rap

Ultrasensitive immunochromatographic strips for fast screening of the nicarbazin marker in chicken breast and liver samples based on monoclonal antibodies

Anal. Methods, 2020, 12,2143-2151
DOI: 10.1039/D0AY00414F, Paper
Xiaoxin Xu, Liqiang Liu, Xiaoling Wu, Hua Kuang, Chuanlai Xu
Nicarbazin is an anticoccidial drug with a residue limit in animal husbandry.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Versatile additively manufactured (3D printed) wall-jet flow cell for high performance liquid chromatography-amperometric analysis: application to the detection and quantification of new psychoactive substances (NBOMes)

Anal. Methods, 2020, 12,2152-2165
DOI: 10.1039/D0AY00500B, Paper
Open Access
Hadil M. Elbardisy, Eduardo M. Richter, Robert D. Crapnell, Michael P. Down, Peter G. Gough, Tarek S. Belal, Wael Talaat, Hoda G. Daabees, Craig E. Banks
Additive manufacturing is an emerging technology of vast applicability, receiving significant interest in a plethora of industrial and research domains as it allows the translation of designs produced via computer software, into 3D printed objects.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements

Anal. Methods, 2020, 12,2082-2092
DOI: 10.1039/C9AY02778E, Paper
Kornelija Lasić, Ana Mornar, Biljana Nigović
Systematic development of a UHPLC method by QbD approach as performed for simultaneous determination of aglycone (genistein, daidzein, biochanin A and formononetin) and glycoside (genistin, daidzin, sissotrin, ononin) forms of isoflavones.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Multi-residue determination of micropollutants in Nigerian fish from Lagos lagoon using ultrasound assisted extraction, solid phase extraction and ultra-high-performance liquid chromatography tandem mass spectrometry

Anal. Methods, 2020, 12,2114-2122
DOI: 10.1039/D0AY00411A, Paper
Idera Fabunmi, Natalie Sims, Kathryn Proctor, Aderonke Oyeyiola, Temilola Oluseyi, Kehinde Olayinka, Barbara Kasprzyk-Hordern
This reports for the first time a simple and robust approach in determining pharmaceuticals in different fish species in Nigeria.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

The influence of lateral flake size in graphene/graphite paste electrodes: an electroanalytical investigation

Anal. Methods, 2020, 12,2133-2142
DOI: 10.1039/D0AY00169D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alejandro García-Miranda Ferrari, Hadil M. Elbardisy, Valentine Silva, Tarek S. Belal, Wael Talaat, Hoda G. Daabees, Craig E. Banks, Dale A. C. Brownson
We report the electroanalytical properties of graphene and graphite paste electrodes comprising varying lateral flake sizes when applied for sensing relevant biomolecules and prominent drugs of abuse.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Comparison of surfactant-mediated liquid chromatographic modes with sodium dodecyl sulphate for the analysis of basic drugs

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00526F, Paper
N. Pankajkumar-Patel, E. Peris-García, M. J. Ruiz-Angel, M. C. García-Alvarez-Coque
A comprehensive overview of the performance of MLC, HSLC and MELC for the analysis of basic compounds.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Miniaturized QuEChERS method for determination of 97 pesticide residues in wine by ultra-high performance liquid chromatography coupled to tandem mass spectrometry

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00744G, Paper
Gabrieli Bernardi, Magali Kemmerich, Martha B Adaime, Osmar Damian Prestes, Renato Zanella
A miniaturized sample preparation method was developed and validated for the multiresidue determination of 97 pesticide residues in wine samples. The proposed extraction procedure is based on QuEChERS acetate method...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

A rapid and colorimetric biosensor based on GR-5 DNAzyme and self-replicating catalyzed hairpin assembly for lead detection

