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Wood Green fire: Huge blaze breaks out at block of flats in north London

A huge blaze has broken out at a block of flats in north London.




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Deptford fire: Firefighters battle early morning blaze in block of flats

Ten fire engines and around 70 firefighters have been battling a blaze in a block of flats in south east London.




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Protesters block Michigan streets to oppose coronavirus lockdown measures

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here




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HS2 Rebellion protesters block Euston building site entrance of controversial new high speed rail line

A group calling themselves 'HS2 Rebellion' have blocked the entrance to a building site at Euston.




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Forty firefighters tackle blaze at 20-storey tower block in west London

Forty firefighters tackled a blaze on the 17th floor of a block of flats in west London on Thursday morning.




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US blocks vote on UN's bid for global ceasefire over reference to WHO

Security council had spent weeks seeking resolution but Trump administration opposed mention of organizationThe US has blocked a vote on a UN security council resolution calling for a global ceasefire during the Covid-19 pandemic, because the Trump administration objected to an indirect reference to the World Health Organization.The security council has been wrangling for more than six weeks over the resolution, which was intended to demonstrate global support for the call for a ceasefire by the UN secretary general, António Guterres. The main source for the delay was the US refusal to endorse a resolution that urged support for the WHO’s operations during the coronavirus pandemic.Donald Trump has blamed the WHO for the pandemic, claiming (without any supporting evidence) that it withheld information in the early days of the outbreak.China insisted that the resolution should include mention and endorsement of the WHO.On Thursday night, French diplomats thought they had engineered a compromise in which the resolution would mention UN “specialized health agencies” (an indirect, if clear, reference to the WHO).The Russian mission signaled that it wanted a clause calling for the lifting of sanctions that affected the delivery of medical supplies, a reference to US punitive measures imposed on Iran and Venezuela. However, most security council diplomats believed Moscow would withdraw the objection or abstain in a vote rather than risk isolation as the sole veto on the ceasefire resolution.On Thursday night, it appeared that the compromise resolution had the support of the US mission, but on Friday morning, that position switched and the US “broke silence” on the resolution, raising objection to the phrase “specialist health agencies”, and blocking movement towards a vote.“We understood that there was an agreement on this thing but it seems that they changed their mind,” a western security council diplomat said.“Obviously they have changed their mind within the American system so that wording is still not good enough for them,” another diplomat close to the discussions said. “It might be that they just need a bit more time to settle it amongst themselves, or it might be that someone very high up has made a decision they don’t want it, and therefore it won’t happen. It is unclear at this moment, which one it is.”A spokesperson for the US mission at the UN suggested that if the resolution was to mention the work of the WHO, it would have to include critical language about how China and the WHO have handled the pandemic.“In our view, the council should either proceed with a resolution limited to support for a ceasefire, or a broadened resolution that fully addresses the need for renewed member state commitment to transparency and accountability in the context of Covid-19. Transparency and reliable data are essential to helping the world combat this ongoing pandemic, and the next one,” the spokesperson said.While the force of the resolution would be primarily symbolic, it would have been symbolism at a crucial moment. Since Guterres made his call for a global ceasefire, armed factions in more than a dozen countries had observed a temporary truce. The absence of a resolution from the world’s most powerful nations, however, undermines the secretary general’s clout in his efforts to maintain those fragile ceasefires.Talks will continue next week at the security council to explore whether some other way around the impasse can be found.





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CenturyLink still hasn’t met 2019 FCC deadline, now faces pandemic roadblocks

Pandemic disrupts broadband progress as cities halt construction.




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'Friday the 13th' at 40: How this horror classic cemented the blockbuster slasher

Sean S. Cunningham's slasher 'Friday the 13th' is celebrating its 40th anniversary this week. Its effect on the horror genre defined the 1980s.




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TV Throws Its Biggest Ad Pitch at a Madison Avenue Filled With Roadblocks

Linda Yaccarino, the hard-charging ad-sales chief of NBCUniversal. will soon be running into uncharted territory. In recent years, Yaccarino has railed against Nielsen and taken a public swipe at Facebook. She has urged advertisers to consider running fewer commercials on NBC and to  work to make the ones that remain more ambitious and interesting. On […]




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White House won't let Fauci testify in House on coronavirus, but denies he's 'blocked'

White House press secretary Kayleigh McEnany denied on Wednesday that the Trump administration had blocked Dr. Anthony Fauci from testifying before a House committee.






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Forty firefighters tackling blaze at 20-storey tower block in west London 




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Chris Hemsworth hopes Marvel blockbusters will bring audiences to reopened cinemas

The Thor star was thankful to finally be on a well-deserved break from his hectic schedule.




