(United States Fifth Circuit) - Affirmed. The jury award of more than $43 mil. for the breach of a Joint Operating Agreement relating to the plugging and abandonment operation of offshore oil and gas wells in the Gulf of Mexico was affirmed because the application of Louisiana Civil Code and interpretation of the contract was appropriate. No bad faith offset entitlement was found.

What spring break taught me about God.

In March, we went on vacation as a family. It was a beautiful trip—clear skies, blue water, white sandy beaches. The resort where we stayed offered a “kids club” in the morning, so I had time for walks by myself and with Peter, for naps in the shade of a palm tree, for times of prayer, for reading lots of books. It was extravagant and luxurious and strangely challenging all at the same time.

Every day after camp, our kids wanted to go to the pool. They wanted to jump into the safe, contained, semi-toxic water. They wanted to dive for rings on the pool’s concrete floor. They wanted to get a drink at the poolside bar. Every day, we tried to cajole them toward the ocean instead. The ocean, filled with rocks and coral, teeming with life. This vast expanse of water required our respect and our attention with its powerful waves, its constant motion. They liked it once we were there—the feeling of their toes in the sand, the sight of hermit crabs scuttling across the beach, the pulsing rhythm of the water. But even then, every day, they wanted to go back to the pool.

I want to teach our children, and I want to challenge myself, to swim in the ocean. I mean this literally, but I also mean it in every other aspect of our lives.

The easiest area to see this tension in our lives is with food. Recently, our kids have been offered candy at every turn—Easter eggs in the backyard from the church youth group, Easter candy from aunts and uncles, Easter candy in Sunday school, and more from a family egg hunt. Jellybeans, Starburst, Twix, Peeps. Tastes great. Rots their teeth. Gives a burst of energy. And then a crash. They would always choose candy over, say, the lentil soup I offered last night. ...

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Her lawsuit against Associated Papers reveals the details.

The series was previously scheduled to roll out Thursday, April 2 on sibling Science Channel.

The IBM Research findings achieve the highest recorded accuracy of 86 percent by using deep learning and pathology insights to identify the severity of diabetic retinopathy.

Given recent news, we felt compelled to share a couple of tips with our readers. Consider them to be ocean pro-moves.

From the darkness emerges a boot. An old leather, steel-toed, work boot. It shouldn’t be there resting on the seafloor nearly two kilometers deep. I’m…

The Deepwater Horizon disaster released approximately 4 million barrels of oil from the Macondo Wellhead over the course of 87 days in 2010.  Thus, becoming…

The deep sea, areas of the ocean below 200 meters, is the largest biome on Earth‐‐vast, remote, and inhospitable. These conditions create unique challenges for…

Ten years ago, April 20, 11 men on the Deepwater Horizon were incinerated when the BP/Transocean oil rig blew out and exploded. Just 17 months before the Deepwater Horizon destroyed 600 miles of Gulf Coast, BP covered up a

The post Deepwater Horizon: BP’s SECOND Blowout<div id='sec-title'>The Secret History - 10 Year Anniversary</div> appeared first on Greg Palast.

WASHINGTON – Today, the U.S. Environmental Protection Agency (EPA) joined federal partners—including the U.S. Coast Guard, Department of the Interior, the U.S.

Scientists studying diamonds from deep within Earth’s mantle found evidence of a reservoir of rocks and gas that may be nearly as old as the planet itself.

The Justice Department weighed in on a social distancing case in Mississippi to strike a blow for Trump's side in the coronavirus culture wars.

It's surprisingly easy to learn the best techniques that help you get the most out of the simple act of breathing.

Several University of California regents expressed deep skepticism about the use of SAT and ACT tests in admissions decisions, signaling the standardized tests may be headed for elimination as an application requirement.

Cinematographers Rodrigo Prieto and Lawrence Sher compare notes on their films, 'The Irishman' and 'Joker.'

Sure, the Oscars are exciting, but what about the film moments they don't celebrate? That's where the Envy Awards step in.

CEO Mary Barra hopes to invigorate investor interest in GM's stock with an aggressive electric vehicle strategy.

Migrants in Calais and the UK say the Covid-19 pandemic is deepening the struggles they face.

