Payback

2019 is nearly over, so let's look ahead to what awaits the video game industry in the first year of the new decade. Informed opinions and hot takes abound.

Election Day is still a few days away, but Delaware students tallied their votes for statewide offices today in Dover at the 2018 Student Mock Election Convention. In what’s become a bellwether for elections in Delaware, students picked incumbents Sen. Tom Carper and Congresswoman Lisa Blunt Rochester to continue representing the First State in Washington.

<b>New Delhi:</b> NCP chief Sharad Pawar on Monday today met Congress president Sonia Gandhi at her residence here amidst an impasse between the BJP and its ally the Shiv Sena on the government formation in Maharashtra. Speaking to reporters after the meeting, Pawar reiterated that the "mandate to NCP given

Today, many assets across multiple industries are becoming more instrumented and connected to enterprise platforms to provide additional insight into their health and operation. IDC estimates that Internet of Things (IoT) investment will reach $1.12 trillion in 2023. One important area for many industrial organizations that are focused in using [...]

An approach to enabling predictive maintenance for industrial assets was published on SAS Voices by Sanjeev Heda

Forecasting is a daunting task during normal conditions, and even more so during a disruption. But in times of greatest stress our smartest and most creative people stand out, and our true leaders emerge. You'll find these kinds of leaders among my colleagues at SAS -- smart and creative people [...]

The post Forecasting during chaos: predicting impact on demand and supply appeared first on The Business Forecasting Deal.

Budget 2019: Study the past to predict the future

The weatherman has predicted a cloudy afternoon with possibility of thunderstorm and gusty winds accompanied by light rains in parts of Delhi.

Some social media users are convinced that an early episode of The Simpsons also came close to predicting the ongoing coronavirus pandemic and the invasion of "murder hornets".

Where will Tommy Brockermeyer, Korey Foreman and other top recruits decide to play?

I recently attended a webinar presented by Wally Rhines about his new book, Predicting Semiconductor Business Trends After Moore's Law . Wally was the CEO of Mentor, as you probably know. Now he...

[[ Click on the title to access the full blog on the Cadence Community site. ]]

Lower fertility rates will boost economic growth, according to a demographic model developed by Renaissance Capital. 

Escalation in protests across the globe in 2019 are forecast to persist into the new decade, according to Verisk Maplecroft report.

Wind or solar now represent the least expensive option for adding new power generation capacity in approximately two-thirds of the world.

Wind or solar now represent the least expensive option for adding new power generation capacity in approximately two-thirds of the world.

Wind or solar now represent the least expensive option for adding new power generation capacity in approximately two-thirds of the world.

Wind or solar now represent the least expensive option for adding new power generation capacity in approximately two-thirds of the world.

The current riots/disturbances in cities across England raise a number of issues in relation to construction sites. These will include fundamental health and safety issues but it also raises important considerations in relation to any damage or...

The founder of Inri Evangelical Spiritual Church, Primate Elijah Ayodele, has predicted that the vaccine for COVID-19 will be discovered in July this year. Scientists around the world are yet to make a breakthrough with regards to a cure for the virus, since it broke out earlier this year in Wuhan, China. In the last […]

COVID-19: Primate Ayodele predicts when vaccine will be discovered

A Dublin Leaving Cert student has said she doesn't believe the Irish education system has the ability to predict grades fairly after it was announced yesterday that the State exams have been cancelled due to public health concerns.

Car sales in China likely rose in April from a year earlier, its top industry body said on Thursday, ending almost two years of declines and signalling that the world’s biggest market is recovering from the coronavirus shock.April’s sales of 2 million units likely pushed sales up 0.9 per cent from a year earlier, and 39.8 per cent from March, the China Association of Automobile Manufacturers (CAAM) said in a post on its official WeChat account.It added its forecast was based on sales data it…

A throwback video of a tarot reader predicting Ranbir Kapoor's relationship with Alia Bhatt back in 2012 is going viral

According to a study by India Ratings, lack of credit availability and ongoing economic slowdown in India due to the coronavirus pandemic could lead to the residential sector witnessing weak demand in the fiscal year 2020-21.  Residential demand could remain muted in the next financial year, 2020-21 due to the increasing risks to India’s growth in case the economic impact of coronavirus continues beyond the first quarter.   Moreover, the housing sector faces a liquidity crunch and refinancing challenges due to increasing uncertainty over the availability of credit in the market, coupled with poor demand. This is in the backdrop of the recent meltdown in the financial market and rising risk […]

A statistical technique called multi-level regression and post-stratification (MRP) correctly predicted the last UK election when other polls failed. This is how it works

Fundamental limits on space and time mean that the motion of three black holes is impossible to predict, even with the most powerful computer that could ever be built

If you read a book painting the very worst-case scenarios about what global warming means for human life you could easily panic. Here’s why you shouldn’t

It took 20 years of planning and lots of hot water to drill 2 kilometres into Antarctica. Andy Smith describes a ground- breaking achievement

History is witness to the many scientific leaders and technology visionaries who all tried to predict what innovations will exist in the future. While not all predictions come to fruition, others were not so far off. We may not have flying cars like The...