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Newcastle takeover: beIN Sports urge Premier League to block Saudi Arabia-backed bid over piracy

The Premier League has been asked to consider blocking a Saudi-backed consortium's attempt to purchase Newcastle United by one of the league's major broadcast partners.




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DJ Jazzy Jeff To Host Virtual Block Party



The all-day extravaganza is set for Saturday.




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Riot Games accuses regulators of 'questionable tactics' to block gender bias settlement

California state agencies argue that women who worked at the video game company could deserve up to $400 million. The company—and the lawyers for women who worked there—strongly disagree.




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Man in hospital after jumping from window of block of flats to escape fire

The fire started in the kitchen of a second floor flat on Wendon Road, in Baguley



  • Greater Manchester News

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Heathrow can appeal against third runway block

The airport has been granted permission to appeal a block on its expansion plans




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China and COVID-19 offer test case for blockchain

The COVID-19 pandemic did not stop China from launching its national blockchain-based service network…



  • China/Coronavirus/Digital Pharma/Focus On/GlobalData/Pharmaceutical

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Checkpoint blocker plus chemo shows impact in lung cancer

A multi-year collaboration between China’s Innovent Biologics and USA-based Eli Lilly is bearing fruit,…



  • Biotechnology/China/Drug Trial/Eli Lilly & Company/Gemzar/Immuno-oncology/Innovent Biologics/Research/Tyvyt/USA

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Novel ADC continues on path to blockbuster status

Tokyo’s Daiichi Sankyo has submitted a supplemental New Drug Application (sNDA) for trastuzumab deruxtecan…



  • Asia Pacific/AstraZeneca/Biotechnology/Daiichi Sankyo/Enhertu/Focus On/Japan/Oncology/Regulation/Research/trastuzumab deruxtecan/UK

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United States Files Suit Against Missouri-Based Pharmaceutical to Block Manufacturing and Shipping of Unapproved Drugs

The United States has filed a lawsuit to block KV Pharmaceutical Company, its subsidiaries, ETHEX Corp. and Ther-Rx Corp., and its principal officers from making and distributing adulterated and unapproved drugs. At the same time, KV agreed to the injunction in a consent decree.



  • OPA Press Releases

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Federal Court Blocks Chicago Tax Preparation Firm from Claiming Improper Tax Credits

A federal court has barred a Chicago tax preparation firm, El Caminante, Inc. and its principal operator, Maria Colica, from preparing federal income tax returns claiming false tax credits. The company and Colica agreed to the injunction. The Government civil injunction complaint filed in the case alleged that Colica fraudulently claimed fuel tax credits for customers who were not entitled to them.



  • OPA Press Releases

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Government Files Seven Lawsuits Nationwide to Block Alleged Scheme Involving Fraudulent Tax-Refund Claims

The federal suits – filed in Los Angeles; Panama City, Fla.; Salt Lake City; Nashville, Tenn.; and Pocatello, Idaho – allege that the defendants promote a tax fraud scheme designed to siphon hundreds of millions of dollars from the U.S. Treasury through fraudulent tax refund claims.



  • OPA Press Releases

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Federal Court Permanently Blocks Tennessee Woman from Preparing Federal Tax Returns for Others

A federal court has issued a permanent injunction barring Karen Liane Miller of Nashville, Tenn., from preparing federal income tax returns for others.



  • OPA Press Releases

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Justice Department Sues to Block Alleged $15 Million Dollar Tax Fraud Scheme Operating in Southern California

The United States has sued a father and two sons, all of Huntington Beach, Calif., seeking to bar them and their business from preparing federal tax returns for others.



  • OPA Press Releases

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Justice Department Reaches Settlement with Blockbuster Inc. Under the Americans with Disabilities Act

The Justice Department today announced a settlement agreement under the Americans with Disabilities Act (ADA) with Blockbuster Inc. to ensure equal access to its stores nationwide for individuals with disabilities who use service animals.



  • OPA Press Releases

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Attorney General Expresses Opposition to Legislation Blocking Transfer of Guantanamo Detainees

Attorney General Eric Holder wrote to Senate Majority Leader Harry Reid and Senate Minority Leader Mitch McConnell today in opposition to language in the proposed 2011 Full-Year Continuing Appropriations Act.



  • OPA Press Releases

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Justice Department Reaches Americans with Disabilities Act Settlement with H&R Block

The Justice Department today announced a comprehensive settlement agreement under the Americans with Disabilities Act with HRB Tax Group Inc., H&R Block Tax Services LLC and HRB Advance LLC (H&R Block) to ensure effective communication with individuals who are deaf or hard of hearing in the provision of income tax preparation services and courses at more than 11,000 owned and franchised offices nationwide.



