Allu Arjun's Butta Bomma from Ala Vaikunthapuramuloo is riding high on success, as it trends on various platforms like TikTok, since its release. The current sensation of the town has got all the attention it needed, thanks to its catchy lyrics

Filmmaker Ram Gopal Varma, who is known for posting controversial tweets, recently made yet another sexist comment on women. On Friday, RGV shared a photo, in which two women are sitting inside a car. The one sitting on the front seat

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

The exponential growth of international travel since the 1960s has left border management systems worldwide struggling to keep up and has exposed weaknesses in states’ abilities to effectively manage their borders, especially regarding terrorist attacks, human trafficking, and illegal migration.

New research reveals the secret behind the remarkable intelligence of some bird species

Related: Blind cave fish evolved a shrunken brain to save energy

Calling someone “bird brain” used to be considered as an insult. Birds’ brains are very small compared to those of mammals, and what’s more, they lack the heavily wrinkled cerebral cortex, which is characteristic of the human brain, and widely believed to the seat of intelligence. It was, therefore, widely assumed that birds aren’t very clever creatures, but recently this has started to change.

Related: Ravens cooperate with friends not foes

Various Pastors joined OM El Salvador on an outreach to Honduras, obeying the Lords command to make disciples.

The Central Government on 2nd April 2020 launched a digital mobile app, namely Aarogya Setu. The name is made up of two Sanskrit words. If loosely translated, it means ‘Health Bridge’ or ‘bridge to being healthy’.

Cadence Encounter® Test uses breakthrough timing-aware and power-aware technologies to enable customers to manufacture higher quality, power-efficient silicon faster and at lower cost. Encounter Diagnostics identifies critical yield-limiting issues and...(read more)

Some Linksys E-Series Routers are vulnerable to an unauthenticated OS command injection. This vulnerability was used from the so called "TheMoon" worm. There are many Linksys systems that might be vulnerable including E4200, E3200, E3000, E2500, E2100L, E2000, E1550, E1500, E1200, E1000, E900. This Metasploit module was tested successfully against an E1500 v1.0.5.

This Metasploit module exploits a command injection vulnerability on WiFi Pineapples versions 2.0 and below and pineapple versions prior to 2.4. We use a combination of default credentials with a weakness in the anti-csrf generation to achieve command injection on fresh pineapple devices prior to configuration. Additionally if default credentials fail, you can enable a brute force solver for the proof-of-ownership challenge. This will reset the password to a known password if successful and may interrupt the user experience. These devices may typically be identified by their SSID beacons of 'Pineapple5_....'; details derived from the TospoVirus, a WiFi Pineapple infecting worm.

Kwara state police command was on Saturday intercepted a lorry fully loaded with over 200 young people of Hausa/Fulani extract at the kwara/Niger state border express road said to be coming from Katsina State. The intercepted young people, suspected to be Almajiris was said to be cutoff by the kwara state police command at Kanbi/Oloru […]

The post Inter state travel ban: Kwara police command intercepts lorry with over 200 Almajiris suspects appeared first on Nigerian Pilot News.

The epitome of unconsummated marriage is silence. The couple is in most cases embarrassed and does not tell what they are going through to anyone.

Wedding bells?! Here's a new celebrity theory making the internet rounds: fans are convinced that Emma Stone is already married to Saturday Night Live writer, Dave...

Emma Stone (31) has left people convinced that she’s secretly married her beau, Dave McCary(34) after she was spotted wearing what appears to be a wedding band. The pair have been dating for three years and were reportedly forced to cancel their wedding date due to the coronavirus pandemic. Some are convinced the “La La […]

The post Did Emma Stone And Dave McCary Tie The Knot? appeared first on Chart Attack.

Wedding bells?! Here's a new celebrity theory making the internet rounds: fans are convinced that Emma Stone is already married to Saturday Night Live writer, Dave...

Gemma Atkinson stunned fans on Saturday after she shared a topless photo of herself...

Mission ‘Get Mike Tyson to Australia’ is on.

Here’s one anecdote you won’t be seeing in the final four instalments of “The Last Dance.”

George Foreman has revealed that Muhammad Ali once admitted to him that he didn’t believe he could have beaten prime Mike Tyson.

Champion forward Wayne Carey has revealed the time he twice turned down meeting boxing legend Muhammad Ali.

The AFL is moving closer to revealing its return to play policy.

There were no fans present but plenty of masks and sanitiser, as UFC got back underway after the coronavirus shutdown with a behind-closed-doors event in Florida.

Wedding bells?! Here's a new celebrity theory making the internet rounds: fans are convinced that Emma Stone is already married to Saturday Night Live writer, Dave...

While people across the country have been spending a lot of time at home owing to the lockdown, superstar Shah Rukh Khan on Saturday provided a unique platform for all the aspiring filmmakers to produce some 'fun, creative and... spooky' video. The 54-year-old actor shared a statement on Instagram, detailing about the opportunity for the filmmakers to channel their inner "filmmaking ghost to make a scary indoor film with an element of horror in it."

