Lyra Therapeutics, a biotech company developing a new way to treat your persistently runny nose, has raised $56 million in its public markets debut. Late Thursday, Lyra offered 3.5 million shares priced at $16 apiece, which was the high end of its projected $14 to $16 price range. Those shares are expected to begin trading […]

Ayala Pharmaceuticals has two clinical-stage cancer drugs licensed from Bristol Myers Squibb. Now it has $55 million to take those drugs further than the pharmaceutical giant did. On Thursday evening, Ayala priced its IPO, which consisted of 3.7 million shares sold for $15 each. That price was the midpoint of the targeted $14 to $16 […]

BrainStorm Cell Therapeutics, a firm developing cellular therapies to tackle neurodegenerative diseases, has named industry Big Pharma veteran Dr David Setboun as its new Executive Vice President and Chief Operating Officer.

Dr Setboun has served for two decades at some of the biggest names in pharma. His most recent role was Vice President of Corporate Development, Strategy & Business at Life Biosciences, where he helped drive development of a range of vital commercial, operating and funding milestones.

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This week, I’m rerunning some popular posts while I prepare for this Friday’s video webinar: Industry Update and COVID-19 Impact: PBMs & Payers.

Part D reform has faded from the policy debate. This rerun explains why it is still needed. FYI, this is my favorite article from 2020 (so far).

Click here to see the original post and comments from January 2020.

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Our high-list-price/high-rebate system remains a fundamental source of warped incentives and cascading problems within the Medicare Part D program.

For proof, check out the previously unpublished data below on market share for products that treat hepatitis C. Despite manufacturers offering products with lower list prices, Medicare Part D plans have rejected the therapeutically identical but lower-priced versions of these drugs.

List prices significantly affect seniors’ out of-pocket costs, so Part D plans are needlessly costing many of them thousands of dollars. The federal government's Medicare spending is also unnecessarily higher.

Anyone concerned about drug prices should pay close attention to this situation. Part D plans and seniors who don’t need specialty medications are benefiting, while seniors who need treatment with specialty medications are ripped off. Just another day inside the gross-to-net bubble!
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A pledging conference led by the European Union (EU) has set an initial target of 7.5 billion euros ($8.1…

Shares of Dr Reddy’s Laboratories rose more than 2% to 3,936.35 rupees, after the Indian drugmaker…

A Chicago police officer pleaded guilty today to violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.

The government has filed two lawsuits against the Union Pacific Railroad Company for allegedly failing to prevent the use of its rail cars to smuggle large quantities of narcotics into the United States. The complaints, filed in San Diego and Houston, seek more than $37 million in monetary penalties. The government alleges the rail cars were brought across the border at the ports of entry at Calexico, Calif., and Brownsville, Texas.

A 32-year-old Colombian citizen, Luz Mery Gutierrez Vergara, who was extradited from the Republic of Colombia on Thursday, made her initial appearance today in federal court in Washington, D.C., to face charges for allegedly participating in a conspiracy to provide material support to the Fuerzas Armadas Revolucionarias de Colombia, commonly known as the “FARC.”

"Helping foreign countries improve their criminal justice systems so they can cooperate more effectively with us and with their neighbors in real time is an important aspect of this department’s mission."

A Virginia man pleaded guilty today to illegally making conduit contributions to a candidate seeking federal office.

William Cozzi, a Chicago police officer, was sentenced today to 40 months in federal prison for violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.

The Department released a new technical assistance fact sheet on legal requirements relating to admitting individuals with HIV or AIDS to occupational training schools and granting state licensure in occupations such as barbering, massage therapy and home health care assistance.

Deputy Attorney General David W. Ogden today announced plans by the Department of Justice to significantly expand its training and education operations at the National Advocacy Center (NAC), the core training facility for local, state and federal attorneys, law enforcement agents and support personnel.

Union Pacific Railroad Company (UP) has agreed to settle alleged violations of the Clean Water Act in Nevada by restoring 122 acres of mountain-desert streams and wetlands, implementing storm water controls at its construction sites, and paying a civil penalty.

Richard David Mitchell was arraigned yesterday on sex tourism charges in the U.S. District Court for the District of Hawaii, after being deported from Cambodia.