  • OPA Press Releases

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U.S. Sues Two California Lawyers & Kentucky Financial Professional to Block Nationwide Promotion of "Intermediary Transaction" Tax Shelter

The United States has sued two Southern California attorneys and a Kentucky financial professional to bar them from promoting an allegedly abusive tax shelter known as an “intermediary transaction.”



  • OPA Press Releases

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Justice Department Files Antitrust Lawsuit to Stop H&R Block Inc. from Buying TaxACT

The Department of Justice filed a civil antitrust lawsuit today to block the proposed acquisition by H&R Block Inc. of TaxACT, a digital do-it-yourself tax preparation software provider.



  • OPA Press Releases

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Assistant Attorney General Christine Varney Holds Conference Call Regarding Justice Department Lawsuit to Stop H&R Block Inc. from Buying TaxACT

"We are blocking this transaction because the proposed merger would substantially lessen competition in the tax preparation software market, resulting in higher prices, lower quality and reduced innovation," said Assistant Attorney General Varney.




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Justice Department Files Lawsuit Against City of New Berlin, Wisconsin, for Blocking Affordable Housing

The Department of Justice announced today that it has filed a lawsuit against the city of New Berlin, Wis., alleging that the city violated the Fair Housing Act by repeatedly taking action to prevent the construction of an affordable housing development by a private developer, MSP Real Estate Inc.



  • OPA Press Releases

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Justice Department Files Antitrust Lawsuit to Block AT&s Acquisition of T-Mobile

The Department of Justice today filed a civil antitrust lawsuit to block AT&s proposed acquisition of T-Mobile USA Inc.



  • OPA Press Releases

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Justice Department Sues U.S. FDA Employee and Former N.Y. Corrections Official to Block Alleged Tax-Fraud Scheme

The United States has sued Rodney Chestnut and Nafeesah Hines to bar them from promoting an alleged tax fraud scheme.



  • OPA Press Releases

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US Files Lawsuit in Miami to Block Promotion of Tax Fraud Scheme

The United States has sued Sharon Angulo and Claudia Zuloaga to bar them from promoting an alleged tax fraud scheme and from preparing federal tax returns for others.



  • OPA Press Releases

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California Federal Court Blocks Bogus Tax Credit Scheme

A federal court in Los Angeles has permanently barred Lamar Ellis of Brea, Calif., from promoting a scheme involving sales of bogus federal tax credits.



  • OPA Press Releases

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Justice Department Settles Lawsuit Against City of New Berlin, Wisconsin, for Blocking Affordable Housing

The Department of Justice announced today that it has settled its lawsuit against the city of New Berlin, Wis., for race discrimination in violation of the Fair Housing Act.



  • OPA Press Releases

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Justice Department Settles Lawsuit Against Sussex County, Delaware, for Blocking Affordable Housing

The Justice Department announced today that it has settled a lawsuit against Sussex County, Del., and the Planning and Zoning Commission of Sussex County for race and national origin discrimination in violation of the Fair Housing Act.



  • OPA Press Releases

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Justice Department Sues Nevada CPA to Block Promotion of Alleged Tax Fraud Scheme

The United States has sued a Las Vegas-based CPA and two others to stop an alleged tax-fraud scheme, the Justice Department announced today. Named as defendants in the civil injunction suit were CPA Wayne Reeves, Reeves’ wife, Diane Vaoga, and their alleged co-promoter, James Stoll. The government complaint was filed last month in Las Vegas with the U.S. District Court for the District of Nevada. Announcement of the court filing was delayed until Reeves was served with court papers this week.



  • OPA Press Releases

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Justice Department Enters Consent Decree with National Tax Preparer H&R Block Requiring Accessibility of Websites and Mobile Apps Under Americans with Disabilities Act

Acting Assistant Attorney General Jocelyn Samuels of the Civil Rights Division and U.S. Attorney Carmen M. Ortiz of the District of Massachusetts announced today that they have entered into a consent decree with HRB Digital LLC and HRB Tax Group Inc., subsidiaries of H&R Block Inc., to remedy alleged violations of the Americans with Disabilities Act.



  • OPA Press Releases

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FDA approval delayed for Sanofi Genzyme’s next blockbuster

Editor's note: This story was originally published Friday morning, and has been updated to reflect the FDA's decision regarding the drug later that day. A U.S. approval decision for a major drug planned to be marketed by Cambridge-based Sanofi Genzyme that had been expected last Friday has been delayed due to “deficiencies” found during a manufacturing site inspection in France. In its third quarter report, released Friday morning, French drugmaker Sanofi (NYSE: SNY) disclosed that “manufacturing…




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Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis




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HIF1α blockade reduces kidney injury in lupus nephritis




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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TRAIL blockade improves heart function




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How swamped preprint servers are blocking bad coronavirus research




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Mechanisms by which angiotensin-receptor blockers increase ACE2 levels




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice