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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation




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HIF1α blockade reduces kidney injury in lupus nephritis





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Hamilton blocked from novelty helmet change

Lewis Hamilton appears to be the first victim of the FIA's controversial helmet ban after being blocked from wearing a novelty lid in Malaysia




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Liuzzi penalised five grid positions for blocking

Tonio Liuzzi has been slapped with a five-place grid penalty for impeding Nico Hulkenberg, meaning the Force India driver will start the British Grand Prix from 20th




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Anti-money laundering rules: An emergency assistance roadblock

While America’s 30 million small businesses are fighting for their lives against the COVID-19 recession, emergency assistance is facing a roadblock: anti-money laundering (AML) rules. Unless Treasury changes this system, which it can, it will cost American businesses and banks billions of dollars, slow down funds when time is of the essence for keeping Americans…

       




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Sovereignty as responsibility: Building block for R2P

Roberta Cohen and Francis M. Deng write on sovereignty and responsibility as the building block for R2P in the "The Oxford Handbook of the Responsibility to Protect."

      
 
 




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The Structure of the TANF Block Grant

The 1996 welfare reform legislation replaced the Aid to Families with Dependent Children (AFDC) program with a new Temporary Assistance for Needy Families (TANF) block grant that is very different than its predecessor. In the old AFDC program, funds were used almost entirely to provide and administer cash assistance to low-income—usually single-parent—families. The federal government…

       




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Two Blocks From the Culture War: A Local Perspective on Charlottesville

       




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Not much to see in Vancouver's first Passive House apartment block

And that's just the way the architect and developer like it.




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Lego plans to make their iconic plastic blocks … without plastic

The company will spend $1 billion and employ a team of 100 to find a sustainable alternative.




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Ollies Wooden Blocks are like LEGO meets Tinkertoys meets Erector sets

These sets of precision-cut oak blocks and planks, combined with clever connectors, are intended to help spark creativity and imagination in kids, and to "make playtime more meaningful."




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Ollies Blocks encourage kids' imagination & creativity (Review)

Building with blocks and construction toys is a great unstructured activity for kids, and Ollies Wooden Blocks are a superb new addition to the category.




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Tiny House Warriors building tiny homes to block construction of oil pipeline (Video)

These are tiny homes with an activist bent, taking a stand against the incursion of a pipeline that could contaminate indigenous lands.




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Solar blocks could replace solar panels on buildings

The blocks could be part of the architecture of a building, generating more power than just rooftop panels.




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Vancouver apartment block looks like a stack of shipping containers

I mean, shipping containers are hot. But does this kind of shipping container architecture make sense?




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On MNN: A totally brilliant bell, common cleaning mistakes and are ad blockers the death of the web?

A look at our favorite posts from our sister site.




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San Diego Homeowners, Unite for Cheaper Solar Power: One Block Off the Grid Expands Program

If you live in San Diego and find the prospect of banding together with your neighbors to get better rates on installing your own solar panels interesting, then this one is for you: 1BOG (that's One Block Off the Grid ...) has announced that they will




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Coburn Vows to Block Senate Resolution Honoring Rachel Carson

This coming Sunday would've been Silent Spring author and environmental hero Rachel Carson's 100th birthday. In recognition of Carson's contributions to the creation of the modern environmental movement, Sen. Benjanmin L. Cardin (D-MD) has announced his




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Protesters in Portland block Shell’s ship by suspending themselves from a bridge

Activists risk arrest in an effort to prevent slow oil drilling exploration in the Arctic.




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Modernist open plan family home reuses 270 concrete blocks

Built for a sculptor and his new family on the site of an old gold mine and sawmill, this house uses reclaimed concrete blocks weighing a ton each.




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How to make heat blocking curtains for $6

This easy DIY project will save you money and reduce energy consumption by making less work for your air conditioner.