"Judge, there is no question why so many of your friends, associates, and former staff members came to honor you and thank you for your service to our nation, and there is no question today why they have returned. They are here because you not only answered the call to service at a turbulent time for our nation and this Department, but you executed your responsibilities with tremendous skill, honor, and integrity."

A Florida doctor was charged today by a federal grand jury in Ft. Lauderdale, Fla., with allegedly orchestrating a fraudulent political fund raising and lobbying scheme through which he secretly diverted to himself more than $350,000 from contributions to political organizations he controlled.

Rodolfo Rodriguez Cabrera, 43, a Cuban national, was arraigned today in U.S. District Court for the District of Nevada on charges of producing and selling counterfeit slot machines and counterfeit computer programs.

The National Football League Players Association (NFLPA) has joined its year-long campaign to commemorate the 15 year anniversary of President Bill Clinton signing the Violence Against Women Act (VAWA) into law.

Norfolk Southern Railway Company has agreed to pay a $4 million penalty to resolve alleged violations of the Clean Water Act (CWA) and hazardous materials laws for a 2005 chlorine spill in Graniteville, S.C.

Gregory Alan Roberts, a resident of Fairfax County and Loudoun County, Va., was arraigned today by U.S. Magistrate Judge Ivan D. Davis on charges that he failed to timely file income tax returns for the years 2003, 2004, 2005 and 2006.

An indictment unsealed today in Philadelphia charged Omelyan Botsvynyuk, Stepan Botsvynyuk, Mykhaylo Botsvynyuk, Dmytro Botsvynyuk, and Yaroslav Botsvynyuk, a/k/a Yaroslav Churuk, with extortion and conspiracy to violate the Racketeer Influenced and Corrupt Organizations Act (RICO) for their alleged involvement in a human trafficking operation.

"This was a moment in time for the Department of Justice and the Obama administration to send a clear signal that the fight against domestic and sexual violence is a national priority," said Associate Attorney General Perrelli.

The Department of Justice and the Rainbow River Child Development Center of Hawthorne, Calif., have joined in a settlement agreement to assure that children with diabetes will receive appropriate care so that they may participate fully in the programs and activities at the center.

In response to a federal enforcement action for excessive train engine idling, the Massachusetts Bay Transportation Authority (MBTA) and the Massachusetts Bay Commuter Railroad Company (MBCR) will spend more than $2 million to reduce diesel locomotive emissions throughout the MBTA’s commuter rail system.

As the Deepwater Horizon oil spill clean-up efforts continue and the Gulf Coast Claims Facility opens its doors, the Department of Justice is reminding members of the public to be aware of and report any instances of suspected fraudulent activity related to relief operations and funding for victims.

Alan D. Mendelsohn, 52, of Broward County, Fla., pleaded guilty today before U.S. District Judge William J. Zloch, to a one-count criminal information, charging him with conspiracy to commit mail fraud, to make false statements and to file false tax returns.

The Department of Justice today has reached a settlement that will require Pittsburgh-based L.B. Foster Company to divest a West Virginia plant used in the development, manufacture and sale of certain railroad joints to Koppers Inc., in order to proceed with Foster’s acquisition of Portec Rail Products Inc.

A former Colombian maritime training instructor and a co-conspirator have pleaded guilty to conspiring to transport thousands of kilograms of cocaine from various ports along the coast of Colombia to waiting vessels that transported the cocaine to the United States and other countries.

The Department of Justice reminds members of the public to be aware of and report any instances of suspected fraudulent charitable contribution schemes related to the natural disasters in Japan.

The Justice Department has issued letters to the attorneys general of all 50 states, as well as U.S. territories to request their assistance in addressing the illegal exclusion of individuals with HIV/AIDS from occupational training and state licensing.

Thomas J. Ernst, formerly a resident of McLean and Arlington, Va., was arraigned today in the Eastern District of Virginia.

The Justice Department announced that it has reached an agreement with Jefferson County, Texas, Drainage District Number Seven on the terms of a consent decree filed today in the U.S. District Court for the District of Columbia.

A Florida physician was sentenced today to four years in prison for his role in a fraud scheme involving lobbying and fund raising for political candidates and organizations.

