ease US Experts: Uranium Enrichment Facility Images Released by N. Korea Differs from that of 2010 By world.kbs.co.kr Published On :: Thu, 19 Sep 2024 17:55:20 +0900 [Science] : Two U.S. experts who inspected North Korea’s uranium enrichment facility at the Yongbyon nuclear complex in 2010 have analyzed recent images of a similar facility in the North and pointed out differences. Stanford University professor emeritus Siegfried Hecker and Robert Carlin, a scholar at the ...[more...] Full Article Science
ease Quarantine Agency Develops Differential Diagnosis Technology for Lumpy Skin Disease By world.kbs.co.kr Published On :: Wed, 25 Sep 2024 16:57:36 +0900 [Science] : The Animal and Plant Quarantine Agency says it has developed, for the first time in the world, a differential diagnosis technology for lumpy skin disease(LSD), a viral disease that affects cattle. With the technology, jointly developed with Median Diagnostics, it can be determined within eight hours if a ...[more...] Full Article Science
ease KBS Hit Drama 'Winter Sonata' to be Released as Film in Japan Next Year By world.kbs.co.kr Published On :: Mon, 07 Oct 2024 15:10:36 +0900 [Culture] : KBS hit drama "Winter Sonata" which led the Korean Wave in the 2000s will be released as a theatrical film in Japan next year. Pan Entertainment, which produced the show, announced Monday that it had decided to release a film version after receiving continuous requests from Japanese distributors and ...[more...] Full Article Culture
ease How to Get Grease Out of Clothes in 5 Easy Steps By home.howstuffworks.com Published On :: Fri, 01 Nov 2024 10:10:03 -0400 Whether it's natural cooking oil, industrial machine grease or motor oil, grease stains can wreak havoc when they come in contact with your favorite clothing item. Read on to learn how to get grease out of clothes, including differing methods for synthetic fabrics and natural fibers. Full Article
ease Stray Kids to release new single featuring Charlie Puth By world.kbs.co.kr Published On :: 2024-04-22 Stray Kids is set to release a new digital single featuring global pop star Charlie Puth.The new single “Lose My Breath” will drop on May 10. Charlie Puth is a familiar name in the K-pop industry and...[more...] Full Article
ease Sunmi to release new single next month By world.kbs.co.kr Published On :: 2024-05-06 Sunmi is set to drop a new single in June. The new single has been written by the singer herself, and she recently finished shooting the music video in Croatia.The upcoming single comes around eight months after...[more...] Full Article
ease EXO's Suho to release new solo album By world.kbs.co.kr Published On :: 2024-05-06 EXO’s Suho will release a new solo album this month. The new EP, titled “1 to 3” will drop on May 31, more than two years after his second solo album “Grey Suit” was released in April...[more...] Full Article
ease RM Releases 2nd Solo Album 'Right Place, Wrong Person' By world.kbs.co.kr Published On :: 2024-05-24 RM of BTS released his second solo album 'Right Place, Wrong Person' on Friday, his first solo album since 'Indigo' in December 2022.The album carries eleven songs, including the title track...[more...] Full Article
ease Lisa of Blackpink preparing for new music release By world.kbs.co.kr Published On :: 2024-06-17 Lisa of Blackpink is signaling a comeback as a solo artist. The singer uploaded a clip on social media and posted a notice on her website on how to “pre-save” her new release. It will be her first...[more...] Full Article
ease BTS Jimin to Release English Version of 'Be Mine' Friday By world.kbs.co.kr Published On :: 2024-08-02 Jimin of BTS is set to release an English version of the single 'Be Mine.' The singer's agency BigHit Music said that the track would be released on Friday. 'Be Mine' is a track listed in...[more...] Full Article
ease TWICE's Tzuyu to Release Solo Album By world.kbs.co.kr Published On :: 2024-08-02 Tzuyu of the girl group TWICE is set to become the third member to launch her solo career. JYP Entertainment dropped the news on Friday via social media, along with an opening trailer.The artist's solo debut...[more...] Full Article
ease Omega X to Release New Japanese EP By world.kbs.co.kr Published On :: 2024-10-08 +09:00 Omega X will release its 2nd Japanese EP next month. The new album is called “To.” and it will be released on Nov. 13. The group’s last Japanese album was its debut EP,...[more...] Full Article Economy&It
ease Jin to Release First Solo Album By world.kbs.co.kr Published On :: 2024-10-22 +09:00 Jin of BTS will release his first solo album next month. Titled “Happy” the album will drop on Nov. 15. His label, BigHit Music, said “Happy” is about finding happiness...[more...] Full Article Economy&It
ease No. of Economically Inactive People Increases 245,000 On-Year in August By world.kbs.co.kr Published On :: Wed, 06 Nov 2024 16:17:04 +0900 [Economy] : The number of economically inactive South Koreans increased by 245-thousand on-year in August. According to Statistics Korea on Wednesday, nearly two-point-57 million people were neither working nor looking for work. Those in their 60s made up 36-point-three percent of the total, while people in their ...[more...] Full Article Economy