Expert

Hany Farid talks about fighting fake videos: "Mathematically, there's a lot of linear algebra, multivariate calculus, probability and statistics, and then a lot of techniques from pattern recognition, signal processing, and image processing."

Jiuzhaigou National Nature Reserve is one of China's most popular tourist attractions, drawing more than five million visitors per year to the sparsely populated mountains of north-western Sichuan. The reserve has been home to farmer-herders for thousands of years, but to conserve the biodiversity and scenic quality of the reserve, park policies prohibit residents from farming, herding and wood cutting.

Côme Huré, Huyên Pham and Xavier Warin
Math. Comp. 89 (2020), 1547-1579.
Abstract, references and article information

DeepMind's cofounder and head of applied artificial intelligence, Mustafa Suleyman, has abruptly left the company for an indefinite period

(American Association for the Advancement of Science) Microplastic particles entering the sea surface were thought to settle to the seafloor directly below them, but now, a new study reveals that slow-moving currents near the bottom of the ocean direct the flow of plastics, creating microplastic hotpots in sediments of the deep sea.

(Marine Biological Laboratory) Microbial life is bubbling up to the ocean floor along with fluids from deeply buried petroleum reservoirs, reports a team of scientists from the University of Calgary and the Marine Biological Laboratory, Woods Hole.

Xien Yu Chua
Apr 1, 2020; 19:730-743
Technological Innovation and Resources

Purpose: To assess the performance of full dose (FD) positron emission tomography (PET) image synthesis in both image and projection space from low-dose (LD) PET images/sinograms without sacrificing diagnostic quality using deep learning techniques. Methods: Clinical brain PET/CT studies of 140 patients were retrospectively employed for LD to FD PET conversion. 5% of the events were randomly selected from the FD list-mode PET data to simulate a realistic LD acquisition. A modified 3D U-Net model was implemented to predict FD sinograms in the projection-space (PSS) and FD images in image-space (PIS) from their corresponding LD sinograms/images, respectively. The quality of the predicted PET images was assessed by two nuclear medicine specialists using a five-point grading scheme. Quantitative analysis using established metrics including the peak signal-to-noise ratio (PSNR), structural similarity index metric (SSIM), region-wise standardized uptake value (SUV) bias, as well as first-, second- and high-order texture radiomic features in 83 brain regions for the test and evaluation dataset was also performed. Results: All PSS images were scored 4 or higher (good to excellent) by the nuclear medicine specialists. PSNR and SSIM values of 0.96 ± 0.03, 0.97 ± 0.02 and 31.70 ± 0.75, 37.30 ± 0.71 were obtained for PIS and PSS, respectively. The average SUV bias calculated over all brain regions was 0.24 ± 0.96% and 1.05 ± 1.44% for PSS and PIS, respectively. The Bland-Altman plots reported the lowest SUV bias (0.02) and variance (95% CI: -0.92, +0.84) for PSS compared with the reference FD images. The relative error of the homogeneity radiomic feature belonging to the Grey Level Co-occurrence Matrix category was -1.07 ± 1.77 and 0.28 ± 1.4 for PIS and PSS, respectively Conclusion: The qualitative assessment and quantitative analysis demonstrated that the FD PET prediction in projection space led to superior performance, resulting in higher image quality and lower SUV bias and variance compared to FD PET prediction in the image domain.

Corporate Members Event

Event participants

Raj Kulasingam, Senior Counsel, Dentons

Megan McDonald, Head of Investment Banking (International), Standard Bank Group

Chair: Dr Alex Vines OBE, Managing Director, Ethics, Risk & Resilience; Director, Africa Programme, Chatham House

Human antibody response studies are largely restricted to periods of high immune activity (e.g. vaccination). To comprehensively understand the healthy B cell immune repertoire and how this changes over time and through natural infection, we conducted immune repertoire RNA sequencing on flow cytometry-sorted B cell subsets to profile a single individual's antibodies over 11 months through two periods of natural viral infection. We found that 1) a baseline of healthy variable (V) gene usage in antibodies exists and is stable over time, but antibodies in memory cells consistently have a different usage profile relative to earlier B cell stages; 2) a single complementarity-determining region 3 (CDR3) is potentially generated from more than one VJ gene combination; and 3) IgG and IgA antibody transcripts are found at low levels in early human B cell development, suggesting that class switching may occur earlier than previously realized. These findings provide insight into immune repertoire stability, response to natural infections, and human B cell development.

