Throughout the fall, unusual white blobs have been washing ashore on beaches in eastern Newfoundland. A Memorial University chemist says the substance is a type of pollution that shouldn't have been in the ocean in the first place.

Democrats will come up with all sorts of explanations for Kamala Harris’s defeat just to avoid the obvious one.

2024 has been a rough year for Sonos. The company’s would-be triumphant entry into the crowded headphones market was overshadowed by a disastrous app redesign. In the fallout of the botched software update, the company decided to delay products that were ready to be shipped to give itself more time to right the course. Consumer trust eroded, and people who already owned Sonos gear were living in a cycle of constant frustration.

Thanks to a number of rumors, we already knew that one of the pending product releases was the Arc Ultra ($999). A few weeks ago the company decided not to wait any longer to reveal it. While the design is mostly unchanged from the Arc that debuted in 2020, there are several key changes on the inside that make this a better all-in-one solution for people who don’t want to add more speakers to their living room setup. Sonos is promising better bass performance thanks to new speaker tech that’s debuting in the Arc Ultra, but just how good can it be?

Design

The refined design of the original Arc was a massive upgrade from that of the Playbar, and showed a progression from Sonos’ compact Beam soundbar. Honestly, the aesthetic is pretty timeless, in my opinion, and it’s a look that should age well for years to come. That said, it makes sense that Sonos would keep the design for the Arc Ultra, only making some minor changes to the exterior.

The Arc Ultra still comes in both black and white options, allowing you to choose what looks best in your living room or home theater. Sonos updated the controls to mirror what’s available on the newer Era 100 and Era 300 speakers, moving them to a top-facing bar at the back. There’s a volume slider on the right with play/pause and skip controls in the center. On the left side, Sonos gives you a microphone control so you can mute the built-in mics as needed.

And that’s really it in terms of design changes that you can see. The Arc Ultra is slightly shorter height-wise than the Arc, and it’s a little wider than its predecessor. Neither of which make a huge difference, and they won’t drastically change how you position the speaker beneath your TV.

Sonos

Inside, Sonos has re-engineered the Arc Ultra to improve audio performance. The biggest piece of this overhaul is the new Sound Motion woofer that enables better bass performance before you add a standalone wireless sub. The achievement here, thanks to the acquisition of audio company Mayht, is that the new component lays flat, taking up less room than a traditional cone-shaped woofer. The Sound Motion driver also helps deliver increased clarity and depth, on top of doubling the bass output of the original Arc.

Sonos redesigned the entire acoustic architecture of the Arc Ultra during the process of adding the Sound Motion woofer. The soundbar now houses three more drivers than the arc, a list that includes seven tweeters (two of which are upfiring), six mid-range drivers (midwoofers, as Sonos calls them) and the aforementioned woofer for a total of 14. The company also employs 15 Class-D digital amplifiers along with far-field mics for tuning and voice control.

There’s still only a single HDMI (eARC) port, which allows most modern TVs the ability to control the soundbar’s volume and mute options from your TV remote. Moreover, the Arc Ultra is compatible with Wi-Fi 6 and newly-added Bluetooth 5.3 connectivity allows you to stream from any device. And of course, AirPlay 2 is still on the spec sheet. One last thing I’ll mention here is that the Arc Ultra doesn’t ship with an optical adapter if you prefer that connection. The company will sell you one for $25.

Software and features

Since the Arc Ultra is a Sonos product, there are a lot of core features that are the same as they are on the company’s other devices. You can use the soundbar as part of a multiroom setup and Trueplay tuning is here to adjust the audio to the acoustics of the room. There’s still an adjustable EQ with options for bass, treble and loudness and a Night Sound mode makes things less boomy when someone in your house may be trying to work or sleep.

While Trueplay will give you the best sound customization for the sonic characteristics of your living room, Sonos is enabling a Quick Tune feature for the first time on the Arc Ultra. Here, the soundbar will use its internal mics, as opposed to your phone, to offer a certain degree of improvement. The company says it wanted to give people the option of something quicker than Trueplay, although the full-fledged tuning process doesn’t take very long at all.

Speech Enhancement has been a handy feature on Sonos soundbars for a while, giving you the ability to improve dialog clarity as needed. Before now, it was an all-or-nothing feature, but on the Arc Ultra, the company introduced three levels of speech boost to give you more options to better suit your needs. This means the soundbar can help you hear clearly over background noise or simply follow along better by elevating dialog above the rest of the soundtrack mix.

Billy Steele for Engadget

The trademark feature of Sonos’ Ace headphones is the ability to beam the audio from a compatible soundbar to the cans for a private home theater. That TV Audio Swap tool is available on the Arc Ultra, so you can instantly send the sound to the headphones with the press of a button. In fact, Sonos bundles the Arc Ultra and Ace headphones in a $1,373 set. What’s more, the Ace supports spatial audio with dynamic head tracking, so you can count on immersive sound even when you’re employing it on an individual basis.

Despite all of the problems that Sonos has had with its app, some of which it's still working to resolve, I didn't encounter any issues during my testing. The software crashed on me once when the Trueplay tuning process completed, but everything had already run its course and I didn’t have to repeat it. Other than that, the app has worked reliably over the last week while I’ve been putting the Arc Ultra through its paces. Most importantly, the software is stable and the full suite of controls for the new soundbar is available at launch.

Sound performance

The original Arc already sounded great, so Sonos really had its work cut out for it to further improve the audio quality for the Arc Ultra. Thanks to the improved bass of the Sound Motion tech, a change that also takes up less space, the company says it had the ability to then overhaul the mid-range and high-frequency components as well. By using multiple sizes of mid-range drivers and tweeters, Sonos was able to tweak the speaker positioning inside of the soundbar for improved projection and more immersive sound.

In addition to the enhanced bass performance, the second thing that was immediately apparent on the Arc Ultra was those improvements to the dimensional sound. Whether it was a quidditch match in a Harry Potter movie or zooming F1 cars in Drive to Survive, the soundbar now has better directional, immersive sound than its predecessor. Sonos says the Arc Ultra now renders Dolby Atmos content in a 9.1.4-channel setup, versus 5.0.2 with the Arc, which further contributes to the enveloping audio. Interestingly, I haven’t seen any of the competition claim four up-firing channels from the soundbar like Sonos does here (those that do are usually accounting for up-firing drivers in the rear speakers). You can really hear the difference from the second you fire up the Arc Ultra, and the effect is consistent across content sources.

Billy Steele for Engadget

The increased bass performance makes the Arc Ultra a much better speaker for music without a separate subwoofer. You won’t get the bombastic low-end tone the newly updated Sonos Sub 4 can produce, but there’s enough from the soundbar to give Kaytranada’s Timeless, Phantogram’s Memory of a Day and Bilmuri’s American Motor Sports plenty of booming backbone when a track demands it. There’s also still the trademark Sonos clarity I’ve come to expect over the years, which means finer details like the texture of synths, layered guitars and the nuance of acoustic instruments cut through the mix cleanly.

And speaking of clarity, the company’s new Speech Enhancement settings are also a big improvement. Being able to select how much of a boost this feature offered depending on either my needs right then or based on the overall tuning of the content is really nice. It allowed me to max out the dialog when watching movies after my toddler was asleep so that speech didn’t suffer when sound effects were louder during intense scenes of The Hobbit: An Unexpected Journey.

The competition

There’s no doubt the Arc Ultra packs in deeper, more immersive sound than its predecessor, but some people will still want a more robust setup to wring every ounce of audio out of a Sonos living room setup. The high-end choice for this is what Sonos calls the Ultimate Immersive Set, which includes the Arc Ultra, two Era 300s and the Sub 4. Right now, that will cost you $2,561. For something less expensive, you can get the Arc Ultra and the new Sub 4 (normally $799) for $1,708 (Premium Entertainment Set). And therein lies the biggest problem with Sonos soundbars: expanding your living room setup to get the most immersive experience gets very pricey very quickly when the centerpiece is already $999.

If you can live without all the conveniences of Sonos products, you can get an all-in-one package from Samsung for $1,500. With the Q990D, you’ll get the soundbar, two rear speakers and a wireless subwoofer in the same box. The setup offers 11.1.4 audio for excellent Atmos sound, thanks in part to up-firing drivers in the rear speakers. Samsung offers a host of handy features, from Q-Symphony audio with TV speakers, SpaceFit Sound Pro room calibration, Adaptive Sound audio enhancement, a dedicated gaming mode and more. The Q990D remains my top pick for the best soundbars for a lot of reasons, a key one being everything you could need comes in one all-inclusive package.

Wrap-up

The Arc Ultra is an obvious improvement over the Arc in the sonic department. New technology delivers on its promise to boost bass, clarity and immersive before you start adding extra components. Expanded features like Speech Enhancements and a quick-tune option offer new tools for dialing in the sound, while the stock Sonos experience remains intact. And thankfully, that includes an app that’s more stable than it was a few months ago. The Arc Ultra is still pricey at $999, but it exhibits a lot more sonic prowess than its predecessor for only $100 more.

This article originally appeared on Engadget at https://www.engadget.com/audio/speakers/sonos-arc-ultra-review-new-tech-powers-a-big-audio-upgrade-130011149.html?src=rss

If you have an iPhone that can run iOS 18, you can now download and install the public beta of iOS 18.2. One of the most useful new features is the capability to share the location of a lost item connected to Apple's Find My network with a third party. You can already share an item's location with people in your contacts list, but Apple says this could help in instances wherein you have to rely on the help of a stranger.