ease BGS releases 10K maps through updated maps portal - British Geological Survey By news.google.com Published On :: Tue, 16 May 2023 07:00:00 GMT BGS releases 10K maps through updated maps portal British Geological Survey Full Article
ease Update released for BGS open-source database software, ETL Helper - British Geological Survey By news.google.com Published On :: Tue, 09 Jul 2024 07:00:00 GMT Update released for BGS open-source database software, ETL Helper British Geological Survey Full Article
ease Update to BGS’s AGS file utilities tool released - British Geological Survey By news.google.com Published On :: Wed, 19 Jun 2024 07:00:00 GMT Update to BGS’s AGS file utilities tool released British Geological Survey Full Article
ease Position-independent product increase rate in a shaker mill revealed by position-resolved in situ synchrotron powder X-ray diffraction By journals.iucr.org Published On :: The position- and time-resolved monitoring of a mechanochemical reaction using synchrotron powder X-ray diffraction revealed a position-independent increase rate of product in the jar of a shaker mill. Full Article text
ease Position-independent product increase rate in a shaker mill revealed by position-resolved in situ synchrotron powder X-ray diffraction By journals.iucr.org Published On :: 2024-11-08 We investigated the position and time dependence of a mechanochemical reaction induced by ball milling using in situ synchrotron powder X-ray diffraction with changing X-ray irradiation position. The mechanochemical reduction of AgCl with Cu was monitored in situ with the X-rays incident at two different vertical positions on the jar. Our previously developed multi-distance Rietveld method was applied to analyze the in situ diffraction data with a 1 min resolution. Both the vertical and the horizontal sample positions were determined using the sample-to-detector distances from the in situ data. Position dependence was found in the powder spreading and induction time. We reveal that the increase rate of the product is independent of the sample position when measured with a 1 min time resolution, confirming the validity of in situ monitoring of part of the space in a milling jar for a gradual mechanochemical reaction. Full Article text
ease Increased spatial coherence length from an asymmetric crystal reflection at grazing exit By journals.iucr.org Published On :: 2024-03-26 Coherent X-ray imaging is an active field at synchrotron sources. The images rely on the available coherent flux over a limited field of view. At many synchrotron beamlines a double-crystal monochromator (DCM) is employed in a standard nondispersive arrangement. For coherent diffraction imaging it is advantageous to increase the available field of view by increasing the spatial coherence length (SCL) of a beam exiting such a DCM. Here, Talbot interferometry data together with ray-tracing simulations for a (+ − − +) four-reflection experimental arrangement are presented, wherein the first two reflections are in the DCM and the final fourth reflection is asymmetric at grazing exit. Analyses of the interferometry data combined with the simulations show that compared with the beam exiting the DCM a gain of 76% in the SCL was achieved, albeit with a factor of 20 reduction in flux density, which may not be a severe penalty at a synchrotron beamline. Previous efforts reported in the literature to increase the SCL that employed asymmetric crystal diffraction at grazing incidence are also discussed. A much reduced SCL is found presently in simulations wherein the same asymmetric crystal is set for grazing incidence instead of grazing exit. In addition, the present study is compared and contrasted with two other means of increasing the SCL. These are (i) focusing the beam onto an aperture to act as a secondary source, and (ii) allowing the beam to propagate in vacuum an additional distance along the beamline. Full Article text
ease Indirect detector for ultra-high-speed X-ray micro-imaging with increased sensitivity to near-ultraviolet scintillator emission By journals.iucr.org Published On :: 2024-08-28 Ultra-high-speed synchrotron-based hard X-ray (i.e. above 10 keV) imaging is gaining a growing interest in a number of scientific domains for tracking non-repeatable dynamic phenomena at spatio-temporal microscales. This work describes an optimized indirect X-ray imaging microscope designed to achieve high performance at micrometre pixel size and megahertz acquisition speed. The entire detector optical arrangement has an improved sensitivity within the near-ultraviolet (NUV) part of the emitted spectrum (i.e. 310–430 nm wavelength). When combined with a single-crystal fast-decay scintillator, such as LYSO:Ce (Lu2−xYxSiO5:Ce), it exploits the potential of the NUV light-emitting scintillators. The indirect arrangement of the detector makes it suitable for high-dose applications that require high-energy illumination. This allows for synchrotron single-bunch hard X-ray imaging to be performed with improved true spatial resolution, as herein exemplified through pulsed wire explosion and superheated near-nozzle gasoline injection experiments at a pixel size of 3.2 µm, acquisition rates up to 1.4 MHz and effective exposure time down to 60 ps. Full Article text
