Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

Australian Prime Minister Anthony Albanese said Thursday his government will introduce legislation to ban children under 16 years of age from social media.

The historic ocean liner SS United States, whose fate had been in limbo for years, will begin its transition into the world's largest sunken artificial reef beginning this week in Philadelphia, its owner says.

Oct. 16, 2024 — Xsight Labs, a leading fabless semiconductor company providing end-to-end connectivity solutions for next-generation hyperscale, edge, and AI data center networks, has announced the tape-out of the […]

The post Xsight Labs Launches E1 SoC Built on TSMC’s 5nm Tech for AI Workloads appeared first on HPCwire.

TEL AVIV, Israel and MINNEAPOLIS, Oct. 30, 2024 — NextSilicon, a pioneer in high-performance computing (HPC) innovation, today announced its emergence from stealth with the launch of Maverick-2, the industry’s first […]

The post NextSilicon Launches Maverick-2, Introducing Software-Defined Acceleration for HPC Workloads appeared first on HPCwire.

A pair of strong earthquakes has struck off the southern coast of Cuba, inflicting damage and causing landslides.

Gerry Faust, who won five Ohio high school football state titles before taking over as coach at Notre Dame in the early 1980s, has died, his family announced. He was 89.

BEAVERTON, Ore., Oct. 29, 2024 — Ultra Accelerator Link (UALink) Consortium, led by Board Members from AMD, Amazon Web Services (AWS), Astera Labs, Cisco, Google, Hewlett Packard Enterprise (HPE), Intel, Meta […]

The post Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards appeared first on HPCwire.

Noritaka Hoshi, Senior Manager, AI Platform Division, talks about the impetus for and challenges within the development of SX-Aurora TSUBASA or a massive SIMD, created to handle enormous computing and […]

The post Advance Science, Technology and Sophistication with SX-Aurora TSUBASA or Vector Processor or Vector Engine (VE) appeared first on HPCwire.

Raghunandan Mathur, Senior Systems Engineer, NEC, discusses now with modern day programming frameworks designed around the paradigms of scalar architectures and vector-like extensions, many present-day programmers expect a major learning […]

The post Ease of programming on NEC’s Vector Engine or SX-Aurora TSUBASA appeared first on HPCwire.

An emperor penguin is being cared for by wildlife experts after becoming the first member of its species to make the 2,200-mile trek from Antarctica to Australia.

A wallaby on the loose in Kentucky was caught on security camera during a nighttime visit to a Perry County family's front yard.

Australian Defense Minister Peter Dutton called for alliances to protect the nations and people of the Indo-Pacific region.

U.S. Defense Secretary Lloyd Austin signed a new security agreement with Georgia Monday, seeking to buttress relations with the Black Sea nation as it continues to face Russian troops in two of its regions.

U.S. Defense Secretary Lloyd Austin said Ukraine continues to have U.S. support against Russian aggression and is free to decide its own foreign policy during a visit to Kyiv Tuesday. 

Divergent Technologies developed a digital production system that can revolutionize automotive and industrial scale manufacturing. Divergent uses new manufacturing solutions and their Divergent Adaptive Production System (DAPS™) software to make […]

The post Transforming Industrial and Automotive Manufacturing appeared first on HPCwire.

Nov. 8, 2024 — Across the United States, research shows that computer science (CS) courses teach a range of transferable skills that help students as they enter the workforce. But in […]

The post UT Austin-UTEP Partnership Supports Growth of Texas CS Education appeared first on HPCwire.

Consumers thinking of dining out for their next meal may want to consider one instruction for the server -- hold the salt.

Discrimination -- prejudiced actions toward people based on their identity -- may cause stress that impairs gut health and lead to the growth of unhealthy bacteria that promote inflammation, a new study has found.

Slivered onions served on McDonald's Quarter Pounders and other menu items caused a recent E. coli outbreak, the U.S. Centers for Disease Control and Prevention announced Wednesday.

IBM and NASA have developed a new AI foundation model for a wide range of climate and weather applications, with contributions from the Department of Energy’s Oak Ridge National Laboratory. […]

The post IBM and NASA Launch Open-Source AI Model for Advanced Climate and Weather Research appeared first on HPCwire.

WALLISELLEN, Switzerland, Nov. 15, 2023 — Hewlett Packard Enterprise (HPE) today announced that Sauber Motorsport AG is partnering with HPE to advance aerodynamics of its Formula One race cars. The […]

The post HPE Unveils Advanced Computational Fluid Dynamics Solutions for Sauber Motorsport appeared first on HPCwire.

March 20, 2024 — The Pawsey Supercomputing Research Centre invites Australian-based research groups to join the Pawsey Uptake Project call. This initiative will provide teams with access to dedicated Pawsey […]

The post Pawsey Invites Australian Researchers to Advance Scientific Innovation Through the Pawsey Uptake Project appeared first on HPCwire.

Nov. 11, 2024 — A team of researchers used the Frontier supercomputer at the Department of Energy’s Oak Ridge National Laboratory and a new methodology for conducting a genome-wide association […]

The post ORNL’s Frontier Powers KAUST-Led Genome Study for Gordon Bell Prize Nomination appeared first on HPCwire.

Billionaire financier John Paulson has declined a likely appointment as U.S Treasury Secretary by President-elect Donald Trump, he announced.

