An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

Provided herein are methods of treatment to regenerate, restore or rejuvenate a tissue. Methods include making adult somatic and germ cells pluripotent for administration to a patient. Alternatively, created pluripotent cells may be differentiated to the desired tissue type and administered to a patient to repair or enhance the target tissue.

A device and methods for bilateral or unilateral physical therapy of lower limbs are disclosed. The device comprises a curved rail mounted on a base and a pair of support members configured to accommodate a portion of a leg of a person, and to slide along the curved rail. The curved rail allows lateral movements of the lower limbs with the support members, the movements being driven by a force of the lower limbs. The methods of the invention allow physical unilateral or bilateral therapy of lower limbs of a person. The initial reinforcement of the lower limbs of a person is improved by the use of this device, which reduces the friction or the resistance caused by the device during the prescribed movements. The invention provides to patients with severe lower limb disability, a physical therapy device that is easy to use with minimum supervision by a physical therapist.

A universally adjustable pillow for use in healthcare and/or therapy includes a base board (1), and pillows for, respectively, right lateral recumbency (4), supine recumbency (2), left lateral recumbency (5) and for the neck (3) that are arranged on said base board (1). The pillows for left and right lateral recumbency (5,4) each include an external cushion, a mechanism enabling adjustment to fit vertebral curvature (52, 42), a mechanism enabling adjustment to inhibit too great an angle of lateral tilt (53, 43) and height adjustment members (51, 41). The longitudinal axes of the pillows for left and right lateral recumbency (5, 4) are set an angles α and β to the longitudinal axis of the pillow for supine recumbency (2).

Method and devices for treating equine laminitis by cryotherapy, comprising a boot to be fitted over the horse's hoof, having a wedge shaped sole that is angled by 20° toward the front; The purpose is accomplished by the boot in conjunction with three opportunely shaped removable soles, and a cryotherapy reservoir of flexible material, that is inserted into the boot and connected to an external device for refrigeration by circulation of a fluid.

A semiconductor device includes a first moisture-resistant ring disposed in a peripheral region surrounding a circuit region on a semiconductor substrate in such a way as to surround the circuit region and a second moisture-resistant ring disposed in the peripheral region in such a way as to surround the first moisture-resistant ring.

A body bag (900) can be assembled by a stitching process while providing increased fluid retention capabilities. An upper outer layer (101) and a lower outer layer (102), each of which can be non-woven materials, form the outer surfaces of the body bag (900). An absorbent layer (103) is disposed between the upper outer layer (101) and the lower outer layer (102). One or more edges (303,403,503,603) can be folded into a periphery (332) of the body bag (900). Stitching (802) can then be applied along the periphery (332) such that the stitching (802) passes through the upper outer layer (101), the lower outer layer (102), an upper edge (994) of the fold in the absorbent layer (103), and a complementary bottom edge (995) of the fold in the absorbent layer (103). Handles (1001,1002,1003,1004) can be included as well.

An electronic device capable of ejecting a peripheral element is disclosed, including a housing, a first wheel and a driving unit. The housing has a chamber, wherein the peripheral element is stored in the chamber. The first wheel is disposed in the housing, wherein the first wheel contacts the peripheral element. The driving unit is disposed in the housing, the driving unit rotates the first wheel, and the first wheel moves the peripheral element from a first position to a second position.

An interior sock is fabricated of a flexible elastic polymer. The interior sock has a cylindrical closed toe section, a cylindrical open ankle section and an intermediate heel section. The heel section is provided between the toe and ankle sections. An exterior sock is fabricated of a knitted blend of cotton and a minor portion of an elastic. The exterior sock has a cylindrical closed toe section, a cylindrical open ankle section and an intermediate heel section. The heel section is provided between the toe and ankle sections. A quantity of therapeutic fluid is located within the interior sock. The therapeutic fluid is in contact with a foot of a user. The interior sock provides support for the therapeutic fluid. The exterior sock provides pressure and warmth to the interior sock and the therapeutic fluid.

In certain example embodiments, a system and/or method of guiding transitions between therapy modes in connection with the treatment and/or diagnosis of a patient for a respiratory disorder is/are provided. Respiratory disorder treatment according to a first therapy mode is provided. Input indicating a second therapy mode to be transitioned to following provision of the first therapy mode is received, with the second therapy mode being different from the first therapy mode. At least one default treatment parameter suitable for the second therapy mode is assigned or calculated. Each default treatment parameter of the second therapy mode is presented, with each default treatment parameter being adjustable by an operator during the presenting. Transitioning from the first therapy mode to the second therapy mode is performed by providing respiratory disorder treatment in accordance with the second therapy mode and each default treatment parameter and any adjustments made thereto prior to the transitioning. Advantageously, the chances of a patient being disturbed by transitioning from mode-to-mode are reduced.

Methods, systems, and apparatuses are described that indicate an amount at which various gas flow rates should be manually adjusted in order to achieve targeted total flow rates and concentration levels.

One embodiment is directed to a method for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source, wherein the targeted tissue structure comprises a sensory neuron of the patient; and automatically operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

As affordable mental health care becomes harder to access, more people are downloading self-help and therapy apps to address problems as wide ranging as phobias, depression, procrastination, and anxiety. But do these apps actually work? In the brave new world of digitally delivered mental health care, will your next therapist be an algorithm? Guests: Elissa Chakoff, Clinical Implementation Manager, Recovery Record Christy Choy, Marriage and Family Therapist and Talkspace Provider C. Barr Taylor, MD, Professor of Psychiatry and Behavioral Sciences, Emeritus, Stanford University and Research Professor and Director of the Center for M2 Health at Palo Alto Universiy. Resources: Psyberguide VA App Store

In this week’s Medical Minute, Dr. Joseph Hobbs, chairman of the Department of Family Medicine at the Medical College of Georgia at Augusta University, discusses a push to study a group of genes that may hold the key to finding better therapies for women with a rare, aggressive uterine cancer. The Medical Minute airs at 8:18 a.m., 1:20 p.m. and 5:18 p.m. every Saturday and Sunday on the 17 GPB radio stations across Georgia. For more Medical Minute episodes, visit the Medical Minute 2020 SoundCloud page.

Die Lira fällt seit Wochen, die Devisenreserven des Landes sind fast schon aufgezehrt. Das könnte sogar zu einem Staatsbankrott führen. Zwei Länder könnten zwar als Retter einspringen – doch sie würden das Grundproblem der Türkei nicht beheben.

In this week’s Medical Minute, Dr. Joseph Hobbs, chairman of the Department of Family Medicine at the Medical College of Georgia at Augusta University, discusses a push to study a group of genes that may hold the key to finding better therapies for women with a rare, aggressive uterine cancer. The Medical Minute airs at 8:18 a.m., 1:20 p.m. and 5:18 p.m. every Saturday and Sunday on the 17 GPB radio stations across Georgia. For more Medical Minute episodes, visit the Medical Minute 2020 SoundCloud page.

Float Therapy is the moniker of 19-year-old musician Padraig Wilson. In fact, he also happens to write and record all the instruments himself. Float Therapy is a relatively new artist with a whole lot to say and he only recently released his first single "Gaffer Tape"- an intense, solid anthem that takes inspiration from the […]

The post Float Therapy unintentionally pays homage to Weekend at Bernie's in "Gaffer Tape" [Video] appeared first on EARMILK.

CHARLESTON, W.Va. (AP) — Dig. Plant. Breathe. As spring’s arrival in the Northern Hemisphere coincides with government stay-at-home orders, the itch to get outside has turned backyard gardens into a getaway for the mind in chaotic times. Gardeners who already know that working with soil is a way to connect with nature say it helps […]

Shares of Pluristem Therapeutics Inc. (PSTI) are rising over 16% in pre-market today, after the company announced that the European Investment Bank has approved a ?50 million non-dilutive financing for the company.

Shares of TherapeuticsMD Inc. (TXMD) are soaring over 17% in pre-market today, after the company announced that the United States Patent and Trademark Office has issued a patent that covers the labeled indication for ANNOVERA, the first and only long-lasting, patient-controlled, procedure-free, reversible prescription contraceptive option for women.

Shares of Akebia Therapeutics, Inc. (AKBA) are gaining over 25% on Tuesday morning after the drug maker reported positive topline results from a late stage study on patients with chronic kidney disease.

Shares of Horizon Therapeutics plc (HZNP) are rising almost 9 percent or $3.29 in Wednesday's morning trade at $40.67 on better-than-expected first-quarter results and upbeat sales outlook for the full year.

The coronavirus hits New York City hard, doctors revisit a century-old blood therapy in the hopes of treating COVID-19, a hockey commentator is doing play-by-play for fans' pet videos, what the coronavirus outbreak means for the zero waste movement, toilet paper shortages spark an interest in bidets, Mariko Tamaki is taking over writing DC's Wonder Woman comic, and more.

Thunder Bay psychologist and the healing power of forest therapy walks, Torbay Nfld boy gets bravery award for saving a classmate's life, London Ontario cabbie of twenty years talks about what he enjoys and what irks him and remembering 97 year old Sara Sexton of Newfoundland who died last month.

A Rotary Club in WA has been trialling a form of cheap and simple therapy for people living with dementia. Having seen some remarkable results, the plan is now to push the program further.

Courts of law exist for good reason, but the judicial process can also retraumatize, rather than heal, victims and witnesses who are exposed to it. Therapeutic jurisprudence offers a different approach

Allison Davies says when she uploaded a cheerful ditty about wellness on her Instagram page she had no idea it would strike a chord with families worldwide.

A team of volunteer dog owners are faithfully visiting aged-care homes with their canine companions, bringing much joy and contentment to many of the residents.

A central Victorian woman is one of only three accredited teachers of a Japanese form of freestyle weaving that is beginning to grow in popularity.

Music teacher and actress Kimmie Jonceski performed a lead role in a musical while undergoing chemotherapy for breast cancer this year and wants her courageous story to inspire other young women facing a cancer diagnosis.

Once the scene of entrenched, intergenerational alcohol abuse, a historical hotel in WA's remote Pilbara region is now a symbol of hope and cultural pride.

Cancer patients in the remote Pilbara will soon be trialling chemotherapy via video link, saving them a 1,500-kilometre trip for life-saving treatment.

Cryotherapy is used by pro athletes and "weekend warriors" alike. But are the benefits of subjecting your body to extreme cold really worth it? I jumped into the chamber to find out.

An openly gay and Christian psychologist says gay conversion therapy nearly killed him and some of his clients and the sooner it is outlawed the better.

The shrinking town of Poochera is pinning its hopes of survival on a big statue and a prehistoric ant, and locals say their plan may just be enough to save their home from dying out completely.

On the outskirts of Bendigo in central Victoria, a farm run by a social worker is helping children and adults with behavioural and mental health issues.