ease Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket By journals.iucr.org Published On :: 2024-01-30 To identify starting points for therapeutics targeting SARS-CoV-2, the Paul Scherrer Institute and Idorsia decided to collaboratively perform an X-ray crystallographic fragment screen against its main protease. Fragment-based screening was carried out using crystals with a pronounced open conformation of the substrate-binding pocket. Of 631 soaked fragments, a total of 29 hits bound either in the active site (24 hits), a remote binding pocket (three hits) or at crystal-packing interfaces (two hits). Notably, two fragments with a pose that was sterically incompatible with a more occluded crystal form were identified. Two isatin-based electrophilic fragments bound covalently to the catalytic cysteine residue. The structures also revealed a surprisingly strong influence of the crystal form on the binding pose of three published fragments used as positive controls, with implications for fragment screening by crystallography. Full Article text
ease Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options By journals.iucr.org Published On :: 2024-04-24 The large Bunyavirales order includes several families of viruses with a segmented ambisense (−) RNA genome and a cytoplasmic life cycle that starts by synthesizing viral mRNA. The initiation of transcription, which is common to all members, relies on an endonuclease activity that is responsible for cap-snatching. In La Crosse virus, an orthobunyavirus, it has previously been shown that the cap-snatching endonuclease resides in the N-terminal domain of the L protein. Orthobunyaviruses are transmitted by arthropods and cause diseases in cattle. However, California encephalitis virus, La Crosse virus and Jamestown Canyon virus are North American species that can cause encephalitis in humans. No vaccines or antiviral drugs are available. In this study, three known Influenza virus endonuclease inhibitors (DPBA, L-742,001 and baloxavir) were repurposed on the La Crosse virus endonuclease. Their inhibition was evaluated by fluorescence resonance energy transfer and their mode of binding was then assessed by differential scanning fluorimetry and microscale thermophoresis. Finally, two crystallographic structures were obtained in complex with L-742,001 and baloxavir, providing access to the structural determinants of inhibition and offering key information for the further development of Bunyavirales endonuclease inhibitors. Full Article text
ease Structural multiplicity in a solvated hydrate of the antiretroviral protease inhibitor Lopinavir By journals.iucr.org Published On :: 2024-10-24 Lopinavir is a potent protease inhibitor that is used as a first-line pharmaceutical drug for the treatment of HIV. The multi-component solvated Lopinavir crystal, systematic name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide–ethane-1,2-diol–water (8/3/7) 8C37H48N4O5·3C2H6O2·7H2O, was prepared using evaporative methods. The crystalline material obtained from this experimental synthesis was characterized and elucidated by single-crystal X-ray diffraction (SC-XRD). The crystal structure is unusual in that the unit cell contains 18 molecules. The stoichiometric ratio of this crystal is eight Lopinavir molecules [8(C37H48N4O5)], three ethane-1,2-diol molecules [3(C2H6O2)] and seven water molecules [7(H2O)]. The crystal packing features both bi- and trifurcated hydrogen bonds between atoms. Full Article text
ease New Michael Jackson/Queen song released: 'There Must Be More to Life Than This' By www.scpr.org Published On :: Fri, 19 Sep 2014 16:37:24 -0700 File: Queen's Freddie Mercury has his mustache groomed. ; Credit: Steve Wood/Express/Getty Images The new Queen compilation "Queen Forever" includes three previously unreleased tracks, but the one that has people talking is a collaboration between two legends: Freddie Mercury and Michael Jackson. The new song, "There Must Be More to Life Than This," was an unfinished track recorded during studio sessions for the 1981 Queen album "Hot Space," according to a press release on the new compilation. Queen also looked at the song for 1984's "The Works," but still don't go with it — the song finally landed, sans Jackson, on 1985's Mercury solo album "Mr. Bad Guy." Listen to the new version of the song here: Michael Jackson/Queen Soundcloud Listen to the originally recorded version of the Queen/Jackson collaboration below: Michael Jackson/Queen collabo The new version was produced by William Orbit, who also did a remix of the song. "Hearing Michael Jackson's