The Global pandemic Covid 19, the outbreak of which started last year, has disrupted lives and brought the world to a standstill. On April 24, globally, the COVID-19 cases exceeded 2.7 million. India recorded 1,752 fresh Covid 19 cases in the

V Ravichandran's younger son, Vikram is currently busy working on his highly awaited debut film, Trivikrama. For the unversed, the film team was all set to head to Australia on April 14 for their final shoot schedule. However, due to the

Tamil filmmaker PK Raj Mohan reportedly passed away at the age of 47 due to cardiac arrest in Chennai. The director, who had made films like Kedayam and Azhaipithazh, was living alone in KK Nagar, Chennai. As per the report published

Nayanthara, the lady superstar is all set to play a goddess for the first time in her career in the upcoming movie Mookuthi Amman. The movie, which is touted to be a satirical comedy, is currently under the post-production stage. Recently,

Inflammatory bowel disease (IBD) represents a group of intestinal disorders that cause chronic inflammation of the digestive tract [1]. The digestive tract, which comprises the mouth, oesophagus, stomach, small intestine, and large intestine, is responsible for breaking down food, extracting the

Archives, Room Use Only - UG605.F8 F73 1917

Archives, Room Use Only - TK5741.R73 1911

Archives, Room Use Only - UG582.V5 R63 1886

Archives, Room Use Only - RC429.G74 1911

Archives, Room Use Only - UG605.F8 F7313 1917

Archives, Room Use Only - UG605.F8 F73 1924

The same object that dazzled skygazers in 1054 C.E. continues to dazzle astronomers today by pumping out radiation at higher energies than anyone expected.

The post Crab pulsar dazzles astronomers with its gamma-ray beams appeared first on Smithsonian Insider.

The newfound jets may be related to mysterious gamma-ray bubbles that Fermi detected in 2010. Those bubbles also stretch 27,000 light-years from the center of the Milky Way.

The post Ghostly gamma-ray beams blast from Milky Way’s center appeared first on Smithsonian Insider.

A rare Longman’s beaked whale found stranded on the Hawaiian island of Maui in 2010 has scientists in Hawaii on the alert for a deadly disease known as morbillivirus which can lead to high mortality rates in dolphins and other marine mammals.

The post Rare whale beached in Hawaii infected with deadly marine-mammal virus appeared first on Smithsonian Insider.

Save the Rhinos! Save the Elephants! Save the humans?! It seems strange to be connecting our own fate to that of wildlife but new research […]

The post Losing large mammals increases human risk from rodent-borne diseases appeared first on Smithsonian Insider.

When some of the world’s largest mammals come your way, most animals steer clear. Not the genet. The small cat-like carnivore was captured on film […]

The post Maybe it’s safer riding a rhino. Genet expert poses new ideas on the mammal’s hitchhiking behavior appeared first on Smithsonian Insider.

In April 2015, after traveling for about half the age of the universe, a flood of powerful gamma rays from a distant galaxy slammed into […]

The post VERITAS Detects Gamma Rays from Galaxy Halfway Across the Visible Universe appeared first on Smithsonian Insider.

One of Earth’s most evolutionarily unique species is also the world’s most trafficked mammal: pangolins, or “scaly anteaters.” A new study from the Smithsonian Conservation […]

The post Using genetics to help save world’s most trafficked mammal: the pangolin appeared first on Smithsonian Insider.

Laurence Haren, Dorian Farache, Laurent Emorine, and Andreas Merdes

-tubulin is a major protein involved in the nucleation of microtubules in all eukaryotes. It forms two different complexes with proteins of the GCP family (gamma-tubulin complex proteins): -tubulin small complexes (TuSCs), containing -tubulin and GCPs 2 and 3, and -tubulin ring complexes (TuRCs), containing multiple TuSCs, in addition to GCPs 4, 5, and 6. Whereas the structure and assembly properties of TuSCs have been intensively studied, little is known about the assembly of TuRCs, and about the specific roles of GCPs 4, 5, and 6. Here, we demonstrate that two copies of GCP4 and one copy each of GCP5 and GCP6 form a salt-resistant sub-complex within the TuRC that assembles independently of the presence of TuSCs. Incubation of this sub-complex with cytoplasmic extracts containing TuSCs leads to the reconstitution of TuRCs that are competent to nucleate microtubules. In addition, we investigate sequence extensions and insertions that are specifically found at the amino-terminus of GCP6, and between the GCP6 grip1 and grip2 motifs, and we demonstrate that these are involved in the assembly or stabilization of the TuRC.