Dynamic tyrosine phosphorylation is fundamental to a myriad of cellular processes. However, the inherently low abundance of tyrosine phosphorylation in the proteome and the inefficient enrichment of phosphotyrosine(pTyr)-containing peptides has led to poor pTyr peptide identification and quantitation, critically hindering researchers' ability to elucidate signaling pathways regulated by tyrosine phosphorylation in systems where cellular material is limited. The most popular approaches to wide-scale characterization of the tyrosine phosphoproteome use pTyr enrichment with pan-specific, anti-pTyr antibodies from a large amount of starting material. Methods that decrease the amount of starting material and increase the characterization depth of the tyrosine phosphoproteome while maintaining quantitative accuracy and precision would enable the discovery of tyrosine phosphorylation networks in rarer cell populations. To achieve these goals, the BOOST (Broad-spectrum Optimization Of Selective Triggering) method leveraging the multiplexing capability of tandem mass tags (TMT) and the use of pervanadate (PV) boost channels (cells treated with the broad-spectrum tyrosine phosphatase inhibitor PV) selectively increased the relative abundance of pTyr-containing peptides. After PV boost channels facilitated selective fragmentation of pTyr-containing peptides, TMT reporter ions delivered accurate quantitation of each peptide for the experimental samples while the quantitation from PV boost channels was ignored. This method yielded up to 6.3-fold boost in pTyr quantification depth of statistically significant data derived from contrived ratios, compared with TMT without PV boost channels or intensity-based label-free (LF) quantitation while maintaining quantitative accuracy and precision, allowing quantitation of over 2300 unique pTyr peptides from only 1 mg of T cell receptor-stimulated Jurkat T cells. The BOOST strategy can potentially be applied in analyses of other post-translational modifications where treatments that broadly elevate the levels of those modifications across the proteome are available.

This special issue focuses on Diabetes, Covid-19 and Inpatient Management.

Recorded April 14, 2020.

This podcast will cover:

1. Inpatient Medication Management for Persons Admitted with Diabetes
2. Outpatient Medication Management for Persons with Diabetes
   1. Hypoglycemic Medication Management
   2. ACE and ARBs
   3. NSAIDs

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Dr. Joshua Neumiller, Vice Chair & Allen I. White Distinguished Associate Professor of Pharmacotherapy at Washington State University

Western Bureau: A number of swimming officials in western Jamaica say that the region’s struggles with underdevelopment will continue even if the COVID-19 pandemic is brought under control. They say this is because they still lack proper pools to...

A TB infection can take two forms, active and latent. Active disease is transmissible, and causes the damage to the lungs which makes TB one of the biggest killers in the world. In the latent form, the bacteria Mycobacterium tuberculosis is quiescent and can stay that way for years until it becomes active and causes those clinical signs. Testing...

Corporate Members Event

Event participants

Raj Kulasingam, Senior Counsel, Dentons

Megan McDonald, Head of Investment Banking (International), Standard Bank Group

Chair: Dr Alex Vines OBE, Managing Director, Ethics, Risk & Resilience; Director, Africa Programme, Chatham House

President Trump has made reshaping the U.S. immigration system a top priority. Yet the fragmented nature of policy-making in the United States—with power split between branches and levels of government—has made it difficult to pursue some of his most ambitious proposals. This report explores the evolution of migration policy under Trump, and what these changes may mean in the long run.

Firefighters in Arizona came to the rescue of a puppy that plunged into a 15-foot-deep hole at a construction site.

While migration once was a lower-priority topic for African governments, the last decade has seen a deepening in governance. Policymakers have integrated migration into their national development strategies and mainstreamed it across policy domains such as health and education. The actions are promising on paper, yet questions remain about the extent to which they will translate to more effective migration management.

When George W. Bush takes the podium tomorrow night to deliver his sixth State of the Union address, what are the chances he will say this? "The war in Iraq has been one gigantic mistake. I am sorry I got us into this mess. I am going to bring the troops home right away."

The Old Dominion is embedding future-ready knowledge and skills into its education system, giving students a personal arsenal of content mastery and core deeper learning skills.