vocals was stirring. So vivid, so cool, and poignant, it was like he was in the studio singing live. With Freddie's vocal solo on the mixing desk, my appreciation for his gift was taken to an even higher level," Orbit said in a press release. The song is a call for peace, talking human rights in a general way. It almost didn't end up on the album — Queen's Brian May said that working with the Jackson family and Jackson's estate was like "wading through glue," according to Philly.com, but the track ended up making the cut. The album also includes unreleased song "Let Me In Your Heart Again" and a new version of a song Mercury released solo, an acoustic take on "Love Kills." "Let Me In Your Heart Again" was previously recorded and released by May's wife Anita Dobson. "Freddie sounds as fresh as yesterday," May said at a press conference while the new compilation was in the works. Listen to Mercury's solo version of "There Must Be More to Life Than This" below: There Must Be More To Life Than This, solo Listen to Anita Dobson's version of "Let Me In (Your Heart Again)" below: Anita Dobson track Full Article
ease Silver Co. Releases High-Grade Results From Golden Triangle Drilling By www.streetwisereports.com Published On :: Tue, 05 Nov 2024 00:00:00 PST Source: Streetwise Reports 11/05/2024 Dolly Varden Silver Corp. (DV:TSX.V; DOLLF:OTCQX) releases new results from its 2024 drilling program at its Kitsault Valley project in British Columbia's Golden Triangle. One analyst says the company is an "attractive target" for large precious metal producers.Dolly Varden Silver Corp. (DV:TSX.V; DOLLF:OTCQX) released results from five drill holes from its completed 2024 drilling program at its Kitsault Valley project in British Columbia's Golden Triangle. In total, the program drilled 69 holes for 31,726 meters — 41 holes totaling more than 15,000 meters at the Dolly Varden area and 28 holes totaling more than 16,000 meters at Homestake Ridge. Highlights of Monday's release include one hole from the Homestake Silver Deposit that found 12.23 grams per tonne gold (g/t Au) and 84 g/t silver (Ag) over 34.93 meters with high-grade breccia veins that included 166 g/t Au and 675 g/t Ag over 0.97 meters. "The identification of a gold-rich, wide and high-grade area within the Homestake Silver Deposit is highly encouraging," said Chief Executive Officer Shawn Khunkhun. "Our geological team is encouraged by overlapping mineralizing phases of silver and gold-rich veins and breccias; the deposit remains open for expansion." Technical Analyst Clive Maund, writing on Sunday, called Dolly Varden "one of the best pure silver companies around." The stock's "breakout at end of last month/early this month was on big volume means it was genuine," Maund wrote. The stock is at a "classic buy spot, although we should remain aware that it could zigzag a little lower over the short-term, but that said it looks like a strong buy here." Highlights From Results Highlights from the Homestake Silver Deposit include: Hole HR24-432: Mineralized envelope including veins: 8.85 g/t Au and 5 g/t Ag over 48.23 meters, including an internal zone of stronger breccia vein intervals grading 29.24 g/t Au and 16 g/t Ag over 13.94 meters, including one breccia vein grading 701 g/t Au and 184 g/t Ag over 0.54 meters. Hole HR24-435: Mineralized envelope including veins: 4.64 g/t Au and 38 g/t Ag over 100.80 meters, including an internal interval of stronger breccia vein mineralization grading 12.23 g/t Au and 84 g/t Ag over 34.93 meters. High-grade breccia veins include 166 g/t Au and 675 g/t Ag over 0.97 meters. Hole HR24-442: Vein breccia zone: 4.58 g/t Au over 9.95 meters, including 14.96 g/t Au over 1.69 meters. "Results from the five holes in this release suggest that the plunge of mineralization at Homestake Silver has a similar orientation as the Homestake Main Deposit, located 300 meters to the northwest," the company said in a release. "The average grades within these core areas are higher, on a precious metal silver equivalent basis, than the average grade of the silver deposits at the Dolly Varden property further south, due to the increased gold content at the Homestake Ridge Deposits." Technical Analyst Clive Maund, writing on Sunday, called Dolly Varden "one of the best pure silver companies around." Drill holes HR24-442 and HR24-445 are step-outs and encountered the mineralized and altered structural corridor of Homestake Silver, the company said. Drill hole HR24-442 intersected a mineralized vein breccia stockwork zone grading 4.58 g/t Au over 9.95 meters, including individual breccias with stronger pyrite mineralization grading 14.96 g/t Au over 1.69 meters. The Homestake Ridge deposits are interpreted as structurally controlled, multi-phase epithermal vein stockwork and vein breccia system hosted in Jurassic Hazelton volcanic rocks, Dolly Varden noted. Mineralization consists of pyrite plus galena and sphalerite with visible gold in a breccia matrix within a silica breccia vein system. "The northwest orientation of