A 3-D rendering of the Apollo 11 Command Module with a view inside the hatch. The seats inside are where astronauts Neil Armstrong, Buzz Aldrin […]

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In this study, the atomic structure of the ternary icosahedral ZnMgTm quasicrystal (QC) is investigated by means of single-crystal X-ray diffraction. The structure is found to be a member of the Bergman QC family, frequently found in Zn–Mg–rare-earth systems. The ab initio structure solution was obtained by the use of the Superflip software. The infinite structure model was founded on the atomic decoration of two golden rhombohedra, with an edge length of 21.7 Å, constituting the Ammann–Kramer–Neri tiling. The refined structure converged well with the experimental diffraction diagram, with the crystallographic R factor equal to 9.8%. The Bergman clusters were found to be bonded by four possible linkages. Only two linkages, b and c, are detected in approximant crystals and are employed to model the icosahedral QCs in the cluster approach known for the CdYb Tsai-type QC. Additional short b and a linkages are found in this study. Short interatomic distances are not generated by those linkages due to the systematic absence of atoms and the formation of split atomic positions. The presence of four linkages allows the structure to be pictured as a complete covering by rhombic triacontahedral clusters and consequently there is no need to define the interstitial part of the structure (i.e. that outside the cluster). The 6D embedding of the solved structure is discussed for the final verification of the model.

The post Roland Kays, curator of mammals at the New York State Museum, discusses a new Smithsonian Website for sharing camera-trap images of wild animals appeared first on Smithsonian Insider.

To mark the 47th anniversary of the Apollo 11 moon-landing mission, the Smithsonian has made available a high-resolution 3-D scan of the command module “Columbia,” […]

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Meet Amy Homma, the Director of Digital Learning at Art Lab+. Learn how Smithsonian’s Hirshhorn Museum and Sculpture Garden has created a dynamic program to […]

The post An Active Environment With Smithsonian Educator: Amy Homma appeared first on Smithsonian Insider.

 When Emma Lawton was 29 she was diagnosed with Parkinson’s disease. As a graphic designer, drawing is a huge part of her life but […]

The post Emma Watch & Parkinson’s disease appeared first on Smithsonian Insider.

Scientists have long known that in the tropics shade-grown coffee plantations provide critical habitat for migratory and resident birds. Now a new survey conducted in […]

The post Shade-grown coffee plantations are mammal friendly as well, study shows appeared first on Smithsonian Insider.

By charting the slopes and crags on animals’ teeth as if they were mountain ranges, scientists at the Smithsonian’s National Museum of Natural History have […]

The post 3D study of teeth in modern mammals opens window to extinct animal diets appeared first on Smithsonian Insider.

Finding a mouse in your morning coffee might give you an unwelcome jolt, but there’s a strong connection between small mammals, birds and the plantations […]

The post Of mice and macchiato: Bird Friendly coffee gives a paw-up to small mammals as well appeared first on Smithsonian Insider.

Rising levels of noise in the ocean have been identified as a growing concern for the well-being of marine mammals, but other threats such as pollution, climate change, and prey depletion by fisheries may also harm marine mammals and influence their response to additional noise.

The National Academies Keck Futures Initiative (NAKFI) is pleased to announce the publication of Collaborations of Consequence - NAKFI’s 15 Years of Igniting Innovation at the Intersections of Disciplines.

A new publication from the U.S. National Academies of Sciences, Engineering, and Medicine, provides a brief summary of presentations and discussions at the Second International Summit on Human Genome Editing, held in Hong Kong on Nov. 27-29, 2018.

From N-95 masks that are protecting health care workers during the COVID-19 pandemic to food packaging found in every aisle of the grocery store, plastics play an essential role in our lives.

The serious inflammatory syndrome sending some children and teens to the hospital remains extremely uncommon, doctors say. But if your child spikes a high, persistent fever, and has severe abdominal pain and vomiting that doesn't make them feel better, call your doctor as a precaution.; Credit: Sally Anscombe/Getty Images

Sixty-four children and teens in New York State are suspected of having a mysterious inflammatory syndrome that is believed to be linked to COVID-19, the New York Department of Health said in an alert issued Wednesday. A growing number of similar cases — including at least one death — have been reported in other parts of the U.S. and Europe, though the phenomenon is still not well-understood.

Pediatricians say parents should not panic; the condition remains extremely rare. But researchers also are taking a close look at this emerging syndrome, and say parents should be on the lookout for symptoms in their kids that might warrant a quick call to the doctor — a persistent high fever over several days and significant abdominal pains with repeated vomiting, after which the child does not feel better.

"If [the child is] looking particularly ill, you should definitely call the doctor," says Dr. Sean O'Leary, a pediatric infectious disease specialist at Children's Hospital Colorado Anschutz Medical Campus and member of the infectious disease committee for the American Academy of Pediatrics.

The new condition associated with COVID-19 is called Pediatric Multi-System Inflammatory Syndrome. Symptoms include persistent fever, extreme inflammation, and evidence of one or more organs that are not functioning properly, says cardiologist Jane Newburger, a professor of pediatrics at Harvard Medical School and director of the Kawasaki Program at Boston Children's Hospital.

"It's still very rare, but there's been a wave of cases. Physicians and scientists are working hard to understanding the mechanisms at play, and why only some children are so severely affected," Newburger says.

