Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

Over 50 pastors and family members from Tacloban enjoy a weekend getaway organised by OM Philippines from 7-9 March.

OM Philippines hosts micro-business workshops that offer a future with hope.

With OM Lifehope, Andrea works with a local church and growing church plant, providing her with many opportunities to build relationships with locals.

At Manna House, in the Greater London Area, guests from all over the world come for accommodation and a place to rest.

The Kid's 'n' Things team visited two churches to run five-day long holiday clubs, with the theme of “Lionheart and the Great Wild West Adventure”.

Five years ago, seven boys were chosen to be discipled as Honest Boys in Mpulungu, Zambia. They carry the values proudly in their adult lives.

The Good News II School in Mpulungu, Zambia, has grown from 20 students to over 180. Students have grown from the values they learnt.

Testimony of a Greek woman.

A local man shares his testimony, endures persecution and encourages others in the Near East to stand firm.

Local OM worker plants a church in a conservative Muslim village and sees fruit after ten years of prayer.

Artists present visual and performing arts during the international art Festival Week hosted by OM Arts International’s Incarnate programme.

As workers wonder how to reach people with the good news, they find God has already prepared the way.

some testimonies from Aussies who attended the 2010 OCZ and outreaches

OM Malaysia is moving away from the concept of TeenStreet and investing into training people to work with the next generation instead.

A scholarship from OM Bosnia gives a young woman from a needy family the chance to go to school.

Providing disadvantaged children with backpacks brings the gospel into homes in remote Muslim villages of Bosnia-Herzegovina.

Recently, OM Ecuador finished its annual medical clinic. This year's medical outreach was held in Zaruma, Ecuador. While the clinic focused on medical attention, God worked to bring another type of restoration to some people's lives.

OM Ecuador experiences God’s awesome hand as they witness the transformation in people’s lives on Santay Island.

Offering concerts in private settings in Tienen, Belgium, proves effective in connecting with youth.

KL Rahul relives his incredible 14-ball fifty, he scored in the 2018 IPL while playing for Punjab Kings (erstwhile Kings XI Punjab) and called it the best T20 year of his career.

India vs South Africa: Tilak Varma played an unbeaten 107-run knock from 56 balls at a strike rate of 191.07

Marketers have a lot on their plate these days. Omnichannel shouldn't be an issue anymore

The CEO and cofounder defines adaptive messaging and shares the number one mistake marketers make when it comes to thinking about this concept. Plus, hear how Mary Poppins inspired his company's name

1. John Krasinski revealed as People magazine's Sexiest Man Alive after Benny Blanco confusion; fans are relieved  Hindustan Times
2. John Krasinski reveals wife Emily Blunt's reaction to his Sexiest Man Alive title  Hindustan Times
3. Not Shah Rukh Khan, Hrithik Roshan, Leonardo Dicaprio, Chris Evans, or Tom Cruise, THIS actor is the sexiest  India.com
4. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
5. Is Jim from The Office really the sexiest man in the world?  The Guardian

1. US stocks rise after in-line inflation data firm up December rate-cut bets  Investing.com India
2. Stocks Eye Fresh Peak as CPI Boosts Rate-Cut Bets: Markets Wrap  Mint
3. Dow rises 100 points as as traders assess state of postelection rally, new inflation data: Live updates  CNBC
4. Yields Sink as CPI Puts December Fed Cut in Play: Markets Wrap  Bloomberg

Two Soter RS full body scanners capable of detecting ingested or hidden contraband have been deployed at the New Bilibid Prison, according to the Bureau of Corrections (BuCor).

Minister Chris Bonett said he sympathises with those who were stuck in traffic on Tuesday evening but added that events of this kind will inevitably result in congestion

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The study reveals that older participants exhibited lower signs of stress and anxiety than younger ones.

The alleged support for Hamas related to online activity, Gloucestershire Police said.

The request requires the approval of ICC judges, but their decision has been delayed, partly because of several rounds of legal filings by Israel that have challenged the court's jurisdiction.

The students, who unfurled a flag of the Palestinian territories from the roof of Leonardo's offices, said the company was supporting Israel.

CIA official Asif W. Rahman held top-secret security clearance and had access to sensitive information, the New York Times reported.

PTI founder Imran Khan has issued a “final call” for a protest in Islamabad on November 24, denouncing what he described as the “stolen mandate”, the “unjust arrests” of people, and the government’s push to pass the 26th constitutional amendment bill last month, it emerged on Wednesday.

Since his arrest in August 2023 on several counts, Imran’s party has been holding protests across the country for his release, and against the alleged “rigging” of the 2024 elections on February 8.

Since the events of May 9, 2023, PTI leaders have faced arrests and detentions from time to time, mostly for leading protests in the country. A day ago, some top PTI leaders were taken into custody from outside Rawalpindi’s Adiala Jail for violating Section 144 but were released shortly afterwards after being issued a warning.

Last month, police arrested several PTI leaders and activists across multiple districts of Punjab for holding protests. In September, the party’s top leadership, along with 11 MNAs, were apprehended but released later.

Similarly, his sisters Aleema Khan and Uzma Khan, together with a dozen party workers, were arrested for allegedly leading a protest in Islamabad last month. Both were released after obtaining bail from a court.

Speaking to journalists after meeting Imran in Adiala Jail on Wednesday, Aleema said that the final call for protest was for everyone, including PTI ticket holders, members of parliament, and workers and supporters of the party.

“This is the moment when you will have to decide [whether] you want to live under martial law or live with freedom,” she quoted Imran as saying.

“You used your right [to vote] on February 8…. but the next day, the foundation you had laid for democracy was stolen,” she further quoted Imran as saying.

Aleema went on to say that Imran has addressed his call to four categories of people —farmers, lawyers, civil society and students— who should come out to protest for their rights.

Speaking on the 26th Amendment being enacted as law, she quoted Imran as saying, “All of your rights have been taken away; the Supreme Court has been occupied, and the current conditions are even worse than previous martial laws.”

This call for protest comes after a series of protests by PTI nationwide throughout October.

During the last protest called for Islamabad on October 4, hundreds of PTI activists, including senior leaders, gathered at multiple locations in the capital after defying heavy police blockades and road closures.

Authorities had dug trenches and placed iron nails on a stretch of the Islamabad-Peshawar motorway to prevent protesters from Khyber Pakhtunkhwa from reaching the capital. Despite these hurdles, PTI workers had managed to reach D-chowk amid heavy rain.

PTI had claimed KP Chief Minister Ali Amin Gandapur, who was part of the protest caravan, was arrested by Rangers from KP House before retracting their claims.

After a mysterious day-long disappearance, he resurfaced in Peshawar as he arrived at the KP Assembly in the evening to address the lawmakers there.

PTI called off its announced D-Chowk protest for October 15 on the eve of the Shanghai Cooperation Organisation (SCO) summit after assurances of a medical check-up for Imran.

On November 8, 14 people, inc­l­u­­ding eight cops, were injured when clashes erupted between the police and PTI supporters in Quetta.

The clashes occurred after the administration cancelled permission for the party to hold a rally at Railway Hockey Ground to demand the release of Imran, citing security threats.

‘Call for chaos and provocation’

Reacting to Imran’s call for protest, PPP Vice-President Senator Sherry Rehman condemned the move, terming it “a call for chaos and provocation” rather than a protest.

“We have also held peaceful protests but never told workers to kill or die,” Rehman said in a statement on Wednesday.

She asked for an explanation regarding the purpose behind the “so-called final and decisive protest.”

“Those who ordered workers to go out with a shroud on their heads should fear God,” she said, adding that despite PPP leaders being hanged and murdered, they never issued calls for violent protests.

Rehman concluded by saying that Imran wants chaos and is using workers as “political fuel for his release”.

‘PTI trying to start armed struggle’

PML-N leader Rana Sanaullah accused Imran of planning to start an “armed struggle” against the government.

Speaking on a private news channel yesterday, Sanaullah said: “It can be ascertained from the statements of the PTI founder that run in the media and newspapers ….. that they are planning to start a struggle, an armed struggle against the government.”

When asked who were the people trying to start the “armed struggle”, Sanaullah said, “All of you are seeing the people who go and meet him every day and then come out and give statements on this.”

He also referred to KP CM Gandapur’s speech at the Swabi jalsa earlier this week, saying that the rhetoric used there “indicated that they are planning an armed struggle”.

Without doubt, Turkiye gave the strongest response to Israel’s atrocities in Palestine through such steps as halting trade, President Recep Tayyip Erdogan said on Wednesday.

Ankara suspended all trade with Israel in May, citing a worsening humanitarian tragedy in Gaza, where Israel has killed more than 43,000 Palestinians since last October.

“As long as arms shipments continue, Israel will be more aggressive, as every day that Israel is not stopped, the situation in Palestine and Lebanon worsens,” Erdogan told reporters on his return flight from visits to Saudi Arabia and Azerbaijan.

One of the concrete steps that can be taken against Israel’s attacks is to work for recognition of the state of Palestine, he underscored, adding: “Without a two-state solution, peace and stability will not come to the region.”

“Trade restrictions and sanctions on Israel are another form of struggle. Active diplomacy to corner Israel in all areas and boost diplomatic pressure is also crucial. We’re in the middle of a great test of humanity,” the president said.