Anal. Methods, 2020, 12,2215-2220
DOI: 10.1039/D0AY00091D, Paper
Fang Wang, Jianyuan Dai, Hongli Shi, Xiaoqian Luo, Lan Xiao, Cuisong Zhou, Yong Guo, Dan Xiao
A rapid and colorimetric biosensor for Pb2+ detection has been constructed on the basis of Pb2+-dependent GR-5 DNAzyme and the self-replicating catalyzed hairpin assembly (SRCHA) reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Identification of Gentiana rigescens from different geographical origins based on HPLC and FTIR fingerprints

Anal. Methods, 2020, 12,2260-2271
DOI: 10.1039/D0AY00309C, Paper
Yanli Zhao, Tianjun Yuan, Lihua Wu, Ji Zhang, Zhitian Zuo, Yuanzhong Wang
Gentiana rigescens is a traditional Chinese medicine with efficacy in liver protection, as a cholagogic, anti-hyperglycemic, and anti-hypertension agent, and in relieving spasms and pain.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Ion chromatography for monitoring [NTf2]− anion contaminants in pure and saline water

Anal. Methods, 2020, 12,2244-2252
DOI: 10.1039/D0AY00337A, Paper
Coby J. Clarke, Liem Bui-Le, Jason Hallett
An optimized ion chromatography method for quantifying highly polarizable [NTf2] anions in high salinity wastewater is presented.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Detection of radium at the attogram per gram level in copper by inductively coupled plasma mass spectrometry after cation-exchange chromatography

Anal. Methods, 2020, 12,2272-2278
DOI: 10.1039/D0AY00512F, Paper
Mélodie Bonin, Dominic Larivière, Pavel P. Povinec
In this study, a new method was developed for the separation and isolation of radium from metallic copper.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Dispersive micro-solid phase extraction based on graphene/polydopamine composite for the extraction of pyrethroids in water samples

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00562B, Paper
Qinqin Xu, Kexin Qiao, Chen Yan, Zikai Liu, Runhua Lu, Wenfeng Zhou
In this study, a simple, rapid, precise, and environmentally friendly microextraction named dispersive micro-solid phase extraction based on graphene/polydopamine composite as sorbent was investigated for the analysis of four pyrethroids...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Rapid and colorimetric detection of nucleic acids based on entropy-driven circuit and DNAzyme mediated autocatalytic reaction

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00341G, Paper
Hongli Shi, Jianyuan Dai, fang Wang, Yushun Xia, Dan Xiao, Cuisong Zhou
In this work, a novel, rapid and enzyme-free colorimetric biosensor for nucleic acids detection has been developed based on entropy-driven circuit (EDC) and DNAzyme mediated autocatalytic reaction. Upon sensing of...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Advances in computer graphics : 36th Computer Graphics International Conference, CGI 2019, Calgary, AB, Canada, June 17-20, 2019 : proceedings / Marina Gavrilova, Jian Chang, Nadia Magnenat Thalmann, Eckhard Hitzer, Hiroshi Ishikawa (eds.)

Computer Graphics International (36th : 2019 : Calgary, Alta)




rap

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

RSC Med. Chem., 2020, 11,455-490
DOI: 10.1039/D0MD00062K, Review Article
Godwin Akpeko Dziwornu, Henrietta Dede Attram, Samuel Gachuhi, Kelly Chibale
After a century since the first antimonial-based drugs were introduced to treat the disease, anti-schistosomiasis drug development is again at a bottleneck with only one drug, praziquantel, available for treatment purposes.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

A primer on process mining: practical skills with Python and Graphviz / Diogo R. Ferreira

Online Resource




rap

Demographic determinants of testing incidence and COVID-19 infections in New York City neighborhoods [electronic resource] / George J. Borjas

Cambridge, Mass. : National Bureau of Economic Research, 2020




rap

Western Australia looking west / [photographer:] Richard Woldendorp ; [commentaries by] Geoffrey Bolton ... [et al]