Lose your bearings in an unfamiliar landscape and fear shreds your navigational brain. But studies are now revealing the common mistakes lost people make, helping rescue teams to find them before it’s too late

The Pine Island glacier has three tipping points that could lead to the collapse of the entire West Antarctic ice sheet, potentially raising sea levels by 3 metres over centuries

The Bank of England says the UK faces its worst slump in 300 years, but on Thursday held off from any moves on rates or bond buying. Julian Satterthwaite reports.

Title: Hormone May Predict Age at Menopause
Category: Health News
Created: 5/1/2008 12:00:00 AM
Last Editorial Review: 5/1/2008 12:00:00 AM

Title: Calcium in Arteries May Predict Heart Risk
Category: Health News
Created: 4/28/2010 9:30:00 AM
Last Editorial Review: 4/28/2010 9:30:07 AM

Title: Progress in Predicting Invasive Breast Cancer
Category: Health News
Created: 4/29/2010 10:21:00 AM
Last Editorial Review: 4/29/2010 10:21:45 AM

Title: Can Blood Test Predict Breast Cancer Risk?
Category: Health News
Created: 5/1/2012 4:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Implanted Device May Predict Epilepsy Seizures, Study Suggests
Category: Health News
Created: 5/2/2013 10:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM

Title: Mom's Pre-Pregnancy Weight May Help Predict Child's Size
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

Title: AHA News: Predicting Heart Disease, Stroke Could Be as Easy as a Blood Test
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: Vaginal Bacteria Could Help Predict Risk of Premature Birth: Study
Category: Health News
Created: 4/8/2020 12:00:00 AM
Last Editorial Review: 4/9/2020 12:00:00 AM

Title: Can AI Predict Who Will Develop Diabetes?
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM

Title: Endometriosis Risk Can Be Predicted in Young Girls: Study
Category: Health News
Created: 3/10/2020 12:00:00 AM
Last Editorial Review: 3/10/2020 12:00:00 AM

Title: AHA News: Dropping Blood Pressure May Predict Frailty, Falls in Older People
Category: Health News
Created: 3/30/2020 12:00:00 AM
Last Editorial Review: 3/31/2020 12:00:00 AM

The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.

All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients.

In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146-17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755-8.044; p=0.007), CD3⁺CD8⁺ T-cells ≤75 cells·μL^–1 (OR 3.982, 95% CI 1.132-14.006; p<0.001) and cardiac troponin I ≥0.05 ng·mL^–1 (OR 4.077, 95% CI 1.166-14.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case–control study, CD3⁺CD8⁺ T-cells ≤75 cells·μL^–1 and cardiac troponin I ≥0.05 ng·mL^–1 remained as predictors for high mortality from COVID-19 pneumonia.

We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3⁺CD8⁺ T-cells ≤75 cells·μL^–1 and cardiac troponin I ≥0.05 ng·mL^–1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.

The treatment for obstructive sleep apnoea (OSA) with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs) is associated with blood pressure (BP) reduction; however, the overall effect is modest. The aim of this systematic review and meta-analysis of randomised controlled trials (RCTs) comparing the effect of such treatments on BP was to identify subgroups of patients who respond best to treatment.

The article search was performed in three different databases with specific search terms and selection criteria. From 2289 articles, we included 68 RCTs that compared CPAP or MADs with either passive or active treatment. When all the studies were pooled together, CPAP and MADs were associated with a mean BP reduction of –2.09 (95% CI –2.78– –1.40) mmHg for systolic BP and –1.92 (95% CI –2.40– –1.43) mmHg for diastolic BP and –1.27 (95% CI –2.34– –0.20) mmHg for systolic BP and –1.11 (95% CI –1.82– –0.41) mmHg for diastolic BP, respectively. The subgroups of patients who showed a greater response were those aged <60 years (systolic BP –2.93 mmHg), with uncontrolled BP at baseline (systolic BP –4.14 mmHg) and with severe oxygen desaturations (minimum arterial oxygen saturation measured by pulse oximetry <77%) at baseline (24-h systolic BP –7.57 mmHg).

Although this meta-analysis shows that the expected reduction of BP by CPAP/MADs is modest, it identifies specific characteristics that may predict a pronounced benefit from CPAP in terms of BP control. These findings should be interpreted with caution; however, they are particularly important in identifying potential phenotypes associated with BP reduction in patients treated for OSA.

Single-cross hybrids have been critical to the improvement of maize (Zea mays L.), but the characterization of their genetic architectures remains challenging. Previous studies of hybrid maize have shown the contribution of within-locus complementation effects (dominance) and their differential importance across functional classes of loci. However, they have generally considered panels of limited genetic diversity, and have shown little benefit from genomic prediction based on dominance or functional enrichments. This study investigates the relevance of dominance and functional classes of variants in genomic models for agronomic traits in diverse populations of hybrid maize. We based our analyses on a diverse panel of inbred lines crossed with two testers representative of the major heterotic groups in the U.S. (1106 hybrids), as well as a collection of 24 biparental populations crossed with a single tester (1640 hybrids). We investigated three agronomic traits: days to silking (DTS), plant height (PH), and grain yield (GY). Our results point to the presence of dominance for all traits, but also among-locus complementation (epistasis) for DTS and genotype-by-environment interactions for GY. Consistently, dominance improved genomic prediction for PH only. In addition, we assessed enrichment of genetic effects in classes defined by genic regions (gene annotation), structural features (recombination rate and chromatin openness), and evolutionary features (minor allele frequency and evolutionary constraint). We found support for enrichment in genic regions and subsequent improvement of genomic prediction for all traits. Our results suggest that dominance and gene annotations improve genomic prediction across diverse populations in hybrid maize.

Isoprene has the highest emission into Earth’s atmosphere of any nonmethane hydrocarbon. Atmospheric processing of alkenes, including isoprene, via ozonolysis leads to the formation of zwitterionic reactive intermediates, known as Criegee intermediates (CIs). Direct studies have revealed that reactions involving simple CIs can significantly impact the tropospheric oxidizing capacity, enhance...

Does infant temperament predict adult personality and life-course patterns? To date, there is scant evidence examining relations between child temperament and adult outcomes, and extant research has relied on limited methods for measuring temperament such as maternal report. This prospective longitudinal study followed a cohort of infants (n = 165)...

Scarlet J. Park and William W. Ja

Factors that mediate ethanol preference in Drosophila melanogaster are not well understood. A major confound has been the use of diverse methods to estimate ethanol consumption. We measured fly consumptive ethanol preference on base diets varying in nutrients, taste, and ethanol concentration. Both sexes showed ethanol preference that was abolished on high nutrient concentration diets. Additionally, manipulating total food intake without altering the nutritive value of the base diet or the ethanol concentration was sufficient to evoke or eliminate ethanol preference. Absolute ethanol intake and food volume consumed were stronger predictors of ethanol preference than caloric intake or the dietary caloric content. Our findings suggest that the effect of the base diet on ethanol preference is largely mediated by total consumption associated with the delivery medium, which ultimately determines the level of ethanol intake. We speculate that a physiologically relevant threshold for ethanol intake is essential for preferential ethanol consumption.

Many noncoding RNAs are known to play a role in the cell directly linked to their structure. Structure prediction based on the sole sequence is, however, a challenging task. On the other hand, thanks to the low cost of sequencing technologies, a very large number of homologous sequences are becoming available for many RNA families. In the protein community, the idea of exploiting the covariance of mutations within a family to predict the protein structure using the direct-coupling-analysis (DCA) method has emerged in the last decade. The application of DCA to RNA systems has been limited so far. We here perform an assessment of the DCA method on 17 riboswitch families, comparing it with the commonly used mutual information analysis and with state-of-the-art R-scape covariance method. We also compare different flavors of DCA, including mean-field, pseudolikelihood, and a proposed stochastic procedure (Boltzmann learning) for solving exactly the DCA inverse problem. Boltzmann learning outperforms the other methods in predicting contacts observed in high-resolution crystal structures.

BACKGROUND:Prolonged ventilatory weaning may expose patients to unnecessary discomfort, increase the risk of complications, and raise the costs of hospital treatment. In this scenario, indexes that reliably predict successful liberation can be helpful.OBJECTIVE:To evaluate the intra- and interobserver reproducibility of the timed inspiratory effort index as a weaning predictor.METHODS:This prospective observational study included subjects judged as able to start liberation from mechanical ventilation. For the intra-observer analysis, the same investigator performed 2 measurements in each selected patient with an interval of 30 min a rest. For interobserver analysis, 2 measurements were obtained in another sample of subjects, also with an interval of 30 min rest, but each of one performed by a different investigator. The Bland-Altman diagram, the coefficient concordance of kappa, and the Pearson correlation coefficient were used to compare the measurements. The performance of the timed inspiratory effort index was assessed by receiver operating characteristic curves. Values of P < .05 were considered significant.RESULTS:We selected 113 subjects (43 males; mean ± SD age, 77 ± 14 y). Fifty-six (49.6%) achieved successful liberation, and 33 (29%) died in the ICU. The mean ± SD duration of mechanical ventilation was 14.4 ± 6.7 d. The Bland-Altman diagrams that addressed intra- and interobservers agreement showed low variability between measurements. Values of the concordance coefficients of kappa were 0.82 (0.68–0.95) and 0.80 (0.65–0.94), and of the linear correlation coefficients, 0.86 (0.77–0.91) and 0.89 (0.82–0.93) for the intra- and interobservers measurements, respectively. The mean ± SD values for the area under the curve for each pair of the intra- and interobserver measurements were 0.96 ± 0.07 versus 0.94 ± 0.07 (P = .41) and 0.94 ± 0.05 versus 0.90 ± 0.07 (P = .14), respectively.CONCLUSIONS:The variability of the measurement of the timed inspiratory effort index by intra- and interobservers showed very high reproducibility, which reinforced the index as a sensible, accurate, and reliable outcome predictor of liberation from mechanical ventilation.