the main Homestake structural trend appears to have numerous subparallel internal structures that are interpreted to form the controls for higher grade gold and silver shoots within a broader mineralized envelope at the Homestake Silver deposit," the company said. "The main structural corridor dips steeply to the northeast at Homestake Main and rolls to vertical or steeply southwest at Homestake Silver." Analyst's Response: 'Boom' Jeff Valks, Senior Analyst for The Gold Advisor newsletter, reacted to the results with the word "BOOM." "Dolly Varden Silver reports more high-grade drill results from its 2024 exploration program at the Homestake Silver Deposit in British Columbia's Golden Triangle," he wrote on Monday. "Results from five drill holes have confirmed significant gold and silver mineralization in an area targeted within the plunge of a previously undrilled high-grade zone, signaling potential expansion opportunities." Jeff Valks, Senior Analyst for The Gold Advisor newsletter, reacted to the results with the word "BOOM." We look forward to the remaining results." Vaks wrote. "In the meantime, the stock is flat as I write but is up over 35% year-to-date. It's not too late to buy, it's down from its recent spike, and as (editor) Jeff (Clark) has said, this is a core holding for the silver bull market. Use a stink bid if you're looking for shares. Both Jeff and I hold long positions." Analyst Marcus Giannini of Haywood Capital Markets noted in a recent research note that Dolly Varden continues to "push the margins of known high-grade mineralization" at the project. Gianini gave the stock a Buy rating with a CA$2.40 per share target price. "We continue to view Dolly's high-grade endowment as an increasingly attractive target for larger North American-focused precious metal producers," he noted. The Catalyst: Analysts Point to Patience While it has chased the record highs gold has been setting this year, silver recently broke through US$35 per ounce, reflecting a year-to-date gain of about 47%. It has since settled but held to the "crucial US$32.50 level," according to Christopher Lewis of FX Empire on Monday. "Keep in mind that this is a market that is extraordinarily volatile and, of course, will continue to be noisy over the next couple of days as we get election results in the United States," Lewis wrote. "And of course, we also get the Federal Reserve interest rate decision on Thursday, both of which could cause chaos." Lewis said he thinks the "least likely path is lower." "I still favor an upside move, but I recognize that we are definitely in a little bit of a holding pattern," he wrote. "Having said that, if we do see momentum to the upside, then there's really not a whole lot here that could keep this market from trying to challenge the (US$)35 level again, obviously, a large round psychologically significant figure, but we'll just have to wait and see how that plays out." The most conductive element in nature, silver is used to coat electrical contacts in computers, phones, cars, and appliances. It's also an important element in solar technology. Mordor Intelligence noted that the white metal is expected to register a compound annual growth rate (CAGR) of more than 5% between 2024 and 2029. Newsletter editor Brien Lundin encouraged investors not to get discouraged, as any price drop-off is temporary, he said. He expects the silver price to soar when the U.S. Federal Reserve doubles down on its efforts to get interest rates much lower, he wrote on Oct. 23. [OWNERSHIP_CHART-5439] Based on silver's charts, Ron Struthers of Struthers Resource Stock Report also predicted a major run-up in the silver price. "Back in April or early May, I highlighted the breakout from a cup and handle formation and [that] that would lead to a major upside move. This is now confirmed," he wrote on Oct. 23. Ownership and Share Structure According to the company's latest corporate presentation, 50% of its stock is held by institutional investors, including Fidelity Management & Research Company LLC, Sprott Asset Management LP, U.S. Global Investors Inc., and Delbrook. About 41% is with strategic investors, including 17% with Fury Gold Mines, 14% with Hecla, and Eric Sprott owns 10% himself. The rest, 9%, is with retail and high-net-worth investors. The company has 301.16 million outstanding shares. Its market cap is CA$380.72 million, and its 52-week trading range is CA$0.62–1.46 per share. Sign up for our FREE newsletter at: www.streetwisereports.com/get-newsImportant Disclosures: Dolly Varden Silver Corp. is a billboard sponsor of Streetwise Reports and pays SWR a monthly sponsorship fee between US$4,000 and US$5,000. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Dolly Varden Silver Corp. Steve Sobek wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company. For additional disclosures, please click here. ( Companies Mentioned: DV:TSX.V; DOLLF:OTCQX, ) Full Article