The U.S. military conducted retaliatory airstrikes Tuesday in Syria, targeting facilities of Iran-backed militias following rockets launched at U.S. forces in the Middle Eastern country.

SpaceX launched 23 Starlink satellites from Cape Canaveral Space Force Center on Wednesday to match its own record of launches in one year.

An unnamed astronaut was released from Ascension Sacred Heart Pensacola in Florida and returned to Johnson Space Center in Houston in good health Saturday, NASA reported.

SpaceX on Saturday successfully launched a Falcon 9 rocket carrying a payload of 22 Starlink Internet communications satellite from Cape Canaveral in Florida, marking a state record 73rd orbital rocket launch this year.

SpaceX has scrubbed Tuesday's launch of 20 Starlink Internet satellites into orbit from the Vandenberg Space Force Base in California until Wednesday, adding to its massive constellation designed to provide online servic

A robot powered by artificial intelligence created an abstract portrait of Alan Turing that could sell for an estimated $180,000.

NASA is inviting pubic participation in some virtual activities to watch the SpaceX space station resupply mission scheduled for a Monday night liftoff from NASA's Kennedy Space Center in Florida.

SpaceX launched a rocket loaded with 6,000 pounds of supplies to the International Space Station on Monday night from the Florida coast.

The Taurid meteor will make its annual appearance in the midnight sky starting Tuesday through Nov. 12, with the "shooting star" appearing best after in the early morning hours.

SpaceX launched another batch of 23 Starlink V2 Mini satellites into low Earth orbit aboard a Falcon 9 rocket from Cape Canaveral Space Force Station Thursday at 3:19 p.m. EST.

The three NASA astronauts that were part of the SpaceX Crew-8 aboard Crew Dragon Endeavour will speak publicly today for the first time since their mission returned to earth late last month.

SpaceX successful launched a South Korean communication satellite from Kennedy Space Center in Florida on Monday afternoon.

"Memories are the architects of our identity," says technologist Pau Aleikum Garcia, but they're not permanent. Photos can be lost amid political unrest or natural disaster, while illnesses like Alzhemier's can rob people of their past. He puts forward a novel solution — "synthetic memories," or dreamlike visualizations of long-gone moments created through generative AI — and explores how it could reconnect families or even enhance cognitive abilities.

TED Fellow and chemosensory researcher Paule Joseph unveils the hidden power of a sense that's too often overlooked: smell. She delves into the science behind smell — from how it evokes memory and emotion to its potential for early disease detection — and advocates for the creation of a baseline test for taste and smell that could open the door to more comprehensive health care.

"Georgia is not heard or seen in the world, and many don't even know the location of the country," says TED Fellow and photographer Daro Sulakauri. Through her striking photographs of life in the shadows of Russian occupation, she uses her camera to create a living archive of her home country and defend against the erasure of its borders, culture and history.

Data isn't just about numbers or trends — it's about capturing the stories that shape our lives, says information designer Giorgia Lupi. Following a long COVID diagnosis, she tracked her symptoms meticulously over four years, the data culminating in a visual "New York Times" narrative that resonated deeply with many others suffering from chronic illness. Lupi invites us to consider data not as a rigid or objective truth, but as a living language used to better understand ourselves, offering a surprising shift in perspective — depending on where you look.

Here's a wild stat: nearly one-third of the world's food production goes to waste each year, a major contributor to the climate crisis. Farmer and UN climate champion Gonzalo Muñoz sheds light on the international negotiations aimed at turning the food system into a climate solution, rather than part of the problem — and shows the progress already underway.

What if you could take something as tiny as a grain of sand — and as common as a glass bottle — and use it to tackle the climate crisis? Waste alchemist Franziska Trautmann shares how the spark of an idea turned into a large-scale operation helping restore the eroded shores of Louisiana and beyond. (Created in collaboration with Ignite Talks)

What will the world look like in 2030? International business consultant Nikolaus S. Lang predicts the evolution of a multipolar world, with multiple emerging coalitions of countries acting in new ways to achieve their economic, technological and military goals. He dives into what this will mean for the global economy, offering five tips for business leaders to prepare for the coming geopolitical landscape.

Seventy-two percent of the world's population lives under some sort of autocratic rule, says freedom fighter Leopoldo Lopez. In a rousing call to defend democracy worldwide, he shares the story of his imprisonment and exile for leading the movement against Venezuela's authoritarian regime — and shares his vision for uniting across borders to champion freedom and stamp out autocracy.

Roger Dooley's Brainfluence has been translated into eleven languages, but the new Spanish reading is the first audio audio translation.

The post Spanish Audiobook for Brainfluence appeared first on Neuromarketing.

Ohio auditor Dave Yost, a Republican, says that virtual schools should be compensated based on what their students learn.

Attendance and login records show that Ohio's Electronic Classroom of Tomorrow was paid for 9,000 students more than it should have been, according to a state audit.

The political landscape for updating school finance systems won’t be any easier in the 2020 legislative season, despite a surging economy, state flexibility under ESSA, and single-party control in many states.

The Maryland State Department of Education "inappropriately stored" personal information of 1.4 million students and more than 230,000 teachers, leaving them vulnerable to potential bad actors, according to an audit published earlier this month.