Holidaymakers hit in the pocket will visit somewhere else, warned Steve Heapy

The move comes after US officials were quoted saying they would not accept Hamas's presence in Qatar.

Sal Naseem tells the BBC he wasn't convinced Mr Kaba presented a sufficient danger to justify being shot.

2 ‘Moody’ Home Design Trends Generating Buzz

The trends of the Premier League season so far that make for interesting reading.

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

Parents of kids with ADHD often say their kids miss social cues, such as when peers are bored, hurt or offended, according to Amori Mikami, a psychology professor at the University of British Columbia in Canada. “It can lead to a lot of outbursts or temper tantrums or whining and complaining or arguing with the friend,” she said. Mikami researches peer relationships, specifically focusing on children with ADHD. Additionally, she developed a parental friendship coaching (PFC) model where parents of elementary school-age kids can learn to support their child in making friends.

Shopify's surge added fuel to Canada's strong market rally, helping its benchmark index cross 25,000 for the first time.

We recently hosted an engaging live discussion with industry experts from G2Crowd, Instapage and Subscription Insider, covering trends and growth tips for online businesses. Check out what these leaders had to say about what they learned last year in the software industry, where people are missing opportunities and what’s coming next.

Kenya's candidate for the top job at the African Union said on Saturday that if US president-elect Donald Trump does not want to work with Africa, the continent has "other friends".

July was a big month for model releases: There are new large models from Mistral and Meta, smaller multilingual models from Mistral and DeepL, another Mistral model that specializes in code generation, and a small version of GPT-4o. The security world saw another software supply chain disaster when CrowdStrike released a bad software update that […]

This month, we’ll give AI a rest. Alex Russell has finished an excellent series of posts titled “Reckoning.” It’s a must-read for web developers. If you want to understand why our networks and laptops are much faster than they were 15 or 20 years ago, but the web is slower, it comes down to one […]

The model release train continues, with Mistral’s multimodal Pixtral 12B, OpenAI’s o1 models, and Roblox’s model for building 3D scenes. We also have another important AI-enabled programming tool: Cursor is an alternative to GitHub Copilot that’s getting rave reviews. Security will never cease to be a problem, but this month seems particularly problematic. The Mirai […]

October had many language model releases. The mid-size models, and even the small models, are catching up to frontier models like GPT-4.5o in performance. But the release that blew us all away wasn’t a language model: It was Claude’s computer use API. Computer use allows you to teach Claude how to use a computer: how […]

Who Can Currently Afford to Buy a Home?

Cross-border conflict, evidence, policy and trends (XCEPT)

This five-year policy-focused research programme seeks to respond to the challenges of long-term cross-border conflicts by exploring the drivers behind them.

Protracted conflicts in the Middle East and North Africa, Horn of Africa and parts of Asia, although usually arising from intra-state disputes, rarely remain contained within national borders. Their effects reverberate outward and external actors are drawn in.

The longer these wars last, the more difficult they are to resolve as the interests of international actors collide and the web of economic and political interactions which sustain violence and connect conflict across borders expand and deepen.

The Cross-border conflict, evidence, policy and trends (XCEPT) research programme brings together world-leading experts to examine conflict-affected borderlands, how conflicts connect across borders, and the drivers of violent and peaceful behaviour.

Chatham House provides research leadership to the programme, as part of the wider consortium, and our research explores:

• the intersection of conflict supply chains which sustain and embed violence
• coping supply chains for survival-based economic activity which occurs in the context of violence

Three geographic case studies will be supported by cross-cutting workstreams on gender and social inclusion, livelihoods, and border security. Each will produce analysis and recommendations to inform international policy responses to conflict across borders.

These case studies will focus on:

• armed actors and financial flows through Iraq and the Levant
• human smuggling across Libya, East and West Africa
• gold mining and weapons flows across Sudanese borderlands

The consortium is made up of a range of other organizations, including the Asia Foundation, the Malcolm H. Kerr Carnegie Middle East Center, the Rift Valley Institute, Chemonics UK and King’s College London.

XCEPT is funded by UK Aid from the UK government.

Dynamic singer Tosh Alexander has been lighting up the music scene with her latest track, ' My Ting Different', a thrilling collaboration with American rapper and songwriter Lady London. The song fuses R...