ease He Inherited A Devastating Disease. A CRISPR Gene-Editing Breakthrough Stopped It By www.scpr.org Published On :: Sat, 26 Jun 2021 10:20:08 -0700 Patrick Doherty volunteered for a new medical intervention of gene-editor infusions for the treatment of genetically-based diseases.; Credit: /Patrick Doherty Rob Stein | NPRPatrick Doherty had always been very active. He trekked the Himalayas and hiked trails in Spain. But about a year and a half ago, he noticed pins and needles in his fingers and toes. His feet got cold. And then he started getting out of breath any time he walked his dog up the hills of County Donegal in Ireland where he lives. "I noticed on some of the larger hill climbs I was getting a bit breathless," says Doherty, 65. "So I realized something was wrong." Doherty found out he had a rare, but devastating inherited disease — known as transthyretin amyloidosis — that had killed his father. A misshapen protein was building up in his body, destroying important tissues, such as nerves in his hands and feet and his heart. Doherty had watched others get crippled and die difficult deaths from amyloidosis. "It's terrible prognosis," Doherty says. "This is a condition that deteriorates very rapidly. It's just dreadful." So Doherty was thrilled when he found out that doctors were testing a new way to try to treat amyloidosis. The approach used a revolutionary gene-editing technique called CRISPR, which allows scientists to make very precise changes in DNA. "I thought: Fantastic. I jumped at the opportunity," Doherty says. On Saturday, researchers reported the first data indicating that the experimental treatment worked, causing levels of the destructive protein to plummet in Doherty's body and the bodies of five other patients treated with the approach. "I feel fantastic," Doherty says. "It's just phenomenal." The advance is being hailed not just for amyloidosis patients but also as a proof-of-concept that CRISPR could be used to treat many other, much more common diseases. It's a new way of using the innovative technology. "This is a major milestone for patients," says Jennifer Doudna of the University of California, Berkeley, who shared a Nobel Prize for her work helping develop CRISPR. "While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," Doudna says. CRISPR has already been shown to help patients suffering from the devastating blood disorders sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer and to restore vision to people blinded by a rare genetic disorder. But those experiments involve taking cells out of the body, editing them in the lab, and infusing them back in or injecting CRISPR directly into cells that need fixing. The study Doherty volunteered for is the first in which doctors are simply infusing the gene-editor directly into patients and letting it find its own way to the right gene in the right cells. In this case, it's cells in the liver making the destructive protein. "This is the first example in which CRISPR-Cas9 is injected directly into the bloodstream — in other words systemic administration — where we use it as a way to reach a tissue that's far away from the site of injection and very specifically use it to edit disease-causing genes," says John Leonard, the CEO of Intellia Therapeutics, which is sponsoring the study. Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein. Within weeks, the levels of protein causing the disease plummeted. Researchers reported at the Peripheral Nerve Society Annual Meeting and in a paper published in The New England Journal of Medicine. "It really is exciting," says Dr. Julian Gillmore, who is leading the study at the University College London, Royal Free Hospital. "This has the potential to completely revolutionize the outcome for these patients who have lived with this disease in their family for many generations. It's decimated some families that I've been looking after. So this is amazing," Gillmore says. The patients will have to be followed longer, and more patients will have to be treated, to make sure the treatment's safe, and determine how much it's helping, Gillmore stresses. But the approach could help those struck by amyloidosis that isn't inherited, which is a far more common version of the disease, he says. Moreover, the promising results potentially open the door for using the same approach to treatment of many other, more common diseases for which taking cells out of the body or directly injecting CRISPR isn't realistic, including heart disease, muscular dystrophy and brain diseases such as Alzheimer's. "This is really opening a new era as we think about gene-editing where we can begin to think about accessing all kinds of different tissue in the body via systemic administration," Leonard says. Other scientists who are not involved in the research agree. "This is a wonderful day for the future of gene-editing as a medicine," agree Fyodor Urnov, a professor of genetics at the University of California, Berkeley. "We as a species are watching this remarkable new show called: our gene-edited future." Doherty says he started feeling better within weeks of the treatment and has continued to improve in the weeks since then. "I definitely feel better," he told NPR. "I'm speaking to you from upstairs in our house. I climbed stairs to get up here. I would have been feeling breathless. I'm thrilled." Copyright 2021 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