When you choose "Share Item Location" in the Find My app on iPhone, iPad or Mac, you'll get the option to share a link that shows the location of your missing item. The link's recipient will be able to open it on any device, and they'll also be able to see your Apple account email and/or phone number so that they can get in touch with you. You'll be able to see how many people visited the link, which expires after you're reunited with your lost belonging or after a week if you haven't found it by then.

Along with benevolent strangers, you'll be able to share the locations of misplaced AirTags and Find My accessories with select airlines. Apple has worked with several of them to integrate this feature into their systems. Only a small number of airline staff can access each Share Item Location link, and Apple says they'll first need to authenticate themselves with an Apple Account or partner email address.

Apple

More than 15 airlines will start supporting this feature in the coming months, including Aer Lingus, Air Canada, Air New Zealand, Austrian Airlines, British Airways, Brussels Airlines, Delta Air Lines, Eurowings, Iberia, KLM Royal Dutch Airlines, Lufthansa, Qantas, Singapore Airlines, Swiss International Air Lines, Turkish Airlines, United, Virgin Atlantic and Vueling. Apple says that more airlines will get involved over time to help track down mishandled or delayed bags.

Air transport tech company SITA is also incorporating Share Item Location into WorldTracer, its baggage-tracing system. According to Apple, this is used by more than 500 airlines and ground handlers at more than 2,800 airports.

Of course, installing beta software does have its downsides. There's a higher chance of running into bugs, and some apps or features might still not work as Apple had intended. If you don't mind and want to test iOS 18.2, you'll have to enable Beta Updates under Software Updates in your device's Settings menu. Apple is expected to roll out iOS 18.2 proper in December.

Meanwhile, as luck would have it, there's an early Black Friday deal on AirTags at the time of writing. You can scoop up a four-pack for a record low of $70.

Update, November 5 2024, 9:10AM ET: This story has been updated to clarify that these new features are in the developer beta of iOS 18.2. The public beta for that software isn't available just yet.

Update, November 11, 2024, 3:12PM ET: This story has been updated to include details of the airline integration and to note that a public beta of iOS 18.2 is now available.

This article originally appeared on Engadget at https://www.engadget.com/mobile/apples-latest-find-my-update-makes-it-easier-to-find-lost-items-133049512.html?src=rss

Signal users may be familiar with the problem of creating group chats just for a group call, but that’s about to become a thing of the past. You can now share a call link and let up to 50 people hop in, all in the span of a few seconds. The days of selecting contacts one by one are over.

Now, all you have to do is create a call link after going to the Calls tab and send it to whomever you want. The link is also reusable, which is convenient if you have fixed call times. Participants can raise their hands and send emojis. Hosts can set the room up so people must be approved before joining the conversation.

Based on Signal’s blog post, the new group call experience highly resembles Zoom. Those interested in privacy yet desire a conference call-like experience may find the new update helpful. Like Zoom, the desktop app offers more options.

Besides Zoom, these features will be familiar to frequent users of Microsoft Teams, Google Meet and some WhatsApp users. Raising hands is found on all three platforms as a non-verbal way to signal the speaker. WhatsApp does have a lower participant count of 32 people after an update in June. While there’s no raise hands function, doing certain gestures can send emojis for all to see. It’s worth noting that many apps with group call functionality are adopting similar features.

These new features are available on Android, iOS, Windows and macOS. If you don’t see them yet, we recommend updating your Signal app.

This article originally appeared on Engadget at https://www.engadget.com/apps/signal-makes-it-easier-to-start-group-video-calls-153519653.html?src=rss

Climate activists won against Shell in 2021 when a Dutch court commanded the oil giant to reduce its carbon emissions by 45 percent by the end of 2030. Three years later, Shell managed to win its appeal against this ruling. In the court's view, Shell doesn’t have a “social standard of care” to curtail emissions, the BBC reports.

The 2021 ruling was noteworthy, as it was the first time a court made a private company obey the 2015 Paris Agreement in addition to Dutch law. However, the appeals court judge said that while Shell had an obligation to reduce emissions, a 45 percent cut could not be established as there is no universally accepted amount. Shell’s statement says it’s planning to reduce its products’ carbon intensity by a comparatively paltry 15 to 20 percent by 2030 compared to a 2016 baseline.

The 2021 ruling would only be effective in the Netherlands as well. Shell wouldn’t have been legally obligated to follow the lower court's ruling for its operations outside Dutch territory. Now even that small gain is off the table for now.