Woldendorp, Richard, 1927-




rap

Ibn Khaldun : an intellectual biography / Robert Irwin

Irwin, Robert, 1946- author




rap

[ASAP] Advanced Liquid Chromatography of Polyolefins Using Simultaneous Solvent and Temperature Gradients

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c01095




rap

[ASAP] Asymmetrical Flow Field Flow Fractionation Coupled to Nanoparticle Tracking Analysis for Rapid Online Characterization of Nanomaterials

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00406




rap

[ASAP] Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05739




rap

[ASAP] Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00784




rap

[ASAP] Highly Sensitive and Selective Detection of Heparin in Serum Based on a Long-Wavelength Tetraphenylethylene–Cyanopyridine Aggregation-Induced Emission Luminogen

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00496




rap

[ASAP] Metal–Organic Framework-Enhanced Solid-Phase Microextraction Mass Spectrometry for the Direct and Rapid Detection of Perfluorooctanoic Acid in Environmental Water Samples

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05524




rap

Covid-19: ICMR gets approval to conduct second phase of plasma therapy trials, says health ministry

The trials will be conducted in 21 hospitals across Maharashtra, Gujarat, Rajasthan, TN, Madhya Pradesh, UP, Punjab, Karnataka, Telangana and Chandigarh.




rap

Vanessa Bryant sues LA County sheriff for taking unauthorised photographs of Kobe’s crash site

Vanessa is seeking damages in the wake of revelations that eight sheriff’s department deputies took graphic photos of the scene and shared them with others.




rap

Transplant Beats Bortezomib-Based Therapy for MM

In a large randomized trial, upfront autologous transplantation bested bortezomib-based intensification therapy for patients with multiple myeloma.
Medscape Medical News




rap

As the Global Community Continues to Grapple with COVID-19, Mathematica is Remotely Maintaining our Operations

At Mathematica, our mission has always been to protect and improve public well-being. In this time of increased concern over the Coronavirus Disease 2019 (COVID-19), the health and safety of all Mathematica employees, clients, and partners is our top priority. We are adhering to guidance and best practices issued by health authorities, including the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO).




rap

Building WordPress Websites With Zurb Foundation or Bootstrap: Comparisons and Starter Themes

WordPress is super versatile. You know that. I know that. But sometimes this can be an overwhelming prospect. How on earth will you get your site up and running? What platform will you use? Zurb Foundation and Bootstrap are two …




rap

Correction: Preparation of electrospray ALG/PDA–PVP nanocomposites and their application in cancer therapy

Soft Matter, 2020, 16,4074-4074
DOI: 10.1039/D0SM90064H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yangjie Xu, Jiulong Zhao, Zhilun Zhang, Jing Zhang, Mingxian Huang, Shige Wang, Pei Xie
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Insight into the Unwrapping of the Dinucleosome

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00161A, Paper
Fatemeh Khodabandeh, Hashem Fatemi, Farshid Mohammad-Rafiee
Dynamics of nucleosomes, the building blocks of the chromatin, has crucial effects on expression, replication and repair of genomes in eukaryotes. Beside constant movements of nucleosomes by thermal fluctuations, ATP-dependent...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Marangoni puffs: dramatically enhanced dissolution of droplets with an entrapped bubble

Soft Matter, 2020, Advance Article
DOI: 10.1039/D0SM00093K, Paper
José M. Encarnación Escobar, Jaap Nieland, Arie van Houselt, Xuehua Zhang, Detlef Lohse
We present a curious effect observed during the dissolution process of water-immersed long-chain alcohol drops with an entrapped bubble. When the drop-water interface and the air bubble contact each other, a rapid cyclic motion that accelerates the drop's dissolution is found. We name this eye-catching phenomenon puffing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Effect of polar amino acid incorporation on Fmoc-diphenylalanine-based tetrapeptides