“Passing this test is only possible by being part of the humanitarian alliance. Otherwise, history will judge both those who stood by Israel and those who remained silent in the face of oppression.”

Erdogan also said Ankara’s initiative at the UN to prevent the shipment of weapons and ammunition to Israel has been supported by 52 countries and two international organizations.

“We recently sent a letter on this initiative to the president of the UN General Assembly, the president of the Security Council, and the UN secretary-general. At the (joint Arab-Muslim) summit in Riyadh, a decision was made to invite all organizations and Arab League members to sign our letter. Our country’s steps to halt the massacre and its humanitarian aid efforts were praised,” he added.

The Turkish president also highlighted that he had the opportunity to hold bilateral meetings during the summit, including with Saudi Crown Prince Mohammed bin Salman, adding that they had a fruitful meeting.

Emphasizing that he also held bilateral meetings in Baku, Azerbaijan, during the COP29 UN Climate Change Conference, Erdogan said that these meetings included discussions of bilateral ties and regional developments.

‘Climate is one of the most critical issues facing world’

On Turkiye’s zero emissions target for 2053, Erdogan said: “The climate issue is one of the most critical issues facing the world. Just as we care about wars, conflicts, and migration, we approach this issue with the same seriousness.”

“Turkiye is persistently discussing what measures we can take with the relevant ministries. We have taken, are taking, and will continue to take measures to use the world’s limited resources most efficiently and to elevate the civilization we have developed over centuries to a much higher level.

“Turkiye cares about this issue and is making every effort to do our part. However, finding a fundamental and lasting solution to this issue is not possible with the efforts of just us or a few countries together.”

He called for collective action to shoulder the burden of climate-related efforts.

“If some countries fully engage in the fight against climate change while others, driven by greed, ignore necessary measures or even increase pollution, we cannot overcome this problem,” warned Erdogan.

President Erdogan added that the importance of the Zero Waste initiative, spearheaded by Turkiye, is gaining more recognition every day and that efforts are being made to spread it and turn it into a way of life.

The initiative, which started in 2017 under First Lady Emine Erdogan’s leadership, aims to raise awareness of the importance of waste elimination in addressing climate change.

Hope ties with US move to different track under Trump

On the US’ incoming administration, Erdogan voiced hope that Donald Trump’s taking office in January will start to put ties between Ankara and Washington on a different track.

“Undoubtedly, there are always opportunities between the two countries. Our basic expectation is to assess these opportunities and take steps that will benefit both countries,” he said.

“The Trump administration views the economy as one of its main priorities. Turkiye, with its strategic geographical location and young population, is a country that offers investment opportunities.

“We can create new opportunities to boost the trade volume and encourage investments between the two countries. Particularly in energy, infrastructure, and technology, we can develop new collaborations,” he underlined.

Erdogan also expressed hope that President-elect Trump would take different steps for the region.

Asked about potential future meetings with US billionaire Elon Musk, one of Trump’s biggest supporters, Erdogan said: “The technological strides Turkiye is making are drawing attention worldwide. Technology is not an area where you can advance alone; you need collaboration. If cooperation opportunities arise in this field, steps can be taken with Musk.”

Possible normalization between Turkiye, Syria

Speaking of a possible reconciliation with Syria, Erdogan said Turkiye has reached out for normalization, expressing its belief that it would open the door to peace and stability in Syrian territories.

Cross-border operations are always in the cards for the country’s security, he said, expressing readiness to launch them anytime the country feels threatened.

Turkiye has launched several cross-border operations in recent years, in both northern Syria and northern Iraq, targeting terrorists who hide out there and destabilize the border or plot attacks on Turkish soil.

Reiterating Turkiye’s commitment to fighting terrorism while respecting Syria’s territorial integrity, Erdogan said that the presence of terrorist groups in northern Syria, notably the PKK, the PYD and the YPG, also poses a threat to its territorial integrity, adding that the Syrian government, well aware of this, must take steps to create a new climate in the country.

Erdogan also said the “threat of Israel,” right next to Syria, is no fairy tale, warning that the fire in the surrounding areas can quickly spread in the unstable lands.

In its 40-year terror campaign against Turkiye, the PKK — listed as a terrorist organization by Turkiye, the US, and the EU — has been responsible for the deaths of over 40,000 people, including women, children, and infants. The YPG is PKK’s Syrian offshoot.

In northern Syria, Ankara has launched a trio of successful anti-terror operations since 2016 to prevent the formation of a terror corridor and enable the peaceful settlement of residents: Euphrates Shield (2016), Olive Branch (2018), and Peace Spring (2019).

