues. In addition, hsa_circ_0014130 functions as a tumor promoter in NSCLC to promote tumor growth through upregulating Bcl-2 partially via "sponging" miR-136-5p.

OBJECTIVE

Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos.

This follow-up study of a randomized, prospective trial included 192 patients with newly diagnosed severe aplastic anemia receiving antithymoglobulin and cyclosporine, with or without granulocyte colony-stimulating factor (G-CSF). We aimed to evaluate the long-term effect of G-CSF on overall survival, event-free survival, probability of secondary myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), clinical paroxysmal nocturnal hemoglobinuria, relapse, avascular osteonecrosis and chronic kidney disease. The median follow-up was 11.7 years (95% CI, 10.9-12.5). The overall survival rate at 15 years was 57±12% in the group given G-CSF and 63±12% in the group not given G-CSF (P=0.92); the corresponding event-free survival rates were 24±10% and 23±10%, respectively (P=0.36). In total, 9 patients developed MDS or AML, 10 only a clonal cytogenetic abnormality, 7 a solid cancer, 18 clinical paroxysmal nocturnal hemoglobinuria, 8 osteonecrosis, and 12 chronic kidney disease, without any difference between patients treated with or without G-CSF. The cumulative incidence of MDS, AML or isolated cytogenetic abnormality at 15 years was 8.5±3% for the G-CSF group and 8.2±3% for the non-G-CSF group (P=0.90). The cumulative incidence of any late event including myelodysplastic syndrome or acute myeloid leukemia, isolated cytogenetic abnormalities, solid cancer, clinical paroxysmal nocturnal hemoglobinuria, aseptic osteonecrosis, chronic kidney disease and relapse was 50±12% for the G-CSF group and 49±12% for the non-G-CSF group (P=0.65). Our results demonstrate that it is unlikely that G-CSF has an impact on the outcome of severe aplastic anemia; nevertheless, very late events are common and eventually affect the prognosis of these patients, irrespectively of their age at the time of immunosuppressive therapy (NCT01163942).

BACKGROUND:

Prescribing of levothyroxine and rates of thyroid function testing may be sensitive to minor changes in the upper limit of the reference range for thyroid-stimulating hormone (TSH) that increase the proportion of abnormal results. We evaluated the population-level change in levothyroxine prescribing and TSH testing after a minor planned decrease in the upper limit of the reference range for TSH in a large urban centre with a single medical laboratory.

This study was an analysis of a national sample of U.S. medical office visits from 2014 to 2016, a period when evidence of effectiveness was emerging for a variety of beneficial type 2 diabetes agents with regard to potential reduction in diabetes comorbidities. Ideal therapy was defined as an American Diabetes Association–identified beneficial agent plus metformin. The associations between atherosclerotic cardiovascular disease or obesity and use of these agents were explored.

Background:

Sex steroid hormones and sex hormone–binding globulin (SHBG) have been implicated in the etiology of invasive breast cancer, but their associations with risk of the precursor lesion, ductal carcinoma in situ (DCIS) of the breast, remain unclear.

Background:

Pancreatic cancer is the third leading cause of cancer death in the United States, and 80% of patients present with advanced, incurable disease. Risk markers for pancreatic cancer have been characterized, but combined models are not used clinically to identify individuals at high risk for the disease.

Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk of mortality than non-Hispanic White women. Studies in U.S. Latinas and Latin American women have reported a high incidence of HER2 positive (+) tumors; however, the factors contributing to this observation are unknown. Genome-wide genotype data for 1,312 patients from the Peruvian Genetics and Genomics of Breast Cancer Study (PEGEN-BC) were used to estimate genetic ancestry. We tested the association between HER2 status and genetic ancestry using logistic and multinomial logistic regression models. Findings were replicated in 616 samples from Mexico and Colombia. Average Indigenous American (IA) ancestry differed by subtype. In multivariate models, the odds of having an HER2+ tumor increased by a factor of 1.20 with every 10% increase in IA ancestry proportion (95% CI, 1.07–1.35; P = 0.001). The association between HER2 status and IA ancestry was independently replicated in samples from Mexico and Colombia. Results suggest that the high prevalence of HER2+ tumors in Latinas could be due in part to the presence of population-specific genetic variant(s) affecting HER2 expression in breast cancer.Significance:The positive association between Indigenous American genetic ancestry and HER2+ breast cancer suggests that the high incidence of HER2+ subtypes in Latinas might be due to population and subtype-specific genetic risk variants.

Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed a case–cohort study including incident cases of breast (n = 207), colorectal (n = 111), lung (n = 70), and prostate (n = 201) cancer as well as a subcohort (n = 465) within the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort. Relative counts of neutrophils, monocytes, and lymphocyte sublineages were measured by qRT-PCR. HRs and 95% confidence intervals were used to measure the associations between relative counts of immune cell and cancer risks. When relative counts of immune cell types were taken individually, a significant positive association was observed between relative counts of FOXP3+ regulatory T cells (Tregs) and lung cancer risk, and significant inverse associations were observed between relative CD8+ counts and risks of lung and breast cancer (overall and ER+ subtype). Multivariable models with mutual adjustments across immune markers showed further significant positive associations between higher relative FOXP3+ T-cell counts and increased risks of colorectal and breast cancer (overall and ER− subtype). No associations were found between immune cell composition and prostate cancer risk. These results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.Significance:This epidemiologic study supports a role for both regulatory and cytotoxic T cells in determining cancer risk among healthy individuals.See related commentary by Song and Tworoger, p. 1801

Preimplantation genetic testing (PGT) is a reproductive technology that, in the course of in vitro fertilization (IVF), allows prospective parents to select their future offspring based on genetic characteristics. PGT could be seen as an exercise of reproductive liberty, thus potentially raising significant socioethical and legal controversy. In this review, we examine—from a comparative perspective—variations in policy approaches to the regulation of PGT. We draw on a sample of 19 countries (Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, India, Israel, Italy, Japan, Mexico, Netherlands, Singapore, South Korea, Switzerland, United Kingdom, and the United States) to provide a global landscape of the spectrum of policy and legislative approaches (e.g., restrictive to permissive, public vs. private models). We also explore central socioethical and policy issues and contentious applications, including permissibility criteria (e.g., medical necessity), nonmedical sex selection, and reproductive tourism. Finally, we further outline genetic counseling requirements across policy approaches.

Found footage from many hours of trawling through night-drive ghost sighting videos on YouTube while on lockdown. The Golden Filter’s Stephen Hindman takes us on a haunted night-drive in the video for ‘But Please’, a new track released under his Isolating alias. ‘But Please’ appears on his new EP for Optimo Music Digital Danceforce, System. […]

The post Isolating finds himself on a haunted night-drive in ‘But Please’ appeared first on FACT Magazine.

Follow our live coronavirus updates HERE Coronavirus: the symptoms

Barclays donates £250,000 to help our appeal to tackle hunger in virus crisis But demand grows amid growing reports one in five at risk of food poverty You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

Dáreece Walker

The post The Pandemic Is Disproportionally Impacting Black, Latino, and Immigrant Communities appeared first on The Nation.

Immigrants in the U.S. sent an estimated $150 billion to their home countries in 2019 — half to Latin America and the Caribbean. The World Bank is predicting a sharp decline in remittances this year.

Plague Inc. is an app and online game in which users play the role of a disease set on infecting the world with a pathogen.

From the intricate storytelling of online culture podcast 'Reply All' to the relaxed gossip of reality star Gemma Collins, Annie Lord ranks the best podcasts to listen to while in quarantine

Morgan announced he'd be taking a leave of absence from the show until he receives the results of a Covid-19 test

They travelled the length of Central and South America for the BBC's Race Across the World, so who better to ask for travel tips?

EXCLUSIVE

The enforcement was meant to protect from coronavirus spread

Westpac joins ANZ in deferring its interim dividend as it braces for the financial impact of COVID-19, but mounting issues around money laundering and tax reporting may cost it almost as much.

Professional tennis is on hold because of the coronavirus pandemic, but that does not stop 20-time major singles champion Roger Federer reaching out to his legion of fans with a bit of friendly advice on how to improve their game while stuck at home.

Originally published in January 1859

-- Read more on ScientificAmerican.com

A Chicago police officer pleaded guilty today to violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.

A complaint was unsealed today in U.S. District Court in Massachusetts against a New York pharmaceutical company for alleged False Claims Act violations arising from the company’s marketing the drugs Celexa and Lexapro for unapproved pediatric use and for paying kickbacks to induce physicians to prescribe the drugs.

Agents with the FBI, Immigration and Customs Enforcement and the Wyoming Department of Criminal Justice arrested Wyoming Highway Patrol Trooper Franklin Joseph Ryle late yesterday in Douglas, Wyo., on criminal civil rights charges.

Latin Node Inc. (Latinode), a privately held Florida corporation, pleaded guilty today to violating the Foreign Corrupt Practices Act (FCPA) in connection with improper payments in Honduras and Yemen. At a hearing before U.S. District Judge Paul Courtney Huck in the Southern District of Florida, Latinode pleaded guilty to a one-count information charging a criminal violation of the FCPA’s anti-bribery provisions.

Eight members of the violent gang known as the "Almighty Latin King and Queen Nation" (ALKQN) have pleaded guilty to a variety of charges, including drug conspiracy and weapons trafficking.

William Cozzi, a Chicago police officer, was sentenced today to 40 months in federal prison for violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.