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00320D, Paper
Alexandra Daryl Ariawan, Biyun Sun, Jonathan Pawel Wojciechowski, Ian Lin, Eric Y Du, Sophia C Goodchild, Charles Gordon Cranfield, Lars M Ittner, Pall Thordarson, Adam David Martin
Peptide hydrogels show great promise as extracellular matrix mimics due to their tuneable, fibrous nature. Through incorporation of polar cationic, polar anionic or polar neutral amino acids into the Fmoc-diphenylalanine...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Rapid analysis of cell-generated forces within a multicellular aggregate using microsphere-based traction force microscopy

Soft Matter, 2020, 16,4192-4199
DOI: 10.1039/C9SM02377A, Paper
Buğra Kaytanlı, Aimal H. Khankhel, Noy Cohen, Megan T. Valentine
We measure cell-generated forces from the deformations of elastic microspheres embedded within multicellular aggregates. Using a computationally efficient analytical model, we directly obtain the full 3D mapping of surface stresses within minutes.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Rapid characterization of neutral polymer brush with a conventional zetameter and a variable pinch of salt

Soft Matter, 2020, 16,4274-4282
DOI: 10.1039/C9SM01850F, Paper
Mena Youssef, Alexandre Morin, Antoine Aubret, Stefano Sacanna, Jérémie Palacci
We take advantage of the nanoscopic nature of the Debye length and used it as a probe to characterize polymer brushes on colloidal particles.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Active noise experienced by a passive particle trapped in an active bath

Soft Matter, 2020, Advance Article
DOI: 10.1039/D0SM00006J, Paper
Simin Ye, Peng Liu, Fangfu Ye, Ke Chen, Mingcheng Yang
We study the properties of active noise experienced by a passive particle harmonically trapped in an active bath. The active noise is shown to depend on the trap stiffness.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Controlled release of entrapped nanoparticles from thermoresponsive hydrogels with tunable network characteristics

Soft Matter, 2020, Advance Article
DOI: 10.1039/D0SM00207K, Paper
Yi Wang, Zhen Li, Jie Ouyang, George Em Karniadakis
Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

Wall entrapment of peritrichous bacteria: A mesoscale hydrodynamics simulation study

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00571A, Paper
S. Mahdiyeh Mousavi, Gerhard Gompper, Roland G. Winkler
Microswimmers such as E. Coli bacteria accumulate and exhibit an intriguing dynamics near walls, governed by hydrodynamic and steric interactions. Insight into the underlying mechanisms and predominant interactions demand a...
The content of this RSS Feed (c) The Royal Society of Chemistry




rap

A Companion to Photography


 

The study of photography has never been more important. A look at today's digital world reveals that a greater number of photographs are being taken each day than at any other moment in history. Countless photographs are disseminated instantly online and more and more photographic images are earning prominent positions—and garnering record prices—in the rarefied realm of top art galleries.

Reflecting this dramatic increase in all things photographic



Read More...




rap

[ASAP] Room Temperature Graphene Mid-Infrared Bolometer with a Broad Operational Wavelength Range

ACS Photonics
DOI: 10.1021/acsphotonics.0c00028




rap

[ASAP] Colloidal Quantum-Dots/Graphene/Silicon Dual-Channel Detection of Visible Light and Short-Wave Infrared

ACS Photonics
DOI: 10.1021/acsphotonics.0c00247




rap

Iconography of Security

Molly Wilson and Eileen Wagner battle the age old Christmas issues of right and wrong, good and evil, and how the messages we send through iconography design can impact the decisions users make around important issues of security. Are you icons wise men, or are they actually King Herod?


Congratulations, you’re locked out! The paradox of security visuals

Designers of technology are fortunate to have an established visual language at our fingertips. We try to use colors and symbols in a way that is consistent with people’s existing expectations. When a non-designer asks a designer to “make it intuitive,” what they’re really asking is, “please use elements people already know, even if the concept is new.”

