These vegan waffles are perfectly crispy and flavored with a hint of vanilla! Super easy to make with a handful of pantry staples, and perfect for an indulgent breakfast or brunch.

craving more? check out TasteSpotting

Tune in online this month to find out how to protect your business from data extortionists

Webcast It's been "the year of ransomware" for about the past three years. And while you may be tired of hearing about the trend and just getting used to the reality, you may also like to remember: instances of attacks are climbing – quickly – and we’re now reaching a level where more than half of ransomware schemes result in a business paying out.…

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.

Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor.

Apple's next-generation Apple Watch and watchOS 7 will focus on new mental health capabilities, according to leaker Jon Prosser who recently spoke on the Geared Up podcast. The mention of new ‌Apple Watch‌ features comes towards the end of the podcast.


The next-generation version of the ‌Apple Watch‌, the ‌Apple Watch‌ Series 6, has been rumored to include a blood oxygen sensor, which Prosser says Apple will take advantage of to implement new mental health-related features, such as detecting panic attacks.

What their biggest focus on is right now and I hope it comes this year, it might come next year, but I hope it's coming to WWDC is mental health capabilities. Where they can take the oxygen levels in your blood with your heart rate and determine if you're hyperventilating.

They can identify a panic attack before it happens and warn you on your watch. Especially if you're driving, they'll ask you to pull over and they'll offer breathing exercises once you get pulled over.

Prosser says that while he hopes the feature is released this year, "it might come next year." He also says he hopes for a WWDC unveiling, but if the new feature relies on a blood oxygen sensor in an unreleased version of the ‌Apple Watch‌, it's not likely Apple will unveil the capability until the fall when new ‌Apple Watch‌ models that support it are released.

There is, however, a possibility that it will be revealed at WWDC if older ‌Apple Watch‌ models have a latent ability to detect blood oxygen level, which is not clear at this time, or if the feature does not involve blood oxygen monitoring.

The panic attack detecting rumor was first shared by EverythingApplePro and leaker Max Weinbach back in April, who said that the ‌Apple Watch‌ will also be able to determine when a user is experiencing high levels of stress. Weinbach and EverythingApplePro did not suggest the feature would rely on blood oxygen monitoring, however, and said that it would be available on the ‌Apple Watch‌ Series 4 or later.

Hints that blood oxygen tracking capabilities are coming to a future version of the ‌Apple Watch‌ were found in a leaked version of iOS 14. Blood oxygen monitoring is an important feature because a drop in blood oxygen levels can suggest a serious respiratory or cardiac problem that requires immediate medical attention.

Multiple prior rumors from Bloomberg and other sources have also indicated that the next-generation ‌Apple Watch‌ and watchOS 7 will include sleep tracking features, allowing the ‌Apple Watch‌ to measure sleep quality, length, and other metrics.
This article, "Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks" first appeared on MacRumors.com

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Animal Crackers (trailer) is a 94-minute computer-animated children's movie. The brainchild of Scott Sava, it caught the early attention of furry fandom at least as far back as 2015. Concept animation showed a guy haphazardly munching on animal-shaped cookies that turned him into the animals. As time went on, Sava brought in financial backers, a co-director (Tony Bancroft, who'd worked on several Disney movies), and a co-writer (Dean Lorey). The finished product premiered at the Annecy Film Festival in 2017... and then vanished.

It turns out that Sava had made the mistake of not securing a distributor ahead of time. With very little bargaining power, it eventually got shown in China in 2018, and some other countries in 2019.

read more

Erowid Exp113948

Chuck Todd tells Andrea Mitchell that Hillary Clinton will win the African-American and Hispanic vote in spite of the intellectual appeal of Bernie Sanders to liberal white voters Continue reading →

we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading →

Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading →

Taking place tomorrow 1:00PM PT/4:00PM ET

The post WB announces a watch party for JL DARK: APOKOLIPS WAR, the endgame of the DC Animated Movie Universe appeared first on The Beat.

Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources.

IBM and Nutanix today announced a multi-year initiative to bring new workloads to hyperconverged deployments.

IBM today announced the first clients to tap into its IBM Q™ early-access commercial quantum computing systems to explore practical applications important to business and science. They include: JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, Oxford University and University of Melbourne.

The Weather Company, an IBM Business, and PRISA Noticias, one of the world’s leading Spanish-language media groups and owner of EL PAÍS newspaper, announced today a collaboration to combine the most accurate forecasts with one of the Spanish-speaking world’s largest media groups. The Weather Company will provide in-depth weather data and forecasts, as well as tailored content across PRISA properties. In turn, PRISA Noticias will provide locally relevant articles, photos and video content within the Spanish versions of The Weather Channel app and website (weather.com). The collaboration will also enable local marketers to access advanced data-driven advertising solutions from IBM Watson Advertising (formerly The Weather Company’s ad sales business) across both companies’ properties.