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Vedanta Resources' Orissa Bauxite Refinery Expansion Blocked by Indian Government

Two months after the Indian government stopped plans by UK-based Vedanta Resources to put a bauxite mine on a mountain held sacred by two indigenous tribal groups in Orissa, on the




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Smart window tints to block sunlight, generates energy

The technology could help keep buildings cooler in the warmer months.




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LeGrow is a smart garden system you build with LEGO-like modular blocks (Video)

Perfect for small city apartments, this system allows you to use a variety of add-on components to build your own indoor garden.




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Dudes in pickup trucks are deliberately blocking Tesla superchargers

And yelling profanities in the process.




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CarbonCure concrete blocks store CO2 for a lower carbon footprint

What to do about all that CO2 emitted when you make cement? Inject it back into the stuff and turn it back into limestone.




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Ericsson wants to block iPhone sales in the US

Apple faces more infringement lawsuits, this time with patent holder Ericsson, which seeks damages and an injunction to block iPhone and iPad sales.




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US blocks vote on UN's bid for global ceasefire over reference to WHO

Security council had spent weeks seeking resolution but Trump administration opposed mention of organization

The US has blocked a vote on a UN security council resolution calling for a global ceasefire during the Covid-19 pandemic, because the Trump administration objected to an indirect reference to the World Health Organization.

The security council has been wrangling for more than six weeks over the resolution, which was intended to demonstrate global support for the call for a ceasefire by the UN secretary general, António Guterres. The main source for the delay was the US refusal to endorse a resolution that urged support for the WHO’s operations during the coronavirus pandemic.

Continue reading...




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Smart windows can let visible light through while blocking out heat

A 3D printed grate can be used to make a smart window that blocks heat from sunlight out in the summer while letting it through in the winter, conserving energy




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New smartphone-based tool may aid patients detect urine blockage

Representational Image

Surgeons are developing a new smartphone-based tool that can detect urethral or urine blockage, potentially making it easier for patients to test themselves for the condition from the comfort of their own homes.

The novel technique could take high-speed photography which could capture subtle differences between a normal steady stream of liquid and a stream of liquid with an obstruction.

Urethral strictures are a slowing or blocking of the natural flow of urine due to an injury or infection. It is normally diagnosed by uroflowmetry, a test administered at a physician's office.

"The problem is that patient follow-up after we treat this condition is very poor," said Matthew Gretzer, Associate Professor at the University of Arizona in the US.

"But we need patients to come back to our clinic for a uroflow test to determine if the obstruction is still present," he added.

In order to test Gretzer's hypothesis on high-speed photography, the team created a model of a urethral structure using tubing hooked to a saline bag that could drain through.

Saline fluid was passed through the tubing with and without blockages, created using 3D printed strictures,placed within the tubing. High-speed photography captured both the regular and blocked stream of liquid exiting the tube.

Gretzer contended that photos can be a medium to diagnose blockages and he hopes that patients could send him these images to analyse and make the diagnosis. He plans to create a mobile app which can be downloaded by the patients.

"All patients would need to do is take high-speed images of their urine flow using a strobe light," Gretzer said.

"Strobe light apps are readily available right now for people to use on their phones".

According to the researchers, as fluid exits an opening, a natural breakpoint occurs where the liquid stream forms droplets, but with obstructions in place, it changes.

The results showed that by analysing photos, they could measure the length to this point of droplet formation. This length then directly related to the presence of an obstruction in the tube.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.




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Sensex Ends Lower, Yes Bank Q4 Results, HUL Block Deal, and Top Stocks in Focus Today

Posted by Equitymaster
      

Indian share markets ended their trading session lower yesterday.

Benchmark indices edged lower tracking weak global cues as investors fretted over weak economic data and rising COVID-19 cases.

Barring energy stocks, all sectoral indices ended on a negative note with stocks in the power sector, telecom sector and consumer durables sector witnessing most of the selling pressure.

At the closing bell yesterday, the�BSE Sensex stood lower by 242 points and the�NSE Nifty�closed down by 72 points.