Lots of options for security icons

We’re starting to see more consistency in the symbols that tech uses for privacy and security features, many of them built into robust, standardized icon sets and UI kits. To name a few: we collaborated with Adobe in 2018 to create the Vault UI Kit, which includes UI elements for security, like touch ID login and sending a secure copy of a file. Adobe has also released a UI kit for cookie banners.

Activity log from the Vault Secure UI Kit, by Adobe and Simply Secure.
Cookie banner, from the Cookie Banner UI Kit, by Adobe.

Even UI kits that aren’t specialized in security and privacy include icons that can be used to communicate security concepts, like InVision’s Smart Home UI Kit. And, of course, nearly every icon set has security-related symbols, from Material Design to Iconic.

Key, lock, unlock, shield, and warning icons from Iconic.
A selection of security-related icons from Material Design.
Security shields from a selection of Chinese apps, 2014. From a longer essay by Dan Grover.

Many of these icons allude to physical analogies for the states and actions we’re trying to communicate. Locks and keys; shields for protection; warning signs and stop signs; happy faces and sad faces. Using these analogies helps build a bridge from the familiar, concrete world of door locks and keyrings to the unfamiliar, abstract realm of public- and private-key encryption.

flickr/Jim Pennucci
GPG Keychain, an open-source application for managing encryption keys. Image: tutsplus.com

When concepts don’t match up

Many of the concepts we’re working with are pairs of opposites. Locked or unlocked. Private or public. Trusted or untrusted. Blocked or allowed. Encouraged or discouraged. Good or evil. When those concept pairs appear simultaneously, however, we quickly run into UX problems.

Take the following example. Security is good, right? When something is locked, that means you’re being responsible and careful, and nobody else can access it. It’s protected. That’s cause for celebration. Being locked and protected is a good state.

“Congratulations, you’re locked out!”

Whoops.

If the user didn’t mean to lock something, or if the locked state is going to cause them any inconvenience, then extra security is definitely not good news.

Another case in point: Trust is good, right? Something trusted is welcome in people’s lives. It’s allowed to enter, not blocked, and it’s there because people wanted it there. So trusting and allowing something is good.

“Good job, you’ve downloaded malware!”

Nope. Doesn’t work at all. What if we try the opposite colors and iconography?

That’s even worse. Even though we, the designers, were trying both times to keep the user from downloading malware, the user’s actual behavior makes our design completely nonsensical.

Researchers from Google and UC Berkeley identified this problem in a 2016 USENIX paper analyzing connection security indicators. They pointed out that, when somebody clicks through a warning to an “insecure” website, the browser will show a “neutral or positive indicator” in the URL bar – leading them to think that the website is now safe. Unlike our example above, this may not look like nonsense from the user point of view, but from a security standpoint, suddenly showing “safe/good” without any actual change in safety is a pretty dangerous move.

The deeper issue

Now, one could file these phenomena under “mismatching iconography,” but we think there is a deeper issue here that concerns security UI in particular. Security interface design pretty much always has at least a whiff of “right vs. wrong.” How did this moralizing creep into an ostensibly technical realm?

Well, we usually have a pretty good idea what we’d like people to do with regards to security. Generally speaking, we’d like them to be more cautious than they are (at least, so long as we’re not trying to sneak around behind their backs with confusing consent forms and extracurricular data use). Our well-intentioned educational enthusiasm leads us to use little design nudges that foster better security practices, and that makes us reach into the realm of social and psychological signals. But these nudges can easily backfire and turn into total nonsense.

Another example: NoScript

“No UX designer would be dense enough to make these mistakes,” you might be thinking.

Well, we recently did a redesign of the open-source content-blocking browser extension NoScript, and we can tell you from experience: finding the right visual language for pairs of opposites was a struggle.

