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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift

Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads.




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Reflections on Practice : Therapeutic Communication / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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Reflections on Practice : Therapeutic Communication / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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Therapists for the mind

Psychology, a field with critical shortage of experts in India as well as all over the world, offers numerous specialisations to choose from.




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An art showcase in Hyderabad heralds the power of Gandhi as a global icon in a pre-digital era

Give Peace Another Chance, artist Adarsh Baji’s series on view at Kalakriti art gallery in Hyderabad, doffs its hat to the life, times and ideology of Mahatma Gandhi ahead of his 154th birth anniversary




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Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights

RSC Adv., 2024, 14,35769-35970
DOI: 10.1039/D4RA06290F, Review Article
Open Access
Nafeesa Naeem, Amina Sadiq, Gehan Ahmed Othman, Habab M. Yassin, Ehsan Ullah Mughal
Heterocyclic compounds represent a prominent class of molecules with diverse pharmacological activities.
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Recent advances in discrete Cu complexes for enhanced chemodynamic therapy

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02380C, Frontier
Zhao-Guo Hong, Liangliang Zhang, Hong Liang, Fu-Ping Huang
Since the concept of metal ion stimulation-mediated chemodynamic therapy was proposed by Bu and Shi 's group in 2016, increasing attention has been directed toward fabricate efficient, safe and stable...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rhenium(I) and technetium(I) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02714K, Paper
Ana Cristina Resende Gonçalves, Silvia Helena Libardi, Júlio Cesar Borges, Ronaldo Junio de Oliveira, Carla Gotzmann, Olivier Blacque, Sergio Albuquerque, Carla Duque Lopes, Roger Alberto, Pedro Ivo da Silva Maia
The diagnosis and treatment of Chagas disease (CD) in the chronic phase remains a challenge. With that in mind, a potential theranostic device based on the trypanocidal agent known as...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Multi-functional biotinylated platinum(IV)–SAHA conjugate for tumor-targeted chemotherapy

Dalton Trans., 2024, 53,17829-17840
DOI: 10.1039/D4DT01571A, Paper
Ajay Gupta, Pijus K. Sasmal
Herein, we have developed a hydrolytically stable biotinylated Pt(IV) complex conjugated with a histone deacetylase inhibitor (SAHA) as a multi-functional tumour targeted chemotherapeutic agent.
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An acidity-triggered aggregation nanoplatform based on degradable mesoporous organosilica nanoparticles for precise drug delivery and phototherapy of focal bacterial infection

Dalton Trans., 2024, 53,17893-17901
DOI: 10.1039/D4DT02111H, Paper
Yunhan Huang, Wei Guo, Xinyu Wang, Jingrui Chang, Bo Lu
An acidity-triggered aggregation antibacterial nanoplatform based on biodegradable mesoporous organic silica nanoparticles, is reported. It enables precise drug release and spatial accuracy for photodynamic therapy and photothermal therapy.
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Alleviating hypoxia by integrating MnO2 with metal-organic frameworks coated upconversion nanocomposites for enhanced photodynamic therapy in vitro

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02605E, Paper
Junxun Zhou, Mengyue Jiang, Qiangqiang Zhang, Yuan Jiang, Haifang Wang, Lining Sun
Photodynamic therapy (PDT) requires the participation of abundant oxygen while the hypoxic tumor microenvironment limits the efficacy of PDT. Here, upconversion luminescent nanocomposites coated with metal-organic frameworks (MOFs) were synthesized...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enhancing radiotherapy with MRI

Bas Raaymakers describes how MRI can help target tumours with improved accuracy




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Tracking proton therapy with acoustic waves

Katia Parodi describes an innovative technique for improving ion-beam therapy




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Circuit breaking [electronic resource] : using neuroscience-informed psychotherapy to treat psychoactive substance abuse / Robert Youdin.

New York, NY : Oxford University Press , 2024.




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Handbook of art therapy [electronic resource] / edited by Cathy A. Malchiodi.

New York : Guilford Press, 2012.




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Integrated motivational interviewing and cognitive behavioral therapy (ICBT) [electronic resource] : a practitioners guide / Joseph Hyde, Maria Torres, Win Turner, R. Lyle Cooper.

