Effective June 1, outdoor gatherings of more than 25 people will be permitted at Delaware’s state forests, subject to compliance with the Division of Public Health's "Guidance on Outdoor Gatherings." While the state's ban on short-term rentals will be lifted on June 1, camping at Blackbird State Forest and Redden State Forest, as well as the Redden Lodge, will be closed to the public until further notice. Plans are underway to implement a new online, fee-based reservation system expected to be operational later this summer. There is no fixed date on the launch of the new system, which will include the addition of two new camp sites each at both Blackbird and Redden. The new system will also handle advance bookings for the popular and historic Redden Lodge. Users can make camping and lodge reservations for future dates, receive electronic confirmations, and make payments and receive refunds via credit card.

The Delaware Department of Agriculture (DDA) is reminding hemp producers to register their growing sites using the annual Growing Site Registration form to register available online before February 1.

Redden State Forest has closed its campsites and many trails still remain inaccessible following the heavy snowstorm on January 3 that dumped up to 14.5 inches in nearby Ellendale. With a potential for additional snowfall of 3 inches or more and wind gusts to 35 m.p.h., Delaware Forest Service staff are currently assessing impacts from the storm and working to mitigate hazardous trees in and around high-use areas and clear trails and access roads. The Redden Education Trail (photo) on the Headquarters Tract is littered with downed trees and covered with heavy snow. Visitors should be aware of the potential for falling tree limbs on all areas of the state forest. The historic Redden Lodge, also on the Headquarters Tract, remains accessible for now and is open for previously scheduled events and bookings.

The Delaware Forest Service has launched a new online portal for reserving campsites and other venues on state forestland. Applicants can make reservations for primitive tent camping, rent the Lodge at Redden State Forest and reserve the pavilions. Additional campsites at Blackbird State Forest and Redden State Forest are also now open to the public.

NEW CASTLE (Jan. 10, 2022) – With Delaware facing the coldest temperatures of the winter Monday and Tuesday nights, Code Purple is being declared across the state by the nonprofit and volunteer organizations that operate the shelters to keep people who are homeless safe during dangerous winter weather. Because of the COVID-19 pandemic and the […]

NEW CASTLE (April 7, 2022) – The Department of Health and Social Services (DHSS) has launched a new website called CostAware to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical claims in Delaware. Hospital […]

DOVER, DE (June 1, 2022) – The Delaware Division of Public Health (DPH) is announcing the launch of Delaware WIC’s new educational website. The website includes information on nutrition, breastfeeding, and WIC’s programming for families, covering all stages of pregnancy, postpartum, infancy and children up to five years of age. It currently includes a link to […]

NEW CASTLE (July 12, 2023) – The Delaware Department of Health and Social Services (DHSS) announced today enhancements to the CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical claims in Delaware. […]

NEW CASTLE – The Delaware Department of Health and Social Services (DHSS) announced today enhancements to the CostAware website, designed to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical and pharmacy claims in Delaware. […]

NEW CASTLE – The Delaware Department of Health and Social Services (DHSS), in a coordinated effort with fellow government agencies, community partners, and Delaware residents, today announced the launch of the new, redesigned, and revamped HelpIsHereDE.com, available in English and Spanish. Designed after months of listening sessions and focus groups, the new HelpIsHereDE.com is the state’s comprehensive […]

State agencies encourage COVID-19 testing WILMINGTON, Del. – Governor John Carney, the Delaware Division of Public Health (DPH), and the Delaware Emergency Management Agency (DEMA) announced the list of community testing sites throughout Delaware this week. Testing locations listed below include pop-up and Curative trailer sites, as well as community sites hosted by St. Francis Hospital […]

State agencies encourage COVID-19 testing WILMINGTON, Del. – Governor John Carney, the Delaware Division of Public Health (DPH), and the Delaware Emergency Management Agency (DEMA) announced the list of community testing sites throughout Delaware next week. Testing locations listed below include pop-up and Curative trailer sites, as well as community sites hosted by New Castle County, […]

State agencies encourage COVID-19 testing WILMINGTON, Del. – Governor John Carney, the Delaware Division of Public Health (DPH), and the Delaware Emergency Management Agency (DEMA) announced the list of community testing sites throughout Delaware this week. Testing locations listed below include pop-up and Curative trailer sites, as well as community sites hosted by the Henrietta Johnson […]

WILMINGTON, Del. – Governor John Carney, the Delaware Division of Public Health (DPH), and the Delaware Emergency Management Agency (DEMA) announced the list of community testing sites throughout Delaware next week. Testing locations listed below include pop-up and Curative trailer sites, as well as community sites hosted by New Castle County and Henrietta Johnson Medical Center. “As we prepare for the holidays, we need […]

By Leoné Cahill-Krout, site supervisor at Cooch’s Bridge Historic Site Every day, thousands of cars drive through the intersection of Old Baltimore Pike and Sunset Lake Drive. They often take […]

DNREC continued to diversify marine habitat for angling and diving experiences on Delaware’s renowned artificial reef system today by sinking two vintage vessels – a retired City of Baltimore fireboat and a World War II-era tugboat – onto Reef Site 11, the Redbird Reef, that also contains 750 retired NYC "Redbird" subway cars.