The SGX Nifty�was trading at 9,200, down by 53 points, at the time of writing.

The�BSE Mid Cap�index and the�BSE Small Cap�index ended their day down by 0.5% and 0.1%, respectively.

Speaking of the current stock market scenario, after a sharp rally in the past few weeks, the markets have turned volatile again.

You would be interested in knowing when the market will likely bottom out.

Vijay Bhambwani, editor of Weekly Cash Alerts, has the answer and he has recorded a video about it.

You can check the same here -�This is When the Stock Market Will Bottom Out

Also, our special report, How to Trade the Coronavirus Crash, is the most comprehensive report on how to trade the coronavirus, both from a short-term and long-term perspective. You can�claim your FREE copy here...

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FREE Guide for You: Find the Next Crorepati Stock in this Futuristic Industry

Tanushree Banerjee, the co-head of research, just shared her latest guide:

Find the Next Crorepati Stock in this Futuristic Industry

And she has agreed to make it available for free for a limited time.

If you've not claimed your free copy, then do so now. It might not remain free for long. One more thing...

Tanushree has also discovered one stock from this futuristic industry... which she strongly believes has the potential to make one Rs 1 crore or more in the long run.

She'll reveal more details about this stock in her 'One Stock Crorepati MEGA Summit'

We expect this to a huge event... with more than 10,000 people attending it LIVE.

You simply can't miss it.

Click Here to Download the Guide & Block Your Seat Now. It's Free.
------------------------------

Top Stocks in Focus Today

From the pharma sector, Dr Reddy's Laboratories share price will be in focus as the company announced that the its NDA (new drug application) Elyxyb ((celecoxib oral solution 25 mg/mL) has been approved by the US Food and Drug Administration.

The drug is indicated for the acute treatment of migraine with or without aura in adults.

From the IT sector, HCL Technologies share price will also be in focus as the company reported a 22.8% year-on-year (YoY) rise in consolidated net profit at Rs 31.5 billion compared with Rs 25.7 billion in the same quarter last year.

Revenue for the quarter rose 16.3% YoY to Rs 185.9 billion from Rs 159.9 billion reported in the year-ago quarter. In dollar terms, revenue rose 11.7% YoY to US$ 2,543.40 million from US$ 2,277.80 million. On a sequential basis, dollar sales were flat. Sales growth in constant currency terms rose 13.5% YoY to US$ 2,584.60 million.

To know more about the company, you can read HCL Technologies' Q4FY20 result analysis on our website.

Market participants will also be tracking RBL Bank share price, Cyient share price and Gillette share price as these companies announced their March quarter results yesterday.

You can read our recently released Q4FY20 results of other companies here: Ambuja Cement,�IndusInd Bank,�Axis Bank,�Tech Mahindra,�HUL,�Reliance Industries,�Marico, Kansai Nerolac, NIIT Technologies, Persistent Systems.

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Corona Crash Alert: 7 Stocks You Absolutely Don't Want to Miss

Our Co-Head of Research, Tanushree Banerjee, has identified 7 stocks that could do exceedingly well in the coming years riding on a rare economic event.

And with the corona crash, this opportunity has only become even more exciting.

And she says those who get into these 7 stocks right now have the chance to make potentially LIFE-CHANGING returns in the long run.

So will you be among those who acts on this opportunity now? Or will you be among those who will kick yourself later not taking action now? The choice is yours.

Full details on these 7 stocks are included in Tanushree's special report. And by acting fast, you can claim a copy of this report virtually FREE.

Click here to find out how you can claim your FREE copy
------------------------------

GSK Sells Stake in HUL via Block Deal

From the FMCG sector, Hindustan Unilever (HUL) share price will be in focus as the UK-based Glaxo-SmithKline (GSK) offloaded its stake in HUL via block deals yesterday.

According to the term sheet, over 133 million shares are being offered in the range of Rs 1,850-1,950 to investors through a special block window. The deal will be valued roughly between Rs 246 billion to Rs 259 billion.