ease USGS Releases New Topographic Maps for Puerto Rico and the U.S. Virgin Islands - Updated Maps for Essential Needs By www.usgs.gov Published On :: Thu, 31 Oct 2024 16:53:06 EDT The USGS is pleased to announce the release of new US Topo maps for Puerto Rico and the U.S. Virgin Islands. These updated topographic maps offer valuable, current geographic information for residents, visitors, and professionals, providing essential resources for communities in these areas. Full Article
ease Study finds big increase in ocean carbon dioxide absorption along West Antarctic Peninsula By news.science360.gov Published On :: 2019-08-29T07:00:00Z Full Text:A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.Image credit: Drew Spacht/The Ohio State University Full Article
ease Micromax releases AI powered mobile launcher, Steroid By cio.economictimes.indiatimes.com Published On :: Wed, 04 Jul 2018 07:00:00 +0530 Micromax forays in the race of in-house mobile launcher driven by Machine Learning and AI to enhance the user experience. Full Article
ease Catawba County Social Services releases data from Livable and Senior Friendly Community Survey. By www.catawbacountync.gov Published On :: Wed, 13 Jan 2010 00:00:00 EST In the fall of 2009, as a part of the Catawba Aging Leadership Planning Project, Catawba County, along with aging service providers, volunteers and local municipalities developed a �Livable & Senior Friendly Community Survey�. This survey was widely distributed throughout Catawba County and targeted the County�s Senior Community, their caregivers and professionals in the aging field. The purpose of the survey was to obtain current and relevant information on the quality of life of seniors. Obtaining this information is important when looking toward the future of Catawba County. Full Article News Release FYI Please Choose
ease Catawba County Public Health brings flu immunization to 2500 students after cases increase in schools. By www.catawbacountync.gov Published On :: Mon, 28 Mar 2011 09:12:00 EST Between February 16 and 24, 2011, more than 2,500 students in Catawba County�s three public school systems received the 2010-11 flu vaccine due to a successful partnership between the schools and Catawba County Public Health. School nurses collected permission forms from parents and coordinated flu vaccine mini-clinics at 43 schools. Full Article News Release FYI Please Choose
ease Catawba County Children's Agenda Planning Committee releases report after two years of gathering information. By www.catawbacountync.gov Published On :: Thu, 12 May 2011 13:33:00 EST The committee compiled existing information about the status of children in the county. It also held public meetings and surveyed members of the public about their priorities and ideas. The committee found that most children in the county are well-cared for, but that a substantial number are falling through the cracks. A major cause of concern is the large number of children living in poverty. Full Article News Release FYI Please Choose
ease NCDOT releases recommendations on widening of Highway 16 South in Catawba County By www.ncdot.org Published On :: Mon, 21 Nov 2011 12:35:00 EST The North Carolina Department of Transportation has released recommendations on widening of Highway 16 South in Catawba County (within the minutes of public meetings). Link to project maps: http://www.ncdot.org/doh/preconstruct/highway/roadway/hearingmaps_by_county/county/Catawba.html Full Article Public Notice News Release FYI
ease An update of the Catawba County Child Data Snapshot has been released. By www.catawbacountync.gov Published On :: Wed, 28 Nov 2012 10:15:00 EST The information was developed and compiled by the Children's Agenda Planning Committee, appointed by the Catawba County Board of Commissioners. The committee's vision is to ensure a safe community where all children are engaged, enriched and equipped to reach their full potential. Full Article News Release Alert Public Notice
ease Report Links Disease to Herbicides - Calls for New Studies of Exposed Vietnam Veterans By Published On :: Tue, 27 Jul 1993 05:00:00 GMT Evidence exists linking three cancers and two other health problems with chemicals used in herbicides in the Vietnam War, a committee of the Institute of Medicine (IOM) has concluded. Full Article
ease National Campaign Needed to Fight The Hidden Epidemic of Sexually Transmitted Diseases By Published On :: Tue, 19 Nov 1996 06:00:00 GMT A bold national initiative is needed to reduce the enormous health burden of sexually transmitted diseases (STDs) in the United States, according to a new report from a committee of the Institute of Medicine. Full Article