Taking it to the captions, the 'Don' actor wrote: "Since we've all got a bit of time on our hands in quarantine, thought I can get us all to work a bit... in a fun, creative and... spooky way!" In the post, titled with a hashtag 'SpookSRK,' the actor has listed down the rules to be followed while making the video and shared the email link to submit their work.

 

 

 

View this post on Instagram

Since we’ve all got a bit of time on our hands in quarantine, thought I can get us all to work a bit... in a fun, creative and... spooky way! #SpookSRK Read on for more details.

A post shared by Shah Rukh Khan (@iamsrk) onMay 9, 2020 at 5:21am PDT

The 'Dilwale' actor also announced that the selected "three winners" will get a chance to video call the star himself.

Wrapping the post on a lighter note, he added: "I will be sending in my film as well...P.S - Ghosts are welcome to send their entries too."

This comes a day after the first trailer launch of Shah Rukh's new Netflix horror series 'Betaal'.

SRK's Red Chillies Entertainment is producing the horror-thriller. The new series also stars Vineet Kumar, Aahana Kumra, Suchitra Pillai, Jitendra Joshi, Manjiri Pupala, and Syna Anand.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

As the nation celebrates the indomitable spirit of motherhood on Sunday, Bollywood celebrities also dedicated heart-warming messages to their mom's on the occasion of Mother's Day."

Sara Ali Khan shared a heart-melting throwback picture where she is seen as an infant in the arms of her grandmother while her mother is looking at baby Sara in a moment of affection. The actor captioned the post as, "Meri Maa ki Maa. Thank you for creating Mommy. #HappyMothersDay."

 

 

 

View this post on Instagram

Meri Maa ki Maa 💁🏻‍♀ï¸ÂðŸ¤°ðŸ¤±ðŸ»ðŸ™‡ðŸ»‍♀ï¸Â Thank you for creating Mommy 💝🙏🏻👩‍👧‍👧🐣🐥🐤 #HappyMothersDay

A post shared by Sara Ali Khan (@saraalikhan95) onMay 9, 2020 at 11:45am PDT

Vicky Kaushal put out a childhood throwback picture on Instagram where the actor is seen caught in a moment of mischief as he jogs at the shore of a beach, while his mother is seen scolding him. Along with the picture Vicky wrote," Dodging them till date. Keep them coming Maa. Love you! 

 

 

 

View this post on Instagram

Dodging them till date. Keep them coming Maa. Love you! ❤ï¸Â

A post shared by Vicky Kaushal (@vickykaushal09) onMay 9, 2020 at 5:40pm PDT

Ananya Panday shared an adorable video from her childhood days where she is seen sporting a while kurta-churidar with a red dotted dupatta. The video initiates with a question by a person behind the camera who asks, "Whom do you love the most in the world?"

 

 

 

View this post on Instagram

it’s clear where I get my crazy from 😜 happy Mama’s day to my Mama and all the beautiful mama’s out there ❤ï¸Â

A post shared by Ananya 💛💫 (@ananyapanday) onMay 9, 2020 at 12:15pm PDT

To which baby Ananya innocently replies, "Mama."

And he asks, "And the second?"

She smilingly replies, "Nobody."

 

 

 

View this post on Instagram

The answer is still the same 😜 love u @bhavanapandey ❤ï¸Â

A post shared by Ananya 💛💫 (@ananyapanday) onMay 9, 2020 at 12:16pm PDT

Along with the caption she wrote, "The answer is still the same. love u @bhavanapandey."

Recalling his childhood moments spent with her mom, Ishaan Khatter shared a couple of throwback pictures with his mom in an Instagram post.

 

 

 

View this post on Instagram

Mom for president ✌🏼

A post shared by Ishaan (@ishaankhatter) onMay 9, 2020 at 1:16pm PDT

The special post featured 3 pictures of which the first one shows baby Ishaan lying in bed while his mother is seen pecking a kiss on his little arms. The second one shows his mom in a glamorous monochromatic picture, and the third one shows baby Ishaan in his childhood days, where he is seen sitting in his mother's lap and passing a smile at the camera.Along with the post he wrote, "Mom for president."

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Gu10 LED bulbs are available in either warm white or cool white and a different variety of beam angles; for softer focus lighting (rooms such as the bedroom, living room, or dining room) opt for a wider angle beam, however if you feel...

OECD recommands to France to modernise and better govern labour migration

Consumers only occasionally choose to buy sustainable products. At the same time these consumers say in surveys that sustainability is important to them, and that the government should promote sustainable consumption. This study takes a closer look at public support for sustainable consumption and the associated dilemmas, with the help of a behavioural economics experiment of group decisions.

This document outlines basic background information on release estimation techniques (RETs) for point sources and provides resources on available RETs of different national/regional Pollutant Release and Transfer Register systems. It was originally published in 2002, and has been updated to reflect new and additional information.

