Some members of South Australia's Aboriginal community have lost 23 members of their family in the past two years and they are desperate for help in dealing with grief.

A court is told a Melbourne man only pretended to plan for terrorist attacks to expose a "mole" he thought was embroiled in a police conspiracy against right-wing groups.

A north Queensland man, whose decomposing and battered body was found in a national park near Townsville in 2015, told friends he owed $10,000 before his body was found in a creek bed, a trial hears.

A clever little baiting device is being hailed as groundbreaking for the way in which it tempts foxes to take a poison bait while discouraging other wildlife.

Alexandros Deligiannis, the man police believe was the original target of Darwin's June mass shooting, faces court charged with three driving offences including driving with a prohibited drug in the body.

The Coalition's cashless welfare card is compared to the intervention and "mission" times by Aboriginal people in the Northern Territory

A leading science institute finds Queensland must move more quickly towards renewable energy and away from coal-fired power by 2030 to meet its share of the nation's emissions reduction targets.

The former superstar sprinter is set to undertake a trial with the Mariners ahead of a possible shock A-League move.

Police storm Kariong's Frank Baxter Centre, bringing all offenders off the rooftop to end a riot at the facility that lasted for almost 24 hours.

A major program to combat fruit fly is underway in two Australian states where the Queensland fruit fly is not native to those areas.

As you might know, Livongo Health, Inc. (NASDAQ:LVGO) just kicked off its latest quarterly results with some very...

It's been a pretty great week for Morphic Holding, Inc. (NASDAQ:MORF) shareholders, with its shares surging 16% to...

Colorado State Patrol will crack down on illegal parking on Loveland and Berthoud passes, the agency said Thursday, days after a video showing scores of cars parked back-to-back along the road went viral amid concerns that the drivers were failing to appropriately social distance.

The feminist parade kicked off last year in Los Angeles.

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

A few people don't want to own one of these intriguing red cement balls. I'm not one of those people.

Lots of gaming headphone deals for those brave enough to go into stores.
These are the deals:

30% Off Turtle Beach Elite Atlas Aero Wireless headset for PC (Expires April 4th)

30% Off Turtle Beach Elite Atlas Pro Wired PC Gaming headset (Expires April 4th)

40% Off Turtle Beach Battle Buds In-ear Gaming headset (Expires April 4th)

15% Off Turtle Beach Stealth 600 Headset All Varieties (Expires April 4th)

30% Off ROCCAT Kone Aimo Owl-Eye Mouse Black & White (Expires April 4th)

30% Off ROCCAT Sense Aimo Mousepad for PC Gaming (Expires April 4th)

As the title states, game is currently $49.99 and finally available for ordering. Add it to your cart plus 2 other $49.99 games, make sure the other 2 are shipped. Either keep them all for around $35 each, or cancel the other 2 games and end up with RE3 on day 1 for $35.

https://www.target.com/p/resident-evil-3-xbox-one/-/A-79468974

https://www.target.com/p/resident-evil-3-playstation-4/-/A-79468973

25% Off ROCCAT Vulcan Aimo Keyboard Black & White/Silver (Expires April 18th)

10% Off My Arcade Gamestation Assorted Items (Expires April 22nd)

30% Off Turtle Beach Elite Atlas Pro Wired PC Gaming Headset (Expires April 25th)

30% Off Turtle Beach Elite Atlas Aero Wireless Headset for PC (Expires April 25th)

25% Off ROCCAT Vulcan Aimo Keyboard Black & White/Silver (Expires April 25th)

25% Off ROCCAT Kain Aimo Wireless Mouse Black & White (Expires April 25th)

25% Off ROCCAT Kain Aimo Mouse Black & White (Expires April 25th)

10% Off My Arcade Gamestation Assorted Items (Expires April 22nd)

25% Off ROCCAT Kain 102 Aimo Mouse PC Gaming, White (Expires April 25th)

Different digital styles to choose from!

Online only.

http://goto.target.com/itunesgiftcards