In a settlement valued at more than $1.7 million, Clean Harbors of Braintree Inc. has agreed to pay a significant penalty and perform additional projects, to settle a complaint filed by the U.S. Department of Justice on behalf of the Environmental Protection Agency (EPA), regarding numerous violations of hazardous waste management and emergency planning laws at the company’s Braintree, Mass., facility.

Today, in response to a letter from the Justice Department, the Massachusetts Board of Elementary and Secondary Education voted to grant the Commissioner of Education authority to draft state regulations that will require training of all Sheltered English Immersion teachers who instruct English Language Learner students.

A former Colombian maritime training instructor and a co-conspirator were sentenced to federal prison today for conspiring to transport thousands of kilograms of cocaine from various ports along the coast of Colombia to waiting vessels that transported the cocaine to the United States and other countries.

The Department of Justice’s Bureau of Justice Assistance (BJA), together with its partners, the Departments of Housing and Urban Development (HUD), Education, Health and Human Services and Treasury, today announced the selection of the Center for the Study of Social Policy as the Building Neighborhood Capacity Program (BNCP) Training and Technical Assistance Coordinator.

The Justice Department announced a settlement today with Lorain County, Ohio, to protect the rights of Spanish-speaking Puerto Rican voters under Section 4(e) of the Voting Rights Act.

Federal officials announced a civil settlement with the state of California Department of Transportation (Caltrans) resolving claims brought by the Presidio Trust and the U.S. Army resulting from Caltrans’ construction and operation of Highway 1 (also known as Park Presidio Boulevard) through the Presidio of San Francisco.

Former Tuscaloosa, Ala., Sheriff’s Sergeant, Althea Mallisham, 52, pleaded guilty today in a federal court in Birmingham, Ala., to three counts of assault with a dangerous weapon while acting under color of law for wrongfully using a Taser during three separate incidents over a four month period in 2008.

"I am especially grateful for the opportunity to salute the important work that you are doing here – to provide a place of learning, healing, and advocacy; to shed light on our nation’s long – and ongoing – struggle for equal justice; and to bring attention to the suffering of millions – all around the world – who remain enslaved," said Attorney General Holder.

Suspected fraudulent activity pertaining to relief efforts associated with the recent series of tornadoes in the Midwest and South should be reported to the NCDF hotline at 866-720-5721.

The Justice and Interior Departments today completed the first in a series of national level training courses, “Criminal Jurisdiction in Indian Country” (CJIC), designed to strengthen the ability of tribal and local law enforcement to participate in the investigation and enforcement of federal crimes in Indian country and fulfill a key training requirement under the Tribal Law and Order Act of 2010 (TLOA).

"Over the last 15 years, more than half of all states – plus the District of Columbia – have created Access to Justice Commissions. Here in Washington, Commission leaders, supporters, and partners have taken a central role in reinvigorating this city’s pro bono culture – and providing representation to those who cannot afford to retain counsel. And, despite the absence of adequate funding, your efforts to reduce barriers to access have made a difference in thousands of lives," said Attorney General Holder.

Six officials of an Upstate New York firm were arraigned yesterday before Magistrate Judge Leslie G. Foschio. On March 21, a federal grand jury in the Western District of New York indicted the six defendants, Philip R. DeLuca, Alfred R. LaGreca, Frank A. Fracassi, Michael A. Elia, Laurence A Elia and Richard A. Elia, on tax charges, including conspiring to defraud the Internal Revenue Service (IRS).

"There are parts of the world where everyone shares the same culture, the same religion, and the same language. But that’s not America. And it’s not Cincinnati. According to the Census Bureau, there are over 13,000 people in this city who were born outside of the United States. There are around 20,000 whose primary language isn’t English. And there are still more who follow customs and traditions that our own upbringing didn’t expose us to," said Deputy Attorney General Cole.

The Justice Department announced today that former Bryan County, Okla., Sheriff’s Office Lieutenant Kevin Bennett Holt, 48, from Achille, Okla., pleaded guilty in federal court to using a Taser to assault a detainee inside of the Bryan County Jail in Durant, Okla., thereby depriving the detainee of his civil rights.

Through an application to register and enforce two orders from United Kingdom courts, the Department of Justice has secured a restraining order against more than $3 million in corruption proceeds located in the United States related to James Onanefe Ibori, the former governor of Nigeria’s oil-rich Delta State.