1. Rare inflammatory syndrome linked to Covid-19 kills 3 kids in New York, says governor Andrew Cuomo  Hindustan Times
2. Children infected with COVID-19 are developing new symptoms similar to Kawasaki disease  WION
3. COVID-19: Cases surpass 4 million worldwide, New York children die from related inflammation  CGTN
4. New York looking further into emerging COVID-19 issue affecting children  The Daily News Online
5. 'Every parent's nightmare': New York is investigating the death of a 5-year-old child from an illness linked t  Business Insider India
6. View Full coverage on Google News

Three children in New York have died and 73 more cases have been reported of a rare inflammatory syndrome exhibiting symptoms similar to Kawasaki disease or toxic shock-like syndrome.

1. Bundu Khan S/o Shri Abdul Gani R/o Meer Colony Kekri Road Near Idhgah Malpura Thana Dist. Tonk At Present Tenant House No 24 Chmnawadi Sanjay Nagar Jhotwara Jaipur (At Present Accused Confined In Central Jail Jaipur)

2. Mohammad Kalim S/o Shri Mohammad Aladdin Khan R/o Bada Mohalla Lalsot Dist.

For Respondent No.2/State: Mr. Anvesh Shrivastava, Panel Lawyer.

Law laid down Suit for specific performance of contract- readiness and willingness for a seeking decree of performance of contract, the plaintiff is required to produce strong documentary evidence relating to his financial condition- only oral evidence in respect of financial condition to establish readiness and willingness is not sufficient- The Court cannot assume or presume the financial status of the plaintiff only on the basis of oral evidence- The suit of specific performance of contract cannot be decreed in favour of the plaintiff unless readiness and willingness to perform his part of the contract is proved by the plaintiff.

It has been pointed out that allegations against the petitioner are to the effect that he had painted the vehicle and fictitious number plates. It has been arguedby learned counsel for the petitioner that co- accused namely Raja who was arrested from the spot has been granted regular bail and Ajay Kumar co-accused has been granted pre-arrest bail by this Court. The custodial interrogation of the petitioner is over and he has been remanded to judicial custody. Investigation of the case is complete. The offences are triable by Judicial Magistrate First Class.

1 of 2 ::: Downloaded on - 08-05-2020 21:20:13 ::: Challan has already been presented in the Court. Petitioner has been sought to be implicated on the basis of the disclosure statement of the co- accused.

Griff Rhys Jones needs to be on stage. 'I love, love, love being funny in front of an audience,' he says. 'I adore it.'

The former Arsenal, Manchester City and Tottenham striker left the South American nation - where he is currently playing his football - to return to his homeland but got held up in Cotonou.

Wilfried Zaha says it is nice to see former Crystal Palace team-mate Aaron Wan-Bissaka getting recognised on the world stage since his move to Manchester United. 

2. The petitioner in Crl.P.NO.101035/2019 is accused No.1 in C.C.No.796/2018. The petitioner is :4: represented in this court as the Branch Manager, ICICI Bank Limited.

3. The petitioner in Crl.P.No.100295/2019 is accused No.1 and accused No.3 and 5 in Crl.P.No.101035/2019 in C.C.No.796/2018.

4. The facts of the matter as per the petitioners in both the matters are as under:

4.1. It is stated that respondent No.1 Sri. Shashikant S. Timmapur had availed a loan of Rs.18,50,000/- in the year 2006 from ICICI Bank Limited ( 'the Bank' for short) by pledging various shares which he held in certain listed companies.

Justin Gaethje tormented Tony Ferguson at UFC 249 on Saturday.Fighting in front of a reduced UFC production crew and no fans, Gaethje put together the best MMA win of the year so far.Gaethje relied on in-and-out footwork, leg kicks, and striking so accurate and powerful that he brutalized his opponent's thighs and tore his face apart.Gaethje now only has one opponent he wants to wage war against — lightweight champ Khabib Nurmagomedov. "I'm happy to represent the United States of America against Dagestan … Russia's best."Visit Insider's homepage for more stories.Justin Gaethje tortured Tony Ferguson at UFC 249 on Saturday, bringing an abrupt end to one of the most intimidating runs in mixed martial arts.Ferguson had been on a 12-fight winning streak which created one half of a salivating match-up

By virtue of order dated 29th January, 2020, it was made clear that if the matter was not argued on next date of hearing the interim directions issued would stand vacated.

Today yet again Mr. Haqani is not present and a request is made for adjournment.

SHAMEEM HAMID MIR 2020.03.24 12:43 I attest to the accuracy and integrity of this document

--2--

Request as made is rejected. The interim direction in all the three cases i.e. SWP No.2002/20132, SWP No.844/2012 and SWP No.2151/2011 are vacated.

List again on 27th May, 2020.

(Dhiraj Singh Thakur) Judge Srinagar:

How could someone not known to her at all prove and establish her identity, while at the same time no one in her own village was authorised to do so? R Balasubramaniam begins a series of Voices from the Grassroots.

Nanjamma, the 60-year-old singer-actor, who shot to fame with her soulful songs in Prithviraj Sukumaran and Biju Menon-starrer Ayyappanum Koshiyum, has proved that age is no bar for creativity. The enthusiastic singer is still ruling everyone's hearts and has now decided