Some symptoms can resemble features of Kawasaki Disease Shock Syndrome. Kawasaki Disease is an acute illness in children involving fever, together with symptoms of rash, conjunctivitis, redness in the lips, tongue and mucous membranes of the mouth and throat, swollen hands and/or feet, and sometimes a large group of lymph nodes on one side of the neck, says Newburger. Some children with the condition develop enlargement of the coronary arteries and aneurysms in those blood vessels.

A small percentage of Kawasaki cases go on to develop symptoms of shock – which can include a steep drop in systolic blood pressure and difficulty with sufficient blood supply to the body's organs. Kawasaki disease and KDSS more often affect young children, although they can sometimes affect teens, Newburger says.

Some cases of the new inflammatory syndrome have features that overlap with KD or with KDSS — including rash, conjunctivitis, and swollen hands or feet. The new inflammatory syndrome can affect not only young children but also older children and teens.

But patients with the new syndrome have lab results that look very different, in particular, "cardiac inflammation to a greater degree than we typically see in Kawasaki shock syndrome," which is usually very rare, O'Leary says. In New York City and London, which have seen large numbers of cases of COVID-19 cases, "those types of patients are being seen with greater frequency."

Some patients "come in very, very sick," with low blood pressure and high fever, O'Leary says. Some children have had coronary artery aneurysms, though most have not, he adds.

Other patients exhibit symptoms more similar to toxic shock syndrome, with abdominal pain, vomiting and diarrhea and high levels of inflammation in the body, as well as the heart, O'Leary says. Most cases are treated in the intensive care unit, he says. Treatment includes intravenous immunoglobulin, which can "calm the immune system," says Newburger, as well as steroids and cytokine blockers.

The evidence so far from Europe, where reports of the syndrome first emerged, suggests most children will recover with proper supportive care, says O'Leary, though one adolescent, a 14-year-old boy in London, has died, according to a report published Wednesday in The Lancet.

Most children with the syndrome, O'Leary and Newburger note, have either tested positive for a current infection with the coronavirus, or for antibodies to the virus, which would suggest they were infected earlier and recovered from it.

And, according to case reports, some of the kids with the inflammatory syndrome who tested negative on coronavirus tests had been exposed at some point to someone known to have COVID-19. The inflammatory syndrome can appear days to weeks after COVID-19 illness, doctors say, suggesting the syndrome arises out of the immune system's response to the virus.

"One theory is that as one begins to make antibodies to SARS-COV-2, the antibody itself may be provoking an immune response," says Newburger. "This is only happening in susceptible individuals whose immune systems are built in a particular way. It doesn't happen in everybody. It's still a really uncommon event in children."

In late April, the U.K.'s National Health Service issued an alert to pediatricians about the syndrome. Reports have also surfaced in France, Spain and Italy, and probably number in the dozens globally, Newburger and O'Leary say, though doctors still don't have hard numbers. Newburger says there needs to be a registry where doctors can report cases "so we can begin to generate some statistics."

"Doctors across countries are talking to each other, but we need for there to be some structure and some science so that everybody can interpret," she says.

Earlier this week, the New York City Health Department issued an alert saying 15 children ranging in age from 2 to 15 had been hospitalized with the syndrome. Newburger says that she's been contacted about cases in New Jersey and Philadelphia, as well.

While the syndrome's precise connection to the coronavirus isn't yet clear, O'Leary says the fact that the children in most of these cases are testing positive for exposure to the virus, one way or another, provides one point of evidence. The sheer number of cases — small in absolute terms, but still "much higher than we would expect normally for things like severe Kawasaki or toxic shock syndrome" — provides another, he says.

And then there's the fact that most reports of the syndrome have come out of the U.K. and New York City, places that have been hit with large numbers of COVID-19 cases.

"It's pure speculation at this point," he says, "but the U.K. cluster kind of went up about a month after their COVID-19 infections went up, which would suggest that it is some kind of an immune phenomenon."

This content is from Southern California Public Radio. View the original story at SCPR.org.

The rapid decline of Arctic sea ice has had dramatic effects on seals, polar bears, whales and other marine mammals. Changes in distribution, body condition, reproduction and abundance are all consequences of reduced sea ice that may escalate over the coming decade, according to a recent analysis.

Small mammals clearly benefit from a UK agri-environment scheme (AES), a recent study concludes. Numbers and diversity of voles, shrews and mice were found to increase on and around farmland with 6 m wide field margins and patches of semi-natural habitat - features encouraged under the government-led AES.

Eradication of invasive mammal species is a strategy used to help conserve biodiversity on islands and restore populations of native species. Researchers have now assessed the success of this strategy globally, highlighting the importance of controlling invasive species to protect biodiversity on islands and achieve global conservation targets.

A new approach to modelling the spread of mammal populations under climate change has been developed. The method overcomes the problem of missing ecological data for most species by using information on species characteristics, or ‘traits’, associated with population demographic rates and individual movements to deduce which species move too slowly to escape climate change’s effects on their habitat. The model’s results suggest that around 30% of mammal species may not be able to disperse quickly enough to survive.