1. India To Play Intra Squad Match At WACA Ahead Of Australia Tests, Public Not Allowed: Report  News18
2. Black veil of secrecy: India begin training in privacy in Perth  ESPNcricinfo
3. 'No request' from BCCI but Australian media report claims India wanted...  The Times of India
4. Of Coffee Date And Fam-Jam: Anushka Sharma And Virat Kohli's Perth Diaries  NDTV Movies
5. Batting time: India begin preparations in lockdown mode  Hindustan Times

1. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
2. Celebs crowned Sexiest Man Alive in last ten years: John Krasinski, Patrick Dempsey, Paul Rudd, to Idris Elba  Hindustan Times
3. Is Jim from The Office really the sexiest man in the world?  The Guardian
4. John Krasinski Is PEOPLE's 2024 Sexiest Man Alive!  PEOPLE
5. John Krasinski chosen as Sexiest Man Alive but fans have declared these stars as Sexiest Musician and Sexi  The Economic Times

1. Officers Carrying Out Illegal Demolitions Liable To Restore Properties At Personal Cost & Pay Damages:...  Live Law - Indian Legal News
2. How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained  The Hindu
3. Akhilsh Yadav`s `Parked In Garage` Jab At Yogi Govt After SC`s Bulldozer Verdict  Zee News
4. SC parked bulldozer in garage forever: Akhilesh Yadav  Hindustan Times
5. What's the message from Supreme Court's order on bulldozer action? Experts debate  India Today

A well-preserved section of the 2,000-year-old road, known as Watling Street, was unearthed under Old Kent Road in Southwark

The fluffy chick’s chunky form is slimming down as he starts to fledge

Top 10 Animals with the Strongest Senses  Moneycontrol

1. Kanguva Box Office Day 1 Advance Booking: Suriya Starrer Jumps By 353%, Already Enters Biggest Tamil Openers Of 2024!  Koimoi
2. 5 Reasons To Watch Suriya and Bobby Deol Starrer 'Kanguva' In Theatres  Zee News
3. Waiting for Suriya's 'Kanguva', watch these blockbuster films by National Award-winning actor for free  India TV News
4. Kanguva budget and actor salaries: Suriya took Rs 39 crore, Bobby Deol earned Rs 5 crore for his role – How much money others charged for the film  The Financial Express
5. Kanguva Movie Release, Review Live Updates: Suriya-starrer has already earned over Rs 7.3 crore before opening day  The Indian Express

1. Amazon Sale 2024 On Best i5 Laptop Brands At A Price Drop Of 41% Off  Jagran English
2. Amazon Laptop days: Get over 50% off on best selling laptops from top brands like Acer, HP. Sale ends today!  Mint
3. Amazon Sale 2024 On Best ASUS Vivobook Laptops: Snag Up To 42% Off  HerZindagi English
4. Best-selling gaming laptops on Amazon: Starting at 44990, get up to 12000 off on exchange, 12-month no-cost EMI  Hindustan Times
5. Amazon Sale: Bumper Discount Of 26% Off On Best Gaming Laptop Under 1 Lakh  Jagran English

1. Your Google Pixel Phone's Newest Android 15 Beta Update Arrived  Droid Life
2. Google rolls out Android 15 QPR2 Beta 1 update  FoneArena
3. Google is preparing to bring back a beloved customization feature from Android 11  Android Authority
4. Android 15 QPR2: Do Not Disturb gets big upgrade with Modes  9to5Google
5. Android 15 QPR2 brings the Pixel 9's new Linux kernel to all Tensor-powered phones and tablets  Android Police

1. 'Congratulations Donald Trump': Gautam Adani says his group will invest $10 billion in US energy, infra p  The Times of India
2. Adani Group commits $10 bn in US energy, infrastructure projects  The Economic Times
3. Adani commits $10 billion in U.S. energy, infra projects  The Hindu
4. Gautam Adani pledges USD 10 billion investment in US energy, infrastructure projects  India TV News
5. Video | Gautam Adani Commits $10 Billion To Energy, Resilient Infra Projects In US  NDTV

1. Market crash: Investors become poorer by ₹13 lakh crore; Sensex tanks 2.27% in two days  The Hindu
2. Bloodbath on D-street: Investors lose Rs 13 lakh crore in last 2 days- Top reasons why market is falling  The Times of India
3. Nifty Drops 2,718 Points From Record High, Hits Below 200-DEMA; What Is Next Target And How To Invest?  Goodreturns
4. 'Everything is being cut,' says Basant Maheshwari as market goes into correction phase; key reasons behind today's fall  Business Today
5. Ahead of Market: 10 things that will decide stock action on Thursday  The Economic Times

Experience interactive storytelling at Vroooom, the virtual reality film festival presented by Goethe Zentrum Hyderabad and Annapurna College of Film and Media

Singer was one of the early favourites to win the talent show

West was a star of the stage and the screen and died in his sleep, his children have announced