DEPARTMENT OF JUSTICE: Fraud and Consumer Protection Division

Marcus Weldon, chief technology officer of Nokia and president of its research arm Nokia Bell Labs, talks about what guided the decision to set up a new global R&D centre and the company’s strategy for driving innovation

An obscure three-story shikumen (stone-gate) building, tucked away in Shanghai’s busy Xintiandi commercial hub, has become a site of pilgrimage for tens of thousands of South Koreans every year.

CHINA’S first commercial spacecraft launch site is ready for operations in south China’s Hainan Province, having completed a rocket launch simulation rehearsal using its two launch pads. According to

Not less than 13 persons have reportedly died after a mining site collapsed in Bassa local government area of Plateau State. Chairman of the local government, Joshua Riti, who confirmed ths incident, said it occurred on November 10. He added that seven of the deceased hail from Bassa LGA, NAN reports. “This is an unfortunate […]

The post Mining site collapses in Plateau, kills 13 first appeared on Business Hallmark.

IDF intelligence had been tracking these underground facilities for years, and over recent weeks, the air force focused on destroying them.

to write a user manual for a website

Geologists hoping to declare a new epoch dominated by humanity’s influence on Earth have chosen Crawford Lake in Canada as the location where the start of the Anthropocene is defined

Evidence from an archaeological site in Ethiopia suggests ancient humans adapted their diet during a dry spell after the Toba volcano eruption 74,000 years ago

Title: Tourist With Measles Visited Southern California Attractions
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Pious Parasites: Medieval Monks Battled Nasty Gut Germs
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

BACKGROUND:Training in mechanical ventilation is a key goal in critical care fellowship education. Web-based simulators offer a cost-effective and readily available alternative to traditional on-site simulators. However, it is unclear how effective they are as teaching tools. In this study, we evaluated the test scores of fellows who underwent mechanical ventilation training by using a web-based simulator compared with fellows who used an on-site simulator during a mechanical ventilation course.METHODS:This was a nonrandomized controlled trial conducted as part of a mechanical ventilation course that involved 70 first-year critical care fellows. The course was identical except for the simulation technology used. One group of instructors used a traditional on-site simulator, the ASL 5000 Lung Solution (n = 39). The second group was instructed in using a web-based simulator, VentSim (n = 31). Each fellow completed a pre-course test and a post-course test by using a validated, case-based ventilator waveform examination that consisted of 5 questions with a total possible score of 100. The primary outcome was a comparison of the mean scores on the posttest between the 2 groups. The study was designed as a non-inferiority trial with a predetermined margin of 10 points.RESULTS:There was no significant difference in the mean ± SD pretest scores between the web-based and the on-site groups (21.1 ± 12.6 and 26.9 ± 13.6 respectively; P = .11). The mean ± SD posttest scores were 45.6 ± 25.0 for the web-based simulator and 43.4 ± 16.5 for on-site simulator (mean difference 2.2; one-sided 95% CI –7.0 to ∞; Pnon-inferiority = .02 [non-inferiority confirmed]). Changes in mean ± SD scores (posttest – pretest) were 25.9 ± 20.9 for the web-based simulator and 16.5 ± 15.9 for the on-site simulator (mean difference 9.4, one-sided 95% CI 0.9 to ∞; Pnon-inferiority < .001 [non-inferiority confirmed]).CONCLUSIONS:In the education of first-year critical care fellows on mechanical ventilation waveform analysis, a web-based mechanical ventilation simulator was non-inferior to a traditional on-site mechanical ventilation simulator.

Internal ribosomal entry sites (IRESs) recruit the ribosome to promote translation, typically in an m7G cap-independent manner. Although IRESs are well-documented in viral genomes, they have also been reported in mammalian transcriptomes, where they have been proposed to mediate cap-independent translation of mRNAs. However, subsequent studies have challenged the idea of these "cellular" IRESs. Current methods for screening and discovering IRES activity rely on a bicistronic reporter assay, which is prone to producing false positive signals if the putative IRES sequence has a cryptic promoter or cryptic splicing sites. Here, we report an assay for screening IRES activity using a genetically encoded circular RNA comprising a split nanoluciferase (nLuc) reporter. The circular split nLuc reporter is less susceptible to the various sources of false positives that adversely affect the bicistronic IRES reporter assay and provides a streamlined method for screening IRES activity. Using the circular split nLuc reporter, we find that nine reported cellular IRESs have minimal IRES activity. Overall, the circular split nLuc reporter offers a simplified approach for identifying and validating IRESs and exhibits reduced propensity for producing the types of false positives that can occur with the bicistronic reporter assay.