ease Adults Need to Increase Intake of Folate - Some Women Should Take More By Published On :: Tue, 07 Apr 1998 05:00:00 GMT Women who might become pregnant need 400 micrograms of folic acid per day to reduce their risk of having a child with neural tube defects, according to the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine. Full Article
ease Allowable Levels of Copper in Drinking Water Should Not Be Increased Until Studies Are Done By Published On :: Thu, 02 Mar 2000 06:00:00 GMT The federal government should not increase the maximum level of copper allowed in drinking water, because higher levels could lead to liver poisoning in infants and children with certain genetic disorders. Full Article
ease Antioxidants Role in Chronic Disease Prevention Still Uncertain - Huge Doses Considered Risky By Published On :: Mon, 10 Apr 2000 05:00:00 GMT Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies. Full Article
ease Report Offers New Eating and Physical Activity Targets To Reduce Chronic Disease Risk By Published On :: Thu, 05 Sep 2002 05:00:00 GMT To meet the bodys daily energy and nutritional needs while minimizing risk for chronic disease, adults should get 45 percent to 65 percent of their calories from carbohydrates, 20 percent to 35 percent from fat, and 10 percent to 35 percent from protein. Full Article
ease Report Sets Dietary Intake Levels for Water, Salt, and Potassium To Maintain Health and Reduce Chronic Disease Risk By Published On :: Wed, 11 Feb 2004 06:00:00 GMT The vast majority of healthy people adequately meet their daily hydration needs by letting thirst be their guide, says the newest report on nutrient recommendations from the Institute of Medicine of the National Academies. Full Article
ease Guidelines Released for Embryonic Stem Cell Research By Published On :: Tue, 26 Apr 2005 05:00:00 GMT The National Academies today recommended guidelines for research involving human embryonic stem cells, and urged all institutions conducting such research to establish oversight committees to ensure that the new guidelines will be followed. Full Article
ease Limited Data Suggest Possible Association Between Agent Orange Exposure And Ischemic Heart Disease And Parkinsons Disease In Vietnam Veterans By Published On :: Fri, 24 Jul 2009 05:00:00 GMT A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinsons disease for Vietnam veterans. Full Article
ease Assessment of U.S. Doctoral Programs Released, Offers Data On More Than 5,000 Programs Nationwide By Published On :: Tue, 28 Sep 2010 05:00:00 GMT The National Research Council today released its assessment of U.S. doctoral programs, which includes data on over 5,000 programs in 62 fields at 212 universities nationwide. Full Article
ease Health Care Reform and Increased Patient Needs Require Transformation of Nursing Profession By Published On :: Tue, 05 Oct 2010 05:00:00 GMT Nurses roles, responsibilities, and education should change significantly to meet the increased demand for care that will be created by health care reform and to advance improvements in Americas increasingly complex health system, says a new report from the Institute of Medicine. Full Article
ease Report Calls for Creation of a Biomedical Research and Patient Data Network For More Accurate Classification of Diseases, Move Toward Precision Medicine By Published On :: Wed, 02 Nov 2011 05:00:00 GMT A new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of disease and ultimately enhance diagnosis and treatment, says a new report from the National Research Council. Full Article
ease U.S. National Academy of Sciences, U.K. Royal Society Release Joint Publication on Climate Change By Published On :: Thu, 27 Feb 2014 06:00:00 GMT The U.S. National Academy of Sciences and the Royal Society, the national science academy of the U.K., released a joint publication today in Washington, D.C., that explains the clear evidence that humans are causing the climate to change, and that addresses a variety of other key questions commonly asked about climate change science. Full Article
ease Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Is a Legitimate Disease That Needs Proper Diagnosis and Treatment, Says IOM Report Identifies Five Symptoms to Diagnose Disease By Published On :: Tue, 10 Feb 2015 05:00:00 GMT Myalgic Encephalomyelitis/Chronic Fatigue Syndrome -- commonly referred to as ME/CFS -- is a legitimate, serious, and complex systemic disease that frequently and dramatically limits the activities of affected individuals, says a new report from the Institute of Medicine. Full Article
ease No Significant Increase in Health Risks for 1960s Project SHAD Veterans - New Report By Published On :: Fri, 08 Jan 2016 06:00:00 GMT Veterans who participated in a series of tests during the 1960s known as Project SHAD (Shipboard Hazard and Defense) show no significant increase in adverse health outcomes, specific causes of death, or death rates compared with a similar group of veterans who were not involved in the tests, says a new report from a committee of the National Academies of Sciences, Engineering, and Medicine. Full Article