The activists, who are largely associated with Milieudefensie (the Dutch branch of Friends of the Earth), issued a statement promising to continue the fight against climate change. “Large polluters are powerful. But united, we as people have the power to change them,” said Donald Pols, Director of Milieudefensie. They’re now trying to take the case to the Supreme Court, but getting a final verdict will likely take years.

This article originally appeared on Engadget at https://www.engadget.com/science/shell-wins-appeal-in-dutch-court-after-three-year-battle-against-green-groups-165543894.html?src=rss

Amazon is closing down Freevee, its free ad-supported video on demand service. This platform was home to original programming as well as more than 100 originals from the Prime Video roster. Freevee will be phased out over the coming weeks, and its content will become available as part of Prime Video. The ad-supported tier of Prime Video is included as part of Amazon's Prime membership for $15 a month.

"To deliver a simpler viewing experience for customers, we have decided to phase out Freevee branding," an Amazon spokesperson told Variety. "There will be no change to the content available for Prime members, and a vast offering of free streaming content will still be accessible for non-Prime members, including select originals from Amazon MGM Studios, a variety of licensed movies and series, and a broad library of FAST channels – all available on Prime Video."

The free viewing platform went through several rebrands since its original launch as IMDb Freedive in January 2019. It entered its final phase as Freevee in April 2022.

This article originally appeared on Engadget at https://www.engadget.com/entertainment/streaming/amazon-sunsets-freevee-platform-for-ad-supported-streaming-video-000614080.html?src=rss

Leylah Fernandez et ses compatriotes auront fort à faire pour conserver leur titre.

A VOLATILE year for our superannuation savings looks likely to end in positive territory as long as global markets don’t crash this week.

Amoury Lapointe a résisté à son arrestation lors d’une intervention de routine à laquelle il refusait de se soumettre dans son «véhicule diplomatique»

Découvrez ci-dessous comment notre caricaturiste Ygreck a imagé son dessin.

Transport Canada quietly changed air cargo importation rules for 55 mostly European countries in September, throwing the system into chaos — all in response to an alleged Russian plot to place firebombs on planes destined for North America.

Supporters say the Supreme Court of Canada's so-called Jordan ruling in 2016 has sped up proceedings and strengthened Charter rights for prompt justice. But some victims say the time limits for trials work in criminals' favour and cases continue to collapse because those limits are breached. 

Les spectateurs québécois auront encore l’embarras du choix durant le temps des Fêtes.

Le chanteur Zach Bryan aurait demandé à son ex-copine Brianna LaPaglia de ne pas parler de leur relation en lui offrant 12 millions de dollars.

Deputy PM admits former Soviet state was until recently a 'highly corrupt country' - but insists things are changing fast.

A court throws out a ruling that the gas and oil giant cut its greenhouse gas emissions.

Labor has urged Malcolm Turnbull to be more transparent about the deal reached to resettle refugees in the US.

Indian pharma and biotech companies are confident that under the new US President Donald Trump, its strengths in high quality generics manufacture and export will continue to command respect. This view is

The recent amendments brought by the Union Ministry of Ayush to the Drugs and Cosmetics Rules, 1945 are significant, as they introduce new regulatory requirements for the manufacturing and sale of traditional

Bormioli Pharma has announced a partnership with Chiesi, an international, research-focused biopharmaceutical company (Chiesi Group), to supply Carbon Capture PET bottles.

A strange supernova remnant first appeared as a “guest star” seen in 1181 by sky watchers in China and Japan

Long before it orbited Earth, the Hubble Space Telescope starred in a famous Superman comic

A galaxy cluster bends light from seven background galaxies around it, letting astronomers peer into space and time

Famous people who die at age 27, such as Janis Joplin, Jimi Hendrix and Amy Winehouse, get even more famous because of the mythology surrounding that number—an example of how modern folklore emerges

A research team at the University of California San Diego have developed a smartphone attachment that can provide information on changes in pupil size, which can be used to assess neurological phenomena, such as traumatic brain injury and Alzheimer’s disease. Such changes in pupil size have been difficult to characterize in the past in those […]

Autumn is here! Curl up with your favorite pumpkin-spiced blog and savor these acorns that we’ve squirrelled away for you:

• Johnson & Johnson Innovative Medicines gives a peek inside its $43 billion gross-to-net bubble

• Optum Rx joins the private label biosimilar bandwagon

• Biosimilars boom for provider-administered drugs

• Fresh evidence of how copay accumulators hurt patients

Plus, words of wisdom from Cencora's soon-to-be-former CEO Steve Collis.

P.S. Join my more than 58,000 LinkedIn followers for daily links to neat stuff along with thoughtful and provocative commentary from the DCI community.

There’s still time to request an invite to the inaugural Drug Channels Leadership Forum. Attendance will be highly limited. We have already begun extending invitations, so apply now to be considered. Click here to view the full agenda.

Read more »

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Last week, the Federal Trade Commission (FTC) released the redacted version of administrative complaint against the three largest pharmacy benefit managers (PBMs). The FTC rightly calls out how the gross-to-net bubble can raise patients’ out-of-pocket costs, while also acknowledging how rebates can reduce a plan's (but not the patient’s) costs. Apparently, the FTC believes that PBMs’ customers are pretty dumb, because PBMs are able to prevent plans from “appreciating” such healthcare financing dynamics.

Section V.E. of the complaint (starting on page 23) focuses on the PBMs’ alleged unlawful conduct related to preferring high-list/high-rebate insulin products over versions with lower list prices. I thought it would therefore be fun to take the Wayback Machine to November 2021, when I wrote about this specific topic.

Below, you can review my commentary about the warped incentives behind Viatris’ dual-pricing strategy for its interchangeable biosimilar of Lantus. Much of the FTC’s description of the drug channel aligns with my commentary. But before you fist pump too hard for Ms. Khan’s FTC, you should pause to reflect on the agency’s legal theories in light of plans’ revealed preferences.

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The Food & Drug Administration (FDA) recently approved the first interchangeable biosimilar insulin product: the insulin glargine-yfgn injection from Viatris. Read the FDA’s press release.

Alas, I’m sad to report that the warped incentives baked into the U.S. drug channel will limit the impact of this impressive breakthrough.

Viatris is being forced to launch both a high-priced and a low-priced version of the biosimilar. However, only the high-list/high-rebate, branded version will be available on Express Scripts’ largest commercial formulary. Express Scripts will block both the branded reference product and the lower-priced, unbranded—but also interchangeable—version. Meanwhile, Prime Therapeutics will place both versions on its formularies, leaving the choice up to its plan sponsor clients.

Consequently, many commercial payers will adopt the more expensive product instead of the identical—but cheaper—version. As usual, patients will be the ultimate victims of our current drug pricing system.

Below, I explain the weird economics behind this decision, highlight the negative impact on patients, and speculate on what this all could mean for biosimilars’ future. Until plan sponsors break their addiction to rebates, today’s U.S. drug channel problems will remain.
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Reality has again failed to support the spin surrounding the 340B Drug Pricing Program.

For 2023, discounted purchases under the 340B program reached a record $66.3 billion—an astounding $12.6 billion (+23.4%) higher than its 2022 counterpart. The gross-to-net difference between list prices and discounted 340B purchases also grew, to $57.8 billion (+$5.5 billion). 340B purchases are now almost 40% larger than Medicaid’s prescription drug purchases.

Hospitals again accounted for 87% of 340B purchases for 2023. Purchases at every 340B covered entity type grew, despite drug prices that grew more slowly than overall inflation.

Lobbyists claim that manufacturers’ 340B contract pharmacy changes are “stripping billions of dollars from the healthcare safety net.” But every year, the data tell a very different story. Only in the U.S. healthcare system can billions more in payments and spreads be considered a cut.

Read on for full details and our analysis, along with fresh details of troubling behavior by the Health Resources and Services Administration (HRSA).
Read more »

Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats:

• Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy

• Vampiric! Prior authorization sinks its fangs into providers’ time

• Wicked! How the IRA will put a stake through specialty physician practices

• Eerie! Google’s monstrous AI podcasts leave me petrified

• Zoinks! Join the vampire hunters at Drug Channels Institute

Plus, Dr. Glaucomflecken tells us a frightening tale of copayments.

P.S. Stretch out your arms and join the ever-growing zombie horde who shamble after me on LinkedIn. You’ll find my ghostly rantings along with commentary from the undead hordes in the DCI community.
Read more »

Today’s guest post comes from Chris Dowd, Senior VP of Market Development at ConnectiveRx.

Chris examines three key trends that will affect patient support programs: the Inflation Reduction Act (IRA), legal/regulatory battles over copay adjustment programs, and uncertainties following a national election. He then outlines three actions that should guide manufacturers' preparation.

To learn more, register for ConnectiveRx’s free webinar on December 11: The Perfect Storm? Patient Support Programming in 2025 and Beyond.

Read on for Chris’s insights.
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<p>On 3^&nbsp;June 2024,&nbsp;Resolution&nbsp;RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1],&nbsp;modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p>

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest

The post The Biotech Startup Contraction Continues… And That’s A Good Thing appeared first on LifeSciVC.

Magnetic resonance imaging (MRI) has revolutionized healthcare by providing radiation-free, non-invasive 3-D medical images. However, MRI scanners often consume 25 kilowatts or more to power magnets producing magnetic fields up to 1.5 tesla. These requirements typically limits scanners’ use to specialized centers and departments in hospitals.

A University of Hong Kong team has now unveiled a low-power, highly simplified, full-body MRI device. With the help of artificial intelligence, the new scanner only requires a compact 0.05 T magnet and can run off a standard wall power outlet, requiring only 1,800 watts during operation. The researchers say their new AI-enabled machine can produce clear, detailed images on par with those from high-power MRI scanners currently used in clinics, and may one day help greatly improve access to MRI worldwide.

To generate images, MRI applies a magnetic field to align the poles of the body’s protons in the same direction. An MRI scanner then probes the body with radio waves, knocking the protons askew. When the radio waves turn off, the protons return to their original alignment, transmitting radio signals as they do so. MRI scanners receive these signals, converting them into images.

More than 150 million MRI scans are conducted worldwide annually, according to the Organization for Economic Cooperation and Development. However, despite five decades of development, clinical MRI procedures remain out of reach for more than two-thirds of the world’s population, especially in low- and middle-income countries. For instance, whereas the United States has 40 scanners per million inhabitants, in 2016 there were only 84 MRI units serving West Africa’s population of more than 370 million.

This disparity largely stems from the high costs and specialized settings required for standard MRI scanners. They use powerful superconducting magnets that require a lot of space, power, and specialized infrastructure. They also need rooms shielded from radio interference, further adding to hardware costs, restricting their mobility, and hampering their availability in other medical settings.

Scientists around the globe have already been exploring low-cost MRI scanners that operate at ultra-low-field (ULF) strengths of less than 0.1 T. These devices may consume much less power and prove potentially portable enough for bedside use. Indeed, as the Hong Kong team notes, MRI development initially focused on low fields of about 0.05 T, until the introduction of the first whole-body 1.5 T superconducting scanner by General Electric in 1983.

The new MRI scanner (top left) is smaller than conventional scanners, and does away with bulky RF shielding and superconducting magnetics. The new scanner’s imaging resolution is on par with conventional scanners (bottom).Ed X. Wu/The University of Hong Kong

Current ULF MRI scanners often rely on AI to help reconstruct images from what signals they gather using relatively weak magnetic fields. However, until now, these devices were limited to solely imaging the brain, extremities, or single organs, Udunna Anazodo, an assistant professor of neurology and neurosurgery at McGill University in Montreal who did not take part in the work, notes in a review of the new study.

The Hong Kong team have now developed a whole-body ULF MRI scanner in which patients are placed between two permanent neodymium ferrite boron magnet plates—one above the body and the other below. Although these permanent magnets are far weaker than superconductive magnets, they are low-cost, readily available, and don’t require liquid helium or to be cooled to superconducting temperatures. In addition, the amount of energy ULF MRI scanners deposit into the body is roughly one-thousandth that from conventional scanners, making heat generation during imaging much less of a concern, Anazodo notes in her review. ULF MRI is also much quieter than regular MRI, which may help with pediatric scanning, she adds.

The new machine consists of two units, each roughly the size of a hospital gurney. One unit houses the MRI device, while the other supports the patient’s body as it slides into the scanner.

To account for radio interference from both the outside environment and the ULF MRI’s own electronics, the scientists deployed 10 small sensor coils around the scanner and inside the electronics cabinet to help the machine detect potentially disruptive radio signals. They also employed deep learning AI methods to help reconstruct images even in the presence of strong noise. They say this eliminates the need for shielding against radio waves, making the new device far more portable than conventional MRI.

In tests on 30 healthy volunteers, the device captured detailed images of the brain, spine, abdomen, heart, lung, and extremities. Scanning each of these targets took eight minutes or less for image resolutions of roughly 2 by 2 by 8 cubic millimeters. In Anazodo’s review, she notes the new machine produced image qualities comparable to those of conventional MRI scanners.

“It’s the beginning of a multidisciplinary endeavor to advance an entirely new class of simple, patient-centric and computing-powered point-of-care diagnostic imaging device,” says Ed Wu, a professor and chair of biomedical engineering at the University of Hong Kong.

The researchers used standard off-the-shelf electronics. All in all, they estimate hardware costs at about US $22,000. (According to imaging equipment company Block Imaging in Holt, Michigan, entry-level MRI scanners start at $225,000, and advanced premium machines can cost $500,000 or more.)

The prototype scanner’s magnet assembly is relatively heavy, weighing about 1,300 kilograms. (This is still lightweight compared to a typical clinical MRI scanner, which can weigh up to 17 tons, according to New York University’s Langone Health center.) The scientists note that optimizing the hardware could reduce the magnet assembly’s weight to about 600 kilograms, which would make the entire scanner mobile.

The researchers note their new device is not meant to replace conventional high-magnetic-field MRI. For instance, a 2023 study notes that next-generation MRI scanners using powerful 7 T magnets could yield a resolution of just 0.35 millimeters. Instead, ULF MRI can complement existing MRI by going to places that can’t host standard MRI devices, such as intensive care units and community clinics.

In an email, Anazodo adds this new Hong Kong work is just one of a number of exciting ULF MRI scanners under development. For instance, she notes that Gordon Sarty at the University of Saskatchewan and his colleagues are developing that device that is potentially even lighter, cheaper and more portable than the Hong Kong machine, which they are researching for use in whole-body imaging on the International Space Station.

Wu and his colleagues detailed their findings online 10 May in the journal Science.

This article appears in the July 2024 print issue as “Compact MRI Ditches Superconducting Magnets.”

Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.

UPDATE 31 OCTOBER 2024: No. 1 no longer. The would-have-been groundbreaking study published in Nature Communications by Amit Goyal et al. claiming the world’s highest-performing high-temperature superconducting wires yet has been retracted by the authors.

The journal’s editorial statement that now accompanies the paper says that after publication, an error in the calculation of the reported performance was identified. All of the study’s authors agreed with the retraction.

The researchers were first alerted to the issue by Evgeny Talantsev at the Mikheev Institute of Metal Physics in Ekaterinburg, Russia, and Jeffery Tallon at the Victoria University of Wellington in New Zealand. In a 2015 study, the two researchers had suggested upper limits for thin-film superconductors, and Tallon notes follow-up papers showed these limits held for more than 100 known superconductors. “The Goyal paper claimed current densities 2.5 times higher, so it was immediately obvious to us that there was a problem here,” he says.

Upon request, Goyal and his colleagues “very kindly agreed to release their raw data and did so quickly,” Tallon says. He and Talantsev discovered a mistake in the conversion of magnetization units.

“Most people who had been in the game for a long time would be fully conversant with the units conversion because the instruments all deliver magnetic data in [centimeter-gram-second] gaussian units, so they always have to be converted to [the International System of Units],” Tallon says. “It has always been a little tricky, but students are asked to take great care and check their numbers against other reports to see if they agree.”

In a statement, Goyal notes he and his colleagues “intend to continue to push the field forward” by continuing to explore ways to enhance wire performance using nanostructural modifications. —Charles Q. Choi

Original article from 17 August, 2024 follows:

Superconductors have for decades spurred dreams of extraordinary technological breakthroughs, but many practical applications for them have remained out of reach. Now a new study reveals what may be the world’s highest-performing high-temperature superconducting wires yet, ones that carry 50 percent as much current as the previous record-holder. Scientists add this advance was achieved without increased costs or complexity to how superconducting wires are currently made.

Superconductors conduct electricity with zero resistance. Classic superconductors work only at super-cold temperatures below 30 degrees Kelvin. In contrast, high-temperature superconductors can operate at temperatures above 77 K, which means they can be cooled to superconductivity using comparatively inexpensive and less burdensome cryogenics built around liquid nitrogen coolant.

Regular electrical conductors all resist electron flow to some degree, resulting in wasted energy. The fact that superconductors conduct electricity without dissipating energy has long lead to dreams of significantly more efficient power grids. In addition, the way in which rivers of electric currents course through them means superconductors can serve as powerful electromagnets, for applications such as maglev trains, better MRI scanners for medicine, doubling the amount of power generated from wind turbines, and nuclear fusion power plants.

“Today, companies around the world are fabricating kilometer-long, high-temperature superconductor wires,” says Amit Goyal, SUNY Distinguished Professor and SUNY Empire Innovation Professor at the University of Buffalo in New York.

However, many large-scale applications for superconductors may stay fantasies until researchers can find a way to fabricate high-temperature superconducting wires in a more cost-effective manner.

In the new research, scientists have created wires that have set new records for the amount of current they can carry at temperatures ranging from 5 K to 77 K. Moreover, fabrication of the new wires requires processes no more complex or costly than those currently used to make high-temperature superconducting wires.

“The performance we have reported in 0.2-micron-thick wires is similar to wires almost 10 times thicker,” Goyal says.

At 4.2 K, the new wires carried 190 million amps per square centimeter without any externally applied magnetic field. This is some 50 percent better than results reported in 2022 and a full 100 percent better than ones detailed in 2021, Goyal and his colleagues note. At 20 K and under an externally applied magnetic field of 20 tesla—the kind of conditions envisioned for fusion applications—the new wires may carry about 9.3 million amps per square centimeter, roughly 5 times greater than present-day commercial high-temperature superconductor wires, they add.

Another factor key to the success of commercial high-temperature superconductor wires is pinning force—the ability to keep magnetic vortices pinned in place within the superconductors that could otherwise interfere with electron flow. (So in that sense higher pinning force values are better here—more conducive to the range of applications expected for such high-capacity, high-temperature superconductors.) The new wires showed record-setting pinning forces of more than 6.4 trillion newtons at 4.3 K under a 7 tesla magnetic field. This is more than twice as much as results previously reported in 2022.

The new wires are based on rare-earth barium copper oxide (REBCO). The wires use nanometer-sized columns of insulating, non-superconducting barium zirconate at nanometer-scale spacings within the superconductor that can help pin down magnetic vortices, allowing for higher supercurrents.

The researchers made these gains after a few years spent optimizing deposition processes, Goyal says. “We feel that high-temperature superconductor wire performance can still be significantly improved,” he adds. “We have several paths to get to better performance and will continue to explore these routes.”

Based on these results, high-temperature superconductor wire manufacturers “will hopefully further optimize their deposition conditions to improve the performance of their wires,” Goyal says. “Some companies may be able to do this in a short time.”

The hope is that superconductor companies will be able to significantly improve performance without too many changes to present-day manufacturing processes. “If high-temperature superconductor wire manufacturers can even just double the performance of commercial high-temperature superconductor wires while keeping capital equipment costs the same, it could make a transformative impact to the large-scale applications of superconductors,” Goyal says.

The scientists detailed their findings on 7 August in the journal Nature Communications.

This story was updated on 19 August 2024 to correct Amit Goyal’s title and affiliation.

CDMO Avid Bioservices is being acquired by the private equity firms GHO Capital Partners and Ampersand Capital Partners. Avid specializes in manufacturing biologic products for companies at all stages of development.

The post Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition appeared first on MedCity News.

While startups in highly regulated industries like healthcare and finance are almost certain to face heightened scrutiny, there are controllable factors that can offset these challenges.

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The Pew Charitable Trusts joined dozens of research, health care, and nonprofit stakeholders in urging President-elect Joe Biden to prioritize and strengthen the national response to antibiotic resistance.

Over the past year, COVID-19 has taken a grave toll in lives as well as on medical and health care systems worldwide. The pandemic has laid bare the importance of public health readiness and the myriad consequences when such a crisis strikes an unprepared population.

Monday blues were non-existent at the Singapore Indoor Stadium yesterday (Nov 11) as fans of Blackpink's Lisa strolled into the venue in their Y2K-style outfits inspired by the Thai singer's Rockstar music video. Singapore was the first stop for the 27-year-old's first solo fan-meet tour and needless to say, the excitement could be felt, and heard. Once the lights turned off and Lisa appeared, the screams were deafening. The show started with a bang, fittingly with her self-titled hit song Lalisa. Usually at fan-meets of K-pop idols, the special effects are kept to a minimum unlike concerts. PHOTO: UnUsUaL Entertainment But at Lisa's, the performances were elevated with bursts of pyrotechnics and visual effects. After the first song, she sat down for a few interactive segments. During Welcome Lisa, she tried local delicacies like kaya toast and chicken rice.

A grand prize of $10 million is up for grabs at the upcoming Toto draw on Thursday (Nov 14) at 9.30pm. The Group 1 prize money has snowballed over the past three draws after no Group 1 winners were picked. According to Singapore Pools' website, the prize started at $1.2 million on Nov 4 before snowballing to $2.9 million on Nov 7 and $6 million on Nov 11. The last draw on Monday yielded three Group 2 winners who won $215,010 each. Tomorrow's draw will be a cascade draw, meaning that the prize money will be split between the Group 2 winners in the event that no Group 1 winner is chosen. If there are no Group 2 winners, the prize will be split among the Group 3 winners, and so on. The last time a Group 1 prize snowballed above $10 million was during the October 21 draw where two lucky winners bagged over $6.6 million each.

I have had a long-standing interest in South Africa, and in 1995 briefly contemplated moving there to work. The country had just had its first multi-racial election, and the great Nelson Mandela had been elected President. I was deeply curious to see, at first-hand, what the land and its people would make of their hard [...]

The resignation drama has helped distract attention from the DMK party's woes in advance of next years Parliamentary elections.

Pending post verification are claims that total $279 million for the March-May 2007 period. The areas of greatest concern to us include costs for helicopter operations ($83 million annually), radar maintenance ($65 million annually) and Joint Staff operations ($5 million annually).

Between August 2006 and July 2007, we received a claim for 26 million USD in barbed wire and pickets. While these items are no doubt helpful in protecting outposts, the claim figures are highly suspect.

Deputy Director Shen acknowledged the message but offered no further comment.