Hoboken, New Jersey : John Wiley & Sons, Inc., [2024]




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Schema-focused working methods for arts and body-based therapies [electronic resource] : a practical guide / edited by Suzanne Haeyen.

New York, NY : Routledge , 2024.




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Solution-focused brief therapy with clients managing trauma [electronic resource] / Adam Froerer, Jacqui von Cziffra-Bergs, Johnny Kim, Elliott Connie.

New York, NY : Oxford University Press , 2018.




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The neuroscience of psychotherapy [electronic resource] : healing the social brain / Louis J. Cozolino

[New York] : W. W. Norton & Company, Incorporated, 2024.




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Nature therapy [electronic resource] / edited by Yonatan Kaplan, Petros Levounis.

Washington, DC : American Psychiatric Association Publishing, [2025]




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Hospital in Coimbatore introduces machine for advanced radiation therapy




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Along the gut-bone marrow signaling pathway: use of longan polysaccharides to regenerate blood cells after chemotherapy-induced myelosuppression

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03758H, Paper
Shiai Zeng, Lan Gao, Kai Wang, Xuwei Liu, Zhuoyan Hu, Lei Zhao
TLPL promoted the production of Lactobacillus in myelosuppressed mice, and promoted the haematopoiesis of bone marrow cells via the gut-bone marrow axis.
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Polyphenols for stroke therapy: the role of oxidative stress regulation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO01900H, Review Article
Yusong Luo, Ruolan Liu, Guoqiang Yuan, Yawen Pan
Molecular mechanisms of the antioxidant effects of polyphenols in stroke.
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New rocket, plus moon and Venus missions, herald new beginnings

‘India in Space’ is a monthly column collecting and analysing developments in the country’s space, spaceflight, and allied sectors




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Unlocking new possibilities: application of MXenes in 3D bioprinting for advanced therapy

Nanoscale, 2024, 16,20037-20047
DOI: 10.1039/D4NR02906B, Minireview
Yusuf Olatunji Waidi, Nipun Jain
This article presents MXenes' potential in 3D bioprinting, discussing their benefits for bio-printed scaffolds, 3D bioprinting techniques, bio-ink criteria, applications of MXene-incorporated constructs, current challenges, and future directions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer

Nanoscale, 2024, 16,20354-20355
DOI: 10.1039/D4NR90194K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ziwei Li, Fan Yang, Di Wu, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu, Leyong Zeng
The content of this RSS Feed (c) The Royal Society of Chemistry




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Glycosylated AIE-active Fe (III) photosensitizer activated by tumor microenvironment for synergistic type I photodynamic and chemodynamic therapy

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03871A, Paper
Gai-li Feng, Wei Zhou, Jinping Qiao, Guang-Jian Liu, Guo-Wen Xing
Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are both promising cancer treatments to inhibit tumor cells by generating highly cytotoxic reactive oxygen species (ROS). Herein, we report a novel tumor...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Applications of nanotheranostics in the second near-infrared window in bioimaging and cancer treatment

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03058C, Review Article
Huimin Li, Pengju Li, Jiarui Zhang, Ziyi Lin, Lintao Bai, Heyun Shen
This review summarized the application of the second near-infrared nano-platform in the field of nano-agents design, optical imaging and cancer treatment, aiming at providing profound insights into its development status and future challenges.
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DON encapsulated carbon dot–vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR00426D, Paper
Afreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh, Prasanta Kumar Das
HACD–TMAV, a carbon dot–vesicle conjugate, selectively delivered glutamine inhibitor DON to CD44-enriched cancer cells, inducing ROS triggered apoptosis by dual targeting CD44 and SLC1A5 through downregulation of PI3K/AKT/mTOR signalling cascade.
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Aptamer-functionalized Nucleic Acid Nanotechnology for Biosensing, Bioimaging and Cancer Therapy

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR04360J, Review Article
Xiaofang Zheng, Zhiyong Huang, Qiang Zhang, Guoli Li, Minghui Song, Ruizi Peng
Nucleic acids have enabled to fabricate self-assemblies and perform dynamic operations. Among different functional nucleic acids, aptamers can specifically bind to wide range of targets including proteins, viral antigens, living...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy

Biomater. Sci., 2024, 12,1716-1725
DOI: 10.1039/D3BM01981K, Paper
Zhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang Li
Through molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Applications of peptide-based nanomaterials in targeting cancer therapy

Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article
Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
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Copper(II)-based metal–organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy via H2O2 self-supply and glutathione depletion

Biomater. Sci., 2024, 12,1871-1882
DOI: 10.1039/D3BM01922E, Paper
Meng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong Zhu
A Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu2+ and Vc-Ca to achieve improved chemodynamic therapy via H2O2 self-supply and GSH depletion.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article
Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Trap & kill: a neutrophil-extracellular-trap mimic nanoparticle for anti-bacterial therapy

Biomater. Sci., 2024, 12,1841-1846
DOI: 10.1039/D4BM00145A, Paper
Jingtao Zheng, Lei Rong, Yao Lu, Jing Chen, Kai Hua, Yongzhong Du, Qiang Zhang, Weishuo Li
A neutrophil-extracellular-trap mimic nanoparticle effectively eliminates bacteria in a trap & kill manner.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sorafenib and tetrakis (4-carboxyphenyl) porphyrin assembled nanoparticles for synergistic targeted chemotherapy and sonodynamic therapy of hepatocellular carcinoma

Biomater. Sci., 2024, 12,1864-1870
DOI: 10.1039/D3BM01994B, Paper
Yongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng Bai
Hepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Biomater. Sci., 2024, 12,1801-1821
DOI: 10.1039/D3BM01688A, Paper
Manju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti Panda
The graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.
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Application of a meshed artificial dermal scaffold and negative-pressure wound therapy in the treatment of full-thickness skin defects: a prospective in vivo study

Biomater. Sci., 2024, 12,1914-1923
DOI: 10.1039/D3BM01675G, Paper
Open Access
Pei Wei, Lijiao Wu, Hongteng Xie, Zhaohong Chen, Rongwei Tan, Zhaorong Xu
A novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.
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Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01875J, Review Article
Yingxue Jiang, Chenhui Zhu, Xiaoxuan Ma, Daidi Fan
In recent years, the design and synthesis of Janus hydrogels have advanced significantly, overcoming single-performance material limitations and broadening applications in tissue engineering and regenerative medicine.
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Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00083H, Paper
Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao Shuai
An ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.
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A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00003J, Paper
Jing Liu, Jie Zhang, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu, Xianglong Hu, Weiling He
Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.
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Photothermal therapy: a novel potential treatment for prostate cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00057A, Review Article
Zirui Dong, Kaming Xue, Anushikha Verma, Jian Shi, Zhihao Wei, Xiaotian Xia, Keshan Wang, Xiaoping Zhang
This review discussed photothermal therapy from basic information to its circumstances and potential in protate cancer treatment.
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Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00159A, Paper
Shulei Zhang, Bo Zheng, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu
Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions.
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Telomerase: a nexus between cancer nanotherapy and circadian rhythm

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00024B, Minireview
Pramit Kumar Ghosh, Maddila Jagapathi Rao, Chandra Lekha Putta, Sandipan Ray, Aravind Kumar Rengan
The use of nanoparticles for identifying and suppressing telomerase presents promising opportunities for anticancer strategies, particularly in relation to circadian regulation.
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Correction: Clodronate-nintedanib-loaded exosome–liposome hybridization enhances the liver fibrosis therapy by inhibiting Kupffer cell activity

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90028F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00357H, Paper
Bin Zhang, Rui Yang, Hongwei Yu, Yamin Peng, Haoyu Huang, Meera Moydeen Abdul Hameed, Han Wang, Guixiang Zhang, Mohamed EL-Newehy, Mingwu Shen, Xiangyang Shi, Shaojun Peng
Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood–brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.
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PET image-guided kidney injury theranostics enabled by a bipyramidal DNA framework

Biomater. Sci., 2024, 12,2086-2095
DOI: 10.1039/D3BM01575K, Paper
Open Access
Pinghui Li, Zhidie Huang, Xiaoyan Duan, Tao Wang, Shaowen Yang, Dawei Jiang, Jianbo Li
We constructed 68Ga-BDF and employed PET imaging to establish its pharmacokinetic model. BDF was eliminated from the body via the urinary system. We observed distinct imaging indicators in UUO and AKI mouse models. Furthermore, we observed the therapeutic effect of BDF on AKI.
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