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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00216


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[ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00006


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[ASAP] Analyzing and Engineering the Product Selectivity of a 2-Methylenebornane Synthase

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Published On :: Mon, 04 May 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00432


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[ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01910


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[ASAP] Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01961


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[ASAP] Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01835


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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00641


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[ASAP] Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00388


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[ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02097


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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035


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[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01392


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[ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00599


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[ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01336


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[ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00202


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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

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Published On :: Tue, 05 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395


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[ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

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Published On :: Tue, 05 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02038


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[ASAP] Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00021


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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337


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[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00628


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[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00192


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[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00664


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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

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Published On :: Tue, 31 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686


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[ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup>

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00641


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[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00043


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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00045


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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063


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[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00594


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[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00561


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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095


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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00206


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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155


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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115


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[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

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Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085


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China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude

By latestsolarnews.com
Published On :: Tue, 06 Jun 2017 16:29:43 +0000

China’s first domestically designed large solar-powered unmanned plane reached above 20,000 meters in altitude on its test flight in the country’s northwest regions recently. The drone was developed by the China Academy of Aerospace Aerodynamics (CAAA), it’s developers kept the exact size of the drone as a secret, but it is believed to be about 14 …

The post China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude appeared first on LatestSolarNews.


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India is planning to achieve 50 GW of prodction from renewbale energy by 2028

By latestsolarnews.com
Published On :: Tue, 08 Jan 2019 10:08:19 +0000

India is planning to achieve 50 gigawatt (GW) of production from renewable energy by 2028, in order to get to its goal of 40 per cent of electricity generation from non-fossil fuels by 2030, Ministry of New and Renewable Energy secretary, Anand Kumar said at the India-Norway Business Summit 2019 in New Delhi. Of this …

The post India is planning to achieve 50 GW of prodction from renewbale energy by 2028 appeared first on LatestSolarNews.


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Popular Design News of the Week: April 20, 2020 – April 26, 2020

By www.webdesignerdepot.com
Published On :: Sun, 26 Apr 2020 10:45:05 +0000

Every week users submit a lot of interesting stuff on our sister site Webdesigner News, highlighting great content from around the web that can be of interest to web designers.  The best way to keep track of all the great stories and news being posted is simply to check out the Webdesigner News site, however, […]


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The Latest Research for Web Designers, April 2020

By www.webdesignerdepot.com
Published On :: Mon, 27 Apr 2020 10:45:10 +0000

Although life hasn’t returned to normal yet, the web design and marketing space doesn’t seem to have been too badly disrupted — at least not with all the new research and surveys floating around. And thank goodness for that. If we can maintain some semblance of normalcy, I think we’ll all get through this crisis in good shape.


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8 Best CMS for 2020

By www.webdesignerdepot.com
Published On :: Fri, 01 May 2020 10:45:36 +0000

Content Management Systems are arguably the internet’s most powerful web development tool. In a rapidly growing market where every business under the sun requires a website that is not only fully functioning, but optimised, easy to update regularly, and implement the latest features, the right CMS is important. As a web developer it can be […]


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Popular Design News of the Week: April 27, 2020 – May 3, 2020

By www.webdesignerdepot.com
Published On :: Sun, 03 May 2020 10:45:45 +0000

Every week users submit a lot of interesting stuff on our sister site Webdesigner News, highlighting great content from around the web that can be of interest to web designers.  The best way to keep track of all the great stories and news being posted is simply to check out the Webdesigner News site, however, […]


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3 Essential Design Trends, May 2020

By www.webdesignerdepot.com
Published On :: Mon, 04 May 2020 10:45:56 +0000

The state of the world around us can greatly impact website design. From emotional changes that correlate to the feel of a design to information and data to deliver, the impact of the worldwide COVID-19 pandemic is making its way into projects (intentionally or not). Here’s what’s trending in design this month. 1. “Unbalanced” Use […]


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Women’s squad raises ₹20 lakh

By www.thehindu.com
Published On :: Mon, 04 May 2020 23:17:41 +0530

The Indian women’s hockey team’s efforts to crowd-fund support for poor and migrant workers has raised ₹20,01,130 through an 18-day online challenge.T