NoScript is a browser extension that helps you block potential malware from the websites you’re visiting. It needs to communicate a lot of states and actions to users. A single script can be blocked or allowed. A source of scripts can be trusted or untrusted. NoScript is a tool for the truly paranoid, so in general, wants to encourage blocking and not trusting. But:

“An icon with a crossed-out item is usually BAD, and a sign without anything is usually GOOD. But of course, here blocking something is actually GOOD, while blocking nothing is actually BAD. So whichever indicators NoScript chooses, they should either aim to indicate system state [allow/block] or recommendation [good/bad], but not both. And in any case, NoScript should probably stay away from standard colors and icons.”

So we ended up using hardly any of the many common security icons available. No shields, no alert! signs, no locked locks, no unlocked locks. And we completely avoided the red/green palette to keep from taking on unintended meaning.

Navigating the paradox

Security recommendations appear in most digital services are built nowadays. As we move into 2020, we expect to see a lot more conscious choice around colors, icons, and words related to security. For a start, Firefox already made a step in the right direction by streamlining indicators for SSL encryption as well as content blocking. (Spoilers: they avoided adding multiple dimensions of indicators, too!)

The most important thing to keep in mind, as you’re choosing language around security and privacy features, is: don’t conflate social and technical concepts. Trusting your partner is good. Trusting a website? Well, could be good, could be bad. Locking your bike? Good idea. Locking a file? That depends.

Think about the technical facts you’re trying to communicate. Then, and only then, consider if there’s also a behavioral nudge you want to send, and if you are, try to poke holes in your reasoning. Is there ever a case where your nudge could be dangerous? Colors, icons, and words give you a lot of control over how exactly people experience security and privacy features. Using them in a clear and consistent way will help people understand their choices and make more conscious decisions around security.


About the author

Molly Wilson is a designer by training and a teacher at heart: her passion is leveraging human-centered design to help make technology clear and understandable. She has been designing and leading programs in design thinking and innovation processes since 2010, first at the Stanford d.school in Palo Alto, CA and later at the Hasso-Plattner-Institut School of Design Thinking in Potsdam, Germany. Her work as an interaction designer has focused on complex products in finance, health, and education. Outside of work, talk to her about cross-cultural communication, feminism, DIY projects, and visual note-taking.

Molly holds a master’s degree in Learning, Design, and Technology from Stanford University, and a bachelor’s degree magna cum laude in History of Science from Harvard University. See more about her work and projects at http://molly.is.

Eileen Wagner is Simply Secure’s in-house logician. She advises teams and organizations on UX design, supports research and user testing, and produces open resources for the community. Her focus is on information architecture, content strategy, and interaction design. Sometimes she puts on her admin hat and makes sure her team has the required infrastructure to excel.

She previously campaigned for open data and civic tech at the Open Knowledge Foundation Germany. There she helped establish the first public funding program for open source projects in Germany, the Prototype Fund. Her background is in analytic philosophy (BA Cambridge) and mathematical logic (MSc Amsterdam), and she won’t stop talking about barbershop music.

More articles by Molly Wilson & Eileen




rap

A Modern Typographic Scale

Rob Weychert reaches for the top notes to sing us a song of typographic scale. A little attention to scale and to the mathematics will help you to hit a high note with your designs this Christmas and beyond.


I’ve been studying music theory this year. While some of its core concepts were already familiar to me, much of their specifics were not. Or so I thought. A funny thing happened when I was learning the major scales.

While playing through a song I had written some years before, I started picking it apart to see how it correlated with the theory I was learning. I had composed the melody without any thought to what the specific notes were, but as I started to transcribe them, a pattern quickly emerged: all the B’s and E’s were flat and the rest of the notes were natural. Lo and behold, long before my music theory studies began, I had written a song in B♭ major. My ears already knew how the major scales worked even if my brain didn’t. (If you know how “do re mi fa so la ti do” is supposed to sound tonally, then your ears know, too.)

When music is composed to a scale, it sounds “right” to us. And just as our ears appreciate harmony and melody with a rational basis, our eyes can appreciate the same concepts applied to spatial relationships.

Have you ever struggled with sizing type in a design project, especially when you need more than just one or two sizes? Have you ever despaired at the number of ad-hoc type sizes on your site spiraling out of control over time? It could be that you’ve been composing the typographic equivalent of a cacophonous symphony. And the first thing any composer will tell you to do is to get that thing on a scale.

Meet the typographic scale

You don’t need to know music theory to work with a typographic scale. You only need to know that a scale is a range of values with an established mathematic relationship. For a typographic scale, that relationship is frequently a steady interval between type sizes. Depending on what you need your type to do, the interval might be fixed (e.g. each size is two pixels bigger than the size before it) or it might be proportional (e.g. each size is twice as big as the size before it). I personally rarely find fixed intervals useful, so I’ll be focusing on proportional intervals.

The most important thing to understand about proportional intervals is thankfully not complicated: The bigger the intervals are, the more drastic the size differences will be in your scale. If your layout calls for contrast, a bigger interval might be the way to go. If you’re aiming for something more nuanced, go smaller. But keep these things in mind:

  • There is such a thing as too much nuance: if a size on your scale is virtually indistinguishable from the sizes adjacent to it, it defeats the purpose of using a scale.
  • On the flip side, too much contrast renders the sizes’ proportional relationship moot. At a certain point, massive display type is arguably more graphic than textual.
  • More is less. The more sizes you use, the less they’ll mean.
A small interval (left, 1.1) offers a smoother range of sizes; a large interval (right, 1.8) offers more contrast.

Setting up the scale variables

The quickest way to get a scale up and running when working on the web is to drop its values into some CSS variables. The naming convention I typically use begins with --scale0, which is the body text size. The size below it is --scale-1 (as in “scale minus one”), the size above it is --scale1, and so on. Keeping the names relative to each other like this helps me move around the scale intuitively as I use it. If, say, --scale4 isn’t big enough for my h1, I can move up to --scale5 or --scale6, and I always know exactly how many steps away from the body text I am. Here’s a first pass at a simple set of scale variables using an interval of 1.5:

:root {
  --scale-2: 7.1px;  /* 10.7 ÷ 1.5 */
  --scale-1: 10.7px; /* 16 ÷ 1.5   */
  --scale0: 16px;    /* body text  */
  --scale1: 24px;    /* 16 × 1.5   */
  --scale2: 36px;    /* 24 × 1.5   */
}

I can use these variables with any CSS property that accepts a numeric value, like so:

p { font-size: var(--scale0); }

Rooting around in rems

I’m off to a good start. However, those px values are a little too absolute for my liking. If I convert them to rems, it’ll give my scale more flexibility. rem stands for “root em.” 1rem is equivalent to the html element’s text size, which in most browsers defaults to 16px. Crucially, though, users can adjust that size in their browser settings, and using rems in my CSS will respect those preferences.

:root {
  --scale-2: 0.4rem;  /* 0.7rem ÷ 1.5 */
  --scale-1: 0.7rem;  /* 1rem ÷ 1.5   */
  --scale0: 1rem;     /* body text    */
  --scale1: 1.5rem;   /* 1rem × 1.5   */
  --scale2: 2.25rem;  /* 1.5rem × 1.5 */
}

Another benefit of the relative nature of rems: I tend to use larger text sizes on large viewports and smaller text sizes on small viewports. Rather than adjusting dozens or hundreds of typographic CSS declarations per breakpoint, I can shift the whole scale up or down merely by adjusting the font-size on the html element:

html { font-size: 100%; }     /* 1rem = 16px */

@media screen and (min-width: 25em) {
  html { font-size: 112.5%; } /* 1rem = 18px */
}

Calculating with calc()

My scale is coming along. Its variables’ intuitive names make it easy for me to use, and its rem values respect the user’s browser preferences and allow me to easily shift the size of the entire scale at different viewport sizes. But my setup still isn’t optimized for one very important adjustment: the interval, which is currently 1.5. If 1.5 isn’t quite working for me and I want to see how an increase or decrease will affect the scale, I need to do the math all over again for every step in the scale every time I adjust the interval. The bigger the scale, the more time that will take. It’s time to put down the abacus and get calc() involved.

:root {
  --int: 1.5;
  --scale0: 1rem;
  --scale-1: calc(var(--scale0) / var(--int));
  --scale-2: calc(var(--scale-1) / var(--int));
  --scale1: calc(var(--scale0) * var(--int));
  --scale2: calc(var(--scale1) * var(--int));
}

My interval now has its very own variable, called --int. calc() determines each scale size by multiplying the preceding size by --int. Now that every size is ultimately dependent on --scale0’s value, --scale0 must appear first in the list. Since the sizes smaller than --scale0 are going down rather than up, their values require division rather than multiplication.

Scaling the scale

I can now quickly and easily tweak my scale’s interval by adjusting --int until the proportions are just right, but if I want to add more sizes to the scale, I need to add more variables and calc() values. This isn’t too big of a deal, but if I want to double or triple the number of sizes, it’s kind of a headache. Luckily, this is the sort of thing Sass is really good at. In the following code, adjusting the first four Sass variables at the top of :root will quickly spin up a set of CSS variables like the scale above, with any interval (proportional or fixed) and any number of scale sizes:

:root {
  $interval: 1.5;    // Unitless for proportional, unit for fixed
  $body-text: 1rem;  // Must have a unit
  $scale-min: -2;    // Unitless negative integer
  $scale-max: 2;     // Unitless positive integer

  --int: #{$interval};
  --scale0: #{$body-text};

  @if $scale-min < 0 {
  // Generate scale variables smaller than the base text size
    @for $i from -1 through $scale-min {
      @if type-of($interval) == number {
        @if unitless($interval) {
          --scale#{$i}: calc(var(--scale#{$i + 1}) / var(--int));
        } @else {
          --scale#{$i}: calc(var(--scale#{$i + 1}) - var(--int));
        }
      }
    }
  }
  @if $scale-max > 0 {
    // Generate scale variables larger than the base text size
    @for $i from 1 through $scale-max {
      @if type-of($interval) == number {
        @if unitless($interval) {
          --scale#{$i}: calc(var(--scale#{$i - 1}) * var(--int));
        } @else {
          --scale#{$i}: calc(var(--scale#{$i - 1}) + var(--int));
        }
      }
    }
  }
}

Go forth and scale

Typographic scales have been an indispensable part of my work for many years, and CSS variables and calc() make setup, adjustments, and experimentation easier than ever. I hope you find these techniques as useful as I do!


About the author

Rob Weychert is a Brooklyn-based designer. He helps shape the reading experience at ProPublica and has previously helped make books at A Book Apart, games at Harmonix, and websites at Happy Cog. In his free time, he obsesses over music and film. Despite all this, he is probably best known as a competitive air guitarist.

More articles by Rob




rap

What we talk about when we talk about rape / Sohaila Abdulali

Hayden Library - HV6558.A295 2018




rap

Clearer than truth: the polygraph and the American Cold War / John Philipp Baesler

Dewey Library - JK468.L5 B34 2018




rap

21st century Prometheus: managing CBRN safety and security affected by cutting-edge technologies / Maurizio Martellini, Ralf Trapp, editors

Online Resource




rap

December 16 Gangrape case: High Court to hear trial court reference on Monday

All four accused were found guilty and awarded death sentence by the sessions court.




rap

Thiruvananthapuram: Dead snake found in soft drink tetrapack

The two and a half year old girl was later rushed to a hospital, condition stated to be stable.




rap

ED set to attach assets of former Karnataka CM B S Yeddyurappa, family

Development comes even as BSY readies to rejoin the BJP before the Lok Sabha election next year.