The recent Chicago Teachers Union strike drew attention from Democratic presidential candidates in Illinois, a state won by Democrats in the last White House contest. For 2020, it's possible we could see a twist on that story: big-city teacher strikes in states with less predictable outcomes.

Keisha Oliver, who is pursuing a dual-title doctoral degree in art education and African American and diaspora studies, was named a fall 2024 artist-in-residence at the Penn State College of Engineering’s Learning Factory.

A Kenyan court ruled on Friday that Facebook's parent company Meta could be sued in the East African nation over the dismissal of dozens of content moderators by a contractor.

Roebuck will discuss his past and future projects, many of which were filmed in the Lehigh Valley.

Churches are alive and thriving in the most surprising places.

The Government Employees' Pension Fund delivered a return of 4.9% on investments for its members in the year to end-March.

India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge.

India has ambitious plans to set up nuclear reactors across the country, especially in states where thermal power plants have either completed its life, or where access to coal is a challenge.

In a twist worthy of a Bollywood movie, the 24-year-old lyricist of a song in an upcoming Salman Khan film has been arrested for issuing a death threat - purportedly from the Lawrence Bishnoi gang - to the actor and himself.

Leonardo DiCaprio has won numerous Golden Globe Awards, Screen Actors Guild Awards, and BAFTA Awards

Earlier, actor Ajith had similarly asked fans to call him AK or Ajith Kumar instead of the title "Thala"

Chris Pratt and Katherine Schwarzenegger married in an intimate ceremony in June 2019

Manoj Mitra had been hospitalised earlier on September 20 due to breathing difficulties

Manoj Mitra appeared in Satyajit Ray's classics Ghare Baire and Ganashatru

Amit said, "In that moment, I let parts of my past carry forward"

Born in 1985, Song Jae Rim made his acting debut in the 2009 film Actresses

The actor got married in an intimate ceremony at a temple in Delhi on Tuesday

The couple's sudden wedding announcement took many by surprise, with fans expressing their shock over the actor's private relationship and quick wedding

Former Australia skipper Ricky Ponting and his longtime teammate Justin Langer could potentially miss out commentating on the opening Test against India at Perth

Dover, Del. (July 15, 2021) – The Delaware Division of Small Business and Office of Management and Budget (OMB) announced today the launch of a Market Pressure Relief Fund designed to assist state contractors facing increased costs for construction materials due to the pandemic. The fund will provide adjustment reimbursements for non-transportation construction materials purchased […]

Attorney General Kathy Jennings’ Consumer Protection Unit promulgated final regulations that establish clear rules of the road for the Home Improvement Services industry in Delaware.  The regulations, issued pursuant to the Consumer Fraud Act, become effective today, November 1. The Regulation is based on hundreds of complaints received by the Department of Justice, and it requires a number […]

FOR IMMEDIATE RELEASE THURSDAY, OCTOBER 1, 2020   MEDIA CONTACT: Kenneth Briscoe Delaware Department of Labor Communications Coordinator kenneth.briscoe@delaware.gov   Thursday, October 1, 2020, The Delaware Department of Labor announced that the effective date of The Delaware Contractor Registration Act has been extended to July 1, 2021.    On September 28, 2020, Governor John Carney […]

OFFICE OF MANAGEMENT AND BUDGET: Division Of Facilities Management

Actor-turned-politician Vijay's party Tamilaga Vettri Kazhagam (TVK) has passed a resolution against the BJP's "One Nation, One Election" plan. In the resolution, the TVK declared that the "One Nation, One Election" plan stands against the principles

War of words between Tamil Nadu's ruling DMK and actor-politician Vijay's fledgling Tamizhaga Vetri Kazhagam flared up again Monday, with Chief Minister MK Stalin accusing "new parties" of wanting to "eliminate" his party

The Supreme Court on Tuesday extended the interim protection from arrest granted to Malayalam film actor Siddique in an alleged rape case.

Liam Payne, who rose to fame as a member of the boy band One Direction has died at the age of 31. The British singer fell to his death from the third-floor balcony of Hotel CasaSur Palermo in Buenos Aires, Argentina.

THE Ministry of Commerce yesterday added two United States companies to the Unreliable Entity List over their involvement in arms sales to China’s Taiwan region. In a statement, the ministry said it

Popular South Korean actor, Song Jae-Rim is dead. DAILY POST reports that Song Jae-Rim was known for his role in K-drama ‘The Moon Embracing The Sun’. He was found dead in his apartment on Tuesday November 12 2024, at 39-year-old. According to Korean media outlet Soompi, a two-page letter was discovered at the scene. As […]

K-drama actor Song Jae-Rim found dead

In Lahore on Sunday, Chaudhry Shafay Hussain, the leader of Pakistan Muslim League-Quaid (PML-Q), asserted that his party has no intentions of merging with any other political group. Hussain clarified, “While seat adjustments may occur in specific constituencies with the Pakistan Muslim League-Nawaz, the PML-Q is committed to maintaining its independent identity.” PML-Q’s commitment to ... Read more

The post PML-Q Affirms Independence and Tractor Symbol for Upcoming Elections appeared first on Pakistan Tribune.

[Dabanga] Airstrikes killed dozens and injured others in Nyala and neighbouring Beleil in South Darfur and Mellit, El Koma, and Kabkabiya in North Darfur on Saturday and Sunday, according to a Radio Dabanga listener. Multiple political actors and groups have condemned the "random" air raids.

Satellite images show China working on nuclear reactor for new warship

Concern over the risks of enabling nuclear weapons development is usually focused on nuclear fission reactors, but the potential harm from more advanced fusion reactors has been underappreciated

Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds

Title: Neighborhood Factors Could Raise Your Child's Odds for Asthma
Category: Health News
Created: 7/25/2022 12:00:00 AM
Last Editorial Review: 7/25/2022 12:00:00 AM

Title: Brain Scans Show Risk Factor for Alzheimer's
Category: Health News
Created: 8/25/2011 11:01:00 AM
Last Editorial Review: 8/25/2011 12:00:00 AM

Title: Mental Decline a Risk Factor for Stroke, Study Suggests
Category: Health News
Created: 8/25/2014 12:36:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM

Title: Cheesecake Factory's Breakfast Burrito Tops Latest Xtreme Eating Awards
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Can Breast Cancer Be a Risk Factor for Opioid Use Among Older Patients?
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Obesity in Youth Could Be Big Risk Factor for MS
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Title: Rheumatoid Factor (RF)
Category: Procedures and Tests
Created: 1/28/2002 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Background

Immature lung development and respiratory morbidity place preterm-born children at high risk of long-term pulmonary sequelae. This systematic review and meta-analysis aims to quantify lung function in preterm-born children and identify risk factors for a compromised lung function.

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

BACKGROUND AND PURPOSE:

Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA).

New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.

It's the RPGCast trio bringing you another week of mild insanity. Kelley struggles because Japanese names are hard. Chris wants to take all the cats camping, but Anna Marie swiftly vetoes the idea. The dad jokes arrive in full force, and everyone's thinking about vacations.

The post RPG Cast – Episode 604: “Press 5 for More Rune Factory” appeared first on RPGamer.