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એમડબ્લ્યુસી 2017: સેમસંગ ગેલેક્ષી એસ7 એજ, બેસ્ટ સ્માર્ટફોન ટાઇટલ

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Published On :: Tue, 28 Feb 2017 18:58:41 +0530

એમડબ્લ્યુસી દુનિયાની સુધી મોટી ટેક્નોલોજી ઇવેન્ટ માનવામાં આવે છે. હાલમાં ચાલી રહેલી એમડબ્લ્યુસી 2017 ટેક્નોલોજી ઇવેન્ટ દરમિયાન સેમસંગ સ્માર્ટફોનને બેસ્ટ સ્માર્ટફોન ટાઇટલ આપવામાં આવ્યું છે.કંપની ઘ્વારા લોન્ચ કરવામાં આવેલો સેમસંગ ગેલેક્ષી એસ7 એજ સ્માર્ટફોનને બેસ્ટ સ્માર્ટફોન 2016 ટાઇટલ આપવામાં આવ્યું છે.


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સેમસંગ ગેલેક્ષી ટેબ એસ2 8.0, જલ્દી એન્ડ્રોઇડ નોગૅટ અપડેટ આવશે

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Published On :: Sat, 04 Mar 2017 15:00:00 +0530

બેંચમાર્કિંગ સાઈટ માટે અલગ અલગ બ્રાન્ડની આવનારી ડિવાઈઝ માટે માહિતી આવતી રહેતી હોય છે. આવનારી ડિવાઈઝ અને લોન્ચ થઇ ચુકેલી ડિવાઈઝના ફીચર અને અપડેટ વિશે માહિતી મેળવવી ખુબ જ રસપ્રદ બાબત છે.આ સાઈટ ઘ્વારા હાલમાં જ સેમસંગ ડિવાઈઝ માટે કેટલીક માહિતી


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એમડબ્લ્યુસી 2017: સોની ઘ્વારા એક્સપિરીયા ઈયરફોન લોન્ચ કરવામાં આવ્યા

By feedproxy.google.com
Published On :: Sun, 05 Mar 2017 07:00:00 +0530

એમડબ્લ્યુસી 2017 ટેક્નોલોજી ઇવેન્ટમાં એક્સપિરીયા એક્સઝેડ પ્રીમિયમ, એક્સઝેડ, એક્સ એ1, અને એક્સ એ1 અલ્ટ્રા સ્માર્ટફોન જાહેર કરવામાં આવ્યા. સોની ઘ્વારા એક્સપિરીયા ઈયર "ઓપન સ્ટાઇલ" ઈયરફોન વિશે પણ જાહેરાત કરવામાં આવી, જે એપલ એરપોડ ને ટક્કર આપી શકે. આ એક નવો વાયરલેસ


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એમડબ્લ્યુસી 2017: વર્ષ 2017, પોકેમોન ગો 3 નવા અપડેટ લોન્ચ કરશે

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Published On :: Sun, 05 Mar 2017 13:01:00 +0530

આ વર્ષે પોકેમોન ગો વધુ મોટું અને સારું બનવા જઈ રહ્યું છે. જોન હંકે, જેઓ નિએન્ટિક લેબમાં સીઈઓ છે. તેમને જાહેરાત કરી છે કે આવનારા મહિનામાં ત્રણ ખુબ જ મેજર અપડેટ કરવામાં આવશે. આ જાહેરાત હાલમાં બાર્સેલોના, સ્પેનમાં ચાલી રહેલી એમડબ્લ્યુસી


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એલજી નવા બે સ્માર્ટફોન X230Z અને M320H એફસીસી ઘ્વારા સર્ટિફાઈડ

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Published On :: Mon, 06 Mar 2017 04:00:00 +0530

એફસીસી ઘ્વારા એલજી ઘ્વારા લાવવામાં આવી રહેલા બે સ્માર્ટફોન મોડલ X230Z અને M320H સર્ટિફાઈડ કરી દેવામાં આવ્યા છે. આ બંને બજેટ સ્માર્ટફોન તરીકે આવી શકે છે.અમને ચોક્કસ ખાતરી છે કે એલજીના આ બંને મોડલમાંથી એક X230Z વિશે પહેલા પણ ઘણી અફવાહો


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