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Comment: Statistical Inference from a Predictive Perspective

Alessandro Rinaldo, Ryan J. Tibshirani, Larry Wasserman.

Source: Statistical Science, Volume 34, Number 4, 599--603.

Abstract:
What is the meaning of a regression parameter? Why is this the de facto standard object of interest for statistical inference? These are delicate issues, especially when the model is misspecified. We argue that focusing on predictive quantities may be a desirable alternative.




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Discussion of Models as Approximations I & II

Dag Tjøstheim.

Source: Statistical Science, Volume 34, Number 4, 575--579.




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Discussion of Models as Approximations I & II

Sara van de Geer.

Source: Statistical Science, Volume 34, Number 4, 566--568.

Abstract:
We discuss the papers “Models as Approximations” I & II, by A. Buja, R. Berk, L. Brown, E. George, E. Pitkin, M. Traskin, L. Zao and K. Zhang (Part I) and A. Buja, L. Brown, A. K. Kuchibhota, R. Berk, E. George and L. Zhao (Part II). We present a summary with some details for the generalized linear model.




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Conditionally Conjugate Mean-Field Variational Bayes for Logistic Models

Daniele Durante, Tommaso Rigon.

Source: Statistical Science, Volume 34, Number 3, 472--485.

Abstract:
Variational Bayes (VB) is a common strategy for approximate Bayesian inference, but simple methods are only available for specific classes of models including, in particular, representations having conditionally conjugate constructions within an exponential family. Models with logit components are an apparently notable exception to this class, due to the absence of conjugacy among the logistic likelihood and the Gaussian priors for the coefficients in the linear predictor. To facilitate approximate inference within this widely used class of models, Jaakkola and Jordan ( Stat. Comput. 10 (2000) 25–37) proposed a simple variational approach which relies on a family of tangent quadratic lower bounds of the logistic log-likelihood, thus restoring conjugacy between these approximate bounds and the Gaussian priors. This strategy is still implemented successfully, but few attempts have been made to formally understand the reasons underlying its excellent performance. Following a review on VB for logistic models, we cover this gap by providing a formal connection between the above bound and a recent Pólya-gamma data augmentation for logistic regression. Such a result places the computational methods associated with the aforementioned bounds within the framework of variational inference for conditionally conjugate exponential family models, thereby allowing recent advances for this class to be inherited also by the methods relying on Jaakkola and Jordan ( Stat. Comput. 10 (2000) 25–37).




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User-Friendly Covariance Estimation for Heavy-Tailed Distributions

Yuan Ke, Stanislav Minsker, Zhao Ren, Qiang Sun, Wen-Xin Zhou.

Source: Statistical Science, Volume 34, Number 3, 454--471.

Abstract:
We provide a survey of recent results on covariance estimation for heavy-tailed distributions. By unifying ideas scattered in the literature, we propose user-friendly methods that facilitate practical implementation. Specifically, we introduce elementwise and spectrumwise truncation operators, as well as their $M$-estimator counterparts, to robustify the sample covariance matrix. Different from the classical notion of robustness that is characterized by the breakdown property, we focus on the tail robustness which is evidenced by the connection between nonasymptotic deviation and confidence level. The key insight is that estimators should adapt to the sample size, dimensionality and noise level to achieve optimal tradeoff between bias and robustness. Furthermore, to facilitate practical implementation, we propose data-driven procedures that automatically calibrate the tuning parameters. We demonstrate their applications to a series of structured models in high dimensions, including the bandable and low-rank covariance matrices and sparse precision matrices. Numerical studies lend strong support to the proposed methods.




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The Importance of Being Clustered: Uncluttering the Trends of Statistics from 1970 to 2015

Laura Anderlucci, Angela Montanari, Cinzia Viroli.

Source: Statistical Science, Volume 34, Number 2, 280--300.

Abstract:
In this paper, we retrace the recent history of statistics by analyzing all the papers published in five prestigious statistical journals since 1970, namely: The Annals of Statistics , Biometrika , Journal of the American Statistical Association , Journal of the Royal Statistical Society, Series B and Statistical Science . The aim is to construct a kind of “taxonomy” of the statistical papers by organizing and clustering them in main themes. In this sense being identified in a cluster means being important enough to be uncluttered in the vast and interconnected world of the statistical research. Since the main statistical research topics naturally born, evolve or die during time, we will also develop a dynamic clustering strategy, where a group in a time period is allowed to migrate or to merge into different groups in the following one. Results show that statistics is a very dynamic and evolving science, stimulated by the rise of new research questions and types of data.




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Statistical Analysis of Zero-Inflated Nonnegative Continuous Data: A Review

Lei Liu, Ya-Chen Tina Shih, Robert L. Strawderman, Daowen Zhang, Bankole A. Johnson, Haitao Chai.

Source: Statistical Science, Volume 34, Number 2, 253--279.

Abstract:
Zero-inflated nonnegative continuous (or semicontinuous) data arise frequently in biomedical, economical, and ecological studies. Examples include substance abuse, medical costs, medical care utilization, biomarkers (e.g., CD4 cell counts, coronary artery calcium scores), single cell gene expression rates, and (relative) abundance of microbiome. Such data are often characterized by the presence of a large portion of zero values and positive continuous values that are skewed to the right and heteroscedastic. Both of these features suggest that no simple parametric distribution may be suitable for modeling such type of outcomes. In this paper, we review statistical methods for analyzing zero-inflated nonnegative outcome data. We will start with the cross-sectional setting, discussing ways to separate zero and positive values and introducing flexible models to characterize right skewness and heteroscedasticity in the positive values. We will then present models of correlated zero-inflated nonnegative continuous data, using random effects to tackle the correlation on repeated measures from the same subject and that across different parts of the model. We will also discuss expansion to related topics, for example, zero-inflated count and survival data, nonlinear covariate effects, and joint models of longitudinal zero-inflated nonnegative continuous data and survival. Finally, we will present applications to three real datasets (i.e., microbiome, medical costs, and alcohol drinking) to illustrate these methods. Example code will be provided to facilitate applications of these methods.




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Comment: Empirical Bayes, Compound Decisions and Exchangeability

Eitan Greenshtein, Ya’acov Ritov.

Source: Statistical Science, Volume 34, Number 2, 224--228.

Abstract:
We present some personal reflections on empirical Bayes/ compound decision (EB/CD) theory following Efron (2019). In particular, we consider the role of exchangeability in the EB/CD theory and how it can be achieved when there are covariates. We also discuss the interpretation of EB/CD confidence interval, the theoretical efficiency of the CD procedure, and the impact of sparsity assumptions.




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Comment: Minimalist $g$-Modeling

Roger Koenker, Jiaying Gu.

Source: Statistical Science, Volume 34, Number 2, 209--213.

Abstract:
Efron’s elegant approach to $g$-modeling for empirical Bayes problems is contrasted with an implementation of the Kiefer–Wolfowitz nonparametric maximum likelihood estimator for mixture models for several examples. The latter approach has the advantage that it is free of tuning parameters and consequently provides a relatively simple complementary method.




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Gaussian Integrals and Rice Series in Crossing Distributions—to Compute the Distribution of Maxima and Other Features of Gaussian Processes

Georg Lindgren.

Source: Statistical Science, Volume 34, Number 1, 100--128.

Abstract:
We describe and compare how methods based on the classical Rice’s formula for the expected number, and higher moments, of level crossings by a Gaussian process stand up to contemporary numerical methods to accurately deal with crossing related characteristics of the sample paths. We illustrate the relative merits in accuracy and computing time of the Rice moment methods and the exact numerical method, developed since the late 1990s, on three groups of distribution problems, the maximum over a finite interval and the waiting time to first crossing, the length of excursions over a level, and the joint period/amplitude of oscillations. We also treat the notoriously difficult problem of dependence between successive zero crossing distances. The exact solution has been known since at least 2000, but it has remained largely unnoticed outside the ocean science community. Extensive simulation studies illustrate the accuracy of the numerical methods. As a historical introduction an attempt is made to illustrate the relation between Rice’s original formulation and arguments and the exact numerical methods.




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Rejoinder: Response to Discussions and a Look Ahead

Vincent Dorie, Jennifer Hill, Uri Shalit, Marc Scott, Dan Cervone.

Source: Statistical Science, Volume 34, Number 1, 94--99.

Abstract:
Response to discussion of Dorie (2017), in which the authors of that piece express their gratitude to the discussants, rebut some specific criticisms, and argue that the limitations of the 2016 Atlantic Causal Inference Competition represent an exciting opportunity for future competitions in a similar mold.




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Comment on “Automated Versus Do-It-Yourself Methods for Causal Inference: Lessons Learned from a Data Analysis Competition”

Susan Gruber, Mark J. van der Laan.

Source: Statistical Science, Volume 34, Number 1, 82--85.

Abstract:
Dorie and co-authors (DHSSC) are to be congratulated for initiating the ACIC Data Challenge. Their project engaged the community and accelerated research by providing a level playing field for comparing the performance of a priori specified algorithms. DHSSC identified themes concerning characteristics of the DGP, properties of the estimators, and inference. We discuss these themes in the context of targeted learning.




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'Smoking is slow-motion suicide' / Biman Mullick.

London (33 Stillness Rd, London, SE23 ING) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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Smoking is anti-social / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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No smoking is the norm / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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No smoking is the norm / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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Cleanair posters to create a smoke-free environment / designed by Biman Mullick ; published by Cleanair.

London (33 Stillness Road, London SE23 ING) : Cleanair, [198-?]




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Smoking is bad for your image / design : Biman Mullick.

[London?], [199-?]




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Bisher Dhoa = Bāśāra dhōyā / design : Biman Mullick.

London, 26 January 2003.




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Danny Smith from No Human Being Is Illegal (in all our glory). Collaged photograph by Deborah Kelly and collaborators, 2014-2018.

[London], 2019.




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The 2019 Victoria’s Secret Fashion Show Is Canceled After Facing Backlash for Lack of Body Diversity

The reaction on social media has been fierce.




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Blake Lively's Favorite Affordable Jeans Brand Is Having a Major Sale Right Now

Here's everything you need to know about Old Navy's Black Friday and Cyber Monday plans.




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Gabrielle Union's Mesmerizing Tie Dye Activewear Set Is On Sale for Black Friday

The rainbow sports bra and leggings set from Splits59 is a must-have for anyone craving a pop of color in their workout wardrobe.




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Jennifer Lopez Is Wearing the Hell Out of These $60 Sneakers—and You Can Buy Them at Zappos

The chic sneaks are part of Zappos' massive Cyber Monday sale.




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Forget Black Booties, Amal Clooney and J.Lo Are Wearing This Weather-Resistant Boot Trend Instead

And it’s on sale at Nordstrom.




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This is the Only Jacket I’ll Be Living in This Winter

Canada Goose has long been a leader in the outdoor gear space.




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Of Course Katie Holmes Found This Year’s Coziest Winter Boot

Keep your feet happy this winter.




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Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization

Catherine Mankiw
May 24, 2017; 37:5221-5231
Development Plasticity Repair




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Multisensory Integration and the Society for Neuroscience: Then and Now

Barry E. Stein
Jan 2, 2020; 40:3-11
Viewpoints




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Metacognitive Mechanisms Underlying Lucid Dreaming

Elisa Filevich
Jan 21, 2015; 35:1082-1088
BehavioralSystemsCognitive




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Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP

Steven Poser
Jun 1, 2003; 23:4420-4427
Cellular




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Physical Exercise Prevents Stress-Induced Activation of Granule Neurons and Enhances Local Inhibitory Mechanisms in the Dentate Gyrus

Timothy J. Schoenfeld
May 1, 2013; 33:7770-7777
BehavioralSystemsCognitive




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Genomic Analysis of Reactive Astrogliosis

Jennifer L. Zamanian
May 2, 2012; 32:6391-6410
Neurobiology of Disease




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Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment

Karim Fifel
Jan 24, 2018; 38:784-786
Journal Club




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Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease

Subhash Kulkarni
Oct 31, 2018; 38:9346-9354
Symposium and Mini-Symposium




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Sleep Deprivation Biases the Neural Mechanisms Underlying Economic Preferences

Vinod Venkatraman
Mar 9, 2011; 31:3712-3718
BehavioralSystemsCognitive




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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

William W. Seeley
Feb 28, 2007; 27:2349-2356
BehavioralSystemsCognitive




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Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

Irune Diaz-Aparicio
Feb 12, 2020; 40:1453-1482
Development Plasticity Repair




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{Delta}9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism

Peter M. Zygmunt
Jun 1, 2002; 22:4720-4727
Behavioral




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The Representation of Semantic Information Across Human Cerebral Cortex During Listening Versus Reading Is Invariant to Stimulus Modality

Fatma Deniz
Sep 25, 2019; 39:7722-7736
BehavioralSystemsCognitive




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Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults

Barbara J. Weiland
Jan 28, 2015; 35:1505-1512
Neurobiology of Disease




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Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease




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Neurobiological Mechanisms of the Placebo Effect

Fabrizio Benedetti
Nov 9, 2005; 25:10390-10402
Symposia and Mini-Symposia




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Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear

Ben Warren
Apr 8, 2020; 40:3130-3140
Neurobiology of Disease




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Where Is the Anterior Temporal Lobe and What Does It Do?

Michael F. Bonner
Mar 6, 2013; 33:4213-4215
Journal Club




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Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence

Catherine Orr
Mar 6, 2019; 39:1817-1827
BehavioralSystemsCognitive




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What Visual Information Is Processed in the Human Dorsal Stream?

Martin N. Hebart
Jun 13, 2012; 32:8107-8109
Journal Club




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Interactions of Top-Down and Bottom-Up Mechanisms in Human Visual Cortex

Stephanie McMains
Jan 12, 2011; 31:587-597
BehavioralSystemsCognitive




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Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance

Masaki Yamamoto
May 22, 2019; 39:4179-4192
Neurobiology of Disease




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Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex

Michele Bellesi
May 24, 2017; 37:5263-5273
Cellular