GSK and�Horlicks�are selling up to US$ 3.4 billion worth of HUL shares through what could be India's biggest secondary market block trades.

The British drug maker is looking to monetise about 5.7% of�HUL stock it had got after last year's merger of GSK Consumer Healthcare and HUL.

As per the scheme of amalgamation amongst GSK Consumer Healthcare and HUL, GlaxoSmithKline Pte had received 54.08 million shares of HUL, meanwhile Horlicks received 79.69 million shares.

Accordingly, parent company Unilever Plc and group companies' stake in HUL reduced to 61.9%, from 67.2% earlier after the issue of new shares.

Yes Bank Q4FY20 Results

Yes Bank reported better-than-expected March quarter (Q4FY20) results.

Yes Bank�posted a net profit of Rs 26.3 billion on the back of one-time gain attributed to an exceptional item of Rs 63 billion.

The bank has written-down additional tier-1 bonds as part of its planned reconstruction scheme, leading to a one-time gain of Rs 63 billion.

In the absence of the exceptional gain, the bank would have reported a net loss of Rs 36.7 billion.

The bank had reported a net loss of Rs 15.1 billion a year ago, while the same was Rs 185.6 billion in Q3FY20.

The bank's net interest income (NII) for the March quarter came in at Rs 12.7 billion, up 19.6% sequentially.

Net interest margin (NIM) for Q4FY20 came in at 1.9%, compared to 3.1% a year ago.

On the asset quality front, gross non-performing assets (NPA) fell 19% QoQ to Rs 328.8 billion, mostly on account of write-offs.

The bank's deposits plunged to Rs 1.05 lakh crore, down 54% YoY compared with Rs 2.27 lakh crore.

Meanwhile, Advances declined 29% YoY to Rs 1.7 lakh crore from Rs 2.4 lakh crore in the year-ago quarter.

For the financial year 2019-20 (FY20), the private lender posted a loss of Rs 164.2 billion, on a standalone basis, compared to net profit of Rs 17.2 billion in the previous year.

To know more, you can read Yes Bank's latest result analysis on our website.

Speaking of the banking sector, the low access to credit for micro small and medium enterprises (MSMEs) tells us there is a huge opportunity for lenders.

This is evident from the chart below:

India's Huge Lending Opportunity

Of the 60 million MSMEs in India, only 11% had access to credit from organised lenders. Most of them are self-financed or get credit from unorganised sources.

Here's what Tanushree Banerjee wrote about this in one of the editions of�The 5 Minute WrapUp...

  • Self-financing limits the growth of these MSMEs. On the other hand, high interest rates from unorganised sources makes it difficult for them to earn profits.

    The Modi government is looking at various ways�to correct this problem. Mudra loans, online loans facilities are being made available to MSMEs.

    Slowly but surely, lenders are sensing the huge opportunity that lies ahead for this sector.

    Banks and other financial firms with prudent lending practices and strong distribution networks will benefit from this�megatrend.

Tanushree is counting on 7 top stocks from the Indian stock market that will benefit from this megatrend.

As per her, now is the right time to buy these stocks to profit from the�Rebirth of India.�You can read about them here.

And to know what's moving the Indian stock markets today, check out the most recent�share market updates here.



This article (Sensex Ends Lower, Yes Bank Q4 Results, HUL Block Deal, and Top Stocks in Focus Today) is authored by Equitymaster.

Equitymaster is a leading 'independent' equity research initiative focused on providing well-researched and unbiased opinions on stocks listed on the Bombay Stock Exchange.




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Blocking Zinc Uptake Could Prevent Gonorrhea Infection

Blocking key mineral zinc uptake was found to stop gonorrhea infection, the widespread sexually transmitted infection, revealed study by the Institute




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Supreme Court Blocks Restrictions on Abortion Clinics in Louisiana

A new Louisiana law was to require doctors at abortion clinics to obtain a formal affiliation with a local hospital. The Supreme Court has blocked these




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Block Deals




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OECD Global Blockchain Policy Forum 2020

30 Sept-1 Oct 2020 - The 3rd OECD Global Blockchain Policy Forum will address the benefits and risks of blockchain for our economies and societies, identify good policy and regulatory approaches, and investigate uses in specific policy areas.




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OECD Blockchain Policy Forum 2018

4-5 September 2018, Paris - The OECD Blockchain Policy Forum on "Distributed Ledgers: Opportunities and Challenges" was the first major international conference to take stock of blockchain’s impacts across the full range of government activities and public priorities.




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OECD Blockchain Policy Forum 2018

4-5 September 2018, Paris - The OECD Blockchain Policy Forum on "Distributed Ledgers: Opportunities and Challenges" was the first major international conference to take stock of blockchain’s impacts across the full range of government activities and public priorities.




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OECD Global Blockchain Policy Forum 2019

12-13 September 2019 - The 2nd OECD Global Blockchain Policy Forum will address the benefits and risks of blockchain for our economies and societies, identify good policy and regulatory approaches, and investigate uses in specific policy areas.




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Unblocking the productivity potential of local businesses in Ireland

New firm-level analysis undertaken in tandem with the OECD Economic Survey of Ireland 2018 finds that the majority of businesses in Ireland have actually experienced falling productivity since the mid-2000s.




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OECD Blockchain Policy Forum

4-5 September 2018, Paris - The OECD Blockchain Policy Forum on "Distributed Ledgers: Opportunities and Challenges" was the first major international conference to take stock of blockchain’s impacts across the full range of government activities and public priorities.




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What is blocking business investment and productivity growth?

21/05/2016 - It is seven years since the global crisis and despite easy monetary policy, financial regulatory reform, and G20 resolutions favouring structural measures, the world economy is not making a lot of progress. Adrian Blundell-Wignall gives a preview of what’s in the 2016 edition of the OECD Business and Finance Outlook.




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OECD Blockchain Policy Forum

4-5 September 2018, Paris - The OECD Blockchain Policy Forum on "Distributed Ledgers: Opportunities and Challenges" will provide a forum for a discussion on the benefits and risks of blockchain for our economies and societies, and on the kind of policy and regulatory frameworks that are needed to unleash this potential.




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JD Sports turns on Mike Ashley as Footasylum deal blocked

Chairman accuses Sports Direct of participating in process for ‘own commercial interests’




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Royal Mail seeks court order to block walkout

Postal group says strike ballot had ‘irregularities’ making it ‘null and void’




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Trudeau faces pressure to end Canada gas pipeline blockade

Indigenous protests over gas project are snarling rail traffic and hurting businesses




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Germany moves to unblock eurozone banking union

Patrick Jenkins and guests discuss Germany's concession that could unblock progress towards a eurozone banking union, investor moves against Deutsche Bank chairman Paul Achkleitner, and what's behind the recent spate of personnel changes in investment banking. With special guest Lorenzo Bini Smaghi, chairman of Société Générale.


Contributors: Patrick Jenkins, financial editor, Martin Arnold, Frankfurt bureau chief, Olaf Storbeck, Frankfurt correspondent, Jonathan Guthrie, Lex editor, David Crow, banking editor, and Laura Noonan, US banking editor. Producer: Fiona Symon

 

See acast.com/privacy for privacy and opt-out information.




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Erdogan move to block minister’s resignation exposes  Turkish power struggle

President’s intervention over Suleyman Soylu suggests division at regime’s heart, analysts say




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Look, don’t sketch: Peter Aspden on the V&A’s blockbuster dilemma

Citing pressure of visitor numbers, the museum banned sketching at its recent “David Bowie Is” exhibition – a move that shows how hard it is for curators to reconcile accessibility and academic values, the FT’s arts writer says  


See acast.com/privacy for privacy and opt-out information.




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Trump appointees vote to block US coal joint venture

Shares in Peabody Energy and Arch Coal fall sharply after regulatory action