One in four A/NZ executives believe their organisations excel in leadership development New Zealand executives focusing on bringing back retired employees The Social Network: Largely absent from A/NZ organisations

Habilita IBM el Crecimiento de las Organizaciones en una Era más Inteligente

Con la finalidad de apoyar el desarrollo de proyectos de alto impacto en la Ciudad de México, la Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología e IBM, ponen en marcha el día de hoy el programa de consultoría Corporate Service Corps (CSC), en su edición Ciudad de México.

Después de un mes de haber iniciado la consultoria pro-bono de IBM denominada Corporate Service Corps (CSC), el día de hoy se hizo la entrega del resumen ejecutivo de cada uno de los proyectos de las organizaciones receptoras de este apoyo: Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología.

IBM, Peace Corps y cuatro instituciones locales dieron inicio el día de hoy al programa de consultoría Corporate Service Corps (CSC), en su edición Cd. de Querétaro; con la finalidad de apoyar el desarrollo de proyectos de alto impacto en esta localidad. IBM y Peace Corps (PC) trabajarán en conjunto con la Secretaría de Desarrollo Social del Estado de Querétaro, el Instituto Queretano de las Mujeres, el Municipio de Querétaro - Delegación Santa Rosa Jáuregui, y la Universidad Politécnica de Santa Rosa Jáuregui (UPSRJ).

IBM today announced the findings of a major new study of over 1,900 Chief Financial Officers (CFOs) and senior finance executives from 81 countries and 35 industries worldwide, which reveals that more than 60 percent of CFOs plan major changes to respond to the new economic climate.

A new IBM study of more than 1,700 Chief Executive Officers from 64 countries and 18 industries worldwide reveals that CEOs are changing the nature of work by adding a powerful dose of openness, transparency and employee empowerment to the command-and-control ethos that has characterised the modern corporation for more than a century.

L’entité sécurité d’IBM a annoncé aujourd'hui les résultats d'une étude mondiale sondant le niveau de préparation des organisations en matière de résistance à une cyberattaque et de récupération ensuite. L'étude, menée par le Ponemon Institute et sponsorisée par IBM Resilient, a révélé qu'une grande majorité des organisations interrogées ne sont toujours pas prêtes à répondre de façon adéquate aux incidents de cybersécurité, 77% des personne interrogées indiquant qu'ils n'ont pas de plan de réponse aux incidents de cybersécurité appliqué de manière cohérente dans l’ensemble de l'organisation.

Tasmania’s St Virgil’s College has signed a two-year agreement with IBM to equip staff and students with Apple iPads and Mobile Device Management (MDM) software as part of its digital education delivery commitment.

Iwatani×宝塚歌劇団 真風涼帆さん初コラボ商品が誕生！真風さん監修のカセットこんろがもうすぐ発売！なんと、カセットこんろがおしゃれアイテムに！？「カセットフーマーベラス?すみれ」限定台数5,000台！詳細は近日公開予定。 #Iwatani #真風涼帆 #コスモこんろちゃん #...

A new IBM (NYSE: IBM) study of more than 1,700 Chief Executive Officers from 64 countries and 18 industries worldwide reveals that CEOs are changing the nature of work by adding a powerful dose of openness, transparency and employee empowerment to the command-and-control ethos that has characterised the modern corporation for more than a century.

After some discussion with the applied math research groups here at UCLA (in particular the groups led by Andrea Bertozzi and Deanna Needell), one of the members of these groups, Chris Strohmeier, has produced a proposal for a Polymath project to crowdsource in a single repository (a) a collection of public data sets relating to […]

I’ll be at Fanime! San Jose, CA, May 22nd - 25th!

I’ll be in the artist alley! I hope to see you if you’re attending! Come say hello~ -Hamlet

I'll be in Germany for the Animuc Convention in April!

I'll be at Fanime in San Jose in May!

This will be our only convention in California this year!

See you there! <3 -Hamlet

This is our second time at AnimeNYC! If you're there, feel free to stop by table H21 and see us in the Artist Alley!

See you there! -Hamlet

Istrie patří k nejoblíbenějším částem Chorvatska. Jako skoro všude na světě se tam hoteliérský a restaurační byznys letos v březnu úplně zastavil, což si ještě nedávno nikdo nedokázal představit. Teď se ale blíží oživení. „Ani přinejmenším ale neočekáváme, že zopakujeme výsledky loňského roku,“ říká v rozhovoru šéf turistického sdružení celé oblasti Denis Ivošević.

In the latest episode of their hot and tangy podcast, Ken and Robin talk handling player absence, video game money laundering, chili, and the Chapel of Sacred Mirrors.

Posted by: cyberghostface

 

NSFW for gore

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Mohlo by se zdát, že pojišťovny budou v koronavirové době zaznamenávat zvýšený zájem o sjednání životních pojistek. Zejména kvůli krytí rizika pracovní neschopnosti, což se vztahuje i na onemocnění infekcí covid-19. Praxe je ale zatím opačná.

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