The spliceosome is a eukaryotic multimegadalton RNA–protein complex that removes introns from transcripts. The spliceosome ensures the selection of each exon-intron boundary through multiple recognition events. Initially, the 5' splice site (5' SS) and branch site (BS) are bound by the U1 small nuclear ribonucleoprotein (snRNP) and the U2 snRNP, respectively, while the 3' SS is mostly determined by proximity to the branch site. A large number of splicing factors recognize the splice sites and recruit the snRNPs before the stable binding of the snRNPs occurs by base-pairing the snRNA to the transcript. Fidelity of this process is crucial, as mutations in splicing factors and U2 snRNP components are associated with many diseases. In recent years, major advances have been made in understanding how splice sites are selected in Saccharomyces cerevisiae and humans. Here, I review and discuss the current understanding of the recognition of splice sites by the spliceosome with a focus on recognition and binding of the branch site by the U2 snRNP in humans.

TP53 plays a critical role as a tumor suppressor by controlling cell cycle progression, DNA repair, and apoptosis. Post-translational modifications such as acetylation of specific lysine residues in the DNA binding and carboxy-terminus regulatory domains modulate its tumor suppressor activities. In this study, we addressed the functional consequences of the germline TP53 p.K164E (NM_000546.5: c.490A>G) variant identified in a patient with early-onset breast cancer and a significant family history of cancer. K164 is a conserved residue located in the L2 loop of the p53 DNA binding domain that is post-translationally modified by acetylation. In silico, in vitro, and in vivo analyses demonstrated that the glutamate substitution at K164 marginally destabilizes the p53 protein structure but significantly impairs sequence-specific DNA binding, transactivation, and tumor cell growth inhibition. Although p.K164E is currently considered a variant of unknown significance by different clinical genetic testing laboratories, the clinical and laboratory-based findings presented here provide strong evidence to reclassify TP53 p.K164E as a likely pathogenic variant.

Kelley gets a sweet message from her husband, while Josh is not convinced he wants to play the Untitled Groose Game. Anna Marie is warned off of spitting in Chris's briefs and calling it rain, and somehow we manage to get through two weeks of news including two big presentations!

The post RPG Cast – Episode 574: “We’re a Real Site in Our Hearts” appeared first on RPGamer.

The UK government's decision to return the Chagos Islands to Mauritius surprisingly threatens the extinction of millions of website addresses ending in ".io", and no one is quite sure what will happen next

Around 25 per cent of the world’s population has intestinal parasite infections – these could hinder the effectiveness of covid-19 vaccines, according to research in mice

Last week the organization tasked with running the the biggest chunk of U.S. CHIPS Act’s US $13 billion R&D program made some significant strides: The National Semiconductor Technology Center (NSTC) released a strategic plan and selected the sites of two of three planned facilities and released a new strategic plan. The locations of the two sites—a “design and collaboration” center in Sunnyvale, Calif., and a lab devoted to advancing the leading edge of chipmaking, in Albany, N.Y.—build on an existing ecosystem at each location, experts say. The location of the third planned center—a chip prototyping and packaging site that could be especially critical for speeding semiconductor startups—is still a matter of speculation.

“The NSTC represents a once-in-a-generation opportunity for the U.S. to accelerate the pace of innovation in semiconductor technology,” Deirdre Hanford, CEO of Natcast, the nonprofit that runs the NSTC centers, said in a statement. According to the strategic plan, which covers 2025 to 2027, the NSTC is meant to accomplish three goals: extend U.S. technology leadership, reduce the time and cost to prototype, and build and sustain a semiconductor workforce development ecosystem. The three centers are meant to do a mix of all three.

New York gets extreme ultraviolet lithography

NSTC plans to direct $825 million into the Albany project. The site will be dedicated to extreme ultraviolet lithography, a technology that’s essential to making the most advanced logic chips. The Albany Nanotech Complex, which has already seen more than $25 billion in investments from the state and industry partners over two decades, will form the heart of the future NSTC center. It already has an EUV lithography machine on site and has begun an expansion to install a next-generation version, called high-NA EUV, which promises to produce even finer chip features. Working with a tool recently installed in Europe, IBM, a long-time tenant of the Albany research facility, reported record yields of copper interconnects built every 21 nanometers, a pitch several nanometers tighter than possible with ordinary EUV.