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein preformed fibrils (PFFs) into the brain. However, the mechanism by which these PFFs induce toxicity is unknown. Iron is implicated in PD pathophysiology, so we investigated whether α-synuclein PFFs induce ferroptosis, an iron-dependent cell death pathway. A range of ferroptosis inhibitors were added to a striatal neuron-derived cell line (STHdhQ7/7 cells), a dopaminergic neuron–derived cell line (SN4741 cells), and WT primary cortical neurons, all of which had been intoxicated with α-synuclein PFFs. Viability was not recovered by these inhibitors except for liproxstatin-1, a best-in-class ferroptosis inhibitor, when used at high doses. High-dose liproxstatin-1 visibly enlarged the area of a cell that contained acidic vesicles and elevated the expression of several proteins associated with the autophagy-lysosomal pathway similarly to the known lysosomal inhibitors, chloroquine and bafilomycin A1. Consistent with high-dose liproxstatin-1 protecting via a lysosomal mechanism, we further de-monstrated that loss of viability induced by α-synuclein PFFs was attenuated by chloroquine and bafilomycin A1 as well as the lysosomal cysteine protease inhibitors, leupeptin, E-64D, and Ca-074-Me, but not other autophagy or lysosomal enzyme inhibitors. We confirmed using immunofluorescence microscopy that heparin prevented uptake of α-synuclein PFFs into cells but that chloroquine did not stop α-synuclein uptake into lysosomes despite impairing lysosomal function and inhibiting α-synuclein toxicity. Together, these data suggested that α-synuclein PFFs are toxic in functional lysosomes in vitro. Therapeutic strategies that prevent α-synuclein fibril uptake into lysosomes may be of benefit in PD.

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human retina: Cav1.4 splice variants with or without exon 47 (Cav1.4+ex47 and Cav1.4Δex47, respectively), and the auxiliary subunits, β2X13 and α2δ-4. We find that IT caused both Cav1.4 splice variants to activate at significantly more negative voltages and with slower deactivation kinetics than the corresponding WT channels. These effects of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in channels lacking exon 47. The weaker ion selectivity caused by IT led to hyperpolarizing shifts in the reversal potential and large outward currents that were evident in channels containing the auxiliary subunits β2X13 and α2δ-4 but not in those with β2A and α2δ-1. We conclude that the IT mutation stabilizes channel opening and alters ion selectivity of Cav1.4 in a manner that is strengthened by exclusion of exon 47 and inclusion of β2X13 and α2δ-4. Our results reveal complex actions of IT in modifying the properties of Cav1.4 channels, which may influence the pathological consequences of this mutation in retinal photoreceptors.

Alex Ovechkin calmly slid into the right circle and sniped a snapshot past a blinded Juuse Saros to lead the Washington Capitals to a 3-2 triumph over the Nashville Predators.

Mike Gesicki and Jonnu Smith are among UPI senior sports writer Alex Butler's four must-start fantasy football tight ends for Week 10.

SpaceX on Saturday successfully launched a Falcon 9 rocket carrying a payload of 22 Starlink Internet communications satellite from Cape Canaveral in Florida, marking a state record 73rd orbital rocket launch this year.

We tend to consider romantic partners and family ties to be our most important relationships, but deep friendships can be just as meaningful. In a perspective-shifting talk, author Rhaina Cohen introduces us to the people unsettling norms by choosing a friend as a life partner — and shows why we're all better off recognizing there's more than one kind of significant other.

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.

The Oklahoma Education Association has ended the nine-day statewide walkout, saying legislators are unwilling to consider any additional revenue-raising measures.

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.

The state's supreme court ruled that it is not its role to tell the legislature how to spend its money, ending a 24-year school-funding battle.

A group of high school students from Anchorage spent spring break at a remote Native Village as part of an unusual cultural exchange program in Alaska. See what they learned.

The supreme court put an end to five years of legal wrangling that landed the state's public school system with millions more dollars from the state and teachers with a pay raise.

Teachers will receive a 5 percent raise, pending a vote by the state legislature. School will resume Thursday.

While people gather around the Gore Park Cenotaph in his hometown of Hamilton, Tyrell will be one of nine Canadians serving as a peacekeeper in the United Nations mission in South Sudan.

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

Ongoing practical friendship wins the trust of a family in Montenegro, opening a door of hope for their future.

Eliminates the Cost and Complexity of Maintaining Online Parts Catalogs; Improves Search, Navigation, and Communication for Engineers Seeking 3D Part Models

Business-Critical Solutions are Now Free to any Subscriber for an Additional Year

Zero-Gravity Arm Reduces Injuries, Saves Money, and Improves Product Quality

DWGgateway plug-in lets AutoCAD users share designs with virtually anyone

Technology Student Association middle and high school winners received SolidWorks 3D CAD software

Starting a Christian micro-finance programme has been a long-time dream for OM Madagascar. In partnership with OM Hong Kong, this will soon become a reality.

The last crew of the Logos reunites for a never-to-be-forgotten weekend.

In April 2016, Logos Hope crew members travelled to over 30 different destinations around the world, involving themselves in presentations, church mobilisation, practical work and other ministry projects.

In April 2016, Logos Hope crew members travelled to over 30 different destinations around the world, involving themselves in presentations, church mobilisation, practical work and other ministry projects.

In April, Logos Hope crewmembers travelled to over 30 destinations around the world, involving themselves in presentations, church mobilisation, practical work and other projects.