“It’s fulfilling to see that this ecosystem can be taken to the national and global level through CHIPS Act funding,” said Mukesh Khare, general manager of IBM’s semiconductors division, speaking from the future site of the NSTC EUV center. “It’s the right time, and we have all the ingredients.”

While only a few companies are capable of manufacturing cutting edge logic using EUV, the impact of the NSTC center will be much broader, Khare argues. It will extend down as far as early-stage startups with ideas or materials for improving the chipmaking process “An EUV R&D center doesn’t mean just one machine,” says Khare. “It needs so many machines around it… It’s a very large ecosystem.”

Silicon Valley lands the design center

The design center is tasked with conducting advanced research in chip design, electronic design automation (EDA), chip and system architectures, and hardware security. It will also host the NSTC’s design enablement gateway—a program that provides NSTC members with a secure, cloud-based access to design tools, reference processes and designs, and shared data sets, with the goal of reducing the time and cost of design. Additionally, it will house workforce development, member convening, and administration functions.

Situating the design center in Silicon Valley, with its concentration of research universities, venture capital, and workforce, seems like the obvious choice to many experts. “I can’t think of a better place,” says Patrick Soheili, co-founder of interconnect technology startup Eliyan, which is based in Santa Clara, Calif.

Abhijeet Chakraborty, vice president of engineering in the technology and product group at Silicon Valley-based Synopsys, a leading maker of EDA software, sees Silicon Valley’s expansive tech ecosystem as one of its main advantages in landing the NSTC’s design center. The region concentrates companies and researchers involved in the whole spectrum of the industry from semiconductor process technology to cloud software.

Access to such a broad range of industries is increasingly important for chip design startups, he says. “To design a chip or component these days you need to go from concept to design to validation in an environment that takes care of the entire stack,” he says. It’s prohibitively expensive for a startup to do that alone, so one of Chakraborty’s hopes for the design center is that it will help startups access the design kits and other data needed to operate in this new environment.

Packaging and prototyping still to come

A third promised center for prototyping and packaging is still to come. “The big question is where does the packaging and prototyping go?” says Mark Granahan, cofounder and CEO of Pennsylvania-based power semiconductor startup Ideal Semiconductor. “To me that’s a great opportunity.” He points out that because there is so little packaging technology infrastructure in the United States, any ambitious state or region should have a shot at hosting such a center. One of the original intentions of the act, after all, was to expand the number of regions of the country that are involved in the semiconductor industry.

But that hasn’t stopped some already tech-heavy regions from wanting it. “Oregon offers the strongest ecosystem for such a facility,” a spokesperson for Intel, whose technology development is done there. “The state is uniquely positioned to contribute to the success of the NSTC and help drive technological advancements in the U.S. semiconductor industry.”

As NSTC makes progress, Granahan’s concern is that bureaucracy will expand with it and slow efforts to boost the U.S. chip industry. Already the layers of control are multiplying. The Chips Office at the National Institute of Standards and Technology executes the Act. The NSTC is administered by the nonprofit Natcast, which directs the EUV center, which is in a facility run by another nonprofit, NY CREATES. “We want these things to be agile and make local decisions.”

In today’s digital age, your website is more than just a virtual storefront—it’s the heart of your online presence. Whether you’re a small business, a growing startup, or an established brand, a custom-designed website can be the key to standing out in a crowded market. But what does it take to truly transform your digital […]

The post How to Transform Your Online Presence with a Custom Website appeared first on Chart Attack.

Founded by Thaalla Vaishnav and Pramod Uppalapati, ‘The Script Craft’ is backed by Prabhas to nurture new talent and provide emerging writers with valuable opportunities

Les Islanders ont une lourde tâche qui les attend ce soir.

Toy giant Mattel says it "deeply" regrets an error on the packaging of its Wicked movie-themed dolls, which mistakenly links toy buyers to a pornographic website.

Recently-released dolls tied to the new Wicked movie inadvertently carry the address of an adult website.

The ACRO D&I Site Resource Grants Program aims to help sites acquire the resources and skills that will get them selected for studies and improve the reach of clinical research into underrepresented communities.

The post ACRO Announces Diversity and Inclusion Site Resource Grants Program first appeared on ACRO.

ACRO is pleased to announce the launch of the ACRO Diversity and Inclusion Site Resource Grants Program! The ACRO D&I Site Resource Grants Program aims to help sites acquire the resources and skills that will get them selected for studies and improve the reach of clinical research into underrepresented communities. “We are excited to invite […]

The post ACRO Announces Diversity and Inclusion Site Resource Grants Program first appeared on ACRO.